CO5150156A1 - IMIDAZO[4,5,1ij] QUINOLINONAS UTILES EN LA MANUFACTURA DE MEDICAMENTOS PARA EL TRATAMIENTO DE PERTURBACIONES SEXUALES . - Google Patents

IMIDAZO[4,5,1ij] QUINOLINONAS UTILES EN LA MANUFACTURA DE MEDICAMENTOS PARA EL TRATAMIENTO DE PERTURBACIONES SEXUALES .

Info

Publication number
CO5150156A1
CO5150156A1 CO99081563A CO99081563A CO5150156A1 CO 5150156 A1 CO5150156 A1 CO 5150156A1 CO 99081563 A CO99081563 A CO 99081563A CO 99081563 A CO99081563 A CO 99081563A CO 5150156 A1 CO5150156 A1 CO 5150156A1
Authority
CO
Colombia
Prior art keywords
halogen
manufacture
kinolinones
imidazo
medicines
Prior art date
Application number
CO99081563A
Other languages
English (en)
Inventor
Martin Durham Meglasson
Robert B Mccall
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CO5150156A1 publication Critical patent/CO5150156A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Abstract

El uso de un compuesto de fórmula (A) en la manufactura de un medicamento para tratar perturbaciones sexuales en un mamífero:<EMI FILE="99081563_1" ID="1" IMF=JPEG >en donde,R1, R2 y R3 son iguales o distintos y son:-H,C1-C6 alquilo,C3-C5 alquenilo,C3-C5 alquinilo,C3-C5 cicloalquilo,C4-C10 cicloalquilo,C1-C6 alquilo substituido con fenilo,-NR1R2 en donde R1 y R2 se ciclizan con el átomo de nitrógeno adherido para producir pirrolidinilo, piperidinilo, morfolinilo, 4-metilpiperazinilo o imidazolilo;X es:-H,C1-C6 alquilo,-F, -CI, - Br, -I,-OH,C1-C6 alcoxilo,ciano,carboxamida,carboxilo,(C1-C6 alcoxi)carbonilo,A es:CH,CH2,CH-(halógeno) en donde halógeno es -F, -CI, -Br, -I,CHCH3,C=OC=S,C-SCH3,C=NH,C-NH2,C-NHCH3,C-NHCOOCH3,C-NHCN,SO2,N;B es:CH2,CH,CH-(halógeno) en donde halógeno se define anteriormente,C=O,N, NH,N-CH3,D es:CH,CH2,CH-(halógeno) en donde halógeno se define anteriormente, ...
CO99081563A 1999-01-06 1999-12-30 IMIDAZO[4,5,1ij] QUINOLINONAS UTILES EN LA MANUFACTURA DE MEDICAMENTOS PARA EL TRATAMIENTO DE PERTURBACIONES SEXUALES . CO5150156A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11484099P 1999-01-06 1999-01-06
US11505199P 1999-01-08 1999-01-08
US11592299P 1999-01-14 1999-01-14
US12054399P 1999-02-17 1999-02-17

Publications (1)

Publication Number Publication Date
CO5150156A1 true CO5150156A1 (es) 2002-04-29

Family

ID=27493976

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99081563A CO5150156A1 (es) 1999-01-06 1999-12-30 IMIDAZO[4,5,1ij] QUINOLINONAS UTILES EN LA MANUFACTURA DE MEDICAMENTOS PARA EL TRATAMIENTO DE PERTURBACIONES SEXUALES .

Country Status (20)

Country Link
US (9) US6455564B1 (es)
EP (1) EP1140092A2 (es)
JP (1) JP2002534376A (es)
KR (1) KR20010089779A (es)
CN (1) CN1332628A (es)
AU (1) AU782596B2 (es)
BR (1) BR9916759A (es)
CA (1) CA2350946A1 (es)
CO (1) CO5150156A1 (es)
CZ (1) CZ20012459A3 (es)
EA (2) EA200401256A1 (es)
HK (1) HK1041812A1 (es)
HU (1) HUP0105036A3 (es)
ID (1) ID30276A (es)
IL (1) IL144172A0 (es)
NZ (1) NZ512820A (es)
PE (1) PE20001374A1 (es)
SK (1) SK7732001A3 (es)
TR (1) TR200101895T2 (es)
WO (1) WO2000040226A2 (es)

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US6455564B1 (en) * 1999-01-06 2002-09-24 Pharmacia & Upjohn Company Method of treating sexual disturbances
HU224425B1 (hu) * 1999-02-05 2005-09-28 Pharmacia & Upjohn Co. (5R)-(Metilamino)-5,6-dihidro-4H-imidazo[4,5,1-ij]-kinolin-2(1H)-on előállítása során alkalmazható heterociklusos intermedierek
EP1175204A4 (en) * 1999-05-04 2006-05-31 Aradigm Corp AEROSOL FORMULATION AND ARTICLES FOR INCREASING LIBIDO IN WOMEN BY MOMENTARY TESTOSTERONE ADMINISTRATION
US7258850B2 (en) 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
PT1593387E (pt) * 1999-06-23 2009-03-18 Pasteur Institut Composições para o tratamento de desordens comportamentais e deficiências interpessoais.
CA2405565A1 (en) 2000-04-21 2001-11-01 Pharmacia & Upjohn Company Compounds for treating fibromyalgia and chronic fatigue syndrome
AR033520A1 (es) * 2000-04-27 2003-12-26 Upjohn Co (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona
AR031152A1 (es) 2000-10-31 2003-09-10 Upjohn Co Tratamientos nuevos para el sindrome de piernas inquietas
MXPA03007081A (es) * 2001-02-08 2004-10-15 Pharmacia Corp Medicamento de accion rapida para el tratamiento de disfuncion sexual.
US20030073609A1 (en) 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TWI312781B (en) 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
US7037257B1 (en) * 2002-08-22 2006-05-02 Koenig J Frank Erectile dysfuction treatments comprising momentary vacuum therapy alone or with medications
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WO2004032853A2 (en) * 2002-10-04 2004-04-22 Pharmacia Corporation Compositions and methods for treating sexual dysfunction
EP1663230A1 (en) * 2003-09-05 2006-06-07 Novartis AG Compositions comprising benzo(g)quinoline derivatives and prostaglandin derivatives
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EP2324886A1 (en) 2005-07-29 2011-05-25 Concert Pharmaceuticals Inc. Novel deuterated analogues of tadalafil
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Also Published As

Publication number Publication date
NZ512820A (en) 2002-12-20
WO2000040226A3 (en) 2001-02-01
WO2000040226A2 (en) 2000-07-13
EA005412B1 (ru) 2005-02-24
BR9916759A (pt) 2001-09-25
US20040214825A1 (en) 2004-10-28
HK1041812A1 (zh) 2002-07-26
AU782596B2 (en) 2005-08-11
US20020198187A1 (en) 2002-12-26
CZ20012459A3 (cs) 2002-01-16
KR20010089779A (ko) 2001-10-08
US20030004152A1 (en) 2003-01-02
US6809112B2 (en) 2004-10-26
CN1332628A (zh) 2002-01-23
US20040214826A1 (en) 2004-10-28
PE20001374A1 (es) 2000-11-19
SK7732001A3 (en) 2001-12-03
US6455564B1 (en) 2002-09-24
TR200101895T2 (tr) 2001-12-21
AU2348200A (en) 2000-07-24
EP1140092A2 (en) 2001-10-10
US6890945B2 (en) 2005-05-10
US20040214823A1 (en) 2004-10-28
EA200100750A1 (ru) 2001-12-24
US6903127B2 (en) 2005-06-07
CA2350946A1 (en) 2000-07-13
US6921771B2 (en) 2005-07-26
EA200401256A1 (ru) 2005-12-29
ID30276A (id) 2001-11-15
HUP0105036A3 (en) 2002-10-28
IL144172A0 (en) 2002-05-23
US20020107247A1 (en) 2002-08-08
US20030013710A1 (en) 2003-01-16
US20040214824A1 (en) 2004-10-28
JP2002534376A (ja) 2002-10-15
HUP0105036A2 (hu) 2002-05-29

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