EA200401256A1 - (5R)-5-(МЕТИЛАМИНО)-5,6-ДИГИДРО-4H-ИМИДАЗО[4,5,1-ij]ХИНОЛИН-2(1H)-ТИОН ИЛИ ЕГО СОЛЬ И СПОСОБ ЕГО ПОЛУЧЕНИЯ - Google Patents

(5R)-5-(МЕТИЛАМИНО)-5,6-ДИГИДРО-4H-ИМИДАЗО[4,5,1-ij]ХИНОЛИН-2(1H)-ТИОН ИЛИ ЕГО СОЛЬ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

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Publication number
EA200401256A1
EA200401256A1 EA200401256A EA200401256A EA200401256A1 EA 200401256 A1 EA200401256 A1 EA 200401256A1 EA 200401256 A EA200401256 A EA 200401256A EA 200401256 A EA200401256 A EA 200401256A EA 200401256 A1 EA200401256 A1 EA 200401256A1
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EA
Eurasian Patent Office
Prior art keywords
imidazo
dihydro
quinolin
ionion
metylamino
Prior art date
Application number
EA200401256A
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English (en)
Inventor
Брэд А. Экер
Ричард Ф. Хайер
Алан К. Джин
Мальколм В. Мун
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Фармация Энд Апджон Компани
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Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of EA200401256A1 publication Critical patent/EA200401256A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение представляет (5R)-5-(метиламино)-5,6-дигидро-4H-имидазо[4,5,1-ij]хинолин-2(1H)-тион или его фармацевтически приемлемую соль и способ его получения, включающий взаимодействие (5R)-(метиламино)-5,6-дигидро-4H-имидазо[4,5,1-ij]хинолин-2(1H)-она с декасульфидом тетрафосфора; предпочтительно указанное взаимодействие осуществляют при температуре около 125°C и в присутствии пиридина в качестве растворителя. Указанное соединение полезно для лечения сексуальных нарушений у людей и стимуляции спаривания у млекопитающих.
EA200401256A 1999-01-06 1999-12-20 (5R)-5-(МЕТИЛАМИНО)-5,6-ДИГИДРО-4H-ИМИДАЗО[4,5,1-ij]ХИНОЛИН-2(1H)-ТИОН ИЛИ ЕГО СОЛЬ И СПОСОБ ЕГО ПОЛУЧЕНИЯ EA200401256A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11484099P 1999-01-06 1999-01-06
US11505199P 1999-01-08 1999-01-08
US11592299P 1999-01-14 1999-01-14
US12054399P 1999-02-17 1999-02-17

Publications (1)

Publication Number Publication Date
EA200401256A1 true EA200401256A1 (ru) 2005-12-29

Family

ID=27493976

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200401256A EA200401256A1 (ru) 1999-01-06 1999-12-20 (5R)-5-(МЕТИЛАМИНО)-5,6-ДИГИДРО-4H-ИМИДАЗО[4,5,1-ij]ХИНОЛИН-2(1H)-ТИОН ИЛИ ЕГО СОЛЬ И СПОСОБ ЕГО ПОЛУЧЕНИЯ
EA200100750A EA005412B1 (ru) 1999-01-06 1999-12-20 Способ лечения сексуальных нарушений

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200100750A EA005412B1 (ru) 1999-01-06 1999-12-20 Способ лечения сексуальных нарушений

Country Status (20)

Country Link
US (9) US6455564B1 (ru)
EP (1) EP1140092A2 (ru)
JP (1) JP2002534376A (ru)
KR (1) KR20010089779A (ru)
CN (1) CN1332628A (ru)
AU (1) AU782596B2 (ru)
BR (1) BR9916759A (ru)
CA (1) CA2350946A1 (ru)
CO (1) CO5150156A1 (ru)
CZ (1) CZ20012459A3 (ru)
EA (2) EA200401256A1 (ru)
HK (1) HK1041812A1 (ru)
HU (1) HUP0105036A3 (ru)
ID (1) ID30276A (ru)
IL (1) IL144172A0 (ru)
NZ (1) NZ512820A (ru)
PE (1) PE20001374A1 (ru)
SK (1) SK7732001A3 (ru)
TR (1) TR200101895T2 (ru)
WO (1) WO2000040226A2 (ru)

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Also Published As

Publication number Publication date
NZ512820A (en) 2002-12-20
WO2000040226A3 (en) 2001-02-01
WO2000040226A2 (en) 2000-07-13
EA005412B1 (ru) 2005-02-24
BR9916759A (pt) 2001-09-25
US20040214825A1 (en) 2004-10-28
HK1041812A1 (zh) 2002-07-26
AU782596B2 (en) 2005-08-11
US20020198187A1 (en) 2002-12-26
CZ20012459A3 (cs) 2002-01-16
KR20010089779A (ko) 2001-10-08
US20030004152A1 (en) 2003-01-02
US6809112B2 (en) 2004-10-26
CN1332628A (zh) 2002-01-23
US20040214826A1 (en) 2004-10-28
PE20001374A1 (es) 2000-11-19
SK7732001A3 (en) 2001-12-03
US6455564B1 (en) 2002-09-24
TR200101895T2 (tr) 2001-12-21
AU2348200A (en) 2000-07-24
EP1140092A2 (en) 2001-10-10
US6890945B2 (en) 2005-05-10
CO5150156A1 (es) 2002-04-29
US20040214823A1 (en) 2004-10-28
EA200100750A1 (ru) 2001-12-24
US6903127B2 (en) 2005-06-07
CA2350946A1 (en) 2000-07-13
US6921771B2 (en) 2005-07-26
ID30276A (id) 2001-11-15
HUP0105036A3 (en) 2002-10-28
IL144172A0 (en) 2002-05-23
US20020107247A1 (en) 2002-08-08
US20030013710A1 (en) 2003-01-16
US20040214824A1 (en) 2004-10-28
JP2002534376A (ja) 2002-10-15
HUP0105036A2 (hu) 2002-05-29

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