DK412389D0 - Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning - Google Patents

Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning

Info

Publication number
DK412389D0
DK412389D0 DK412389A DK412389A DK412389D0 DK 412389 D0 DK412389 D0 DK 412389D0 DK 412389 A DK412389 A DK 412389A DK 412389 A DK412389 A DK 412389A DK 412389 D0 DK412389 D0 DK 412389D0
Authority
DK
Denmark
Prior art keywords
extraction
pct
procedure
processing solution
epi protein
Prior art date
Application number
DK412389A
Other languages
English (en)
Inventor
Ole Nordfang
Soeren Carlsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK412389A priority Critical patent/DK412389D0/da
Publication of DK412389D0 publication Critical patent/DK412389D0/da
Priority to ES90902177T priority patent/ES2049021T3/es
Priority to EP90902177A priority patent/EP0454739B1/en
Priority to DE90902177T priority patent/DE69005618T2/de
Priority to AU50244/90A priority patent/AU5024490A/en
Priority to DK90902177.6T priority patent/DK0454739T3/da
Priority to US07/730,860 priority patent/US5219993A/en
Priority to AT90902177T priority patent/ATE99323T1/de
Priority to PCT/DK1990/000016 priority patent/WO1990008158A1/en
Priority to JP3502550A priority patent/JP2896605B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK412389A 1989-01-19 1989-01-19 Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning DK412389D0 (da)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK412389A DK412389D0 (da) 1989-01-19 1989-01-19 Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning
ES90902177T ES2049021T3 (es) 1989-01-19 1990-01-18 Metodo de recuperar la proteina epi purificada a partir de una solucion, especialmente una solucion de fermentacion.
EP90902177A EP0454739B1 (en) 1989-01-19 1990-01-18 Method of recovering purified epi protein from a solution especially a fermentation solution
DE90902177T DE69005618T2 (de) 1989-01-19 1990-01-18 Verfahren zur wiedergewinnung eines gereinigten epi-proteins aus einer lösung, insbesondere einer gärungslösung.
AU50244/90A AU5024490A (en) 1989-01-19 1990-01-18 Method of recovering purified epi protein from a solution especially a fermentation solution
DK90902177.6T DK0454739T3 (da) 1989-01-19 1990-01-18 Fremgangsmåde til isolering af oprenset EPI protein fra en opløsning, især en fermenteringsopløsning
US07/730,860 US5219993A (en) 1989-01-19 1990-01-18 Method of recovering purified epi protein from a solution especially a fermentation solution
AT90902177T ATE99323T1 (de) 1989-01-19 1990-01-18 Verfahren zur wiedergewinnung eines gereinigten epi-proteins aus einer loesung, insbesondere einer gaerungsloesung.
PCT/DK1990/000016 WO1990008158A1 (en) 1989-01-19 1990-01-18 Method of recovering purified epi protein from a solution especially a fermentation solution
JP3502550A JP2896605B2 (ja) 1989-01-19 1990-12-31 新しいペプチド基質，調整法及びプロティンｃ定量における用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK412389A DK412389D0 (da) 1989-01-19 1989-01-19 Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning

Publications (1)

Publication Number Publication Date
DK412389D0 true DK412389D0 (da) 1989-01-19

Family

ID=8130438

Family Applications (2)

Application Number Title Priority Date Filing Date
DK412389A DK412389D0 (da) 1989-01-19 1989-01-19 Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning
DK90902177.6T DK0454739T3 (da) 1989-01-19 1990-01-18 Fremgangsmåde til isolering af oprenset EPI protein fra en opløsning, især en fermenteringsopløsning

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK90902177.6T DK0454739T3 (da) 1989-01-19 1990-01-18 Fremgangsmåde til isolering af oprenset EPI protein fra en opløsning, især en fermenteringsopløsning

Country Status (9)

Country Link
US (1) US5219993A (da)
EP (1) EP0454739B1 (da)
JP (1) JP2896605B2 (da)
AT (1) ATE99323T1 (da)
AU (1) AU5024490A (da)
DE (1) DE69005618T2 (da)
DK (2) DK412389D0 (da)
ES (1) ES2049021T3 (da)
WO (1) WO1990008158A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
JP3428687B2 (ja) 1993-06-30 2003-07-22 財団法人化学及血清療法研究所 組織因子凝固系インヒビターの調製法
CA2463655A1 (en) 2001-10-15 2003-04-24 Chiron Corporation Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (tfpi)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices

Also Published As

Publication number Publication date
EP0454739B1 (en) 1993-12-29
DE69005618D1 (de) 1994-02-10
JP2896605B2 (ja) 1999-05-31
ES2049021T3 (es) 1994-04-01
EP0454739A1 (en) 1991-11-06
WO1990008158A1 (en) 1990-07-26
AU5024490A (en) 1990-08-13
JPH05505385A (ja) 1993-08-12
ATE99323T1 (de) 1994-01-15
DE69005618T2 (de) 1994-04-28
DK0454739T3 (da) 1994-04-25
US5219993A (en) 1993-06-15

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