JP2005511096A5 - - Google Patents
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- Publication number
- JP2005511096A5 JP2005511096A5 JP2003551326A JP2003551326A JP2005511096A5 JP 2005511096 A5 JP2005511096 A5 JP 2005511096A5 JP 2003551326 A JP2003551326 A JP 2003551326A JP 2003551326 A JP2003551326 A JP 2003551326A JP 2005511096 A5 JP2005511096 A5 JP 2005511096A5
- Authority
- JP
- Japan
- Prior art keywords
- primer
- annealing
- sequence
- cdna
- mrna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000137 annealing Methods 0.000 claims 151
- 230000003321 amplification Effects 0.000 claims 93
- 238000003199 nucleic acid amplification method Methods 0.000 claims 93
- 239000002299 complementary DNA Substances 0.000 claims 87
- 125000003729 nucleotide group Chemical group 0.000 claims 64
- 239000002773 nucleotide Substances 0.000 claims 63
- 230000000295 complement effect Effects 0.000 claims 54
- 108020004999 messenger RNA Proteins 0.000 claims 54
- 150000007523 nucleic acids Chemical class 0.000 claims 51
- 238000000034 method Methods 0.000 claims 48
- 108020004414 DNA Proteins 0.000 claims 46
- 239000012634 fragment Substances 0.000 claims 38
- 238000004925 denaturation Methods 0.000 claims 36
- 230000036425 denaturation Effects 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 34
- 102000053602 DNA Human genes 0.000 claims 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 22
- 238000006243 chemical reaction Methods 0.000 claims 21
- 108091034117 Oligonucleotide Proteins 0.000 claims 16
- 230000035772 mutation Effects 0.000 claims 15
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 108091092584 GDNA Proteins 0.000 claims 12
- 230000001105 regulatory effect Effects 0.000 claims 12
- 102100034343 Integrase Human genes 0.000 claims 8
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 8
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 8
- 230000002255 enzymatic effect Effects 0.000 claims 8
- 238000010839 reverse transcription Methods 0.000 claims 8
- 230000006820 DNA synthesis Effects 0.000 claims 7
- 229940104302 cytosine Drugs 0.000 claims 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 5
- LOJNBPNACKZWAI-UHFFFAOYSA-N 3-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C=1C=CNC=1 LOJNBPNACKZWAI-UHFFFAOYSA-N 0.000 claims 5
- OZFPSOBLQZPIAV-UHFFFAOYSA-N 5-nitro-1h-indole Chemical compound [O-][N+](=O)C1=CC=C2NC=CC2=C1 OZFPSOBLQZPIAV-UHFFFAOYSA-N 0.000 claims 5
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical class O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 5
- 229960003786 inosine Drugs 0.000 claims 5
- NEJMFSBXFBFELK-UHFFFAOYSA-N 4-nitro-1h-benzimidazole Chemical compound [O-][N+](=O)C1=CC=CC2=C1N=CN2 NEJMFSBXFBFELK-UHFFFAOYSA-N 0.000 claims 4
- 108020004635 Complementary DNA Proteins 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000010804 cDNA synthesis Methods 0.000 claims 4
- 238000002703 mutagenesis Methods 0.000 claims 4
- 231100000350 mutagenesis Toxicity 0.000 claims 4
- YKBGVTZYEHREMT-KVQBGUIXSA-N 2'-deoxyguanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 YKBGVTZYEHREMT-KVQBGUIXSA-N 0.000 claims 3
- CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 claims 3
- CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 claims 3
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 3
- 229930010555 Inosine Natural products 0.000 claims 3
- 108700005084 Multigene Family Proteins 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- WETFHJRYOTYZFD-YIZRAAEISA-N (2r,3s,5s)-2-(hydroxymethyl)-5-(3-nitropyrrol-1-yl)oxolan-3-ol Chemical compound C1[C@H](O)[C@@H](CO)O[C@@H]1N1C=C([N+]([O-])=O)C=C1 WETFHJRYOTYZFD-YIZRAAEISA-N 0.000 claims 2
- NZJKEQFPRPAEPO-UHFFFAOYSA-N 1h-benzimidazol-4-amine Chemical compound NC1=CC=CC2=C1N=CN2 NZJKEQFPRPAEPO-UHFFFAOYSA-N 0.000 claims 2
- VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 claims 2
- 108091028664 Ribonucleotide Proteins 0.000 claims 2
- 239000005547 deoxyribonucleotide Substances 0.000 claims 2
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 2
- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002336 ribonucleotide Substances 0.000 claims 2
- 125000002652 ribonucleotide group Chemical group 0.000 claims 2
- BCJOBEIODHUZEF-UHFFFAOYSA-N 2-(2-methoxyethyl)-5-nitro-1h-indole Chemical compound [O-][N+](=O)C1=CC=C2NC(CCOC)=CC2=C1 BCJOBEIODHUZEF-UHFFFAOYSA-N 0.000 claims 1
- FRYOZNAQLGCIKS-UHFFFAOYSA-N 4-(3-nitro-1h-pyrrol-2-yl)morpholine Chemical compound C1=CNC(N2CCOCC2)=C1[N+](=O)[O-] FRYOZNAQLGCIKS-UHFFFAOYSA-N 0.000 claims 1
- QTJTWXGFPBTKRR-UHFFFAOYSA-N 4-(4-nitro-1h-benzimidazol-2-yl)morpholine Chemical compound N=1C=2C([N+](=O)[O-])=CC=CC=2NC=1N1CCOCC1 QTJTWXGFPBTKRR-UHFFFAOYSA-N 0.000 claims 1
- UTHBAKVGHIUWIP-UHFFFAOYSA-N 4-(5-nitro-1h-indol-2-yl)morpholine Chemical compound C=1C2=CC([N+](=O)[O-])=CC=C2NC=1N1CCOCC1 UTHBAKVGHIUWIP-UHFFFAOYSA-N 0.000 claims 1
- QFFLRMDXYQOYKO-KVQBGUIXSA-N 7-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-imidazo[4,5-d]triazin-4-one Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NN=NC(O)=C2N=C1 QFFLRMDXYQOYKO-KVQBGUIXSA-N 0.000 claims 1
- OXYNAKURPIFROL-PYUPQCDSSA-N 9-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-morpholin-4-yloxolan-2-yl]-3h-purin-6-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@]1(N1C2=NC=NC(O)=C2N=C1)N1CCOCC1 OXYNAKURPIFROL-PYUPQCDSSA-N 0.000 claims 1
- 108700028369 Alleles Proteins 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- LTTZPKKPMZCXJD-UHFFFAOYSA-N aminophosphonic acid;3-nitro-1h-pyrrole Chemical compound NP(O)(O)=O.[O-][N+](=O)C=1C=CNC=1 LTTZPKKPMZCXJD-UHFFFAOYSA-N 0.000 claims 1
- JRTXBRPKDAKSSH-UHFFFAOYSA-N aminophosphonic acid;4-nitro-1h-benzimidazole Chemical compound NP(O)(O)=O.[O-][N+](=O)C1=CC=CC2=C1NC=N2 JRTXBRPKDAKSSH-UHFFFAOYSA-N 0.000 claims 1
- ATWWOPGVWCAISQ-UHFFFAOYSA-N aminophosphonic acid;5-nitro-1h-indole Chemical compound NP(O)(O)=O.[O-][N+](=O)C1=CC=C2NC=CC2=C1 ATWWOPGVWCAISQ-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000001216 nucleic acid method Methods 0.000 claims 1
- -1 phospho Chemical class 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000002741 site-directed mutagenesis Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2001/002133 WO2003050304A1 (en) | 2001-12-08 | 2001-12-08 | Annealing control primer system for regulating primer annealing specificity and its applications |
| KRPCT/KR01/02133 | 2001-12-08 | ||
| PCT/KR2002/000816 WO2003093509A1 (en) | 2002-05-01 | 2002-05-01 | Methods and compositions for improving specificity of pcr amplication |
| KRPCT/KR02/00816 | 2002-05-01 | ||
| PCT/KR2002/001781 WO2003050305A1 (en) | 2001-12-08 | 2002-09-19 | Annealing control primer and its uses |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2005511096A JP2005511096A (ja) | 2005-04-28 |
| JP2005511096A6 JP2005511096A6 (ja) | 2005-08-04 |
| JP2005511096A5 true JP2005511096A5 (enExample) | 2005-12-22 |
| JP4263612B2 JP4263612B2 (ja) | 2009-05-13 |
Family
ID=26625778
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003551326A Expired - Lifetime JP4263612B2 (ja) | 2001-12-08 | 2002-09-19 | アニーリング調節プライマーおよびその使用 |
| JP2003551327A Pending JP2005522190A (ja) | 2001-12-08 | 2002-11-04 | ハイブリダイゼーション部分調節オリゴヌクレオチド及びその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003551327A Pending JP2005522190A (ja) | 2001-12-08 | 2002-11-04 | ハイブリダイゼーション部分調節オリゴヌクレオチド及びその用途 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050164184A1 (enExample) |
| EP (2) | EP1448793B1 (enExample) |
| JP (2) | JP4263612B2 (enExample) |
| KR (2) | KR100649165B1 (enExample) |
| CN (2) | CN1578841B (enExample) |
| AT (1) | ATE407224T1 (enExample) |
| AU (2) | AU2002329104B2 (enExample) |
| BR (2) | BRPI0214741B1 (enExample) |
| CA (2) | CA2468754C (enExample) |
| DE (1) | DE60228750D1 (enExample) |
| ES (1) | ES2314093T3 (enExample) |
| IL (2) | IL162317A0 (enExample) |
| NZ (2) | NZ532531A (enExample) |
| RU (2) | RU2004120771A (enExample) |
| WO (2) | WO2003050305A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030175749A1 (en) | 2001-12-08 | 2003-09-18 | Jong-Yoon Chun | Annealing control primer and its uses |
| US8680063B2 (en) | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| DE602004011546T2 (de) * | 2003-10-02 | 2008-05-29 | Basf Se | Verfahren zur sequenz-saturations-mutagenese (sesam) |
| WO2005045073A1 (en) * | 2003-11-10 | 2005-05-19 | Seegene, Inc. | Method for amplifying unknown dna sequence adjacent to known sequence |
| WO2005083121A1 (en) * | 2004-02-27 | 2005-09-09 | Seegene, Inc. | Method for amplifying members of a gene family |
| US7524631B2 (en) * | 2005-02-02 | 2009-04-28 | Patterson Bruce K | HPV E6, E7 mRNA assay and methods of use thereof |
| RU2400538C2 (ru) * | 2005-03-05 | 2010-09-27 | Сиджен, Инк. | Олигонуклеотид с двойственной специфичностью и способы, в которых он используется |
| WO2006095941A1 (en) | 2005-03-05 | 2006-09-14 | Seegene, Inc. | Processes using dual specificity oligonucleotide and dual specificity oligonucleotide |
| US7892795B2 (en) * | 2005-08-02 | 2011-02-22 | Focus Diagnostics, Inc. | Methods and compositions for detecting BK virus |
| EP2239328A3 (en) | 2005-08-18 | 2011-01-05 | Alnylam Pharmaceuticals Inc. | Methods and compositions for treating neurological disease |
| JP5137118B2 (ja) | 2005-08-30 | 2013-02-06 | 国立大学法人高知大学 | ユニバーサル塩基 |
| KR20070052890A (ko) * | 2005-11-18 | 2007-05-23 | 주식회사 씨젠 | 호흡기 바이러스 핵산 검출용 올리고뉴클레오타이드 |
| KR100860619B1 (ko) * | 2006-02-23 | 2008-09-29 | 주식회사 씨젠 | 성인성 질환 유발 병원체 핵산 검출용올리고뉴클레오타이드 |
| US8192940B2 (en) | 2006-05-04 | 2012-06-05 | Seegene, Inc. | Method for amplifying unknown DNA sequence adjacent to known sequence |
| KR20080037128A (ko) * | 2006-10-25 | 2008-04-30 | 주식회사 씨젠 | 뉴클레오타이드 변이 검출 방법 |
| EP3095873B1 (en) * | 2006-12-21 | 2018-04-18 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| US7820389B2 (en) * | 2007-01-10 | 2010-10-26 | Geneohm Sciences, Inc. | Inhibition of mismatch hybridization by a universal competitor DNA |
| KR100881924B1 (ko) * | 2007-03-14 | 2009-02-04 | 주식회사 씨젠 | 레이블링된 프라이머를 이용한 뉴클레오타이드 변이 검출방법 |
| WO2008143367A1 (en) * | 2007-05-21 | 2008-11-27 | Seegene, Inc. | Haplotyping method by multiplex amplification |
| KR100987352B1 (ko) | 2008-04-15 | 2010-10-12 | 주식회사 인트론바이오테크놀로지 | 비특이 증폭을 감소시킬 수 있는 ｐｃｒ용 프라이머 및이를 이용한 ｐｃｒ 방법 |
| US9534255B2 (en) | 2008-12-17 | 2017-01-03 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| EP3249053A1 (en) | 2009-03-27 | 2017-11-29 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| JP5687414B2 (ja) | 2009-04-20 | 2015-03-18 | オリンパス株式会社 | 多型の識別方法 |
| US20120142004A1 (en) * | 2009-05-21 | 2012-06-07 | Siemens Healthcare Diagnostics Inc. | Universal Tags With Non-Natural Nucleobases |
| KR20210056458A (ko) | 2011-05-04 | 2021-05-18 | 바이오셉트 인코포레이티드 | 핵산 서열 변이체를 검출하는 방법 |
| US8809238B2 (en) * | 2011-05-09 | 2014-08-19 | Fluidigm Corporation | Probe based nucleic acid detection |
| US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
| WO2013038534A1 (ja) * | 2011-09-14 | 2013-03-21 | 日本碍子株式会社 | 標的核酸の検出方法 |
| JP5503021B2 (ja) * | 2011-09-14 | 2014-05-28 | 日本碍子株式会社 | 標的核酸の検出方法 |
| EP2839039B1 (en) * | 2012-04-18 | 2017-06-07 | F. Hoffmann-La Roche AG | Hev assay |
| CN103421777B (zh) * | 2013-09-11 | 2015-05-13 | 北京市农林科学院林业果树研究所 | 无需pcr仪的侧翼核酸序列快速准确扩增方法及应用 |
| KR101525495B1 (ko) * | 2013-11-15 | 2015-06-03 | (주)다이오진 | 덤벨 구조 올리고뉴클레오티드, 이를 포함한 핵산 증폭용 프라이머 및 이를 이용한 핵산 증폭 방법 |
| US20190032122A1 (en) * | 2014-12-19 | 2019-01-31 | Geco Aps | Indel detection by amplicon analysis |
| KR101723207B1 (ko) * | 2015-01-29 | 2017-04-05 | (주)다이오진 | 덤벨 구조의 올리고뉴클레오티드 및 이를 이용한 유전자 변이 검출 방법 |
| US20180073082A1 (en) * | 2015-02-25 | 2018-03-15 | Diogene Co., Ltd | Dumbbell-structure oligonucleotide, nucleic acid amplification primer comprising same, and nucleic acid amplification method using same |
| HUE044940T2 (hu) * | 2016-01-27 | 2019-11-28 | Devyser Holding Ab | Kívánt nukleinsavrégiók szelektív amplifikálása egy célbavett szekvenciában |
| KR101961642B1 (ko) | 2016-04-25 | 2019-03-25 | (주)진매트릭스 | 절단된 상보적인 태그 절편을 이용한 표적 핵산 서열 검출 방법 및 그 조성물 |
| WO2017209575A1 (en) * | 2016-06-03 | 2017-12-07 | Seegene, Inc. | Evaluation of specificity of oligonucleotides |
| KR101856205B1 (ko) * | 2017-11-16 | 2018-06-20 | 제노플랜코리아 주식회사 | 핵산의 대립형질 특이적 프라이머 및 이를 이용한 유전형 판별 방법 |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| CN109868309B (zh) * | 2019-03-05 | 2022-11-11 | 苏州恩可医药科技有限公司 | 基于通用碱基替换插入的单链dna扩增方法 |
| CN110592200B (zh) * | 2019-09-25 | 2023-04-18 | 人和未来生物科技（长沙）有限公司 | 一种改善扩增特异性和均一性的多重pcr方法 |
| CN111635930B (zh) * | 2020-05-12 | 2023-10-24 | 中国农业科学院农业基因组研究所 | 一种高通量测序调取未知rna全长序列的方法 |
| CN113832147B (zh) * | 2021-09-08 | 2024-06-14 | 华南农业大学 | 一种高效的大片段dna合成与扩增的pcr引物、方法及应用 |
| CN115976173B (zh) * | 2022-12-21 | 2026-05-19 | 生工生物工程（上海）股份有限公司 | 一种用于扩增cDNA 5’末端的通用接头引物及5’RACE方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2544292A (en) * | 1991-09-11 | 1993-04-05 | Medical Research Council | Improvements in oligonucleotide primers and probes |
| US6197556B1 (en) * | 1991-12-20 | 2001-03-06 | The University Of Chicago | Nucleic acid amplification using modular branched primers |
| WO1993014217A1 (en) * | 1992-01-10 | 1993-07-22 | Life Technologies, Inc. | Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules |
| US6077668A (en) * | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
| US20020042048A1 (en) * | 1997-01-16 | 2002-04-11 | Radoje Drmanac | Methods and compositions for detection or quantification of nucleic acid species |
| US20020187470A1 (en) * | 1998-06-24 | 2002-12-12 | Casey Warren Michael | Detection of single nucleotide polymorphisms |
| AU7733200A (en) * | 1999-09-30 | 2001-04-30 | Qiagen Genomics, Inc. | Compositions and methods for reducing oligonucleotide hybridization and priming specificity |
| CN1312274A (zh) * | 2000-03-07 | 2001-09-12 | 上海博德基因开发有限公司 | 一种新的多肽——人bcr蛋白10和编码这种多肽的多核苷酸 |
| US6562572B1 (en) * | 2000-09-27 | 2003-05-13 | Mayo Foundation For Medical Education And Research | Methods for amplifying nucleic acid sequences |
-
2002
- 2002-09-19 WO PCT/KR2002/001781 patent/WO2003050305A1/en not_active Ceased
- 2002-09-19 RU RU2004120771/13A patent/RU2004120771A/ru not_active Application Discontinuation
- 2002-09-19 EP EP02765682A patent/EP1448793B1/en not_active Expired - Lifetime
- 2002-09-19 AU AU2002329104A patent/AU2002329104B2/en not_active Ceased
- 2002-09-19 CN CN028225090A patent/CN1578841B/zh not_active Expired - Lifetime
- 2002-09-19 AT AT02765682T patent/ATE407224T1/de not_active IP Right Cessation
- 2002-09-19 BR BRPI0214741-6A patent/BRPI0214741B1/pt unknown
- 2002-09-19 DE DE60228750T patent/DE60228750D1/de not_active Expired - Lifetime
- 2002-09-19 CA CA2468754A patent/CA2468754C/en not_active Expired - Fee Related
- 2002-09-19 KR KR1020047008441A patent/KR100649165B1/ko not_active Expired - Lifetime
- 2002-09-19 BR BR0214741-6A patent/BR0214741A/pt not_active IP Right Cessation
- 2002-09-19 IL IL16231702A patent/IL162317A0/xx unknown
- 2002-09-19 ES ES02765682T patent/ES2314093T3/es not_active Expired - Lifetime
- 2002-09-19 NZ NZ532531A patent/NZ532531A/en not_active IP Right Cessation
- 2002-09-19 JP JP2003551326A patent/JP4263612B2/ja not_active Expired - Lifetime
- 2002-11-04 CA CA002469383A patent/CA2469383A1/en not_active Abandoned
- 2002-11-04 US US10/498,108 patent/US20050164184A1/en not_active Abandoned
- 2002-11-04 AU AU2002348612A patent/AU2002348612A1/en not_active Abandoned
- 2002-11-04 NZ NZ533221A patent/NZ533221A/en unknown
- 2002-11-04 CN CNA028245016A patent/CN1602361A/zh active Pending
- 2002-11-04 KR KR1020047008678A patent/KR100557329B1/ko not_active Expired - Lifetime
- 2002-11-04 EP EP02782004A patent/EP1448795A1/en not_active Withdrawn
- 2002-11-04 WO PCT/KR2002/002051 patent/WO2003050306A1/en not_active Ceased
- 2002-11-04 RU RU2004120769/13A patent/RU2004120769A/ru not_active Application Discontinuation
- 2002-11-04 JP JP2003551327A patent/JP2005522190A/ja active Pending
-
2004
- 2004-06-02 IL IL162317A patent/IL162317A/en active IP Right Grant
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