JP2005504836A5 - - Google Patents

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Publication number
JP2005504836A5
JP2005504836A5 JP2003533944A JP2003533944A JP2005504836A5 JP 2005504836 A5 JP2005504836 A5 JP 2005504836A5 JP 2003533944 A JP2003533944 A JP 2003533944A JP 2003533944 A JP2003533944 A JP 2003533944A JP 2005504836 A5 JP2005504836 A5 JP 2005504836A5
Authority
JP
Japan
Prior art keywords
compound
prostaglandin
dihydro
alkyl
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003533944A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005504836A (ja
JP4786866B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2002/008705 external-priority patent/WO2003030912A1/en
Publication of JP2005504836A publication Critical patent/JP2005504836A/ja
Publication of JP2005504836A5 publication Critical patent/JP2005504836A5/ja
Application granted granted Critical
Publication of JP4786866B2 publication Critical patent/JP4786866B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003533944A 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ Expired - Lifetime JP4786866B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31591701P 2001-08-31 2001-08-31
US60/315,917 2001-08-31
US37210402P 2002-04-15 2002-04-15
US60/372,104 2002-04-15
PCT/JP2002/008705 WO2003030912A1 (en) 2001-08-31 2002-08-29 Prostaglandin analogs as chloride channel opener

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011001763A Division JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Publications (3)

Publication Number Publication Date
JP2005504836A JP2005504836A (ja) 2005-02-17
JP2005504836A5 true JP2005504836A5 (https=) 2006-01-05
JP4786866B2 JP4786866B2 (ja) 2011-10-05

Family

ID=26980134

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003533944A Expired - Lifetime JP4786866B2 (ja) 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Country Status (11)

Country Link
US (2) US7064148B2 (https=)
EP (1) EP1420794B1 (https=)
JP (2) JP4786866B2 (https=)
AR (1) AR036391A1 (https=)
AU (1) AU2002330747B2 (https=)
BR (1) BR0212233A (https=)
CA (1) CA2458471C (https=)
MX (1) MXPA04002006A (https=)
NZ (1) NZ531503A (https=)
TW (1) TWI298256B (https=)
WO (1) WO2003030912A1 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE387204T1 (de) * 2001-05-18 2008-03-15 Sucampo Ag Zusammensetzung mit induzierendem kathartischen effekt
AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
TWI263505B (en) * 2001-11-19 2006-10-11 Sucampo Ag Pharmaceutical composition comprising a C1C-2 channel opener
NZ539582A (en) * 2002-10-23 2007-07-27 Sucampo Ag Prostaglandin compounds for the treatment of obesity
EP1575596B1 (en) * 2002-12-27 2016-06-22 Sucampo AG Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI495471B (zh) 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
TWI387454B (zh) * 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
ES2714198T3 (es) * 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
RU2468800C2 (ru) * 2005-04-12 2012-12-10 Сукампо Аг Комбинированное применение производного простагландина и ингибитора протонового насоса для лечения желудочно-кишечных заболеваний
CA2642744C (en) * 2006-02-28 2015-02-24 Sucampo Ag Method and composition for treating chronic obstructive pulmonary disease
JP5427029B2 (ja) * 2006-09-06 2014-02-26 スキャンポ・アーゲー 消化管の重炭酸分泌を促進するための方法および組成物
US20080207759A1 (en) * 2007-02-27 2008-08-28 Sucampo Ag Method for protecting mitochondria
US20090012165A1 (en) * 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
US20090030072A1 (en) * 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
CA2702094C (en) 2007-10-10 2018-05-01 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
CN101318948B (zh) * 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
RS53234B (sr) * 2009-08-07 2014-08-29 Scipharm Sàrl Kompozicija za lečenje cistične fibroze
AU2010295464B2 (en) * 2009-09-18 2015-11-26 Merck Sharp & Dohme Corp. Use of opioid receptor antagonist for gastrointestinal tract disorders
LT2672957T (lt) * 2011-02-07 2017-02-10 Scipharm Sarl Naujoji kompozicija, skirta cistinės fibrozės gydymui
EP2717855A4 (en) 2011-06-07 2014-11-12 Parion Sciences Inc Methods of Treatment
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
WO2014085655A1 (en) * 2012-11-29 2014-06-05 Indiana University Research And Technology Corporation Dielectric electrolyte measurement device
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US20150057351A1 (en) * 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
US20160228403A1 (en) 2013-10-04 2016-08-11 Tohoku University Agent for preventing or ameliorating renal dysfunction
JP6957610B2 (ja) 2016-10-06 2021-11-02 スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ 医薬品用途のための多層ビーズ
CN110267670B (zh) 2016-10-20 2023-08-15 表飞鸣制药株式会社 对肠道的离子跨细胞转运体的作用剂、氯离子通道活化剂、肾脏疾病的预防或治疗剂或者排便促进剂
US10457623B1 (en) * 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

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IE43462B1 (en) * 1975-06-23 1981-03-11 Pfizer Substituted tetranorprostaglandins
US4091207A (en) * 1976-04-22 1978-05-23 Pfizer Inc. Prostaglandin intermediate including oxathio heterocyclic ring
IT1098350B (it) * 1977-07-28 1985-09-07 Upjohn Co Derivati prostaglandinici
JPS6033429B2 (ja) * 1980-04-28 1985-08-02 小野薬品工業株式会社 プロスタグランジン類似化合物
US5166174A (en) 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
CA1322749C (en) 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5221763A (en) 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
JPH0681728B2 (ja) * 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
ES2051862T3 (es) * 1987-10-02 1994-07-01 Ueno Seiyaku Oyo Kenkyujo Kk Un metodo para producir un medicamento que tiene un efecto catartico.
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
CA2030344C (en) 1989-11-22 2000-04-18 Ryuji Ueno Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
JPH0791192B2 (ja) * 1989-11-22 1995-10-04 株式会社上野製薬応用研究所 ガス交換機能不全処置剤
TW224942B (https=) 1990-04-04 1994-06-11 Adka Ueno Kk
ATE174221T1 (de) * 1990-05-01 1998-12-15 R Tech Ueno Ltd Behandlung von pankreaskrankheit mit 15-keto- prostaglandin e-derivaten
CA2150287C (en) * 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
US6015828A (en) 1996-05-31 2000-01-18 Cuppoletti; John Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
WO1997047595A1 (en) 1996-06-10 1997-12-18 R-Tech Ueno, Ltd. Endothelin antagonist
CA2274670C (en) * 1997-10-13 2011-04-12 R-Tech Ueno, Ltd. 15-keto prostaglandins as portal hypertension inhibitors
AU739343B2 (en) * 1997-11-28 2001-10-11 Sucampo Ag Endothelin antagonist
CA2333038C (en) * 1998-05-25 2008-12-02 Taisho Pharmaceutical Co., Ltd. Sleep-inducing preparation
TWI284535B (en) 2000-03-24 2007-08-01 Sucampo Ag Apoptosis inhibitor
EP1267883B1 (en) 2000-04-06 2009-06-17 Sucampo AG Bile secretion promoting composition for liver transplantation containing a 15-keto-prostaglandin
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
FR2829293B1 (fr) * 2001-08-31 2003-11-14 Centre Nat Rech Scient Memoire moleculaire et son procede de fabrication

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