NZ531503A - Prostaglandin analogs as chloride channel opener - Google Patents
Prostaglandin analogs as chloride channel openerInfo
- Publication number
- NZ531503A NZ531503A NZ531503A NZ53150302A NZ531503A NZ 531503 A NZ531503 A NZ 531503A NZ 531503 A NZ531503 A NZ 531503A NZ 53150302 A NZ53150302 A NZ 53150302A NZ 531503 A NZ531503 A NZ 531503A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkyl
- compound
- hydroxy
- halogen
- hydrogen
- Prior art date
Links
- 102000011045 Chloride Channels Human genes 0.000 title claims description 21
- 108010062745 Chloride Channels Proteins 0.000 title claims description 21
- 150000003180 prostaglandins Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 127
- 125000000217 alkyl group Chemical group 0.000 claims description 106
- -1 prostaglandin compound Chemical class 0.000 claims description 87
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 77
- 239000000203 mixture Substances 0.000 claims description 71
- 125000003545 alkoxy group Chemical group 0.000 claims description 55
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 54
- 239000001257 hydrogen Substances 0.000 claims description 47
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
- 229920006395 saturated elastomer Polymers 0.000 claims description 47
- 229910052736 halogen Inorganic materials 0.000 claims description 46
- 229940125904 compound 1 Drugs 0.000 claims description 44
- 125000003118 aryl group Chemical group 0.000 claims description 42
- 150000002367 halogens Chemical class 0.000 claims description 41
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 29
- 108091006146 Channels Proteins 0.000 claims description 28
- 125000004104 aryloxy group Chemical group 0.000 claims description 24
- 238000012360 testing method Methods 0.000 claims description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
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- 125000001931 aliphatic group Chemical group 0.000 claims description 17
- 125000005843 halogen group Chemical group 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
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- 229910052717 sulfur Chemical group 0.000 claims description 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
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- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
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- A—HUMAN NECESSITIES
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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Landscapes
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- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31591701P | 2001-08-31 | 2001-08-31 | |
| US37210402P | 2002-04-15 | 2002-04-15 | |
| PCT/JP2002/008705 WO2003030912A1 (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ531503A true NZ531503A (en) | 2006-01-27 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ531503A NZ531503A (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
Country Status (11)
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|---|---|
| US (2) | US7064148B2 (https=) |
| EP (1) | EP1420794B1 (https=) |
| JP (2) | JP4786866B2 (https=) |
| AR (1) | AR036391A1 (https=) |
| AU (1) | AU2002330747B2 (https=) |
| BR (1) | BR0212233A (https=) |
| CA (1) | CA2458471C (https=) |
| MX (1) | MXPA04002006A (https=) |
| NZ (1) | NZ531503A (https=) |
| TW (1) | TWI298256B (https=) |
| WO (1) | WO2003030912A1 (https=) |
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| ATE387204T1 (de) * | 2001-05-18 | 2008-03-15 | Sucampo Ag | Zusammensetzung mit induzierendem kathartischen effekt |
| AR037524A1 (es) * | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
| TWI263505B (en) * | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
| NZ539582A (en) * | 2002-10-23 | 2007-07-27 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
| EP1575596B1 (en) * | 2002-12-27 | 2016-06-22 | Sucampo AG | Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia |
| DE602004030245D1 (de) * | 2003-07-03 | 2011-01-05 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
| TWI495471B (zh) | 2003-08-12 | 2015-08-11 | R Tech Ueno Ltd | 促進毛髮生長之組成物及方法 |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| ES2714198T3 (es) * | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| RU2468800C2 (ru) * | 2005-04-12 | 2012-12-10 | Сукампо Аг | Комбинированное применение производного простагландина и ингибитора протонового насоса для лечения желудочно-кишечных заболеваний |
| CA2642744C (en) * | 2006-02-28 | 2015-02-24 | Sucampo Ag | Method and composition for treating chronic obstructive pulmonary disease |
| JP5427029B2 (ja) * | 2006-09-06 | 2014-02-26 | スキャンポ・アーゲー | 消化管の重炭酸分泌を促進するための方法および組成物 |
| US20080207759A1 (en) * | 2007-02-27 | 2008-08-28 | Sucampo Ag | Method for protecting mitochondria |
| US20090012165A1 (en) * | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
| US20090030072A1 (en) * | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
| CA2702094C (en) | 2007-10-10 | 2018-05-01 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
| US20110034424A1 (en) * | 2009-06-30 | 2011-02-10 | Sucampo Ag | Method for the long term nsaid use |
| RS53234B (sr) * | 2009-08-07 | 2014-08-29 | Scipharm Sàrl | Kompozicija za lečenje cistične fibroze |
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2002
- 2002-08-29 EP EP02767866.3A patent/EP1420794B1/en not_active Expired - Lifetime
- 2002-08-29 CA CA2458471A patent/CA2458471C/en not_active Expired - Lifetime
- 2002-08-29 MX MXPA04002006A patent/MXPA04002006A/es active IP Right Grant
- 2002-08-29 JP JP2003533944A patent/JP4786866B2/ja not_active Expired - Lifetime
- 2002-08-29 BR BR0212233-2A patent/BR0212233A/pt not_active Application Discontinuation
- 2002-08-29 NZ NZ531503A patent/NZ531503A/en not_active IP Right Cessation
- 2002-08-29 AU AU2002330747A patent/AU2002330747B2/en not_active Expired
- 2002-08-29 WO PCT/JP2002/008705 patent/WO2003030912A1/en not_active Ceased
- 2002-08-30 AR ARP020103284A patent/AR036391A1/es active IP Right Grant
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5568021B2 (ja) | 2014-08-06 |
| JP2011102313A (ja) | 2011-05-26 |
| AU2002330747B2 (en) | 2007-07-19 |
| JP2005504836A (ja) | 2005-02-17 |
| CA2458471C (en) | 2012-07-31 |
| BR0212233A (pt) | 2004-10-05 |
| CA2458471A1 (en) | 2003-04-17 |
| AR036391A1 (es) | 2004-09-08 |
| MXPA04002006A (es) | 2004-06-07 |
| US7064148B2 (en) | 2006-06-20 |
| WO2003030912A1 (en) | 2003-04-17 |
| US7253295B2 (en) | 2007-08-07 |
| JP4786866B2 (ja) | 2011-10-05 |
| EP1420794A1 (en) | 2004-05-26 |
| EP1420794B1 (en) | 2017-12-27 |
| US20060122411A1 (en) | 2006-06-08 |
| US20030130352A1 (en) | 2003-07-10 |
| TWI298256B (en) | 2008-07-01 |
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