BR0108950A - Novos análogos de ácido graxo - Google Patents
Novos análogos de ácido graxoInfo
- Publication number
- BR0108950A BR0108950A BR0108950-1A BR0108950A BR0108950A BR 0108950 A BR0108950 A BR 0108950A BR 0108950 A BR0108950 A BR 0108950A BR 0108950 A BR0108950 A BR 0108950A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon
- fatty acid
- alkyl
- coor2
- proviso
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C391/00—Compounds containing selenium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Edible Oils And Fats (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"NOVOS ANáLOGOS DE áCIDO GRAXO". A presente invenção se refere a novos análogos de ácido graxo de fórmula geral (I): R~ 1~-[X~ i~-CH~ 2~]n-COOR~ 2~ em que: - R~ 1~ representa: - UM C~ 6~-C~ 24~ alceno com uma ou mais duplas ligações e/ou com uma ou mais triplas ligações, e/ou - um C~ 6~-C~ 24~ alcino, e/ou - um C~ 6~-C~ 24~ alquila substituído em uma ou diversas posições, por um ou mais compostos selecionados do grupo que compreende fluoreto, cloreto, hidróxi, C~ 1~-C~ 4~ alcóxi, C~ 1~C~ 1~ alquiltio, C~ 2~-C~ 5~ acilóxi OU C~ 1~-C~ 4~ alquila; e - R~ 2~ representa hidrogênio ou um grupo C~ 1~-C~ 4~ alquila, e - n representa um número inteiro de 1 a 12, e - i representa um número ímpar e indica a posição relativa em relação a COOR~ 2~, e - em que x~ i~, independentemente de cada um, é selecionado do grupo que consiste de 0, S, SO, SO~ 2~, Se e CH~ 2~, e - com a condição de que pelo menos um de x~ 1~ não seja CH~ 2~, e - com a condição de que se R~ 1~ for alcino, então uma das ligações tríplices carbono-carbono será posicionada entre o carbono (<sym>-1) e o carbono (<sym>-2) ou ainda entre o carbono (<sym>-2) e o carbono (<sym>-3) ou ainda entre o carbono (<sym>-3) e o carbono (<sym>-4), e um sal, pró-droga ou complexo do mesmo, que podem ser usados para o tratamento e/ou prevenção de uma condição doentia selecionada do grupo que consiste de síndrome X, obesidade, hipertensão, fígado gorduroso, diabetes, hiperglicemia, hiperinsulinemia, e estenose. Além disso, a invenção se refere a uma composição nutricional, que compreende os ditos análogos de ácido graxo e a um método para redução total do peso ou da quantidade de tecido adiposo em um animal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20001123A NO328803B1 (no) | 2000-03-03 | 2000-03-03 | Nye fettsyreanaloger |
| PCT/NO2001/000082 WO2001068582A1 (en) | 2000-03-03 | 2001-03-02 | Novel fatty acid analogous |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0108950A true BR0108950A (pt) | 2003-01-28 |
Family
ID=19910832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0108950-1A BR0108950A (pt) | 2000-03-03 | 2001-03-02 | Novos análogos de ácido graxo |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7902399B2 (pt) |
| EP (1) | EP1265838B9 (pt) |
| JP (1) | JP5122050B2 (pt) |
| KR (3) | KR100940373B1 (pt) |
| CN (1) | CN1283611C (pt) |
| AT (1) | ATE305447T1 (pt) |
| AU (2) | AU2001237835B2 (pt) |
| BR (1) | BR0108950A (pt) |
| CA (1) | CA2401757C (pt) |
| DE (1) | DE60113663T2 (pt) |
| DK (1) | DK1265838T3 (pt) |
| ES (1) | ES2250360T3 (pt) |
| HK (1) | HK1050182A1 (pt) |
| MX (1) | MX236472B (pt) |
| NO (1) | NO328803B1 (pt) |
| NZ (1) | NZ521137A (pt) |
| RU (1) | RU2288215C2 (pt) |
| WO (1) | WO2001068582A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20004844L (no) | 2000-09-27 | 2002-05-10 | Thia Medica As | Fettsyre analoger for behandling av proliferative hudsykdommer |
| AU2003278602C1 (en) * | 2002-06-20 | 2010-08-12 | Pronova Biopharma Norge As | Sulfur-containing phospholipid derivatives |
| EP1718602A4 (en) * | 2004-01-30 | 2007-12-12 | Peplin Biolipids Pty Ltd | THERAPEUTIC AND CARRIER MOLECULES |
| NO324533B1 (no) * | 2004-07-19 | 2007-11-19 | Thia Medica As | Materiale fremstilt fra en kombinasjon av ikke-β-oksiderbare fettsyreanaloger og et proteinmateriale, samt anvendelse derav. |
| EP1784223A2 (en) * | 2004-07-19 | 2007-05-16 | Thia Medica AS | Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities |
| EP2217224B1 (en) | 2007-11-09 | 2019-05-08 | Basf As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
| NO20075894L (no) * | 2007-11-15 | 2009-05-18 | Thia Medica As | Redusert kjonnsmodning i fisk |
| EP2147910A1 (en) * | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| US8735436B2 (en) | 2009-05-08 | 2014-05-27 | Pronova Biopharma Norge As | Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas |
| UA111475C2 (uk) | 2010-11-05 | 2016-05-10 | Пронова Байофарма Нордж Ас | Способи лікування із застосуванням ліпідних сполук |
| CN105120842B (zh) | 2013-02-28 | 2020-12-01 | 普罗诺瓦生物医药挪威公司 | 包含脂质化合物、甘油三酯和表面活性剂的组合物以及使用它们的方法 |
| CA2904898C (en) | 2013-03-11 | 2019-10-15 | Jan Remmereit | Lipid compositions containing bioactive fatty acids |
| EP2968568A2 (en) | 2013-03-11 | 2016-01-20 | Life Science Nutrition AS | Natural lipids containing non-oxidizable fatty acids |
| AU2016256552B2 (en) | 2015-04-28 | 2021-04-01 | Pronova Biopharma Norge As | Use of structurally enhanced fatty acids containing sulphur for preventing and/or treating non-alcoholic steatohepatitis |
| CN111712240A (zh) | 2017-12-06 | 2020-09-25 | 巴斯夫股份公司 | 用于治疗非酒精性脂肪性肝炎的脂肪酸衍生物 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2210230A1 (de) * | 1972-03-03 | 1973-09-06 | Kolmar Laboratories | Verwendung bestimmter thioaether als antimikrobielle und zytostatische mittel |
| BE809894A (nl) * | 1973-01-30 | 1974-07-18 | Antikleursluierstoffen voor fotografische kleurenmaterialen | |
| JPS5531778B2 (pt) * | 1973-02-15 | 1980-08-20 | ||
| DE3620685A1 (de) | 1986-06-20 | 1987-12-23 | Henkel Kgaa | Neue mittel zur abdeckung unverletzter und/oder verletzter bereiche menschlicher oder tierischer haut |
| DK167188B1 (da) * | 1987-07-22 | 1993-09-13 | Wellcome Found | Substituerede heterobicyclooctaner, pesticide praeparater indeholdende saadanne forbindelser, ikke terapeutiske fremgangsmaader til bekaempelse af arthropoder eller orm eller angreb af skadelige organismer samt fremgangsmaade til fremstilling af forbindelserne |
| US5268494A (en) * | 1988-05-10 | 1993-12-07 | Centre International De Recherches Dermatologiques C.I.R.D. | Sulphur-containing eicosanoides and their application in pharmacy and in cosmetics |
| FR2631339B1 (fr) * | 1988-05-10 | 1990-11-16 | Cird | Nouveaux eicosanoides sulfures et leur application en pharmacie et en cosmetique |
| GB8813012D0 (en) * | 1988-06-02 | 1988-07-06 | Norsk Hydro As | Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals |
| JPH0379659A (ja) | 1989-08-22 | 1991-04-04 | Mitsubishi Gas Chem Co Inc | 光学用成形材料 |
| WO1991003542A1 (en) | 1989-09-11 | 1991-03-21 | Kao Corporation | Bleaching composition |
| CA2030174C (en) * | 1990-01-10 | 1996-12-24 | Anthony H. Cincotta | Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hypoglycemia in vertebrates |
| JP3079659B2 (ja) | 1991-08-07 | 2000-08-21 | 松下電器産業株式会社 | 車載用空気清浄器 |
| US6602861B1 (en) | 1992-04-16 | 2003-08-05 | Research Corporation Technologies, Inc. | Acylated phospholipid drugs |
| US5554646A (en) * | 1992-04-29 | 1996-09-10 | Wisconsin Alumni Research Foundation | Method for reducing body fat in animals |
| US5290960A (en) * | 1993-02-25 | 1994-03-01 | The United States Of America As Represented By The Secretary Of The Navy | Diacetylenic phospholipids containing heteroatom near diacetylenic functionality for modulation of microstructure morphology |
| EP0869941B1 (en) * | 1994-10-13 | 2001-12-12 | Peptech Limited | Modified polyunsaturated fatty acids |
| NO952796D0 (no) * | 1995-07-14 | 1995-07-14 | Rolf Berge | Fettsyre analoger med ikkeoksyderbart B-sete, fremstilling og anvendelse i krapeutiske preparater |
| WO1997038688A1 (en) * | 1996-04-12 | 1997-10-23 | Peptide Technology Pty. Limited | Methods of treating immunopathologies using polyunsaturated fattyacids |
| CA2257084A1 (en) * | 1996-06-06 | 1997-12-11 | Anthony H. Cincotta | Treatment of lipid and glucose metabolism disorders with dopamine and serotonin agonists |
| AU7240398A (en) * | 1998-05-08 | 1999-11-29 | Rolf Berge | Use of non-beta-oxidizable fatty acid analogues for treatment of syndrome-x conditions |
| JP2002519341A (ja) * | 1998-06-29 | 2002-07-02 | パーカー ヒューズ インスティテュート | 強力な抗がん剤としてのアルキルケトン類 |
| US6656498B1 (en) | 1998-11-25 | 2003-12-02 | Vanderbilt University | Cationic liposomes for gene transfer |
| FR2792312B1 (fr) | 1999-04-15 | 2001-06-08 | Oreal | Composes (poly)thia-alcynoiques et leurs derives, compositions les comprenant et leur utilisation |
| AUPQ291499A0 (en) * | 1999-09-17 | 1999-10-07 | Women's And Children's Hospital Adelaide | Novel nitro and sulphur containing compounds |
| NO20003591L (no) | 2000-07-13 | 2002-01-14 | Thia Medica As | Fettsyreanaloger for behandling av kreft |
| NO20004844L (no) | 2000-09-27 | 2002-05-10 | Thia Medica As | Fettsyre analoger for behandling av proliferative hudsykdommer |
| NO20006008L (no) | 2000-11-28 | 2002-05-29 | Thia Medica As | Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer |
| US20020188023A1 (en) * | 2000-12-12 | 2002-12-12 | Michael Jorgensen | Compound |
| GB0118517D0 (en) * | 2001-07-30 | 2001-09-19 | Mitsubishi Tokyo Pharm Inc | Compound |
| FR2828487B1 (fr) | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
| AU2003278602C1 (en) | 2002-06-20 | 2010-08-12 | Pronova Biopharma Norge As | Sulfur-containing phospholipid derivatives |
| EP1784223A2 (en) * | 2004-07-19 | 2007-05-16 | Thia Medica AS | Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities |
-
2000
- 2000-03-03 NO NO20001123A patent/NO328803B1/no not_active IP Right Cessation
-
2001
- 2001-03-02 AU AU2001237835A patent/AU2001237835B2/en not_active Ceased
- 2001-03-02 AU AU3783501A patent/AU3783501A/xx active Pending
- 2001-03-02 KR KR1020087009732A patent/KR100940373B1/ko not_active IP Right Cessation
- 2001-03-02 RU RU2002123590/04A patent/RU2288215C2/ru not_active IP Right Cessation
- 2001-03-02 US US10/220,502 patent/US7902399B2/en not_active Expired - Fee Related
- 2001-03-02 DK DK01910259T patent/DK1265838T3/da active
- 2001-03-02 ES ES01910259T patent/ES2250360T3/es not_active Expired - Lifetime
- 2001-03-02 AT AT01910259T patent/ATE305447T1/de active
- 2001-03-02 MX MXPA02008629 patent/MX236472B/es active IP Right Grant
- 2001-03-02 NZ NZ521137A patent/NZ521137A/en not_active IP Right Cessation
- 2001-03-02 WO PCT/NO2001/000082 patent/WO2001068582A1/en active IP Right Grant
- 2001-03-02 DE DE60113663T patent/DE60113663T2/de not_active Expired - Lifetime
- 2001-03-02 CN CNB018071112A patent/CN1283611C/zh not_active Expired - Fee Related
- 2001-03-02 KR KR1020097020038A patent/KR100982228B1/ko not_active IP Right Cessation
- 2001-03-02 EP EP01910259A patent/EP1265838B9/en not_active Expired - Lifetime
- 2001-03-02 JP JP2001567680A patent/JP5122050B2/ja not_active Expired - Fee Related
- 2001-03-02 KR KR1020027011476A patent/KR100857626B1/ko not_active IP Right Cessation
- 2001-03-02 CA CA2401757A patent/CA2401757C/en not_active Expired - Fee Related
- 2001-03-02 BR BR0108950-1A patent/BR0108950A/pt not_active Application Discontinuation
-
2003
- 2003-03-31 HK HK03102294A patent/HK1050182A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15V | Prolongation of time limit allowed |
Free format text: RECONHECIDO O OBSTACULO ADMINISTRATIVO E CONCEDIDO DEVOLUCAO DE PRAZO DE 90 DIAS, NOS TERMOS DO ARTIGO 221 2O DA LPI E RESOLUCAO 116/2004. |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |