JP2005500266A5 - - Google Patents
Info
- Publication number
- JP2005500266A5 JP2005500266A5 JP2002590924A JP2002590924A JP2005500266A5 JP 2005500266 A5 JP2005500266 A5 JP 2005500266A5 JP 2002590924 A JP2002590924 A JP 2002590924A JP 2002590924 A JP2002590924 A JP 2002590924A JP 2005500266 A5 JP2005500266 A5 JP 2005500266A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- heterocycle
- arylalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 215
- 125000003710 aryl alkyl group Chemical group 0.000 claims 180
- 229910052739 hydrogen Inorganic materials 0.000 claims 128
- 239000001257 hydrogen Substances 0.000 claims 128
- 150000001875 compounds Chemical class 0.000 claims 115
- 125000000217 alkyl group Chemical group 0.000 claims 95
- 125000003118 aryl group Chemical group 0.000 claims 91
- 125000000547 substituted alkyl group Chemical group 0.000 claims 90
- 150000002431 hydrogen Chemical class 0.000 claims 87
- 125000003107 substituted aryl group Chemical group 0.000 claims 71
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 54
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 41
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 39
- 229910052760 oxygen Inorganic materials 0.000 claims 39
- 239000001301 oxygen Substances 0.000 claims 39
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 32
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 229910052757 nitrogen Inorganic materials 0.000 claims 17
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 13
- 229940002612 prodrug Drugs 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 12
- 229910052717 sulfur Chemical group 0.000 claims 12
- 239000011593 sulfur Chemical group 0.000 claims 12
- 241001465754 Metazoa Species 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 8
- 229910052794 bromium Inorganic materials 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims 1
- 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- -1 dialkyl Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29364201P | 2001-05-24 | 2001-05-24 | |
| PCT/US2002/016963 WO2002094203A2 (en) | 2001-05-24 | 2002-05-24 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005500266A JP2005500266A (ja) | 2005-01-06 |
| JP2005500266A5 true JP2005500266A5 (https=) | 2005-12-15 |
| JP4346312B2 JP4346312B2 (ja) | 2009-10-21 |
Family
ID=23129922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002590924A Expired - Fee Related JP4346312B2 (ja) | 2001-05-24 | 2002-05-24 | マクロファージ遊走阻止因子インヒビターおよびそれを同定する方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (14) | US7105519B2 (https=) |
| EP (1) | EP1389110B1 (https=) |
| JP (1) | JP4346312B2 (https=) |
| KR (1) | KR100896973B1 (https=) |
| CN (1) | CN1523989A (https=) |
| AR (1) | AR036032A1 (https=) |
| AT (1) | ATE461920T1 (https=) |
| AU (2) | AU2002303906B2 (https=) |
| BR (1) | BR0209948A (https=) |
| CA (1) | CA2447103A1 (https=) |
| CZ (1) | CZ20033503A3 (https=) |
| DE (1) | DE60235750D1 (https=) |
| ES (1) | ES2342877T3 (https=) |
| HU (1) | HUP0500101A3 (https=) |
| IL (1) | IL158550A0 (https=) |
| MX (1) | MXJL03000038A (https=) |
| MY (1) | MY140679A (https=) |
| NZ (1) | NZ529244A (https=) |
| PL (1) | PL367127A1 (https=) |
| PT (1) | PT1389110E (https=) |
| RU (1) | RU2327695C2 (https=) |
| UY (1) | UY27304A1 (https=) |
| WO (1) | WO2002094203A2 (https=) |
| ZA (1) | ZA200309738B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK1383919T3 (da) * | 2001-03-29 | 2010-11-08 | Cytokine Pharmasciences Inc | Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor |
| UY27304A1 (es) * | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
| US20030195192A1 (en) * | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
| US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| EP1500402A4 (en) | 2002-04-26 | 2009-12-30 | Takeda Pharmaceutical | INHIBITOR OF CELL DEATH |
| BR0312204A (pt) | 2002-06-27 | 2005-04-26 | Schering Ag | Antagonista de receptor ccr5 de quinolina substituìda |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| US7364869B2 (en) * | 2003-07-29 | 2008-04-29 | The J. David Gladstone Institutes | Method of detecting antigen-specific T lymphocytes |
| CN1839133A (zh) * | 2003-08-22 | 2006-09-27 | 阿文尼尔药品公司 | 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 |
| US7592466B2 (en) | 2003-10-09 | 2009-09-22 | Abbott Laboratories | Ureas having antiangiogenic activity |
| AU2011265309B2 (en) * | 2003-11-21 | 2014-06-05 | Array Biopharma, Inc. | AKT protein kinase inhibitors |
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| EP1740167B1 (en) * | 2004-03-29 | 2013-08-28 | The Feinstein Institute for Medical Research | Treatment of type 1 diabetes with inhibitors of macrophage migration inhibitory factor |
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| CA2623072A1 (en) * | 2005-09-26 | 2007-04-05 | Avigen, Inc. | Use of ibudilast for treating drug and behavioral addictions |
| GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| EP2004192B1 (en) | 2006-03-24 | 2014-03-12 | The Feinstein Institute for Medical Research | Modified macrophage migration inhibitory factor inhibitors |
| CN100457895C (zh) * | 2006-05-24 | 2009-02-04 | 中国科学院生物物理研究所 | 鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用 |
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| US20070281924A1 (en) * | 2006-05-31 | 2007-12-06 | Gaeta Federico C | MIF inhibitors for treating neuropathic pain and associated syndromes |
| US7845914B2 (en) * | 2007-02-15 | 2010-12-07 | Deere & Company | Self-priming fast fill sprayer pump system |
| WO2009045543A1 (en) * | 2007-10-04 | 2009-04-09 | The Regents Of The University Of California | Treatment of conditions related to shock |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| EP2198879A1 (en) | 2008-12-11 | 2010-06-23 | Institut Curie | CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell |
| US9050334B2 (en) | 2010-07-16 | 2015-06-09 | Innov88 Llc | MIF inhibitors and their uses |
| GB2497476B (en) | 2010-09-06 | 2018-01-10 | Guangzhou Inst Biomed & Health | Amide Compounds |
| WO2012045083A2 (en) | 2010-10-02 | 2012-04-05 | The Regents Of The University Of California | Minimizing intestinal dysfunction |
| US9958456B2 (en) | 2011-10-07 | 2018-05-01 | Baxalta Incorporated | OxMIF as a diagnostic marker |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| AU2013255050B2 (en) | 2012-05-01 | 2016-07-28 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| WO2014200872A1 (en) | 2013-06-09 | 2014-12-18 | Rjs Biologics Llc | Pharmaceutical compounds targeted by mif affinity-tethered moieties |
| US11397182B2 (en) | 2014-10-07 | 2022-07-26 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
| AU2016297037B9 (en) * | 2015-07-17 | 2020-10-29 | Fujifilm Toyama Chemical Co., Ltd. | Nitrogen-containing heterocyclic compound |
| CN111406050B (zh) * | 2018-01-17 | 2023-02-03 | 厦门宝太生物科技股份有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其用途 |
| BR112020020930A2 (pt) | 2018-04-11 | 2021-03-02 | Ohio State Innovation Foundation | composição de liberação de fármaco, método para tratar um distúrbio oftalmológico e kit |
| CA3095371A1 (en) | 2018-04-13 | 2019-10-17 | Cancer Research Technology Limited | Bcl6 inhibitors |
| KR102767739B1 (ko) | 2018-06-27 | 2025-02-12 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물 |
| CN112585139B (zh) | 2018-06-27 | 2023-12-01 | 百时美施贵宝公司 | 用作t细胞激活剂的萘啶酮化合物 |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| GB201914860D0 (en) | 2019-10-14 | 2019-11-27 | Cancer Research Tech Ltd | Inhibitor compounds |
| CA3162979A1 (en) | 2019-12-23 | 2021-07-01 | Upender Velaparthi | Substituted piperazine derivatives useful as t cell activators |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| KR20220119456A (ko) * | 2019-12-23 | 2022-08-29 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 치환된 퀴놀리노닐 피페라진 화합물 |
| BR112022012179A2 (pt) | 2019-12-23 | 2022-09-06 | Bristol Myers Squibb Co | Compostos de quinazolina substituída úteis como ativadores de célula t |
| CN113121435B (zh) * | 2021-04-20 | 2022-08-30 | 辽宁大学 | 一种2,4-二氯喹啉类化合物的合成方法 |
| CN119074725B (zh) * | 2024-09-11 | 2026-03-17 | 北京大学第一医院(北京大学第一临床医学院) | 靶向mif在制备用于治疗特应性皮炎的药物中应用 |
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| TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| US7361474B2 (en) | 2003-02-24 | 2008-04-22 | United States Of America As Represented By The Department Of Veterans Affairs | Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer |
| CN1839133A (zh) | 2003-08-22 | 2006-09-27 | 阿文尼尔药品公司 | 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 |
| WO2006102191A1 (en) * | 2005-03-24 | 2006-09-28 | Avanir Pharmaceuticals | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors |
-
2002
- 2002-05-23 UY UY27304A patent/UY27304A1/es not_active Application Discontinuation
- 2002-05-23 MY MYPI20021922A patent/MY140679A/en unknown
- 2002-05-24 JP JP2002590924A patent/JP4346312B2/ja not_active Expired - Fee Related
- 2002-05-24 EP EP02731971A patent/EP1389110B1/en not_active Expired - Lifetime
- 2002-05-24 IL IL15855002A patent/IL158550A0/xx unknown
- 2002-05-24 CZ CZ20033503A patent/CZ20033503A3/cs unknown
- 2002-05-24 DE DE60235750T patent/DE60235750D1/de not_active Expired - Lifetime
- 2002-05-24 PL PL02367127A patent/PL367127A1/xx unknown
- 2002-05-24 AT AT02731971T patent/ATE461920T1/de active
- 2002-05-24 NZ NZ529244A patent/NZ529244A/en unknown
- 2002-05-24 WO PCT/US2002/016963 patent/WO2002094203A2/en not_active Ceased
- 2002-05-24 MX MXJL03000038A patent/MXJL03000038A/es active IP Right Grant
- 2002-05-24 US US10/156,650 patent/US7105519B2/en not_active Expired - Fee Related
- 2002-05-24 AU AU2002303906A patent/AU2002303906B2/en not_active Ceased
- 2002-05-24 ES ES02731971T patent/ES2342877T3/es not_active Expired - Lifetime
- 2002-05-24 RU RU2003132534/04A patent/RU2327695C2/ru not_active IP Right Cessation
- 2002-05-24 CA CA002447103A patent/CA2447103A1/en not_active Abandoned
- 2002-05-24 HU HU0500101A patent/HUP0500101A3/hu unknown
- 2002-05-24 BR BR0209948-9A patent/BR0209948A/pt not_active Application Discontinuation
- 2002-05-24 KR KR1020037015359A patent/KR100896973B1/ko not_active Expired - Fee Related
- 2002-05-24 CN CNA02810501XA patent/CN1523989A/zh active Pending
- 2002-05-24 PT PT02731971T patent/PT1389110E/pt unknown
- 2002-05-24 AR ARP020101966A patent/AR036032A1/es unknown
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2003
- 2003-12-17 ZA ZA200309738A patent/ZA200309738B/xx unknown
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2005
- 2005-07-15 US US11/182,360 patent/US7514225B2/en not_active Expired - Fee Related
- 2005-07-15 US US11/182,241 patent/US7732146B2/en not_active Expired - Fee Related
- 2005-11-07 US US11/268,375 patent/US7084141B2/en not_active Expired - Fee Related
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2006
- 2006-01-31 US US11/344,938 patent/US7202248B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/416,165 patent/US7230106B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,628 patent/US7192961B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,842 patent/US7238809B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/416,004 patent/US7157469B2/en not_active Expired - Fee Related
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- 2006-05-02 US US11/415,785 patent/US7192955B2/en not_active Expired - Fee Related
- 2006-12-07 US US11/635,319 patent/US7435737B2/en not_active Expired - Fee Related
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2007
- 2007-03-16 US US11/687,611 patent/US7432374B2/en not_active Expired - Fee Related
- 2007-04-04 AU AU2007201493A patent/AU2007201493A1/en not_active Abandoned
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