JP2004537985A - セファロスポリン誘導体を製造する方法 - Google Patents

セファロスポリン誘導体を製造する方法 Download PDF

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Publication number
JP2004537985A
JP2004537985A JP2002583656A JP2002583656A JP2004537985A JP 2004537985 A JP2004537985 A JP 2004537985A JP 2002583656 A JP2002583656 A JP 2002583656A JP 2002583656 A JP2002583656 A JP 2002583656A JP 2004537985 A JP2004537985 A JP 2004537985A
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JP
Japan
Prior art keywords
formula
compound
cephalosporin
thiolated
aca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2002583656A
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English (en)
Japanese (ja)
Inventor
サンチェス−フェレール，アルバロ
アニセト ロペス−マス，ホセ
ガルシア−カルモナ，フランシスコ
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Bioferma Murcia SA
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Bioferma Murcia SA
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Application filed by Bioferma Murcia SA filed Critical Bioferma Murcia SA
Publication of JP2004537985A publication Critical patent/JP2004537985A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
JP2002583656A 2001-04-19 2002-04-18 セファロスポリン誘導体を製造する方法 Pending JP2004537985A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP01201426 2001-04-19
EP01201718 2001-05-09
EP01201699 2001-05-09
IE20011025 2001-11-30
IE20011024 2001-11-30
PCT/EP2002/004354 WO2002086143A2 (en) 2001-04-19 2002-04-18 Enzymatic process for preparing cephalosporin derivatives

Publications (1)

Publication Number Publication Date
JP2004537985A true JP2004537985A (ja) 2004-12-24

Family

ID=27513105

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002583656A Pending JP2004537985A (ja) 2001-04-19 2002-04-18 セファロスポリン誘導体を製造する方法
JP2002583440A Pending JP2004538265A (ja) 2001-04-19 2002-04-18 α−ケト酸誘導体を使用して３−セファロスポラン酸誘導体を製造する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2002583440A Pending JP2004538265A (ja) 2001-04-19 2002-04-18 α−ケト酸誘導体を使用して３−セファロスポラン酸誘導体を製造する方法

Country Status (7)

Country Link
US (5) US6730497B2 (US20030073156A1-20030417-C00003.png)
EP (2) EP1379531A2 (US20030073156A1-20030417-C00003.png)
JP (2) JP2004537985A (US20030073156A1-20030417-C00003.png)
KR (2) KR20040014498A (US20030073156A1-20030417-C00003.png)
CN (2) CN1531598A (US20030073156A1-20030417-C00003.png)
AU (2) AU2002316862A1 (US20030073156A1-20030417-C00003.png)
WO (2) WO2002085914A2 (US20030073156A1-20030417-C00003.png)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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AU2002316862A1 (en) * 2001-04-19 2002-11-05 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporin derivatives
ATE302283T1 (de) * 2002-10-31 2005-09-15 Bioferma Murcia S A Einfaches enzymatisches verfahren zur herstellung von cefazolin
KR100650207B1 (ko) 2005-07-29 2006-11-27 종근당바이오 주식회사 글루타릴 7-아미노-3-비닐-세팔로스포란산 유도체와 이의 제조방법
CN103635586A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 结晶头孢氧哌唑中间体、其制备方法及其制药用途
PL2723882T3 (pl) 2011-06-23 2020-01-31 Centrient Pharmaceuticals Netherlands B.V. Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny
CN102605033B (zh) * 2012-01-17 2013-11-27 湖南福来格生物技术有限公司 头孢唑啉中间体tda的制备方法
CN102633813A (zh) * 2012-04-17 2012-08-15 黑龙江豪运精细化工有限公司 一种头孢唑林钠中间体tda的制备方法
CN102627659A (zh) * 2012-04-17 2012-08-08 黑龙江豪运精细化工有限公司 一种头孢哌酮中间体7-tmca的制备方法
CN102659818B (zh) * 2012-04-19 2014-02-19 海南合瑞制药股份有限公司 一种盐酸头孢替安晶体化合物及其制备方法及含该化合物的药物组合物
CN102993214B (zh) * 2012-12-07 2015-01-28 西北大学 一种头孢菌素的脱色方法
CN104230958A (zh) * 2014-08-22 2014-12-24 赵明亮 一种头孢西酮的制备方法
CN106317079B (zh) * 2016-08-19 2018-08-21 上海上药新亚药业有限公司 一种头孢曲松钠的固相合成法
CN107964558B (zh) * 2017-11-07 2021-09-03 河北九派制药股份有限公司 一种盐酸头孢替安杂质脱四氮唑头孢替安的制备方法
CN113929704A (zh) * 2021-11-24 2022-01-14 焦作丽珠合成制药有限公司 一种利用水相法制备7-act的方法

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Also Published As

Publication number Publication date
WO2002085914A3 (en) 2003-02-06
EP1381690A2 (en) 2004-01-21
US20030073156A1 (en) 2003-04-17
US20030104515A1 (en) 2003-06-05
WO2002085914A2 (en) 2002-10-31
US20040181056A1 (en) 2004-09-16
CN1531598A (zh) 2004-09-22
KR20040014498A (ko) 2004-02-14
CN1531539A (zh) 2004-09-22
US6730497B2 (en) 2004-05-04
JP2004538265A (ja) 2004-12-24
WO2002086143A2 (en) 2002-10-31
AU2002310863A1 (en) 2002-11-05
AU2002316862A1 (en) 2002-11-05
US20040175783A1 (en) 2004-09-09
US6642020B2 (en) 2003-11-04
WO2002086143A3 (en) 2003-01-09
US20040067549A1 (en) 2004-04-08
KR20040014499A (ko) 2004-02-14
EP1379531A2 (en) 2004-01-14

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