JP2004533454A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004533454A5 JP2004533454A5 JP2002589483A JP2002589483A JP2004533454A5 JP 2004533454 A5 JP2004533454 A5 JP 2004533454A5 JP 2002589483 A JP2002589483 A JP 2002589483A JP 2002589483 A JP2002589483 A JP 2002589483A JP 2004533454 A5 JP2004533454 A5 JP 2004533454A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- amino
- phenyl
- pyrrolo
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 234
- 150000001875 compounds Chemical class 0.000 claims 71
- 125000000623 heterocyclic group Chemical group 0.000 claims 38
- -1 di-substituted amino Chemical group 0.000 claims 36
- 229910052757 nitrogen Inorganic materials 0.000 claims 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 22
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 20
- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 239000001301 oxygen Substances 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 14
- 125000003282 alkyl amino group Chemical group 0.000 claims 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 239000011593 sulfur Chemical group 0.000 claims 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 9
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 4
- 125000006501 nitrophenyl group Chemical group 0.000 claims 4
- 125000005236 alkanoylamino group Chemical group 0.000 claims 3
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- MINLECAKOASWQA-UHFFFAOYSA-N 7-[3-(aminomethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound C1C(CN)CC1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 MINLECAKOASWQA-UHFFFAOYSA-N 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 229950001413 metamfepramone Drugs 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- CZAXYMOAFIXZDY-UHFFFAOYSA-N 1-[[3-[4-amino-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]methyl]-3-propan-2-ylurea Chemical compound C1C(CNC(=O)NC(C)C)CC1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 CZAXYMOAFIXZDY-UHFFFAOYSA-N 0.000 claims 1
- GQGMUKOYILWOIQ-UHFFFAOYSA-N 6-methyl-5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound C12=C(N)N=CN=C2N(C2CC(CN3CCCC3)C2)C(C)=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 GQGMUKOYILWOIQ-UHFFFAOYSA-N 0.000 claims 1
- AECDBHGVIIRMOI-UHFFFAOYSA-N 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound C1=2C(N)=NC=NC=2N(C2CC(CN3CCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 AECDBHGVIIRMOI-UHFFFAOYSA-N 0.000 claims 1
- ICHGNLVHYDFSAR-RZFKFIIISA-N C12=C(N)N=CN=C2N([C@@H]2C[C@@H](CNC3CCOCC3)C2)C(C)=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 Chemical compound C12=C(N)N=CN=C2N([C@@H]2C[C@@H](CNC3CCOCC3)C2)C(C)=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 ICHGNLVHYDFSAR-RZFKFIIISA-N 0.000 claims 1
- XQMSYQDZIAGQPB-MXVIHJGJSA-N C12=C(N)N=CN=C2N([C@@H]2C[C@H](C2)C(=O)OC)C(CC)=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 Chemical compound C12=C(N)N=CN=C2N([C@@H]2C[C@H](C2)C(=O)OC)C(CC)=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 XQMSYQDZIAGQPB-MXVIHJGJSA-N 0.000 claims 1
- AECDBHGVIIRMOI-AQYVVDRMSA-N C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 Chemical compound C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 AECDBHGVIIRMOI-AQYVVDRMSA-N 0.000 claims 1
- IONLBUKCCPUJIH-HCGLCNNCSA-N C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCCCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 Chemical compound C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCCCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 IONLBUKCCPUJIH-HCGLCNNCSA-N 0.000 claims 1
- IPUIQYUWBBQMLR-DUYHBEBVSA-N C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCN(CC3)C=3N=CC=CC=3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 Chemical compound C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCN(CC3)C=3N=CC=CC=3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 IPUIQYUWBBQMLR-DUYHBEBVSA-N 0.000 claims 1
- KUUHULDUODEQHB-AFARHQOCSA-N C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCOCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 Chemical compound C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCOCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 KUUHULDUODEQHB-AFARHQOCSA-N 0.000 claims 1
- ZXYAKTRUTLRFEX-YFJLJUBXSA-N C1C(C)OC(C)CN1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC=4C=CC=CC=4)C=CC=3)=C2)C1 Chemical compound C1C(C)OC(C)CN1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC=4C=CC=CC=4)C=CC=3)=C2)C1 ZXYAKTRUTLRFEX-YFJLJUBXSA-N 0.000 claims 1
- REXRZICSDNALRF-HCGLCNNCSA-N C1CN(C)CCN1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC=4C=CC=CC=4)C=CC=3)=C2)C1 Chemical compound C1CN(C)CCN1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC=4C=CC=CC=4)C=CC=3)=C2)C1 REXRZICSDNALRF-HCGLCNNCSA-N 0.000 claims 1
- LDRXGQRNDOVOLA-MXVIHJGJSA-N C1[C@@H](C(=O)N(C)C)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 Chemical compound C1[C@@H](C(=O)N(C)C)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 LDRXGQRNDOVOLA-MXVIHJGJSA-N 0.000 claims 1
- FITJQXRHQKAHRQ-WGSAOQKQSA-N C1[C@@H](C(=O)NC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 Chemical compound C1[C@@H](C(=O)NC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 FITJQXRHQKAHRQ-WGSAOQKQSA-N 0.000 claims 1
- NTMLQBGOQOGFFT-IYARVYRRSA-N C1[C@@H](C(=O)OC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1Br Chemical compound C1[C@@H](C(=O)OC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1Br NTMLQBGOQOGFFT-IYARVYRRSA-N 0.000 claims 1
- MGADSANUGJPJTF-MXVIHJGJSA-N C1[C@@H](C(=O)OC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1C Chemical compound C1[C@@H](C(=O)OC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1C MGADSANUGJPJTF-MXVIHJGJSA-N 0.000 claims 1
- MINLECAKOASWQA-UAPYVXQJSA-N C1[C@@H](CN)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 Chemical compound C1[C@@H](CN)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 MINLECAKOASWQA-UAPYVXQJSA-N 0.000 claims 1
- WBYYXJHMBIEJCC-AFARHQOCSA-N C1[C@@H](CNC(=O)N(CC)CC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 Chemical compound C1[C@@H](CNC(=O)N(CC)CC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 WBYYXJHMBIEJCC-AFARHQOCSA-N 0.000 claims 1
- CQQQRDIANWGYBY-KESTWPANSA-N C1[C@@H](CNC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 Chemical compound C1[C@@H](CNC)C[C@@H]1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 CQQQRDIANWGYBY-KESTWPANSA-N 0.000 claims 1
- XRMMWXGVGDPTGL-AQYVVDRMSA-N CC(C)(C)NC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CC(C)(C)NC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 XRMMWXGVGDPTGL-AQYVVDRMSA-N 0.000 claims 1
- JSOCIINBZIRFJJ-AQYVVDRMSA-N CC(C)C(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CC(C)C(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 JSOCIINBZIRFJJ-AQYVVDRMSA-N 0.000 claims 1
- UNUAWXMVQLZJRI-AQYVVDRMSA-N CC(C)S(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CC(C)S(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 UNUAWXMVQLZJRI-AQYVVDRMSA-N 0.000 claims 1
- CZOJVEPPEOWDQJ-YFJLJUBXSA-N CC1CCC(C)N1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC=4C=CC=CC=4)C=CC=3)=C2)C1 Chemical compound CC1CCC(C)N1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC=4C=CC=CC=4)C=CC=3)=C2)C1 CZOJVEPPEOWDQJ-YFJLJUBXSA-N 0.000 claims 1
- VCEIHCLYWKZRCQ-AFARHQOCSA-N CCCCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCCCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 VCEIHCLYWKZRCQ-AFARHQOCSA-N 0.000 claims 1
- LDTLIYZCJAHYBU-AQYVVDRMSA-N CCCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 LDTLIYZCJAHYBU-AQYVVDRMSA-N 0.000 claims 1
- CWHGEXXQNLPSHD-ALOJWSFFSA-N CCN(CC)CCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCN(CC)CCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 CWHGEXXQNLPSHD-ALOJWSFFSA-N 0.000 claims 1
- IHDHVOBYVYYNDS-XUTJKUGGSA-N CCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 IHDHVOBYVYYNDS-XUTJKUGGSA-N 0.000 claims 1
- COONFDJMHJHRBM-ALOJWSFFSA-N CCOC(=O)N1CCN(C[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 Chemical compound CCOC(=O)N1CCN(C[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 COONFDJMHJHRBM-ALOJWSFFSA-N 0.000 claims 1
- PYYNBGZIQCNCCI-XUTJKUGGSA-N CCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 PYYNBGZIQCNCCI-XUTJKUGGSA-N 0.000 claims 1
- VFKIZJLNGDYBKT-AQYVVDRMSA-N CCOCC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCOCC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 VFKIZJLNGDYBKT-AQYVVDRMSA-N 0.000 claims 1
- OWXINVKOOZWOEN-XUTJKUGGSA-N CCS(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CCS(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 OWXINVKOOZWOEN-XUTJKUGGSA-N 0.000 claims 1
- WNLYZRUMUOYMRP-KESTWPANSA-N CCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CO)C1 Chemical compound CCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CO)C1 WNLYZRUMUOYMRP-KESTWPANSA-N 0.000 claims 1
- HFMCZQFICHRAFM-XUTJKUGGSA-N CN(C)C(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CN(C)C(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 HFMCZQFICHRAFM-XUTJKUGGSA-N 0.000 claims 1
- HODGCSQBGRCWLO-HCGLCNNCSA-N CN(C)CCCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CN(C)CCCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 HODGCSQBGRCWLO-HCGLCNNCSA-N 0.000 claims 1
- JTAVVFISQTXCHE-AFARHQOCSA-N CN(C)CCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CN(C)CCNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 JTAVVFISQTXCHE-AFARHQOCSA-N 0.000 claims 1
- USHBLDDYCVMTBO-AFARHQOCSA-N CN(C)CCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CN(C)CCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 USHBLDDYCVMTBO-AFARHQOCSA-N 0.000 claims 1
- MQBSLITVUSARHC-XUTJKUGGSA-N CN(C)C[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CN(C)C[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 MQBSLITVUSARHC-XUTJKUGGSA-N 0.000 claims 1
- HIPDDNUTKGLJGM-ALOJWSFFSA-N CN1CCN(CC(=O)NC[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 Chemical compound CN1CCN(CC(=O)NC[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 HIPDDNUTKGLJGM-ALOJWSFFSA-N 0.000 claims 1
- MEDPKRVFVDCJBF-YOCNBXQISA-N CN1CCN(CCOC(=O)NC[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 Chemical compound CN1CCN(CCOC(=O)NC[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 MEDPKRVFVDCJBF-YOCNBXQISA-N 0.000 claims 1
- OOFFWNVNYZXYNM-ALOJWSFFSA-N CN1CCN(C[C@H]2C[C@@H](C2)n2c(C)c(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 Chemical compound CN1CCN(C[C@H]2C[C@@H](C2)n2c(C)c(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)CC1 OOFFWNVNYZXYNM-ALOJWSFFSA-N 0.000 claims 1
- OQIGTHHTVJUMHD-KESTWPANSA-N CNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CNC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 OQIGTHHTVJUMHD-KESTWPANSA-N 0.000 claims 1
- FEBYEMVQPQEWMY-KESTWPANSA-N COC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound COC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 FEBYEMVQPQEWMY-KESTWPANSA-N 0.000 claims 1
- BEULOCGXDTYSCT-AQYVVDRMSA-N COCCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound COCCOC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 BEULOCGXDTYSCT-AQYVVDRMSA-N 0.000 claims 1
- MGHHKOHAEAPKFP-AFARHQOCSA-N COCCOCC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound COCCOCC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 MGHHKOHAEAPKFP-AFARHQOCSA-N 0.000 claims 1
- UNFLVZMMYVSVKS-HCGLCNNCSA-N COc1ccc(cc1)S(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound COc1ccc(cc1)S(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 UNFLVZMMYVSVKS-HCGLCNNCSA-N 0.000 claims 1
- NCLPAIVFVXOXAA-KESTWPANSA-N CS(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound CS(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 NCLPAIVFVXOXAA-KESTWPANSA-N 0.000 claims 1
- FOANWBYUHRTOOL-AFARHQOCSA-N Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CN2CCC2)C1 Chemical compound Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CN2CCC2)C1 FOANWBYUHRTOOL-AFARHQOCSA-N 0.000 claims 1
- DJLBNZPUIHXQFP-QLBJFCOMSA-N Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CN2CCC[C@@H]2CO)C1 Chemical compound Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CN2CCC[C@@H]2CO)C1 DJLBNZPUIHXQFP-QLBJFCOMSA-N 0.000 claims 1
- HRYFOWNOBBOWFG-KESTWPANSA-N Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CO)C1 Chemical compound Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@H](CO)C1 HRYFOWNOBBOWFG-KESTWPANSA-N 0.000 claims 1
- JMLNWLNOJJFSMV-ALOJWSFFSA-N Cc1ccc(cc1)S(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound Cc1ccc(cc1)S(=O)(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 JMLNWLNOJJFSMV-ALOJWSFFSA-N 0.000 claims 1
- OBOLLMDLQKRYKB-DUYHBEBVSA-N Cc1cccc(CNC(=O)NC[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)c1 Chemical compound Cc1cccc(CNC(=O)NC[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)c1 OBOLLMDLQKRYKB-DUYHBEBVSA-N 0.000 claims 1
- 239000007818 Grignard reagent Substances 0.000 claims 1
- ZNQWHKOHXUWMLD-UAPYVXQJSA-N NC(=N)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound NC(=N)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 ZNQWHKOHXUWMLD-UAPYVXQJSA-N 0.000 claims 1
- BZMLRFHDZLWAEN-UCWUDVSLSA-N NC(=O)C1CCCN(C[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)C1 Chemical compound NC(=O)C1CCCN(C[C@H]2C[C@@H](C2)n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc23)C1 BZMLRFHDZLWAEN-UCWUDVSLSA-N 0.000 claims 1
- PNEPNZDINPZUFR-UAPYVXQJSA-N NC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 Chemical compound NC(=O)NC[C@H]1C[C@@H](C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 PNEPNZDINPZUFR-UAPYVXQJSA-N 0.000 claims 1
- FONYISGQUQXHMY-UAPYVXQJSA-N NC=1C2=C(N=CN1)N(C=C2C2=CC(=CC=C2)OCC2=CC=CC=C2)[C@@H]2C[C@H](C2)CNC(O)=O Chemical compound NC=1C2=C(N=CN1)N(C=C2C2=CC(=CC=C2)OCC2=CC=CC=C2)[C@@H]2C[C@H](C2)CNC(O)=O FONYISGQUQXHMY-UAPYVXQJSA-N 0.000 claims 1
- AMEJSINMHMEDLL-AFARHQOCSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCC(O)CC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCC(O)CC2)C1 AMEJSINMHMEDLL-AFARHQOCSA-N 0.000 claims 1
- VHKIWYHFKMOBQJ-ALOJWSFFSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCCCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCCCC2)C1 VHKIWYHFKMOBQJ-ALOJWSFFSA-N 0.000 claims 1
- FVDWCEYQBCTACG-AFARHQOCSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCSCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCSCC2)C1 FVDWCEYQBCTACG-AFARHQOCSA-N 0.000 claims 1
- JUFWVKHHKZAVCR-ALOJWSFFSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)CN2CCCCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)CN2CCCCC2)C1 JUFWVKHHKZAVCR-ALOJWSFFSA-N 0.000 claims 1
- GVSBCSHBBJBDIZ-AFARHQOCSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)N2CCCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)N2CCCC2)C1 GVSBCSHBBJBDIZ-AFARHQOCSA-N 0.000 claims 1
- KIWNKRSGKFTXPP-HCGLCNNCSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)N2CCCCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)N2CCCCC2)C1 KIWNKRSGKFTXPP-HCGLCNNCSA-N 0.000 claims 1
- RLCZUYQBURMNDZ-AFARHQOCSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)N2CCOCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)N2CCOCC2)C1 RLCZUYQBURMNDZ-AFARHQOCSA-N 0.000 claims 1
- LPQONMCVBNYRRX-YOCNBXQISA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)NCCCN2CCOCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)NCCCN2CCOCC2)C1 LPQONMCVBNYRRX-YOCNBXQISA-N 0.000 claims 1
- KDJUOUXKVYJHEQ-ALOJWSFFSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)NCCN2CCOCC2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)NCCN2CCOCC2)C1 KDJUOUXKVYJHEQ-ALOJWSFFSA-N 0.000 claims 1
- HTRBGRLCGGGPPN-YOCNBXQISA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)NCc2ccccc2)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC(=O)NCc2ccccc2)C1 HTRBGRLCGGGPPN-YOCNBXQISA-N 0.000 claims 1
- UZEIODJMSHKOGA-NDZWVUITSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC23CC4CC(CC(C4)C2)C3)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNC23CC4CC(CC(C4)C2)C3)C1 UZEIODJMSHKOGA-NDZWVUITSA-N 0.000 claims 1
- MWCCQHZMZNIJFZ-SAIGFBBZSA-N Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)C1 Chemical compound Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CNS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)C1 MWCCQHZMZNIJFZ-SAIGFBBZSA-N 0.000 claims 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- LSFLAQVDISHMNB-AFARHQOCSA-N chembl399021 Chemical compound C1=2C(N)=NC=NC=2N([C@@H]2C[C@@H](CN3CCCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 LSFLAQVDISHMNB-AFARHQOCSA-N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000004795 grignard reagents Chemical class 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 239000012280 lithium aluminium hydride Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- BUCAFRXFNHCHRU-UHFFFAOYSA-N n-[[3-[4-amino-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]methyl]acetamide Chemical compound C1C(CNC(=O)C)CC1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 BUCAFRXFNHCHRU-UHFFFAOYSA-N 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0111764A GB0111764D0 (en) | 2001-05-14 | 2001-05-14 | Organic compounds |
| GB0204752A GB0204752D0 (en) | 2002-02-28 | 2002-02-28 | Organic compounds |
| PCT/EP2002/005239 WO2002092599A1 (en) | 2001-05-14 | 2002-05-13 | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d) pyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533454A JP2004533454A (ja) | 2004-11-04 |
| JP2004533454A5 true JP2004533454A5 (enExample) | 2005-07-07 |
| JP4099399B2 JP4099399B2 (ja) | 2008-06-11 |
Family
ID=26246078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002589483A Expired - Fee Related JP4099399B2 (ja) | 2001-05-14 | 2002-05-13 | ４−アミノ−５−フェニル−７−シクロブチル−ピロロ［２，３−ｄ］ピリミジン誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7326699B2 (enExample) |
| EP (1) | EP1390369B1 (enExample) |
| JP (1) | JP4099399B2 (enExample) |
| KR (1) | KR100583704B1 (enExample) |
| CN (1) | CN1264844C (enExample) |
| AR (1) | AR035885A1 (enExample) |
| AT (1) | ATE309245T1 (enExample) |
| AU (1) | AU2002312905B2 (enExample) |
| BR (1) | BR0209658A (enExample) |
| CA (1) | CA2446435C (enExample) |
| CO (1) | CO5540346A2 (enExample) |
| CZ (1) | CZ20033067A3 (enExample) |
| DE (1) | DE60207241T2 (enExample) |
| ES (1) | ES2252465T3 (enExample) |
| HU (1) | HUP0304082A3 (enExample) |
| IL (1) | IL158697A0 (enExample) |
| MX (1) | MXPA03010402A (enExample) |
| MY (1) | MY124853A (enExample) |
| NO (1) | NO20034929D0 (enExample) |
| NZ (1) | NZ529256A (enExample) |
| PE (1) | PE20021096A1 (enExample) |
| PL (1) | PL363866A1 (enExample) |
| RU (1) | RU2305682C2 (enExample) |
| SK (1) | SK14022003A3 (enExample) |
| TW (1) | TWI238824B (enExample) |
| WO (1) | WO2002092599A1 (enExample) |
Families Citing this family (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| MXPA04011624A (es) | 2002-05-24 | 2005-03-07 | Schering Corp | Anticuerpo neutralizante humano anti-igfr. |
| GB0226370D0 (en) * | 2002-11-12 | 2002-12-18 | Novartis Ag | Organic compounds |
| GB0302748D0 (en) * | 2003-02-06 | 2003-03-12 | Novartis Ag | Organic compounds |
| AR046071A1 (es) * | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
| WO2005011598A2 (en) * | 2003-07-31 | 2005-02-10 | University Of South Florida | Leukemia treatment method and composition |
| EP1653973A1 (en) * | 2003-08-08 | 2006-05-10 | Novartis AG | Combinations comprising staurosporines |
| ES2372694T3 (es) | 2003-10-15 | 2012-01-25 | OSI Pharmaceuticals, LLC | Inhibidores de tirosina cinasa de imidazo[1,5-a]pirazina. |
| EP1694850B1 (en) | 2003-11-12 | 2011-06-29 | Schering Corporation | Plasmid system for multigene expression |
| AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| WO2005082415A2 (en) | 2004-02-25 | 2005-09-09 | Dana Farber Cancer Institute, Inc. | Inhibitors of insulin-like growth factor receptor-1 for inhibiting tumor cell growth |
| MXPA06011423A (es) | 2004-04-02 | 2007-01-23 | Osi Pharm Inc | Inhibidores de proteina cinasa heterobiciclica sustituida en el anillo 6,6-biciclico. |
| PL2253614T3 (pl) | 2004-04-07 | 2013-03-29 | Novartis Ag | Inhibitory IAP |
| MY139689A (en) | 2004-07-20 | 2009-10-30 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| MX2007001399A (es) | 2004-08-02 | 2007-04-18 | Osi Pharm Inc | Compuestos que inhiben pirrolopirimidina multi-cinasa aril-amino sustituidas. |
| EP2281841A3 (en) | 2004-12-03 | 2013-10-23 | Merck Sharp & Dohme Corp. | Biomarkers for pre-selection of patients for anti-IGF1R therapy |
| CN101222926B (zh) * | 2005-04-15 | 2013-07-17 | 默沙东公司 | 用于治疗或预防癌症的方法和组合物 |
| EP1874769B1 (de) * | 2005-04-25 | 2011-09-14 | Merck Patent GmbH | Neuartige aza-heterozyklen als kinase-inhibitoren |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| US7825244B2 (en) | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
| BRPI0611800A2 (pt) | 2005-06-15 | 2008-12-09 | Schering Corp | formulaÇço estÁvel de anticorpo |
| US7566721B2 (en) * | 2005-08-08 | 2009-07-28 | Osi Pharmaceuticals, Inc. | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors |
| AU2006292278B2 (en) | 2005-09-20 | 2012-03-08 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| GB0520164D0 (en) * | 2005-10-04 | 2005-11-09 | Novartis Ag | Organic compounds |
| AU2006304897B2 (en) | 2005-10-18 | 2012-07-12 | Janssen Pharmaceutica N.V. | Method of inhibiting FLT3 kinase |
| EP1945222B1 (en) * | 2005-11-02 | 2012-12-26 | Bayer Pharma Aktiengesellschaft | Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
| AR057960A1 (es) | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
| US20080299113A1 (en) * | 2005-12-19 | 2008-12-04 | Arnold Lee D | Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents |
| US8575164B2 (en) * | 2005-12-19 | 2013-11-05 | OSI Pharmaceuticals, LLC | Combination cancer therapy |
| GB0605120D0 (en) | 2006-03-14 | 2006-04-26 | Novartis Ag | Organic Compounds |
| DE102006016426A1 (de) * | 2006-04-07 | 2007-10-11 | Merck Patent Gmbh | Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren |
| US20090203718A1 (en) * | 2006-04-13 | 2009-08-13 | Smithkline Beecham (Cork) Ltd. | Cancer treatment method |
| EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| JP2009536180A (ja) | 2006-05-09 | 2009-10-08 | ノバルティス アクチエンゲゼルシャフト | 鉄キレート剤と抗新生物剤を含む組合せ剤およびそれらの使用 |
| JP2010504933A (ja) | 2006-09-29 | 2010-02-18 | ノバルティス アーゲー | Ｐｉ３ｋ脂質キナーゼ阻害剤としてのピラゾロピリミジン |
| US20080119463A1 (en) * | 2006-11-16 | 2008-05-22 | Wyeth | 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML) |
| TW200838559A (en) * | 2006-11-29 | 2008-10-01 | Imclone Systems Inc | Insulin-like growth factor-1 receptor antagonists for modulation of weight and liposity |
| EP2104501B1 (en) * | 2006-12-13 | 2014-03-12 | Merck Sharp & Dohme Corp. | Methods of cancer treatment with igf1r inhibitors |
| WO2008076143A1 (en) * | 2006-12-18 | 2008-06-26 | Osi Pharmaceuticals, Inc. | Combination of igfr inhibitor and anti-cancer agent |
| CA2677651A1 (en) | 2007-02-15 | 2008-08-21 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| KR20100116607A (ko) | 2008-01-11 | 2010-11-01 | 낫코 파마 리미티드 | 항암제로서의 신규한 피라졸로[3,4-ｄ]피리미딘 유도체 |
| EP2250173A1 (en) * | 2008-01-18 | 2010-11-17 | OSI Pharmaceuticals, Inc. | Imidazopyrazinol derivatives for the treatment of cancers |
| ES2524259T3 (es) | 2008-03-24 | 2014-12-04 | Novartis Ag | Inhibidores de metaloproteinasa de matriz a base de arilsulfonamida |
| EA019033B1 (ru) | 2008-03-26 | 2013-12-30 | Новартис Аг | Ингибиторы дезацетилазы в, основанные на гидроксамате |
| ES2396613T3 (es) * | 2008-05-19 | 2013-02-22 | OSI Pharmaceuticals, LLC | Imidazopirazinas e imidazotriazinas sustituidas |
| WO2010054264A1 (en) | 2008-11-07 | 2010-05-14 | Triact Therapeutics, Inc. | Use of catecholic butane derivatives in cancer therapy |
| WO2010083617A1 (en) | 2009-01-21 | 2010-07-29 | Oncalis Ag | Pyrazolopyrimidines as protein kinase inhibitors |
| ES2396023T3 (es) | 2009-01-29 | 2013-02-18 | Novartis Ag | Bencimidazoles sustituidos para el tratamiento de astrocitomas |
| US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US20110171124A1 (en) | 2009-02-26 | 2011-07-14 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the EMT status of tumor cells in vivo |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| US8642834B2 (en) | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2012520893A (ja) | 2009-03-18 | 2012-09-10 | オーエスアイ・ファーマシューティカルズ，エルエルシー | Ｅｇｆｒ阻害薬及びｉｇｆ−１ｒ阻害剤の投与を含む組み合わせ癌治療 |
| EP2421837A1 (en) | 2009-04-20 | 2012-02-29 | OSI Pharmaceuticals, LLC | Preparation of c-pyrazine-methylamines |
| WO2010129740A1 (en) * | 2009-05-07 | 2010-11-11 | Osi Pharmaceuticals, Inc. | Use of osi-906 for treating adrenocortical carcinoma |
| PE20121048A1 (es) | 2009-06-26 | 2012-08-25 | Novartis Ag | Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17 |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
| UA111579C2 (uk) | 2009-08-17 | 2016-05-25 | Інтеллікіне Ллк | ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ |
| IN2012DN01453A (enExample) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
| EA201200321A1 (ru) | 2009-08-26 | 2012-09-28 | Новартис Аг | Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4 |
| CA2773661A1 (en) * | 2009-09-10 | 2011-03-17 | Novartis Ag | Ether derivatives of bicyclic heteroaryls |
| BR112012010519A2 (pt) | 2009-11-04 | 2017-12-05 | Novartis Ag | derivados de sulfonamida heterocíclicos |
| WO2011064211A1 (en) * | 2009-11-25 | 2011-06-03 | Novartis Ag | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls |
| PE20121384A1 (es) | 2009-12-08 | 2012-10-13 | Novartis Ag | Derivados de sulfonamida heterociclicos |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| WO2011083391A2 (en) | 2010-01-05 | 2011-07-14 | Pfizer Inc. | Biomarkers for anti-igf-ir cancer therapy |
| US9109227B2 (en) | 2010-01-05 | 2015-08-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FLT3 receptor antagonists for the treatment or the prevention of pain disorders |
| CN102812022B (zh) | 2010-01-12 | 2016-02-03 | Ab科学有限公司 | 噻唑和噁唑激酶抑制剂 |
| AU2011223655A1 (en) | 2010-03-03 | 2012-06-28 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| AU2011223643A1 (en) | 2010-03-03 | 2012-06-28 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| US20130005733A1 (en) | 2010-03-09 | 2013-01-03 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| EP2627648A1 (en) | 2010-09-16 | 2013-08-21 | Novartis AG | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS |
| SI2640467T1 (sl) | 2010-11-19 | 2015-04-30 | Novartis Ag | Kristalinična oblika inhibitorja interakcije MDM2/4 in P53 |
| EA201390917A1 (ru) | 2010-12-21 | 2013-12-30 | Новартис Аг | Дигетероарильные соединения в качестве ингибиторов vps34 |
| WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| WO2012116040A1 (en) | 2011-02-22 | 2012-08-30 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma |
| WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
| CN103492390A (zh) * | 2011-03-08 | 2014-01-01 | 诺瓦提斯公司 | 氟苯基双环杂芳基化合物 |
| WO2012129145A1 (en) | 2011-03-18 | 2012-09-27 | OSI Pharmaceuticals, LLC | Nscle combination therapy |
| JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用 |
| MX359399B (es) | 2011-04-28 | 2018-09-27 | Novartis Ag | Inhibidores de 17alfa-hidroxilasa/c17-20-liasa. |
| WO2012151137A1 (en) * | 2011-05-04 | 2012-11-08 | Merck Sharp & Dohme Corp. | Amino-pyridine-containing spleen tyrosine kinase (syk) inhibitors |
| IN2014DN00123A (enExample) | 2011-06-09 | 2015-05-22 | Novartis Ag | |
| EP2721007B1 (en) | 2011-06-20 | 2015-04-29 | Novartis AG | Cyclohexyl isoquinolinone compounds |
| EP2721008B1 (en) | 2011-06-20 | 2015-04-29 | Novartis AG | Hydroxy substituted isoquinolinone derivatives as p53 (mdm2 or mdm4) inhibitors |
| EP2723740A1 (en) | 2011-06-27 | 2014-04-30 | Novartis AG | Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives |
| CA2863679A1 (en) | 2011-08-17 | 2014-05-30 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol |
| UY34329A (es) | 2011-09-15 | 2013-04-30 | Novartis Ag | Compuestos de triazolopiridina |
| BR112014007788A2 (pt) * | 2011-10-03 | 2017-04-18 | Univ North Carolina Chapel Hill | compostos de pirrolopirimidina para tratamento do câncer |
| WO2013080141A1 (en) | 2011-11-29 | 2013-06-06 | Novartis Ag | Pyrazolopyrrolidine compounds |
| IN2014CN04174A (enExample) | 2011-12-22 | 2015-09-04 | Novartis Ag | |
| EP2794594A1 (en) | 2011-12-22 | 2014-10-29 | Novartis AG | Quinoline derivatives |
| AU2012355623A1 (en) | 2011-12-23 | 2014-07-17 | Novartis Ag | Compounds for inhibiting the interaction of BCL2 with binding partners |
| AU2012355624A1 (en) | 2011-12-23 | 2014-07-17 | Novartis Ag | Compounds for inhibiting the interaction of BCL2 with binding partners |
| CA2859873A1 (en) | 2011-12-23 | 2013-06-27 | Novartis Ag | Compounds for inhibiting the interaction of bcl2 with binding partners |
| AU2012355613A1 (en) | 2011-12-23 | 2014-07-17 | Novartis Ag | Compounds for inhibiting the interaction of BCL2 with binding partners |
| UY34591A (es) | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
| MX371119B (es) | 2012-04-03 | 2020-01-17 | Novartis Ag | Productos de combinacion con los inhibidores de cinasa de tirosina y su uso. |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| JP6427097B2 (ja) | 2012-06-15 | 2018-11-21 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 癌を処置するための組成物および該組成物を製造するための方法 |
| ES2607807T3 (es) | 2012-08-07 | 2017-04-04 | Janssen Pharmaceutica Nv | Procedimiento para la preparación de los inibidores de las quinasas c-fms |
| AU2013299922B2 (en) | 2012-08-07 | 2018-06-21 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| TW201422625A (zh) | 2012-11-26 | 2014-06-16 | Novartis Ag | 二氫－吡啶并－□衍生物之固體形式 |
| BR112015016282A2 (en) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals, Inc. | crenolanib for treatment of mutated flt3 proliferative disorders |
| WO2014115080A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
| US9403827B2 (en) | 2013-01-22 | 2016-08-02 | Novartis Ag | Substituted purinone compounds |
| WO2014128612A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Quinazolin-4-one derivatives |
| AU2014223548A1 (en) | 2013-02-26 | 2015-10-15 | Triact Therapeutics, Inc. | Cancer therapy |
| HK1219421A1 (zh) | 2013-03-15 | 2017-04-07 | 因特利凯有限责任公司 | 激酶抑制剂的组合及其用途 |
| WO2014155268A2 (en) | 2013-03-25 | 2014-10-02 | Novartis Ag | Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| US20150018376A1 (en) | 2013-05-17 | 2015-01-15 | Novartis Ag | Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof |
| UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
| WO2015022664A1 (en) | 2013-08-14 | 2015-02-19 | Novartis Ag | Compounds and compositions as inhibitors of mek |
| US9227969B2 (en) | 2013-08-14 | 2016-01-05 | Novartis Ag | Compounds and compositions as inhibitors of MEK |
| WO2015022663A1 (en) | 2013-08-14 | 2015-02-19 | Novartis Ag | Compounds and compositions as inhibitors of mek |
| WO2015035410A1 (en) | 2013-09-09 | 2015-03-12 | Triact Therapeutic, Inc. | Cancer therapy |
| KR20160060100A (ko) | 2013-09-22 | 2016-05-27 | 칼리토르 사이언시즈, 엘엘씨 | 치환된 아미노피리미딘 화합물 및 이용 방법 |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途 |
| US9399637B2 (en) | 2014-03-28 | 2016-07-26 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| WO2015153345A1 (en) | 2014-04-03 | 2015-10-08 | Invictus Oncology Pvt. Ltd. | Supramolecular combinatorial therapeutics |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| BR112017002001B1 (pt) | 2014-07-31 | 2022-10-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compostos e composição farmacêutica |
| US10195208B2 (en) | 2014-07-31 | 2019-02-05 | Novartis Ag | Combination therapy |
| EP3347097B1 (en) | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
| EP3254698A1 (en) | 2016-06-08 | 2017-12-13 | Universite De Montpellier | Flt3 receptor inhibitor at low dosage for the treatment of neuropathic pain |
| US12662706B2 (en) | 2016-11-02 | 2026-06-23 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| US12534764B2 (en) | 2016-11-02 | 2026-01-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| KR20180074792A (ko) | 2016-11-02 | 2018-07-03 | 아로그 파마슈티칼스, 인코퍼레이티드 | 돌연변이 연관된 flt3 돌연변이된 증식성 장애를 치료하기 위한 크레노라닙 |
| WO2018211018A1 (en) | 2017-05-17 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 inhibitors for improving pain treatments by opioids |
| WO2019057649A1 (en) | 2017-09-19 | 2019-03-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA |
| WO2019099311A1 (en) | 2017-11-19 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| EP3730483B1 (en) | 2017-12-21 | 2023-08-30 | Hefei Institutes of Physical Science, Chinese Academy of Sciences | Class of pyrimidine derivative kinase inhibitors |
| EP3740468B1 (en) | 2018-01-20 | 2025-12-31 | Sunshine Lake Pharma Co., Ltd. | Substituted Aminopyrimidine Compounds and Methods of Use |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP2022545835A (ja) | 2019-08-28 | 2022-10-31 | ホライゾン セラピューティクス アイルランド デジグネイテッド アクティビティ カンパニー | 甲状腺眼症の治療方法 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115916966A (zh) * | 2020-01-30 | 2023-04-04 | 加利福尼亚大学董事会 | Strad结合剂及其用途 |
| WO2022019998A1 (en) | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| CN122003247A (zh) | 2023-07-07 | 2026-05-08 | 维里迪安治疗公司 | 治疗活动性和慢性甲状腺眼病的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2223081C (en) * | 1995-06-07 | 2001-03-06 | Pfizer Inc. | Heterocyclic ring-fused pyrimidine derivatives |
| CH690773A5 (de) | 1996-02-01 | 2001-01-15 | Novartis Ag | Pyrrolo(2,3-d)pyrimide und ihre Verwendung. |
| AU3176297A (en) | 1996-06-25 | 1998-01-14 | Novartis Ag | Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof |
| IL129825A0 (en) | 1996-11-27 | 2000-02-29 | Pfizer | Fused bicyclic pyrimidine derivatives |
| BR9808281A (pt) * | 1997-03-19 | 2000-05-16 | Basf Ag | Compostos, composições farmacêuticas, processo para tratar doenças proliferativas e/ou distúrbios do sistema imune e para preparar um composto, e, uso de um composto |
| HUP0103836A3 (en) | 1998-06-02 | 2003-05-28 | Osi Pharmaceuticals Inc Uniond | Pyrrolo[2,3d]pyrimidine compositions and their use |
| WO2000009145A1 (en) | 1998-08-13 | 2000-02-24 | Thomas Jefferson University | Treatment of tumors with oligonucleotides directed to insulin-like growth factor-i receptor |
| CZ2001959A3 (cs) | 1998-09-18 | 2001-12-12 | Basf Aktiengesellschaft | 4-Aminopyrrolopyrimidiny jako inhibitory kinasy |
| NZ510588A (en) | 1998-09-18 | 2003-08-29 | Abbott Gmbh & Co | Pyrrolopyrimidines as protein kinase inhibitors |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| AU2000240570A1 (en) | 2000-03-29 | 2001-10-08 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| EP1476192B1 (en) | 2002-02-14 | 2007-04-25 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for treating hyperproliferative conditions |
| US20050215564A1 (en) * | 2002-02-14 | 2005-09-29 | Stiles Charles D | Methods and compositions for treating hyperproliferative conditions |
-
2002
- 2002-05-10 TW TW091109801A patent/TWI238824B/zh active
- 2002-05-10 AR ARP020101716A patent/AR035885A1/es not_active Application Discontinuation
- 2002-05-13 PL PL02363866A patent/PL363866A1/xx unknown
- 2002-05-13 EP EP02738065A patent/EP1390369B1/en not_active Expired - Lifetime
- 2002-05-13 KR KR1020037014725A patent/KR100583704B1/ko not_active Expired - Fee Related
- 2002-05-13 AT AT02738065T patent/ATE309245T1/de active
- 2002-05-13 NZ NZ529256A patent/NZ529256A/en unknown
- 2002-05-13 SK SK1402-2003A patent/SK14022003A3/sk unknown
- 2002-05-13 CN CNB028100034A patent/CN1264844C/zh not_active Expired - Fee Related
- 2002-05-13 JP JP2002589483A patent/JP4099399B2/ja not_active Expired - Fee Related
- 2002-05-13 WO PCT/EP2002/005239 patent/WO2002092599A1/en not_active Ceased
- 2002-05-13 CZ CZ20033067A patent/CZ20033067A3/cs unknown
- 2002-05-13 DE DE60207241T patent/DE60207241T2/de not_active Expired - Lifetime
- 2002-05-13 MY MYPI20021716A patent/MY124853A/en unknown
- 2002-05-13 IL IL15869702A patent/IL158697A0/xx unknown
- 2002-05-13 BR BR0209658-7A patent/BR0209658A/pt not_active IP Right Cessation
- 2002-05-13 ES ES02738065T patent/ES2252465T3/es not_active Expired - Lifetime
- 2002-05-13 CA CA002446435A patent/CA2446435C/en not_active Expired - Fee Related
- 2002-05-13 RU RU2003134149/04A patent/RU2305682C2/ru not_active IP Right Cessation
- 2002-05-13 US US10/477,594 patent/US7326699B2/en not_active Expired - Fee Related
- 2002-05-13 AU AU2002312905A patent/AU2002312905B2/en not_active Ceased
- 2002-05-13 HU HU0304082A patent/HUP0304082A3/hu unknown
- 2002-05-13 MX MXPA03010402A patent/MXPA03010402A/es active IP Right Grant
- 2002-05-14 PE PE2002000402A patent/PE20021096A1/es not_active Application Discontinuation
-
2003
- 2003-11-05 NO NO20034929A patent/NO20034929D0/no not_active Application Discontinuation
- 2003-12-01 CO CO03105541A patent/CO5540346A2/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2003134149A (ru) | Производные 4-амино-5-фенил-7- циклобутилпирроло[2,3-d]пиримидина | |
| CA2453881A1 (en) | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | |
| JP2005502683A5 (enExample) | ||
| EP2389382B1 (en) | Amino-heterocyclic compounds used as pde9 inhibitors | |
| JP2005501077A5 (enExample) | ||
| JP5647998B2 (ja) | 免疫抑制剤としてのチアゾロピリミジン調節因子 | |
| US20110165183A1 (en) | Piperidine derivatives as jak3 inhibitors | |
| WO2019165073A1 (en) | Shp2 phosphatase inhibitors and methods of use thereof | |
| CA2407593A1 (en) | Fused heteroaryl derivatives | |
| RU2012111215A (ru) | Гетероциклические соединения в качестве ингибиторов янускиназы | |
| JP2024536858A5 (enExample) | ||
| US20090176785A1 (en) | Method of treating arthritis | |
| RU2005117340A (ru) | Производные пиримидо {4,5-d}пиримидина, обладающие противораковой активностью | |
| JP2014503566A5 (enExample) | ||
| EP1476192B1 (en) | Methods and compositions for treating hyperproliferative conditions | |
| JP2003535864A5 (enExample) | ||
| JP2021523177A5 (enExample) | ||
| JP2021042204A (ja) | キナーゼ阻害剤を用いた汗腺炎の処置 | |
| US20130184273A1 (en) | Bicyclic pyrimidines | |
| US20050215564A1 (en) | Methods and compositions for treating hyperproliferative conditions | |
| RU2007147595A (ru) | Производные индактерола и фосфодиэстеразные ингибиторы для лечения заболеваний дыхательных путей | |
| JP2004529119A5 (enExample) | ||
| CN111588724A (zh) | 含有吡咯并嘧啶衍生物的组合物在制备用于治疗Janus激酶介导的疾病的药物中的用途 | |
| JP2013512215A5 (enExample) | ||
| ZA200308378B (en) | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-D) pyrimidine derivatives. |