JP2004531501A5 - - Google Patents
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- Publication number
- JP2004531501A5 JP2004531501A5 JP2002576253A JP2002576253A JP2004531501A5 JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5 JP 2002576253 A JP2002576253 A JP 2002576253A JP 2002576253 A JP2002576253 A JP 2002576253A JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- -1 hydroxy-phenylene Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- WTYGESWNSUGPKO-HSZRJFAPSA-N (2r)-2-amino-2-ethyl-4-[3-methoxy-4-(4-phenylbutoxy)phenyl]butan-1-ol Chemical compound COC1=CC(CC[C@@](N)(CO)CC)=CC=C1OCCCCC1=CC=CC=C1 WTYGESWNSUGPKO-HSZRJFAPSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- CETMIEJVKCOWKS-HXUWFJFHSA-N (2r)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1=CC=CC=C1 CETMIEJVKCOWKS-HXUWFJFHSA-N 0.000 claims 1
- TTWYWDKXOGKVDD-HXUWFJFHSA-N (2r)-2-amino-4-[4-(3-cyclohexylpropoxy)phenyl]-2-methylbutan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1CCCCC1 TTWYWDKXOGKVDD-HXUWFJFHSA-N 0.000 claims 1
- UIFQPECWUIOGLQ-UHFFFAOYSA-N 1-[4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl]-5-cyclohexylpentan-1-one Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(=O)CCCCC1CCCCC1 UIFQPECWUIOGLQ-UHFFFAOYSA-N 0.000 claims 1
- FROOZUIUGSQXIX-JOCHJYFZSA-N [(2r)-2-amino-2-methyl-4-[4-(5-phenylpentoxy)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CC[C@](N)(C)COP(O)(O)=O)=CC=C1OCCCCCC1=CC=CC=C1 FROOZUIUGSQXIX-JOCHJYFZSA-N 0.000 claims 1
- XGJCXFMLNLXLFE-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(5-phenylpentanoyl)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1=CC=CC=C1 XGJCXFMLNLXLFE-UHFFFAOYSA-N 0.000 claims 1
- HZRGEJWFLNYLGP-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(7-phenylheptanoyl)phenyl]butyl] dihydrogen phosphate Chemical class C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCCCC1=CC=CC=C1 HZRGEJWFLNYLGP-UHFFFAOYSA-N 0.000 claims 1
- HNYWOJFTDKYXMR-UHFFFAOYSA-N [2-amino-4-[4-(5-cyclohexylpentanoyl)phenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1CCCCC1 HNYWOJFTDKYXMR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107506A GB0107506D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0107507A GB0107507D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0108346A GB0108346D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
| PCT/EP2002/003389 WO2002076995A2 (en) | 2001-03-26 | 2002-03-26 | 2-amino-propanol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531501A JP2004531501A (ja) | 2004-10-14 |
| JP2004531501A5 true JP2004531501A5 (https=) | 2005-06-02 |
| JP4012823B2 JP4012823B2 (ja) | 2007-11-21 |
Family
ID=27256123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576253A Expired - Fee Related JP4012823B2 (ja) | 2001-03-26 | 2002-03-26 | ２−アミノ−誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7326801B2 (https=) |
| EP (1) | EP1377593B1 (https=) |
| JP (1) | JP4012823B2 (https=) |
| KR (1) | KR20030093279A (https=) |
| CN (1) | CN1620461A (https=) |
| AT (1) | ATE314383T1 (https=) |
| BR (1) | BR0208365A (https=) |
| CA (1) | CA2442178A1 (https=) |
| CZ (1) | CZ20032560A3 (https=) |
| DE (1) | DE60208355T2 (https=) |
| DK (1) | DK1377593T3 (https=) |
| ES (1) | ES2254675T3 (https=) |
| IL (1) | IL157773A0 (https=) |
| MX (1) | MXPA03008755A (https=) |
| NO (1) | NO20034291L (https=) |
| PL (1) | PL367348A1 (https=) |
| SK (1) | SK11942003A3 (https=) |
| WO (1) | WO2002076995A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0306811A (pt) | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
| RU2358717C2 (ru) * | 2002-05-16 | 2009-06-20 | Новартис Аг | Применение средств, связывающих edg-рецептор, в лечении ракового заболевания |
| PL372103A1 (en) | 2002-05-16 | 2005-07-11 | Novartis Ag | Use of edg receptor binding agents in cancer |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| CA2533587A1 (en) | 2002-07-30 | 2004-02-05 | University Of Virginia Patent Foundation | Compounds active in sphingosine 1-phosphate signaling |
| US7612238B2 (en) | 2002-09-13 | 2009-11-03 | Novartis Ag | Amino-propanol derivatives |
| KR101003877B1 (ko) | 2002-09-19 | 2010-12-30 | 교린 세이야꾸 가부시키 가이샤 | 아미노알코올 유도체와 그 부가염 및 면역 억제제 |
| KR20080103117A (ko) | 2002-09-24 | 2008-11-26 | 노파르티스 아게 | 탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트 |
| MXPA05008531A (es) * | 2003-02-11 | 2005-11-17 | Irm Llc | Compuestos biciclicos novedosos y composiciones. |
| US7456157B2 (en) | 2003-02-18 | 2008-11-25 | Kyorin Pharmaceutical Co., Ltd. | Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators |
| CA2521325C (en) | 2003-04-08 | 2010-09-14 | Novartis Ag | Solid pharmaceutical compositions comprising a s1p receptor agonist and a sugar alcohol |
| CA2523677A1 (en) * | 2003-04-30 | 2004-11-11 | Novartis Ag | Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators |
| EP1622860B1 (en) | 2003-04-30 | 2012-02-29 | Novartis AG | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORs |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| CN1874996B (zh) * | 2003-08-28 | 2011-05-18 | 诺瓦提斯公司 | 氨基丙醇衍生物 |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| WO2005044780A1 (ja) * | 2003-11-10 | 2005-05-19 | Kyorin Pharmaceutical Co., Ltd. | アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤 |
| GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
| GB0405289D0 (en) * | 2004-03-09 | 2004-04-21 | Novartis Ag | Organic compounds |
| AU2005237254B2 (en) * | 2004-05-03 | 2010-02-04 | Novartis Ag | Combinations comprising a S1P receptor agonist and a JAK3 kinase inhibitor |
| GB0411929D0 (en) | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| CN101014329B (zh) | 2004-07-16 | 2010-09-08 | 杏林制药株式会社 | 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物 |
| MX2007001236A (es) | 2004-07-30 | 2007-03-23 | Novartis Ag | Formulaciones de compuestos de 2-amino-1, 3-propanodiol. |
| MX2007001661A (es) | 2004-08-13 | 2007-04-23 | Praecis Pharm Inc | Metodos y composiciones para modular la actividad del receptor de esfingosina -1 fosfato (sip). |
| EP1806338B1 (en) * | 2004-10-12 | 2016-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof |
| KR20140095109A (ko) | 2004-11-29 | 2014-07-31 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| AU2006214314B2 (en) | 2005-02-14 | 2012-02-09 | University Of Virginia Patent Foundation | Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups |
| GB0504544D0 (en) * | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| JP2009507003A (ja) | 2005-09-01 | 2009-02-19 | アレス トレーディング ソシエテ アノニム | 視神経炎の治療 |
| SI1932522T1 (sl) * | 2005-10-07 | 2012-08-31 | Kyorin Seiyaku Kk | Terapevtsko sredstvo za jetrno bolezen, ki vsebuje 2-amino-1,3- propandiolni derivat kot aktivno sestavino |
| KR101346527B1 (ko) * | 2005-12-15 | 2013-12-31 | 미쓰비시 타나베 파마 코퍼레이션 | 아민 화합물 및 그 의약 용도 |
| KR20080086546A (ko) | 2006-01-27 | 2008-09-25 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 신경병증성 통증의 치료 방법 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| AU2007212193A1 (en) | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| AU2007249668B2 (en) | 2006-04-11 | 2011-04-07 | Novartis Ag | HCV/HIV inhibitors and their uses |
| MX2009001457A (es) | 2006-08-08 | 2009-02-19 | Kyorin Seiyaku Kk | Derivados de aminoalcohol e inmunosupresores que contienen lo mismo como ingrediente activo. |
| JP5188972B2 (ja) * | 2006-08-08 | 2013-04-24 | 杏林製薬株式会社 | アミノリン酸エステル誘導体及びそれらを有効成分とするｓ１ｐ受容体調節剤 |
| CA2669102A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| CA2669104A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
| AU2007323557A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| TWI439263B (zh) | 2007-06-14 | 2014-06-01 | Mitsubishi Tanabe Pharma Corp | 胺化合物及其醫藥用途 |
| WO2009099174A1 (ja) * | 2008-02-07 | 2009-08-13 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| EA201390532A1 (ru) | 2010-10-08 | 2013-09-30 | Новартис Аг | Композиции сульфамидых ингибиторов ns3, содержащие витамин е |
| GB201715786D0 (en) | 2017-09-29 | 2017-11-15 | Univ College Cardiff Consultants Ltd | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604229A (en) * | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| ES2065855B1 (es) * | 1993-05-31 | 1995-09-01 | Menarini Lab | Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos. |
| DE69524962D1 (de) * | 1994-08-22 | 2002-02-14 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| ATE298740T1 (de) | 1997-04-04 | 2005-07-15 | Mitsubishi Pharma Corp | 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese |
| WO2002006268A1 (en) | 2000-07-13 | 2002-01-24 | Sankyo Company, Limited | Amino alcohol derivatives |
| WO2002018395A1 (en) | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
-
2002
- 2002-03-26 EP EP02727484A patent/EP1377593B1/en not_active Expired - Lifetime
- 2002-03-26 IL IL15777302A patent/IL157773A0/xx unknown
- 2002-03-26 US US10/472,127 patent/US7326801B2/en not_active Expired - Fee Related
- 2002-03-26 JP JP2002576253A patent/JP4012823B2/ja not_active Expired - Fee Related
- 2002-03-26 PL PL02367348A patent/PL367348A1/xx not_active Application Discontinuation
- 2002-03-26 CZ CZ20032560A patent/CZ20032560A3/cs unknown
- 2002-03-26 SK SK1194-2003A patent/SK11942003A3/sk unknown
- 2002-03-26 AT AT02727484T patent/ATE314383T1/de active
- 2002-03-26 ES ES02727484T patent/ES2254675T3/es not_active Expired - Lifetime
- 2002-03-26 CN CNA028068378A patent/CN1620461A/zh active Pending
- 2002-03-26 DE DE60208355T patent/DE60208355T2/de not_active Expired - Lifetime
- 2002-03-26 MX MXPA03008755A patent/MXPA03008755A/es unknown
- 2002-03-26 DK DK02727484T patent/DK1377593T3/da active
- 2002-03-26 KR KR10-2003-7012474A patent/KR20030093279A/ko not_active Ceased
- 2002-03-26 CA CA002442178A patent/CA2442178A1/en not_active Abandoned
- 2002-03-26 WO PCT/EP2002/003389 patent/WO2002076995A2/en not_active Ceased
- 2002-03-26 BR BR0208365-5A patent/BR0208365A/pt not_active Application Discontinuation
-
2003
- 2003-09-25 NO NO20034291A patent/NO20034291L/no not_active Application Discontinuation
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