JP2007536240A5 - - Google Patents

Info

Publication number

JP2007536240A5

JP2007536240A5 JP2007511484A JP2007511484A JP2007536240A5 JP 2007536240 A5 JP2007536240 A5 JP 2007536240A5 JP 2007511484 A JP2007511484 A JP 2007511484A JP 2007511484 A JP2007511484 A JP 2007511484A JP 2007536240 A5 JP2007536240 A5 JP 2007536240A5

Authority

JP

Japan

Prior art keywords

composition

alkyl

aryl

heterocycloalkyl

independently

Prior art date

2005-05-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 55
• 125000000217 alkyl group Chemical group 0.000 claims 45
• 125000003118 aryl group Chemical group 0.000 claims 33
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 32
• 150000001875 compounds Chemical class 0.000 claims 30
• 125000001072 heteroaryl group Chemical group 0.000 claims 29
• 125000000753 cycloalkyl group Chemical group 0.000 claims 27
• 241000711573 Coronaviridae Species 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 7
• 241000315672 SARS coronavirus Species 0.000 claims 6
• 208000001528 Coronaviridae Infections Diseases 0.000 claims 5
• 229940125782 compound 2 Drugs 0.000 claims 5
• 239000000651 prodrug Substances 0.000 claims 5
• 229940002612 prodrug Drugs 0.000 claims 5
• 239000012453 solvate Substances 0.000 claims 5
• 241000725303 Human immunodeficiency virus Species 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 241000713800 Feline immunodeficiency virus Species 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• 101900225426 Feline immunodeficiency virus Protease Proteins 0.000 claims 1
• 229940125810 compound 20 Drugs 0.000 claims 1
• JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 claims 1
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 0 CC*C(*)(C(*)(*)C(*)(*)NC(*)=O)C(*)(*)NC(C(*)(*)NC(*)=O)=O Chemical compound CC*C(*)(C(*)(*)C(*)(*)NC(*)=O)C(*)(*)NC(C(*)(*)NC(*)=O)=O 0.000 description 9
• RPPKGGKXORNOHP-QXCLCYAZSA-N CC(C)(C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(/C=C/C(C=C1)=CCC1OC)=O Chemical compound CC(C)(C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(/C=C/C(C=C1)=CCC1OC)=O RPPKGGKXORNOHP-QXCLCYAZSA-N 0.000 description 1
• OPSAIBJIKRLERT-NIHKGPPOSA-N CC(C)C(C1)[C@@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(CSc1ncccc1)=O Chemical compound CC(C)C(C1)[C@@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(CSc1ncccc1)=O OPSAIBJIKRLERT-NIHKGPPOSA-N 0.000 description 1
• QSHAKYBQPNPOMV-PZZSAPDUSA-N CC(C)[C@@H](C1)C1(C(CCCC(C)[C@@H](Cc1ccccc1)[C@H](C[C@H](Cc1ccccc1)NC(COc1c(C)cccc1C)=O)O)=O)NC(c1ccc(C(F)(F)F)cc1)=O Chemical compound CC(C)[C@@H](C1)C1(C(CCCC(C)[C@@H](Cc1ccccc1)[C@H](C[C@H](Cc1ccccc1)NC(COc1c(C)cccc1C)=O)O)=O)NC(c1ccc(C(F)(F)F)cc1)=O QSHAKYBQPNPOMV-PZZSAPDUSA-N 0.000 description 1
• KJAGBIDBURADDL-MRLUAOGESA-N CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2=C(C)CCC=C2C)=O)CC1)=O)NC(CCNC(OC(C)(C)C)=O)O Chemical compound CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2=C(C)CCC=C2C)=O)CC1)=O)NC(CCNC(OC(C)(C)C)=O)O KJAGBIDBURADDL-MRLUAOGESA-N 0.000 description 1
• TXXBJSQQOGOAOJ-AFUXAMQGSA-N CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2C(C)=CC=CC2C)=O)CC1)=O)NC(C1=CC2C=CC=CC2N1)=O Chemical compound CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COC2C(C)=CC=CC2C)=O)CC1)=O)NC(C1=CC2C=CC=CC2N1)=O TXXBJSQQOGOAOJ-AFUXAMQGSA-N 0.000 description 1
• UXTIVPMTVLXBMR-KPEXPGEQSA-N CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(COc1cc2ccccc2cc1)=O Chemical compound CC(C)[C@@H](C1)[C@]1(C(N[C@@H](Cc1ccccc1)C1(C[C@H](Cc2ccccc2)NC(COc2c(C)cccc2C)=O)CC1)=O)NC(COc1cc2ccccc2cc1)=O UXTIVPMTVLXBMR-KPEXPGEQSA-N 0.000 description 1