JP2007536240A - 抗コロナウイルス化合物 - Google Patents

抗コロナウイルス化合物 Download PDF

Info

Publication number
JP2007536240A
JP2007536240A JP2007511484A JP2007511484A JP2007536240A JP 2007536240 A JP2007536240 A JP 2007536240A JP 2007511484 A JP2007511484 A JP 2007511484A JP 2007511484 A JP2007511484 A JP 2007511484A JP 2007536240 A JP2007536240 A JP 2007536240A
Authority
JP
Japan
Prior art keywords
alkyl
compound
aryl
heterocycloalkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007511484A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007536240A5 (https=
Inventor
ウォン,チ−フエイ
ウ,チュン−イ
ジャン,ジャ−ツロン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Academia Sinica
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Publication of JP2007536240A publication Critical patent/JP2007536240A/ja
Publication of JP2007536240A5 publication Critical patent/JP2007536240A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
JP2007511484A 2004-05-04 2005-05-03 抗コロナウイルス化合物 Pending JP2007536240A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56808004P 2004-05-04 2004-05-04
PCT/US2005/015227 WO2006073456A2 (en) 2004-05-04 2005-05-03 Anti-coronavirus compounds

Publications (2)

Publication Number Publication Date
JP2007536240A true JP2007536240A (ja) 2007-12-13
JP2007536240A5 JP2007536240A5 (https=) 2008-03-27

Family

ID=36647910

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007511484A Pending JP2007536240A (ja) 2004-05-04 2005-05-03 抗コロナウイルス化合物

Country Status (7)

Country Link
US (1) US8481571B2 (https=)
JP (1) JP2007536240A (https=)
CN (1) CN1949977B (https=)
AU (1) AU2005323435A1 (https=)
NZ (1) NZ550945A (https=)
TW (1) TWI372048B (https=)
WO (1) WO2006073456A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014533710A (ja) * 2011-11-25 2014-12-15 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH 抗菌性チロシン誘導体およびその製造方法
JP2015518896A (ja) * 2012-06-06 2015-07-06 ユニザー ヴィロロジー,エルエルシー 新規イミノ糖およびそれらの用途

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017059118A1 (en) * 2015-09-29 2017-04-06 Duke University Compositions and methods for identifying and treating dystonia disorders
WO2017201052A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating zika virus infection
CN107595906B (zh) * 2017-11-10 2020-10-30 中国药科大学 常春藤皂苷元及其糖苷在制备抗病毒的药物中的应用
EA202193251A1 (ru) 2019-06-05 2022-03-10 Эмори Юниверсити Пептидомиметики для лечения коронавирусной и пикорнавирусной инфекций
CN115698035A (zh) * 2020-04-10 2023-02-03 共晶制药公司 诺如病毒及冠状病毒复制的抑制剂
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01265023A (ja) * 1988-04-13 1989-10-23 Taiyo Kagaku Co Ltd 下痢症ウイルス感染阻害剤
JPH03128335A (ja) * 1989-05-23 1991-05-31 Abbott Lab レトロウイルスプロテアーゼ抑制化合物
JPH04297475A (ja) * 1991-03-26 1992-10-21 Yamanouchi Pharmaceut Co Ltd 抗ウイルス剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156973A (en) 1988-11-23 1992-10-20 Edward Shanbrom Antiviral blood sampling process and apparatus
HUT64738A (en) 1990-06-01 1994-02-28 Du Pont Merck Pharma Process for preparing 1,4-diamino-2,3-dihydroxi-butane compounds and pharmaceutical compositions contianing them
US6803466B1 (en) 1997-12-08 2004-10-12 The Scripps Research Institute HIV/FIV protease inhibitors having a small P3 residue

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01265023A (ja) * 1988-04-13 1989-10-23 Taiyo Kagaku Co Ltd 下痢症ウイルス感染阻害剤
JPH03128335A (ja) * 1989-05-23 1991-05-31 Abbott Lab レトロウイルスプロテアーゼ抑制化合物
JPH04297475A (ja) * 1991-03-26 1992-10-21 Yamanouchi Pharmaceut Co Ltd 抗ウイルス剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014533710A (ja) * 2011-11-25 2014-12-15 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH 抗菌性チロシン誘導体およびその製造方法
JP2015518896A (ja) * 2012-06-06 2015-07-06 ユニザー ヴィロロジー,エルエルシー 新規イミノ糖およびそれらの用途

Also Published As

Publication number Publication date
TW200600084A (en) 2006-01-01
US8481571B2 (en) 2013-07-09
CN1949977B (zh) 2010-09-29
NZ550945A (en) 2010-04-30
TWI372048B (en) 2012-09-11
AU2005323435A1 (en) 2006-07-13
US20060160866A1 (en) 2006-07-20
CN1949977A (zh) 2007-04-18
WO2006073456A2 (en) 2006-07-13
WO2006073456A3 (en) 2006-09-14

Similar Documents

Publication Publication Date Title
JP7795521B2 (ja) 抗ウイルス剤としての官能化ペプチド
US11970502B2 (en) Macrocyclic antiviral agents
RU2505534C2 (ru) Производные хиназолина, ингибирующие активность egfr
JP2023537402A (ja) 抗ウイルス剤としての機能化ペプチド
EA029099B1 (ru) Замещенные циклофаны для использования при лечении инфекции вгс
EA019893B1 (ru) Фармацевтическая композиция и способ лечения вич-инфекции
CN109071423A (zh) 吲哚胺-2,3-双加氧酶(ido)抑制剂
CN114008024A (zh) 具有铁死亡诱导活性的化合物以及使用其的方法
JP6615207B2 (ja) 複素環式化合物及びその使用
RU2557235C1 (ru) Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты
CN111410661A (zh) 帽依赖性内切核酸酶抑制剂及其用途
CN119548495A (zh) (取代的1h-咪唑-4-基)(3,4,5-三甲氧基苯基)甲酮在制备治疗冠状病毒的药物中的用途
JP2007536240A (ja) 抗コロナウイルス化合物
US20220389061A1 (en) Immunomodulators
JPH05501879A (ja) Hivおよび他のレトロウイルスを処理する方法およびそれに有用な化合物
JP6698083B2 (ja) 抗hcmvの組成物及び方法
EP0792271B1 (en) Furan derivatives for inhibiting pneumocystis carinii pneumonia, giardia lamblia and cryptosporidium parvum
CN105555266A (zh) 用于治疗丙型肝炎病毒的包含三环十六碳六烯衍生物的组合产品
JPWO2006082821A1 (ja) ヘルペスウイルスが関与する疾患の予防若しくは治療剤
EP4052726B1 (en) Cd4 mimic compound with anti-hiv activity
AU2024285970A1 (en) Solid forms of n-(methoxycarbonyl)-3-methyl-l-valyl-(4r)- n-{(1s)-1-cyano-2-[(3s)-2-oxopyrrolidin-3-yl]ethyl}-4-(trifluoromethyl)-l-prolinamide and solvates thereof
RU2723482C1 (ru) Пангенотипичный ингибитор белка NS5A вируса гепатита С, фармацевтическая композиция и способы их получения и применения
CN121735956A (zh) 一种病毒nsp12蛋白降解剂及其制备方法和应用
CN106999488A (zh) 以二环式含氮芳香族杂环酰胺化合物作为有效成分的药物组合物
TW201144296A (en) Tetrazolones as inhibitors of fatty acid synthase

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080204

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080204

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101221

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110913