JP2004512263A - オピオイド受容体親和性を有する3−アザビシクロ(3.1.0)ヘキサン誘導体 - Google Patents
オピオイド受容体親和性を有する3−アザビシクロ(3.1.0)ヘキサン誘導体 Download PDFInfo
- Publication number
- JP2004512263A JP2004512263A JP2002504223A JP2002504223A JP2004512263A JP 2004512263 A JP2004512263 A JP 2004512263A JP 2002504223 A JP2002504223 A JP 2002504223A JP 2002504223 A JP2002504223 A JP 2002504223A JP 2004512263 A JP2004512263 A JP 2004512263A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- optionally substituted
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CCC*C*N Chemical compound CCC*C*N 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0015562.2A GB0015562D0 (en) | 2000-06-23 | 2000-06-23 | Heterocycles |
PCT/IB2001/001035 WO2001098267A1 (fr) | 2000-06-23 | 2001-06-07 | Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2004512263A true JP2004512263A (ja) | 2004-04-22 |
Family
ID=9894368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002504223A Withdrawn JP2004512263A (ja) | 2000-06-23 | 2001-06-07 | オピオイド受容体親和性を有する3−アザビシクロ(3.1.0)ヘキサン誘導体 |
Country Status (34)
Country | Link |
---|---|
EP (1) | EP1292574A1 (fr) |
JP (1) | JP2004512263A (fr) |
KR (1) | KR20040002386A (fr) |
CN (1) | CN1639121A (fr) |
AP (1) | AP2002002698A0 (fr) |
AR (1) | AR028969A1 (fr) |
AU (1) | AU781837B2 (fr) |
BG (1) | BG107329A (fr) |
BR (1) | BR0111867A (fr) |
CA (1) | CA2412188A1 (fr) |
CZ (1) | CZ20023967A3 (fr) |
DO (1) | DOP2001000187A (fr) |
DZ (1) | DZ3368A1 (fr) |
EA (1) | EA005117B1 (fr) |
GB (1) | GB0015562D0 (fr) |
HR (1) | HRP20020998A2 (fr) |
HU (1) | HUP0301228A3 (fr) |
IL (1) | IL153427A0 (fr) |
IS (1) | IS6637A (fr) |
MA (1) | MA26915A1 (fr) |
MX (1) | MXPA02012878A (fr) |
NO (1) | NO20026168L (fr) |
NZ (1) | NZ523141A (fr) |
OA (1) | OA12293A (fr) |
PA (1) | PA8519401A1 (fr) |
PE (1) | PE20020253A1 (fr) |
PL (1) | PL365956A1 (fr) |
SK (1) | SK17172002A3 (fr) |
TN (1) | TNSN01094A1 (fr) |
UA (1) | UA73176C2 (fr) |
UY (1) | UY26787A1 (fr) |
WO (1) | WO2001098267A1 (fr) |
YU (1) | YU91802A (fr) |
ZA (1) | ZA200210278B (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008535888A (ja) * | 2005-04-15 | 2008-09-04 | グラクソ グループ リミテッド | ドーパミンd3受容体のモジュレーターとして有用なアザビシクロ(3.1.0)ヘキサン誘導体 |
JP2008543801A (ja) * | 2005-06-14 | 2008-12-04 | グラクソ グループ リミテッド | ドーパミンd3受容体のモジュレーターとしてのアザビシクロ[3.1.0]ヘキサン誘導体 |
JP2010537978A (ja) * | 2007-08-27 | 2010-12-09 | セラヴァンス, インコーポレーテッド | μオピオイド受容体拮抗薬としての8−アザビシクロ[3.2.1]オクチル−2−ヒドロキシベンズアミド化合物 |
JP2015107980A (ja) * | 2010-06-11 | 2015-06-11 | ローズ テクノロジーズ | N−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
JP2020508300A (ja) * | 2017-02-17 | 2020-03-19 | トレベナ・インコーポレイテッドTrevena, Inc. | 5員アザ複素環を含有するデルタ−オピオイド受容体調節化合物、その使用方法及び製造方法 |
US11912713B2 (en) | 2017-02-17 | 2024-02-27 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60226161T2 (de) * | 2001-10-22 | 2009-07-02 | Pfizer Products Inc., Groton | 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren |
KR101108014B1 (ko) * | 2002-05-17 | 2012-01-25 | 티오가 파마슈티칼스, 인코포레이티드 | 선택성 아편제 수용체 조절인자로서 효과적인 화합물의 용도 |
DE10259245A1 (de) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
SI1745040T1 (sl) | 2004-02-23 | 2010-04-30 | Venue Glaxo Group Ltd | Derivati azabiciklo(3.1.0)heksana, uporabni kot modulatorji dopaminskih receptorjev d3 |
DE602007012531D1 (de) * | 2006-04-03 | 2011-03-31 | Glaxo Group Ltd | Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren |
WO2008121496A1 (fr) | 2007-03-30 | 2008-10-09 | Tioga Pharmaceuticals Inc. | Agonistes du récepteur opiacé kappa pour le traitement du syndrome du côlon irritable avec alternance ou à diarrhée prédominante |
WO2012042539A2 (fr) | 2010-09-28 | 2012-04-05 | Panacea Biotec Ltd | Nouveaux composés bicycliques |
US9663463B2 (en) * | 2013-11-20 | 2017-05-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose |
RU2017144548A (ru) | 2015-05-20 | 2019-06-20 | Санва Кагаку Кенкюсо Ко., Лтд. | Кристаллическая соль нового производного 3-азабицикло[3.1.0]гексана и ее применение в медицине |
CA3054122A1 (fr) | 2017-03-02 | 2018-09-07 | Sanwa Kagaku Kenkyusho Co., Ltd. | Agent therapeutique pour troubles lies a la consommation d'alcool |
CN108250088B (zh) * | 2018-01-04 | 2020-10-30 | 四川之江高新材料股份有限公司 | N,n,n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3065230A (en) * | 1959-03-16 | 1962-11-20 | Burroughs Wellcome Co | Azabicyclohexanes and method of preparing them |
IL86061A (en) * | 1987-04-16 | 1992-07-15 | Lilly Co Eli | Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
-
2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
-
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 EP EP01936728A patent/EP1292574A1/fr not_active Withdrawn
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Application Discontinuation
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/fr active
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 CA CA002412188A patent/CA2412188A1/fr not_active Abandoned
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/fr not_active Application Discontinuation
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
-
2002
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-12-12 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008535888A (ja) * | 2005-04-15 | 2008-09-04 | グラクソ グループ リミテッド | ドーパミンd3受容体のモジュレーターとして有用なアザビシクロ(3.1.0)ヘキサン誘導体 |
JP2008543801A (ja) * | 2005-06-14 | 2008-12-04 | グラクソ グループ リミテッド | ドーパミンd3受容体のモジュレーターとしてのアザビシクロ[3.1.0]ヘキサン誘導体 |
JP2010537978A (ja) * | 2007-08-27 | 2010-12-09 | セラヴァンス, インコーポレーテッド | μオピオイド受容体拮抗薬としての8−アザビシクロ[3.2.1]オクチル−2−ヒドロキシベンズアミド化合物 |
JP2015107980A (ja) * | 2010-06-11 | 2015-06-11 | ローズ テクノロジーズ | N−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
US9499557B2 (en) | 2010-06-11 | 2016-11-22 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
US9593124B2 (en) | 2010-06-11 | 2017-03-14 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
US9624232B2 (en) | 2010-06-11 | 2017-04-18 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
US9657030B2 (en) | 2010-06-11 | 2017-05-23 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
JP2020508300A (ja) * | 2017-02-17 | 2020-03-19 | トレベナ・インコーポレイテッドTrevena, Inc. | 5員アザ複素環を含有するデルタ−オピオイド受容体調節化合物、その使用方法及び製造方法 |
US11702408B2 (en) | 2017-02-17 | 2023-07-18 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
JP7316216B2 (ja) | 2017-02-17 | 2023-07-27 | トレベナ・インコーポレイテッド | 5員アザ複素環を含有するデルタ-オピオイド受容体調節化合物、その使用方法及び製造方法 |
US11912713B2 (en) | 2017-02-17 | 2024-02-27 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
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