IS6637A - 3-azabísýkló[3.1.0]hexan afleiður sem eru nytsamlegar í meðferð - Google Patents

3-azabísýkló[3.1.0]hexan afleiður sem eru nytsamlegar í meðferð

Info

Publication number
IS6637A
IS6637A IS6637A IS6637A IS6637A IS 6637 A IS6637 A IS 6637A IS 6637 A IS6637 A IS 6637A IS 6637 A IS6637 A IS 6637A IS 6637 A IS6637 A IS 6637A
Authority
IS
Iceland
Prior art keywords
azabicyclo
treatment
derivatives useful
hexane derivatives
hexane
Prior art date
Application number
IS6637A
Other languages
English (en)
Icelandic (is)
Inventor
Joseph Banks Bernard
James Critcher Douglas
Edward Fenwick Ashley
Morris Gethin David
Paul Gibson Stephen
Lunn Graham
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of IS6637A publication Critical patent/IS6637A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IS6637A 2000-06-23 2002-11-28 3-azabísýkló[3.1.0]hexan afleiður sem eru nytsamlegar í meðferð IS6637A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (fr) 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Publications (1)

Publication Number Publication Date
IS6637A true IS6637A (is) 2002-11-28

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6637A IS6637A (is) 2000-06-23 2002-11-28 3-azabísýkló[3.1.0]hexan afleiður sem eru nytsamlegar í meðferð

Country Status (34)

Country Link
EP (1) EP1292574A1 (fr)
JP (1) JP2004512263A (fr)
KR (1) KR20040002386A (fr)
CN (1) CN1639121A (fr)
AP (1) AP2002002698A0 (fr)
AR (1) AR028969A1 (fr)
AU (1) AU781837B2 (fr)
BG (1) BG107329A (fr)
BR (1) BR0111867A (fr)
CA (1) CA2412188A1 (fr)
CZ (1) CZ20023967A3 (fr)
DO (1) DOP2001000187A (fr)
DZ (1) DZ3368A1 (fr)
EA (1) EA005117B1 (fr)
GB (1) GB0015562D0 (fr)
HR (1) HRP20020998A2 (fr)
HU (1) HUP0301228A3 (fr)
IL (1) IL153427A0 (fr)
IS (1) IS6637A (fr)
MA (1) MA26915A1 (fr)
MX (1) MXPA02012878A (fr)
NO (1) NO20026168L (fr)
NZ (1) NZ523141A (fr)
OA (1) OA12293A (fr)
PA (1) PA8519401A1 (fr)
PE (1) PE20020253A1 (fr)
PL (1) PL365956A1 (fr)
SK (1) SK17172002A3 (fr)
TN (1) TNSN01094A1 (fr)
UA (1) UA73176C2 (fr)
UY (1) UY26787A1 (fr)
WO (1) WO2001098267A1 (fr)
YU (1) YU91802A (fr)
ZA (1) ZA200210278B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0213464A (pt) 2001-10-22 2004-11-09 Pfizer Prod Inc Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide
EP2074997A1 (fr) * 2002-05-17 2009-07-01 Tioga Pharmaceuticals, Inc. Utilisation de l'asimadoline pour le traitement de troubles digestifs
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
DK1745040T3 (da) 2004-02-23 2010-04-12 Glaxo Group Ltd Som modulatorer af dopamin-D3-receptorer anvendelige azabicyclo(3.1.0)hexanederivater
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
JP5068747B2 (ja) * 2005-06-14 2012-11-07 グラクソ グループ リミテッド ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体
WO2007113258A1 (fr) * 2006-04-03 2007-10-11 Glaxo Group Limited Dérivés d'azabicyclo [3. 1. o] hexane utilisés comme modulateurs des récepteurs de la dopamine d3
EP2561870A1 (fr) 2007-03-30 2013-02-27 Tioga Pharmaceuticals, Inc. Agonistes du récepteur opiacé kappa pour le traitement du syndrome du côlon irritable avec alternance ou à diarrhée prédominante
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
WO2012042539A2 (fr) 2010-09-28 2012-04-05 Panacea Biotec Ltd Nouveaux composés bicycliques
KR102305244B1 (ko) * 2013-11-20 2021-09-27 우베 고산 가부시키가이샤 신규 3-아자비사이클로[3.1.0]헥산 유도체 및 그 의약 용도
JP6087035B1 (ja) 2015-05-20 2017-03-01 株式会社三和化学研究所 新規３−アザビシクロ［３．１．０］ヘキサン誘導体の塩の結晶及びその医薬用途
BR112019016827A2 (pt) * 2017-02-17 2020-04-07 Trevena Inc compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
CA3052479A1 (fr) 2017-02-17 2018-08-23 Trevena, Inc. Composes modulateurs du recepteur des opioides delta contenant des heterocycles aza a 7 chainons, et leurs procedes de preparation et d'utilisation
AU2018229062A1 (en) 2017-03-02 2019-09-26 Ube Industries, Ltd. Therapeutic agent for alcohol use disorders
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) * 2022-10-21 2024-09-20 昆明理工大学 一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
ES2058265T3 (es) * 1987-04-16 1994-11-01 Lilly Co Eli Piperidinas antagonistas de opiaceos.
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5

Also Published As

Publication number Publication date
AR028969A1 (es) 2003-05-28
BG107329A (en) 2003-07-31
HUP0301228A2 (hu) 2003-08-28
HUP0301228A3 (en) 2005-08-29
YU91802A (sh) 2006-05-25
PL365956A1 (en) 2005-01-24
UY26787A1 (es) 2002-01-31
EA200201269A1 (ru) 2003-06-26
DZ3368A1 (fr) 2001-12-27
PE20020253A1 (es) 2002-04-08
IL153427A0 (en) 2003-07-06
SK17172002A3 (sk) 2004-09-08
AU6259101A (en) 2002-01-02
BR0111867A (pt) 2003-07-01
NO20026168L (no) 2003-02-18
MXPA02012878A (es) 2003-05-14
ZA200210278B (en) 2003-12-19
EA005117B1 (ru) 2004-10-28
AP2002002698A0 (en) 2002-12-31
HRP20020998A2 (en) 2004-02-29
PA8519401A1 (es) 2002-12-30
DOP2001000187A (es) 2002-03-30
WO2001098267A1 (fr) 2001-12-27
OA12293A (en) 2004-03-18
NZ523141A (en) 2005-06-24
EP1292574A1 (fr) 2003-03-19
CZ20023967A3 (cs) 2004-02-18
GB0015562D0 (en) 2000-08-16
KR20040002386A (ko) 2004-01-07
UA73176C2 (en) 2005-06-15
WO2001098267A8 (fr) 2003-02-27
MA26915A1 (fr) 2004-12-20
JP2004512263A (ja) 2004-04-22
CN1639121A (zh) 2005-07-13
TNSN01094A1 (fr) 2005-11-10
CA2412188A1 (fr) 2001-12-27
NO20026168D0 (no) 2002-12-20
AU781837B2 (en) 2005-06-16

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