JP2004507442A - 複素環式ジヒドロピリミジン化合物 - Google Patents

複素環式ジヒドロピリミジン化合物 Download PDF

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Publication number
JP2004507442A
JP2004507442A JP2001540986A JP2001540986A JP2004507442A JP 2004507442 A JP2004507442 A JP 2004507442A JP 2001540986 A JP2001540986 A JP 2001540986A JP 2001540986 A JP2001540986 A JP 2001540986A JP 2004507442 A JP2004507442 A JP 2004507442A
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Prior art keywords
dihydro
dichlorophenyl
carbonyl
pyrimidin
methylpyrazolo
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JP2001540986A
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Japanese (ja)
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JP2004507442A5 (enExample
Inventor
カーネイル・エス・アトワル
ウェイン・バッカロ
ジョン・ロイド
ヘザー・フィンレイ
リン・ヤン
ラオ・エス・バンダル
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2004507442A publication Critical patent/JP2004507442A/ja
Publication of JP2004507442A5 publication Critical patent/JP2004507442A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
JP2001540986A 1999-12-06 2000-12-04 複素環式ジヒドロピリミジン化合物 Pending JP2004507442A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16909199P 1999-12-06 1999-12-06
US23603700P 2000-09-28 2000-09-28
PCT/US2000/032785 WO2001040231A1 (en) 1999-12-06 2000-12-04 Heterocyclic dihydropyrimidines as potassium channel inhibitors

Publications (2)

Publication Number Publication Date
JP2004507442A true JP2004507442A (ja) 2004-03-11
JP2004507442A5 JP2004507442A5 (enExample) 2008-02-14

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ID=26864749

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001540986A Pending JP2004507442A (ja) 1999-12-06 2000-12-04 複素環式ジヒドロピリミジン化合物

Country Status (25)

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US (3) US6706720B2 (enExample)
EP (1) EP1237891B1 (enExample)
JP (1) JP2004507442A (enExample)
KR (1) KR20020060255A (enExample)
CN (1) CN1407985A (enExample)
AR (1) AR029457A1 (enExample)
AT (1) ATE526329T1 (enExample)
AU (1) AU781862B2 (enExample)
BR (1) BR0016166A (enExample)
CA (1) CA2393809C (enExample)
CO (1) CO5570109A1 (enExample)
CZ (1) CZ20021949A3 (enExample)
HK (1) HK1048808A1 (enExample)
HU (1) HUP0301834A3 (enExample)
IL (2) IL149473A0 (enExample)
MX (1) MXPA02005533A (enExample)
MY (1) MY125533A (enExample)
NO (1) NO323588B1 (enExample)
NZ (1) NZ518663A (enExample)
PE (1) PE20011029A1 (enExample)
PL (1) PL364926A1 (enExample)
RU (1) RU2296766C2 (enExample)
TW (1) TWI291465B (enExample)
UY (1) UY26472A1 (enExample)
WO (1) WO2001040231A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010526103A (ja) * 2007-05-02 2010-07-29 ポートラ ファーマシューティカルズ， インコーポレイテッド 血小板ａｄｐ受容体阻害剤として作用する化合物による併用療法
JP2019513776A (ja) * 2016-04-15 2019-05-30 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ ピラゾロピリミジン誘導体
JP2020503264A (ja) * 2016-12-21 2020-01-30 シエッシ ファーマスーティシ エス．ピー．エー． Ｒｈｏキナーゼ阻害剤としての二環式ジヒドロピリミジンカルボキサミド誘導体
JP2020523388A (ja) * 2017-06-14 2020-08-06 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9901691D0 (en) 1999-01-26 1999-03-17 Cerebrus Ltd Chemical compounds
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
SK18412002A3 (sk) * 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
CN100341506C (zh) * 2000-12-25 2007-10-10 三共株式会社 含有阿斯匹林的药用组合物
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
EP1435955A2 (en) * 2001-05-05 2004-07-14 SmithKline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
ES2299567T3 (es) 2001-05-05 2008-06-01 Smithkline Beecham Plc N-aroilaminas ciclicas.
US7139344B2 (en) * 2001-05-16 2006-11-21 Lexmark International, Inc. Method and apparatus for effecting synchronous pulse generation for use in variable speed serial communications
WO2003002561A1 (en) * 2001-06-28 2003-01-09 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
AU2002341693B2 (en) 2001-09-21 2008-05-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
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JP2020503264A (ja) * 2016-12-21 2020-01-30 シエッシ ファーマスーティシ エス．ピー．エー． Ｒｈｏキナーゼ阻害剤としての二環式ジヒドロピリミジンカルボキサミド誘導体
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