HUP0301834A2 - Heterociklusos dihidropirimidin-származékok alkalmazása káliumcsatorna inhibitor hatású gyógyszerkészítmények elżállítására, valamint új származékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Heterociklusos dihidropirimidin-származékok alkalmazása káliumcsatorna inhibitor hatású gyógyszerkészítmények elżállítására, valamint új származékok és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0301834A2 HUP0301834A2 HU0301834A HUP0301834A HUP0301834A2 HU P0301834 A2 HUP0301834 A2 HU P0301834A2 HU 0301834 A HU0301834 A HU 0301834A HU P0301834 A HUP0301834 A HU P0301834A HU P0301834 A2 HUP0301834 A2 HU P0301834A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- pharmaceutical compositions
- heterocyclic
- nz5z6
- Prior art date
Links
- -1 heterocyclic dihydropyrimidine derivatives Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 108091006146 Channels Proteins 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 101100439663 Arabidopsis thaliana CHR7 gene Proteins 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000003450 potassium channel blocker Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
A találmány tárgyát az általános képletű, részben új vegyületek - aholX1, X2 és X3 egymástól függetlenül nitrogénatom, karbonilcsoport, -NR6-, -(CR7)q- vagy -(CHR7)q- általános képletű csoport, és ezek 5-7-tagú gyűrűt képeznek; R1-R7 azonos vagy különböző -(CH2)n-(Z1)m-(CH2)p-Z2 általános képletű csoport; vagy közülük megfelelőenkiválasztott kettő együttesen az atomokkal, amelyekhez kapcsolódnak,karbociklusos, illetve heterociklusos gyűrűt képez; Z1 -CZ3Z4-, -NZ3-,-C(O)Z3-, -C(O)NZ4- vagy -C(=NOZ3)- általános képletű csoport, oxigén-vagy kénatom, szulfinil-, szulfonil-, karbonil- vagytiokarbonilcsoport vagy kétértékű, nyílt láncú vagy ciklusosszénhidrogéncsoport vagy heterociklusos csoport; Z2 hidrogén- vagyhalogénatom, -OZ5, -OC(O)Z5, -NZ5-C(O)-Z6, NZ5-CO2-Z6, -NZ5(CO)-NZ6Z7,-NZ5Z6, -C(O)Z5, -CO2Z5, -C(S)Z5, -C(=NOZ5)Z6, -C(O)NZ5Z6, -C(S)NZ5Z6,-SZ5, -SOZ5, -SO2Z5 vagy -SO2NZ5Z6 általános képletű csoport, nitro-,ciano- vagy adott esetben szubsztituált alkil-, alkenil-,alkinilkarbociklil-, aril- vagy heterociklilcsoport; Z3-Z7 hidrogén-vagy halogénatom vagy adott esetben szubsztituált alkil-, alkenil-,alkinil-, karbocilklil-, aril- vagy heterociklilcsoport; vagy kettőegyüttesen heterociklusos, illetve karbociklusos gyűrűt képez; n és pegész 0-tól 10-ig, de ha m 0, p szintén 0; m egész szám, 0 vagy 1; ésq egész szám 1-től 3-ig - és izomerjeik, valamint sóik szelektívkáliumcsatorna-blokkolóként, így bizonyos IKur-asszociált betegségek,főként aritmiák kezelésére való alkalmazása, továbbá az új vegyületekés ezeket tartalmazó gyógyszerkészítmények képezik. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16909199P | 1999-12-06 | 1999-12-06 | |
US23603700P | 2000-09-28 | 2000-09-28 | |
PCT/US2000/032785 WO2001040231A1 (en) | 1999-12-06 | 2000-12-04 | Heterocyclic dihydropyrimidines as potassium channel inhibitors |
Publications (2)
Publication Number | Publication Date |
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HUP0301834A2 true HUP0301834A2 (hu) | 2003-09-29 |
HUP0301834A3 HUP0301834A3 (en) | 2004-11-29 |
Family
ID=26864749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301834A HUP0301834A3 (en) | 1999-12-06 | 2000-12-04 | Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them |
Country Status (25)
Country | Link |
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US (3) | US6706720B2 (hu) |
EP (1) | EP1237891B1 (hu) |
JP (1) | JP2004507442A (hu) |
KR (1) | KR20020060255A (hu) |
CN (1) | CN1407985A (hu) |
AR (1) | AR029457A1 (hu) |
AT (1) | ATE526329T1 (hu) |
AU (1) | AU781862B2 (hu) |
BR (1) | BR0016166A (hu) |
CA (1) | CA2393809C (hu) |
CO (1) | CO5570109A1 (hu) |
CZ (1) | CZ20021949A3 (hu) |
HK (1) | HK1048808A1 (hu) |
HU (1) | HUP0301834A3 (hu) |
IL (2) | IL149473A0 (hu) |
MX (1) | MXPA02005533A (hu) |
MY (1) | MY125533A (hu) |
NO (1) | NO323588B1 (hu) |
NZ (1) | NZ518663A (hu) |
PE (1) | PE20011029A1 (hu) |
PL (1) | PL364926A1 (hu) |
RU (1) | RU2296766C2 (hu) |
TW (1) | TWI291465B (hu) |
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- 2000-12-04 JP JP2001540986A patent/JP2004507442A/ja active Pending
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