NO330964B1 - Kolkisosidanaloger - Google Patents

Kolkisosidanaloger

Info

Publication number
NO330964B1
NO330964B1 NO20055754A NO20055754A NO330964B1 NO 330964 B1 NO330964 B1 NO 330964B1 NO 20055754 A NO20055754 A NO 20055754A NO 20055754 A NO20055754 A NO 20055754A NO 330964 B1 NO330964 B1 NO 330964B1
Authority
NO
Norway
Prior art keywords
kolkisosidanaloger
formula
deraethyl
demethylthiocolcicine
inflammatory
Prior art date
Application number
NO20055754A
Other languages
English (en)
Other versions
NO20055754L (no
Inventor
Gabriele Fontana
Ezio Bombardelli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NO20055754L publication Critical patent/NO20055754L/no
Publication of NO330964B1 publication Critical patent/NO330964B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Den foreliggende oppfinnelse vedrører kolkisinderivater, spesielt 3-deraetyl- og 3-demetyltiokolkisinet med den generelle formel (I) hvor X er oksygen eller svovel, en fremgangsmåte for fremstillingen derav og farmasøytiske sammensetninger inneholdende dem. Forbindelsene med formel (I) har muskelrelakse-rende, antiinflammatorisk og antigikt aktivitet.
NO20055754A 2003-06-06 2005-12-05 Kolkisosidanaloger NO330964B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001144A ITMI20031144A1 (it) 2003-06-06 2003-06-06 Analoghi del colchicoside.
PCT/EP2004/005645 WO2004111068A1 (en) 2003-06-06 2004-05-26 Colchicoside analogues

Publications (2)

Publication Number Publication Date
NO20055754L NO20055754L (no) 2005-12-05
NO330964B1 true NO330964B1 (no) 2011-08-29

Family

ID=30131160

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055754A NO330964B1 (no) 2003-06-06 2005-12-05 Kolkisosidanaloger

Country Status (24)

Country Link
US (1) US7683163B2 (no)
EP (1) EP1631574B1 (no)
JP (1) JP4718449B2 (no)
KR (1) KR101121374B1 (no)
CN (1) CN100348605C (no)
AT (1) ATE425174T1 (no)
AU (1) AU2004247346B2 (no)
BR (1) BRPI0411068B8 (no)
CA (1) CA2528223C (no)
CY (1) CY1109019T1 (no)
DE (1) DE602004019914D1 (no)
DK (1) DK1631574T3 (no)
ES (1) ES2321838T3 (no)
HK (1) HK1090062A1 (no)
IL (1) IL172358A (no)
IT (1) ITMI20031144A1 (no)
MX (1) MXPA05013161A (no)
NO (1) NO330964B1 (no)
NZ (1) NZ543943A (no)
PL (1) PL1631574T3 (no)
PT (1) PT1631574E (no)
RU (1) RU2343157C2 (no)
SI (1) SI1631574T1 (no)
WO (1) WO2004111068A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20051418A1 (it) * 2005-07-22 2007-01-23 Indena Spa Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
US8232254B2 (en) 2006-10-06 2012-07-31 Wisconsin Alumni Research Foundation Colchicine neoglycosides and methods for their synthesis and use
PL2128170T3 (pl) * 2008-05-28 2011-05-31 Indena Spa Sposób glikozydacji kolchicyny i tiokolchicyny
US8722205B2 (en) 2009-03-23 2014-05-13 Universal Display Corporation Heteroleptic iridium complex
EP2435403A4 (en) * 2009-05-27 2015-04-01 Takeda Pharmaceuticals Usa Inc THIOCOLCHICINE DERIVATIVES AND MANUFACTURING AND USE METHOD THEREFOR
WO2013149109A1 (en) * 2012-03-30 2013-10-03 Takeda Pharmaceuticals U.S.A., Inc. Colchicine formulations; methods of making; and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH341831A (fr) 1955-06-10 1959-10-31 Uclaf Societe Anonyme Procédé de préparation de produits de condensation de saccharides sur l'azote des N-désacétyl-alcoylthiocolchicéines
GB773729A (en) * 1955-06-10 1957-05-01 Roussel Uclaf New derivatives of n-deacetylalkylthiocolchiceines and process for their production
JPS5619357B2 (no) * 1972-05-02 1981-05-07
JP2894366B2 (ja) * 1990-12-25 1999-05-24 有限会社尾源研究所 デアセチルコルヒチンの製造方法
AU634921B2 (en) * 1990-12-25 1993-03-04 Ohgen Research Laboratories Ltd. Deacetylcolchicine derivatives
IT1270124B (it) * 1994-10-05 1997-04-28 Indena Spa Derivati della colchicina e loro impiego terapeutico
IT1276996B1 (it) * 1995-06-27 1997-11-04 Indena Spa Derivati della colchicina, loro uso e formulazioni che li contengono
IT1282584B1 (it) * 1996-02-08 1998-03-31 Indena Spa Processo di glicosidazione di derivati colchicinici e prodotti ottenuti
IT1285777B1 (it) * 1996-10-07 1998-06-18 Indena Spa Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
CN1208003A (zh) * 1997-08-08 1999-02-17 韩财元 摆翼式直升飞机
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique

Also Published As

Publication number Publication date
IL172358A0 (en) 2009-02-11
CN1802383A (zh) 2006-07-12
IL172358A (en) 2012-01-31
JP4718449B2 (ja) 2011-07-06
DK1631574T3 (da) 2009-05-25
US7683163B2 (en) 2010-03-23
BRPI0411068A (pt) 2006-08-01
BRPI0411068B8 (pt) 2021-05-25
AU2004247346B2 (en) 2008-12-18
CA2528223A1 (en) 2004-12-23
SI1631574T1 (sl) 2009-06-30
ES2321838T3 (es) 2009-06-12
ITMI20031144A0 (it) 2003-06-06
RU2005137870A (ru) 2006-06-10
PT1631574E (pt) 2009-05-05
BRPI0411068B1 (pt) 2017-12-26
CY1109019T1 (el) 2014-07-02
HK1090062A1 (en) 2006-12-15
DE602004019914D1 (de) 2009-04-23
JP2006527173A (ja) 2006-11-30
ATE425174T1 (de) 2009-03-15
NO20055754L (no) 2005-12-05
PL1631574T3 (pl) 2009-07-31
KR101121374B1 (ko) 2012-03-09
EP1631574B1 (en) 2009-03-11
AU2004247346A1 (en) 2004-12-23
NZ543943A (en) 2008-09-26
RU2343157C2 (ru) 2009-01-10
US20070129315A1 (en) 2007-06-07
CA2528223C (en) 2011-11-22
EP1631574A1 (en) 2006-03-08
ITMI20031144A1 (it) 2004-12-07
MXPA05013161A (es) 2006-03-17
KR20060057536A (ko) 2006-05-26
WO2004111068A1 (en) 2004-12-23
CN100348605C (zh) 2007-11-14

Similar Documents

Publication Publication Date Title
NO20051962L (no) Fenetanolaminderivater for behandling av respiratoriske sykdommer
NO20092342L (no) Azaspiroderivativater
ATE381535T1 (de) Phenethanolaminderivate
NO20074592L (no) Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
NO20060324L (no) [1,8]Naftyridin-2-oner og relaterte forbindelser for behandling av Schizofreni
NO20063761L (no) Sulfonamidderivater for behandling av sykdommer
NO20050134L (no) Difenylazetidioner substituert med syregrupper, fremgangsmate for fremstilling av disse, medikamenter inneholdende disse forbindelser og deres anvendelse
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20073719L (no) Kjemiske forbindelser
BRPI0409109A (pt) novos compostos
NO20076059L (no) 2,4-Diamino-pyrimidiner anvendt som aurorainhibitorer
ATE411280T1 (de) Phenoxyessigsäure-derivate zur behandlung von störungen der atemwege
NO20090327L (no) Nye forbindelser 384
NO20091766L (no) Spiro-piperidinderivater
NO20076682L (no) Nye pyridinanaloger
NO330964B1 (no) Kolkisosidanaloger
NO20092149L (no) Spiro-piperidinderivater
NO20091831L (no) Indoler
NO20091830L (no) Spiro-piperidinderivater som VIa reseptorantagonister
NO20092264L (no) Spiro-piperidinderivater
TNSN06233A1 (en) 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, methods for production and use thereof as medicaments
NO20092413L (no) Pyrazolanaloger
NO20085215L (no) Nye pyridinanaloger
NO20080377L (no) Tiokochikosidanaloger med myorelakserende og antiinflammatorisk aktivitet
ATE317380T1 (de) Bernsteinsäurederivate

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees