RU2005137870A - Аналоги и колхикозида - Google Patents
Аналоги и колхикозида Download PDFInfo
- Publication number
- RU2005137870A RU2005137870A RU2005137870/04A RU2005137870A RU2005137870A RU 2005137870 A RU2005137870 A RU 2005137870A RU 2005137870/04 A RU2005137870/04 A RU 2005137870/04A RU 2005137870 A RU2005137870 A RU 2005137870A RU 2005137870 A RU2005137870 A RU 2005137870A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- pharmaceutical compositions
- preparation
- sulfur
- demethylthiocolchicine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Claims (12)
1. Соединения общей формулы (I)
()
где Х представляет собой кислород или серу.
2. Соединение по п.1, где Х представляет собой кислород.
3. Соединение по п.1, где Х представляет собой серу.
4. Соединение, выбранное из
3-О--D-ксилопиранозил-3-О-деметилтиоколхицина и
3-О--L-ксилопиранозил-3-О-деметилтиоколхицина.
5. Соединение по любому из пп.1-4, которое представляет собой лекарственное средство.
6. Применение соединения по любому из пп.1-4 для приготовления миорелаксантных лекарственных средств.
7. Применение соединения по любому из пп.1-4 для приготовления противовоспалительных лекарственных средств.
8. Применение соединения по любому из пп.1-4 для приготовления противоподагрических лекарственных средств.
9. Фармацевтические композиции, содержащие соединение по любому из пп.1-4 в смеси с подходящими наполнителями и/или носителями.
10. Фармацевтические композиции по п.9 для местного применения.
11. Фармацевтические композиции по п.9 для парентерального применения.
12. Фармацевтические композиции по п.10 или 11, в которых наполнители выбраны из натуральных и синтетических фосфолипидов.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001144A ITMI20031144A1 (it) | 2003-06-06 | 2003-06-06 | Analoghi del colchicoside. |
| ITMI2003A001144 | 2003-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005137870A true RU2005137870A (ru) | 2006-06-10 |
| RU2343157C2 RU2343157C2 (ru) | 2009-01-10 |
Family
ID=30131160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005137870/04A RU2343157C2 (ru) | 2003-06-06 | 2004-05-26 | Аналоги колхикозида |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7683163B2 (ru) |
| EP (1) | EP1631574B1 (ru) |
| JP (1) | JP4718449B2 (ru) |
| KR (1) | KR101121374B1 (ru) |
| CN (1) | CN100348605C (ru) |
| AT (1) | ATE425174T1 (ru) |
| AU (1) | AU2004247346B2 (ru) |
| BR (1) | BRPI0411068B8 (ru) |
| CA (1) | CA2528223C (ru) |
| CY (1) | CY1109019T1 (ru) |
| DE (1) | DE602004019914D1 (ru) |
| DK (1) | DK1631574T3 (ru) |
| ES (1) | ES2321838T3 (ru) |
| HK (1) | HK1090062A1 (ru) |
| IL (1) | IL172358A (ru) |
| IT (1) | ITMI20031144A1 (ru) |
| MX (1) | MXPA05013161A (ru) |
| NO (1) | NO330964B1 (ru) |
| NZ (1) | NZ543943A (ru) |
| PL (1) | PL1631574T3 (ru) |
| PT (1) | PT1631574E (ru) |
| RU (1) | RU2343157C2 (ru) |
| SI (1) | SI1631574T1 (ru) |
| WO (1) | WO2004111068A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20051418A1 (it) * | 2005-07-22 | 2007-01-23 | Indena Spa | Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria |
| US8232254B2 (en) | 2006-10-06 | 2012-07-31 | Wisconsin Alumni Research Foundation | Colchicine neoglycosides and methods for their synthesis and use |
| PL2128170T3 (pl) * | 2008-05-28 | 2011-05-31 | Indena Spa | Sposób glikozydacji kolchicyny i tiokolchicyny |
| US8722205B2 (en) | 2009-03-23 | 2014-05-13 | Universal Display Corporation | Heteroleptic iridium complex |
| WO2010138670A2 (en) * | 2009-05-27 | 2010-12-02 | Mutual Pharmaceutical Company, Inc. | Thiocolchicine derivatives, method of making and methods of use thereof |
| US20150164831A1 (en) * | 2012-03-30 | 2015-06-18 | Takeda Pharmaceuticals U.S.A., Inc. | Colchicine formulations; methods of making; and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB773729A (en) * | 1955-06-10 | 1957-05-01 | Roussel Uclaf | New derivatives of n-deacetylalkylthiocolchiceines and process for their production |
| CH341831A (fr) | 1955-06-10 | 1959-10-31 | Uclaf Societe Anonyme | Procédé de préparation de produits de condensation de saccharides sur l'azote des N-désacétyl-alcoylthiocolchicéines |
| JPS5619357B2 (ru) * | 1972-05-02 | 1981-05-07 | ||
| AU634921B2 (en) * | 1990-12-25 | 1993-03-04 | Ohgen Research Laboratories Ltd. | Deacetylcolchicine derivatives |
| JP2894366B2 (ja) * | 1990-12-25 | 1999-05-24 | 有限会社尾源研究所 | デアセチルコルヒチンの製造方法 |
| IT1270124B (it) * | 1994-10-05 | 1997-04-28 | Indena Spa | Derivati della colchicina e loro impiego terapeutico |
| IT1276996B1 (it) * | 1995-06-27 | 1997-11-04 | Indena Spa | Derivati della colchicina, loro uso e formulazioni che li contengono |
| IT1282584B1 (it) * | 1996-02-08 | 1998-03-31 | Indena Spa | Processo di glicosidazione di derivati colchicinici e prodotti ottenuti |
| IT1285777B1 (it) * | 1996-10-07 | 1998-06-18 | Indena Spa | Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati |
| CN1208003A (zh) * | 1997-08-08 | 1999-02-17 | 韩财元 | 摆翼式直升飞机 |
| FR2779147B1 (fr) * | 1998-05-27 | 2000-06-30 | Synthelabo | Derive de thiocolchicoside sa preparation et son application en therapeutique |
-
2003
- 2003-06-06 IT IT001144A patent/ITMI20031144A1/it unknown
-
2004
- 2004-05-26 CN CNB2004800156654A patent/CN100348605C/zh not_active Expired - Lifetime
- 2004-05-26 EP EP04739355A patent/EP1631574B1/en not_active Expired - Lifetime
- 2004-05-26 PT PT04739355T patent/PT1631574E/pt unknown
- 2004-05-26 JP JP2006508205A patent/JP4718449B2/ja not_active Expired - Fee Related
- 2004-05-26 MX MXPA05013161A patent/MXPA05013161A/es active IP Right Grant
- 2004-05-26 RU RU2005137870/04A patent/RU2343157C2/ru active
- 2004-05-26 BR BRPI0411068A patent/BRPI0411068B8/pt not_active IP Right Cessation
- 2004-05-26 CA CA2528223A patent/CA2528223C/en not_active Expired - Lifetime
- 2004-05-26 SI SI200431102T patent/SI1631574T1/sl unknown
- 2004-05-26 ES ES04739355T patent/ES2321838T3/es not_active Expired - Lifetime
- 2004-05-26 DK DK04739355T patent/DK1631574T3/da active
- 2004-05-26 KR KR1020057023042A patent/KR101121374B1/ko active IP Right Grant
- 2004-05-26 PL PL04739355T patent/PL1631574T3/pl unknown
- 2004-05-26 WO PCT/EP2004/005645 patent/WO2004111068A1/en active Application Filing
- 2004-05-26 AT AT04739355T patent/ATE425174T1/de active
- 2004-05-26 AU AU2004247346A patent/AU2004247346B2/en not_active Ceased
- 2004-05-26 US US10/559,462 patent/US7683163B2/en active Active
- 2004-05-26 DE DE602004019914T patent/DE602004019914D1/de not_active Expired - Lifetime
- 2004-05-26 NZ NZ543943A patent/NZ543943A/en unknown
-
2005
- 2005-12-05 IL IL172358A patent/IL172358A/en active IP Right Grant
- 2005-12-05 NO NO20055754A patent/NO330964B1/no not_active IP Right Cessation
-
2006
- 2006-09-25 HK HK06110651A patent/HK1090062A1/xx not_active IP Right Cessation
-
2009
- 2009-05-05 CY CY20091100483T patent/CY1109019T1/el unknown
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