NO330964B1 - Kolkisosidanaloger - Google Patents
KolkisosidanalogerInfo
- Publication number
- NO330964B1 NO330964B1 NO20055754A NO20055754A NO330964B1 NO 330964 B1 NO330964 B1 NO 330964B1 NO 20055754 A NO20055754 A NO 20055754A NO 20055754 A NO20055754 A NO 20055754A NO 330964 B1 NO330964 B1 NO 330964B1
- Authority
- NO
- Norway
- Prior art keywords
- kolkisosidanaloger
- formula
- deraethyl
- demethylthiocolcicine
- inflammatory
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229960002708 antigout preparations Drugs 0.000 abstract 1
- 229940045695 antineooplastic colchicine derivative Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Den foreliggende oppfinnelse vedrører kolkisinderivater, spesielt 3-deraetyl- og 3-demetyltiokolkisinet med den generelle formel (I) hvor X er oksygen eller svovel, en fremgangsmåte for fremstillingen derav og farmasøytiske sammensetninger inneholdende dem. Forbindelsene med formel (I) har muskelrelakse-rende, antiinflammatorisk og antigikt aktivitet.The present invention relates to colchicine derivatives, in particular the 3-deraethyl and 3-demethylthiocolcicine of the general formula (I) wherein X is oxygen or sulfur, a process for their preparation and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001144A ITMI20031144A1 (en) | 2003-06-06 | 2003-06-06 | COLCHICOSIDE ANALOGUES. |
PCT/EP2004/005645 WO2004111068A1 (en) | 2003-06-06 | 2004-05-26 | Colchicoside analogues |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20055754L NO20055754L (en) | 2005-12-05 |
NO330964B1 true NO330964B1 (en) | 2011-08-29 |
Family
ID=30131160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20055754A NO330964B1 (en) | 2003-06-06 | 2005-12-05 | Kolkisosidanaloger |
Country Status (24)
Country | Link |
---|---|
US (1) | US7683163B2 (en) |
EP (1) | EP1631574B1 (en) |
JP (1) | JP4718449B2 (en) |
KR (1) | KR101121374B1 (en) |
CN (1) | CN100348605C (en) |
AT (1) | ATE425174T1 (en) |
AU (1) | AU2004247346B2 (en) |
BR (1) | BRPI0411068B8 (en) |
CA (1) | CA2528223C (en) |
CY (1) | CY1109019T1 (en) |
DE (1) | DE602004019914D1 (en) |
DK (1) | DK1631574T3 (en) |
ES (1) | ES2321838T3 (en) |
HK (1) | HK1090062A1 (en) |
IL (1) | IL172358A (en) |
IT (1) | ITMI20031144A1 (en) |
MX (1) | MXPA05013161A (en) |
NO (1) | NO330964B1 (en) |
NZ (1) | NZ543943A (en) |
PL (1) | PL1631574T3 (en) |
PT (1) | PT1631574E (en) |
RU (1) | RU2343157C2 (en) |
SI (1) | SI1631574T1 (en) |
WO (1) | WO2004111068A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20051418A1 (en) * | 2005-07-22 | 2007-01-23 | Indena Spa | ANALOGUES OF THIOILCYCOSIDE WITH HYDRO-LASER ACTIVITY AND ANTI-INFLAMMATORY |
WO2008067039A2 (en) * | 2006-10-06 | 2008-06-05 | Wisconsin Alumni Research Foundation | Colchicine neoglycosides and methods for their synthesis and use |
PT2128170E (en) * | 2008-05-28 | 2011-02-23 | Indena Spa | "process for the glycosidation of colchicine and thiocolchicine" |
US8722205B2 (en) | 2009-03-23 | 2014-05-13 | Universal Display Corporation | Heteroleptic iridium complex |
US8497290B2 (en) * | 2009-05-27 | 2013-07-30 | Takeda Pharmaceuticals U.S.A., Inc. | Thiocolchicine derivatives, method of making and methods of use thereof |
JP2015514715A (en) * | 2012-03-30 | 2015-05-21 | タケダ ファーマシューティカルズ ユー.エス.エー. インコーポレイティド | Colchicine preparation, method for producing and using the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH341831A (en) | 1955-06-10 | 1959-10-31 | Uclaf Societe Anonyme | Process for the preparation of condensation products of saccharides with nitrogen of N-desacetyl-alkylthiocolchiceins |
GB773729A (en) * | 1955-06-10 | 1957-05-01 | Roussel Uclaf | New derivatives of n-deacetylalkylthiocolchiceines and process for their production |
JPS5619357B2 (en) * | 1972-05-02 | 1981-05-07 | ||
AU634921B2 (en) * | 1990-12-25 | 1993-03-04 | Ohgen Research Laboratories Ltd. | Deacetylcolchicine derivatives |
JP2894366B2 (en) * | 1990-12-25 | 1999-05-24 | 有限会社尾源研究所 | Method for producing deacetylcolchicine |
IT1270124B (en) * | 1994-10-05 | 1997-04-28 | Indena Spa | COLCHICINE DERIVATIVES AND THEIR THERAPEUTIC USE |
IT1276996B1 (en) * | 1995-06-27 | 1997-11-04 | Indena Spa | COLCHICINE DERIVATIVES, THEIR USE AND FORMULATIONS CONTAINING THEM |
IT1282584B1 (en) * | 1996-02-08 | 1998-03-31 | Indena Spa | PROCESS OF GLYCOSIDATION OF COLCHICINE DERIVATIVES AND OBTAINED PRODUCTS |
IT1285777B1 (en) * | 1996-10-07 | 1998-06-18 | Indena Spa | PROCESS OF BIOTRANSFORMATION OF COLCHICINOID COMPOUNDS INTO THE CORRESPONDING 3-GLYCOSYLDERIVATES |
CN1208003A (en) * | 1997-08-08 | 1999-02-17 | 韩财元 | Swing wing type helicopter |
FR2779147B1 (en) * | 1998-05-27 | 2000-06-30 | Synthelabo | THIOCOLCHICOSIDE DERIVATIVE ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS |
-
2003
- 2003-06-06 IT IT001144A patent/ITMI20031144A1/en unknown
-
2004
- 2004-05-26 BR BRPI0411068A patent/BRPI0411068B8/en not_active IP Right Cessation
- 2004-05-26 JP JP2006508205A patent/JP4718449B2/en not_active Expired - Fee Related
- 2004-05-26 DE DE602004019914T patent/DE602004019914D1/en not_active Expired - Lifetime
- 2004-05-26 CN CNB2004800156654A patent/CN100348605C/en not_active Expired - Lifetime
- 2004-05-26 PL PL04739355T patent/PL1631574T3/en unknown
- 2004-05-26 SI SI200431102T patent/SI1631574T1/en unknown
- 2004-05-26 AT AT04739355T patent/ATE425174T1/en active
- 2004-05-26 DK DK04739355T patent/DK1631574T3/en active
- 2004-05-26 WO PCT/EP2004/005645 patent/WO2004111068A1/en active Application Filing
- 2004-05-26 US US10/559,462 patent/US7683163B2/en active Active
- 2004-05-26 ES ES04739355T patent/ES2321838T3/en not_active Expired - Lifetime
- 2004-05-26 MX MXPA05013161A patent/MXPA05013161A/en active IP Right Grant
- 2004-05-26 EP EP04739355A patent/EP1631574B1/en not_active Expired - Lifetime
- 2004-05-26 CA CA2528223A patent/CA2528223C/en not_active Expired - Lifetime
- 2004-05-26 PT PT04739355T patent/PT1631574E/en unknown
- 2004-05-26 NZ NZ543943A patent/NZ543943A/en unknown
- 2004-05-26 AU AU2004247346A patent/AU2004247346B2/en not_active Ceased
- 2004-05-26 RU RU2005137870/04A patent/RU2343157C2/en active
- 2004-05-26 KR KR1020057023042A patent/KR101121374B1/en active IP Right Grant
-
2005
- 2005-12-05 IL IL172358A patent/IL172358A/en active IP Right Grant
- 2005-12-05 NO NO20055754A patent/NO330964B1/en not_active IP Right Cessation
-
2006
- 2006-09-25 HK HK06110651A patent/HK1090062A1/en not_active IP Right Cessation
-
2009
- 2009-05-05 CY CY20091100483T patent/CY1109019T1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20051962L (en) | Phenethanolamine derivatives for the treatment of respiratory diseases | |
NO20092342L (en) | Azaspiroderivativater | |
ATE381535T1 (en) | PHENETHANOLAMINE DERIVATIVES | |
NO20060324L (en) | [1,8] Naphthyridin-2-ones and related compounds for the treatment of schizophrenia | |
NO20063761L (en) | Sulfonamide derivatives for the treatment of diseases | |
NO20050134L (en) | Diphenyllazidide ions substituted with acid groups, process for their preparation, drugs containing these compounds and their use | |
NO20070224L (en) | 2-urea-4-phenylthiazole derivatives, preparation and therapeutic use thereof | |
BRPI0409109A (en) | new compounds | |
NO20076059L (en) | 2,4-Diamino-pyrimidines used as aurora inhibitors | |
ATE411280T1 (en) | PHENOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISORDERS | |
NO20090327L (en) | New connections 384 | |
NO20064078L (en) | Substituted azetidine compositions, their preparation and use as drugs | |
NO20091766L (en) | Spiro-piperidine | |
NO20076682L (en) | New pyridine analogs | |
NO330964B1 (en) | Kolkisosidanaloger | |
NO20063859L (en) | Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and use thereof as medicaments | |
MY146802A (en) | Novel drugs for treating respiratory diseases | |
NO20092149L (en) | Spiro-piperidine | |
NO20091831L (en) | indoles | |
NO20090067L (en) | Pharmaceutical combinations for the treatment of respiratory diseases | |
NO20091830L (en) | Spiro-piperidine derivatives as VIa receptor antagonists | |
NO20092264L (en) | Spiro-piperidine | |
NO20092413L (en) | Pyrazolanaloger | |
NO20085215L (en) | New pyridine analogs | |
NO20080377L (en) | Thiocochicoside analogues with myorelaxative and anti-inflammatory activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |