NO20080377L - Thiocochicoside analogues with myorelaxative and anti-inflammatory activity - Google Patents

Thiocochicoside analogues with myorelaxative and anti-inflammatory activity

Info

Publication number
NO20080377L
NO20080377L NO20080377A NO20080377A NO20080377L NO 20080377 L NO20080377 L NO 20080377L NO 20080377 A NO20080377 A NO 20080377A NO 20080377 A NO20080377 A NO 20080377A NO 20080377 L NO20080377 L NO 20080377L
Authority
NO
Norway
Prior art keywords
inflammatory activity
thiocochicoside
myorelaxative
analogues
formula
Prior art date
Application number
NO20080377A
Other languages
Norwegian (no)
Inventor
Paolo Morazzoni
Gabriele Fontana
Antonella Riva
Ezio Bombardelli
Donato Pocar
Maria Luisa Gelmi
Guido Pontremoli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NO20080377L publication Critical patent/NO20080377L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører 3-demetoksy-3-aminotiokolchisinglykosyl-derivater med generell formel (I) hvor R er hydrogen, metyl eller hydroksymetyl. Forbindelsene med formel (I) har muskelavslappende og antiinflammatorisk aktivitet.The present invention relates to 3-demethoxy-3-aminothiocolchising glycosyl derivatives of general formula (I) wherein R is hydrogen, methyl or hydroxymethyl. The compounds of formula (I) have muscle relaxant and anti-inflammatory activity.

NO20080377A 2005-07-22 2008-01-21 Thiocochicoside analogues with myorelaxative and anti-inflammatory activity NO20080377L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001418A ITMI20051418A1 (en) 2005-07-22 2005-07-22 ANALOGUES OF THIOILCYCOSIDE WITH HYDRO-LASER ACTIVITY AND ANTI-INFLAMMATORY
PCT/EP2006/007108 WO2007009772A1 (en) 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity

Publications (1)

Publication Number Publication Date
NO20080377L true NO20080377L (en) 2008-02-01

Family

ID=37420844

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080377A NO20080377L (en) 2005-07-22 2008-01-21 Thiocochicoside analogues with myorelaxative and anti-inflammatory activity

Country Status (14)

Country Link
EP (1) EP1907405A1 (en)
JP (1) JP2009502755A (en)
KR (1) KR20080036585A (en)
CN (1) CN101228175A (en)
AU (1) AU2006271923A1 (en)
BR (1) BRPI0613680A2 (en)
CA (1) CA2615860A1 (en)
IL (1) IL188900A0 (en)
IT (1) ITMI20051418A1 (en)
MX (1) MX2008000968A (en)
NO (1) NO20080377L (en)
NZ (1) NZ565265A (en)
RU (1) RU2008102251A (en)
WO (1) WO2007009772A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8421747B2 (en) * 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
WO2010138670A2 (en) * 2009-05-27 2010-12-02 Mutual Pharmaceutical Company, Inc. Thiocolchicine derivatives, method of making and methods of use thereof
CN102741223A (en) * 2010-01-22 2012-10-17 共有药物有限公司 Thiocolchicine and colchicine analogs, methods of making and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291550B1 (en) * 1997-04-11 1999-01-11 Indena Spa DERIVATIVES OF COLCHICINE AND THIOCOLCHICINE WITH ANTI-INFLAMMATORY AND MYORELAXING ACTIVITIES
ITMI20031144A1 (en) * 2003-06-06 2004-12-07 Indena Spa COLCHICOSIDE ANALOGUES.

Also Published As

Publication number Publication date
RU2008102251A (en) 2009-07-27
JP2009502755A (en) 2009-01-29
BRPI0613680A2 (en) 2011-01-25
ITMI20051418A1 (en) 2007-01-23
MX2008000968A (en) 2008-03-26
EP1907405A1 (en) 2008-04-09
KR20080036585A (en) 2008-04-28
AU2006271923A1 (en) 2007-01-25
CN101228175A (en) 2008-07-23
WO2007009772A1 (en) 2007-01-25
CA2615860A1 (en) 2007-01-25
NZ565265A (en) 2010-01-29
IL188900A0 (en) 2008-04-13

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application