JP2004505992A5 - - Google Patents

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Publication number
JP2004505992A5
JP2004505992A5 JP2002518258A JP2002518258A JP2004505992A5 JP 2004505992 A5 JP2004505992 A5 JP 2004505992A5 JP 2002518258 A JP2002518258 A JP 2002518258A JP 2002518258 A JP2002518258 A JP 2002518258A JP 2004505992 A5 JP2004505992 A5 JP 2004505992A5
Authority
JP
Japan
Prior art keywords
antigen
hepatitis
reducing agent
vaccine
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002518258A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004505992A (ja
Filing date
Publication date
Priority claimed from GBGB0019728.5A external-priority patent/GB0019728D0/en
Priority claimed from GB0101334A external-priority patent/GB0101334D0/en
Application filed filed Critical
Priority claimed from PCT/EP2001/009100 external-priority patent/WO2002012287A1/en
Publication of JP2004505992A publication Critical patent/JP2004505992A/ja
Publication of JP2004505992A5 publication Critical patent/JP2004505992A5/ja
Pending legal-status Critical Current

Links

JP2002518258A 2000-08-10 2001-08-07 ワクチンに使用するためのｈｂｖ抗原の精製 Pending JP2004505992A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0019728.5A GB0019728D0 (en) 2000-08-10 2000-08-10 Novel treatment
GB0101334A GB0101334D0 (en) 2001-01-18 2001-01-18 Novel compounds
PCT/EP2001/009100 WO2002012287A1 (en) 2000-08-10 2001-08-07 Purification of hbv antigens for use in vaccines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012180462A Division JP5559847B2 (ja) 2000-08-10 2012-08-16 ワクチンに使用するためのｈｂｖ抗原の精製

Publications (2)

Publication Number Publication Date
JP2004505992A JP2004505992A (ja) 2004-02-26
JP2004505992A5 true JP2004505992A5 (enExample) 2005-03-03

Family

ID=26244821

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002518258A Pending JP2004505992A (ja) 2000-08-10 2001-08-07 ワクチンに使用するためのｈｂｖ抗原の精製
JP2012180462A Expired - Lifetime JP5559847B2 (ja) 2000-08-10 2012-08-16 ワクチンに使用するためのｈｂｖ抗原の精製

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012180462A Expired - Lifetime JP5559847B2 (ja) 2000-08-10 2012-08-16 ワクチンに使用するためのｈｂｖ抗原の精製

Country Status (35)

Country Link
US (3) US20030235590A1 (enExample)
EP (2) EP1666487B1 (enExample)
JP (2) JP2004505992A (enExample)
KR (1) KR100804922B1 (enExample)
CN (1) CN1468256B (enExample)
AP (1) AP2003002734A0 (enExample)
AR (1) AR030325A1 (enExample)
AT (2) ATE313558T1 (enExample)
AU (2) AU2001282073B2 (enExample)
BG (1) BG66038B1 (enExample)
BR (1) BRPI0113155C1 (enExample)
CA (2) CA2740282A1 (enExample)
CY (2) CY1106310T1 (enExample)
CZ (1) CZ303217B6 (enExample)
DE (2) DE60136400D1 (enExample)
DK (2) DK1666487T3 (enExample)
DZ (1) DZ3470A1 (enExample)
EA (1) EA006433B1 (enExample)
EG (1) EG25829A (enExample)
ES (2) ES2254464T3 (enExample)
HU (1) HU228932B1 (enExample)
IL (2) IL154301A0 (enExample)
MX (1) MXPA03001235A (enExample)
MY (1) MY128999A (enExample)
NO (1) NO20030635L (enExample)
NZ (1) NZ524012A (enExample)
OA (1) OA12361A (enExample)
PE (1) PE20020287A1 (enExample)
PL (1) PL204736B1 (enExample)
PT (1) PT1666487E (enExample)
SI (2) SI1666487T1 (enExample)
SK (2) SK288079B6 (enExample)
UA (1) UA79735C2 (enExample)
UY (1) UY26882A1 (enExample)
WO (1) WO2002012287A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79735C2 (uk) * 2000-08-10 2007-07-25 Глаксосмітклайн Байолоджікалз С.А. Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах
GB0202901D0 (en) * 2002-02-07 2002-03-27 Glaxosmithkline Biolog Sa Novel vaccine
US20100034840A1 (en) * 2005-07-11 2010-02-11 David Apelian Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
DK1909830T3 (da) * 2005-08-02 2011-12-19 Novartis Vaccines & Diagnostic Formindskelse af interferens mellem olieholdige adjuvanser og antigener indeholdende overfladeaktivt middel
GB0522765D0 (en) * 2005-11-08 2005-12-14 Chiron Srl Combination vaccine manufacture
GB0612142D0 (en) 2006-06-20 2006-08-02 Secr Defence Spreading modulation spectrum control
CN103357003A (zh) 2006-09-07 2013-10-23 葛兰素史密丝克莱恩生物有限公司 疫苗
US20100074918A1 (en) 2007-05-02 2010-03-25 Jan Poolman Vaccine
US8436514B2 (en) * 2007-10-30 2013-05-07 Kyocera Corporation Acoustic wave device comprising an inter-digital transducer electrode
US8250102B2 (en) * 2008-03-14 2012-08-21 Microsoft Corporation Remote storage and management of binary object data
KR100959145B1 (ko) 2008-03-21 2010-05-25 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사 입자의 생산 및 정제 방법
EP2293813A4 (en) 2008-05-23 2012-07-11 Univ Michigan NANO EMULSION VACCINES
BRPI1012078A2 (pt) * 2009-05-27 2019-09-24 Glaxosmithkline Biologicals Sa construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica
WO2012095834A1 (en) * 2011-01-14 2012-07-19 Hal Allergy Holding B.V. Immunoassay for direct determination of antigen content of products comprising adjuvant-coupled-antigen particles
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
CN106222129A (zh) * 2016-07-29 2016-12-14 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
JP7404226B2 (ja) 2017-07-18 2023-12-25 セラム インスティテュート オブ インディア プライベート リミティド 向上した安定性、高度の免疫原性、及び減少した反応源性を有する免疫原性組成物、並びにその調製プロセス
GB201721068D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B immunisation regimen and compositions
GB201721069D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B Immunisation regimen and compositions
US20220339281A1 (en) 2019-03-05 2022-10-27 GalxoSmithKline Biologicals SA Hepatitis b immunisation regimen and compositions
JP7779838B2 (ja) * 2019-12-13 2025-12-03 遠大賽威信生命科学（南京）有限公司 免疫刺激性組成物及びその用途

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1030777A (en) * 1963-12-06 1966-05-25 Ciba Ltd Method of preparing a vaccine against trypanosoma cruzi infections
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4372945A (en) 1979-11-13 1983-02-08 Likhite Vilas V Antigen compounds
IL61904A (en) 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
US4720385A (en) * 1983-03-29 1988-01-19 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents
JPS6013718A (ja) 1983-07-05 1985-01-24 Chemo Sero Therapeut Res Inst Ｂ型肝炎ワクチン
KR850001534A (ko) 1983-08-22 1985-03-30 제임스 에프. 나우톤 형질전환된 효모로 부터 유도된 면역원성 HBsAg
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
FI861417A0 (fi) 1985-04-15 1986-04-01 Endotronics Inc Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav.
US4649192A (en) * 1985-05-30 1987-03-10 Smith Kline-Rit Method for the isolation and purification of hepatitis B surface antigen using polysorbate
US4895800A (en) 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
AP56A (en) 1987-01-30 1989-09-26 Smithkline Biologicals S A Hepatitis B virus surface antigens and hybrid antigehs containing them.
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
EP0304578B1 (en) 1987-06-22 2001-10-24 Medeva Holdings Bv Peptide comprising hepatitis B surface antigen
EP0299108B1 (en) 1987-07-17 1994-05-18 Rhein Biotech Gesellschaft für biotechnologische Prozesse und Produkte mbH DNA-molecules coding for FMDH control regions and structured gene for a protein having FMDH-activity and their uses
EP0314240A3 (en) * 1987-10-26 1990-03-28 Merck & Co. Inc. Process for purifying recombinant hepatitis antigens
JPH085804B2 (ja) 1988-04-28 1996-01-24 財団法人化学及血清療法研究所 Ａ型及びｂ型肝炎混合アジュバントワクチン
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5242812A (en) * 1989-02-07 1993-09-07 Bio-Technology General Corp. Method for production and purification of hepatitis B vaccine
US5274081A (en) * 1989-09-20 1993-12-28 Immuno A.G. Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen
GB9007024D0 (en) 1990-03-29 1990-05-30 Imperial College Novel vaccine
JPH06503821A (ja) 1990-12-20 1994-04-28 スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） Ｂ型肝炎表面抗原に基づくワクチン
JP3026029B2 (ja) 1991-04-26 2000-03-27 財団法人阪大微生物病研究会 組換え水痘ウイルスとその作製法
AU657168B2 (en) 1991-09-18 1995-03-02 Amgen, Inc. Hepatitis B vaccine with bile salt adjuvant
US6620414B2 (en) * 1992-03-27 2003-09-16 Smithkline Beecham Biologicals (S.A.) Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
EP0761231B1 (en) 1992-06-25 2000-01-12 SMITHKLINE BEECHAM BIOLOGICALS s.a. Vaccine composition containing adjuvants
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
EP0772619B2 (en) 1994-07-15 2010-12-08 The University of Iowa Research Foundation Immunomodulatory oligonucleotides
DE69535530D1 (de) * 1994-10-24 2007-08-16 Ophidian Pharm Inc Impfstoff und Antitoxine zur Behandlung und Vorbeugung von C. Difficile Krankheiten
KR960023066A (ko) * 1994-12-10 1996-07-18 성재갑 전에스 (s) 2 펩티드 함유 비 (b) 형 간염 표면항원의 정제 방법
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
KR20010041629A (ko) * 1998-03-09 2001-05-25 장 스테판느 혼합 백신 조성물
DK1104306T3 (da) 1998-08-10 2006-05-22 Antigenics Inc Præparater af CpG- og saponinadjuvanser og fremgangsmåder til anvendelse deraf
CA2355680A1 (en) * 1998-12-23 2000-06-29 Qinjian Zhao Improved recombinant hepatitis b surface antigen
UA79735C2 (uk) * 2000-08-10 2007-07-25 Глаксосмітклайн Байолоджікалз С.А. Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах

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