NO20030635L - Rensing av HBV-antigener for anvendelse i vaksiner - Google Patents
Rensing av HBV-antigener for anvendelse i vaksinerInfo
- Publication number
- NO20030635L NO20030635L NO20030635A NO20030635A NO20030635L NO 20030635 L NO20030635 L NO 20030635L NO 20030635 A NO20030635 A NO 20030635A NO 20030635 A NO20030635 A NO 20030635A NO 20030635 L NO20030635 L NO 20030635L
- Authority
- NO
- Norway
- Prior art keywords
- vaccines
- purification
- hbv antigens
- hbv
- antigens
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
- A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0019728.5A GB0019728D0 (en) | 2000-08-10 | 2000-08-10 | Novel treatment |
GB0101334A GB0101334D0 (en) | 2001-01-18 | 2001-01-18 | Novel compounds |
PCT/EP2001/009100 WO2002012287A1 (en) | 2000-08-10 | 2001-08-07 | Purification of hbv antigens for use in vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20030635D0 NO20030635D0 (no) | 2003-02-07 |
NO20030635L true NO20030635L (no) | 2003-04-01 |
Family
ID=26244821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20030635A NO20030635L (no) | 2000-08-10 | 2003-02-07 | Rensing av HBV-antigener for anvendelse i vaksiner |
Country Status (36)
Country | Link |
---|---|
US (3) | US20030235590A1 (no) |
EP (2) | EP1307473B1 (no) |
JP (2) | JP2004505992A (no) |
KR (1) | KR100804922B1 (no) |
CN (1) | CN1468256B (no) |
AP (1) | AP2003002734A0 (no) |
AR (1) | AR030325A1 (no) |
AT (2) | ATE412665T1 (no) |
AU (2) | AU2001282073B2 (no) |
BG (1) | BG66038B1 (no) |
BR (1) | BRPI0113155C1 (no) |
CA (2) | CA2740282A1 (no) |
CY (2) | CY1106310T1 (no) |
CZ (1) | CZ303217B6 (no) |
DE (2) | DE60116107T2 (no) |
DK (2) | DK1666487T3 (no) |
DZ (1) | DZ3470A1 (no) |
EA (1) | EA006433B1 (no) |
EG (1) | EG25829A (no) |
ES (2) | ES2254464T3 (no) |
HK (1) | HK1056884A1 (no) |
HU (1) | HU228932B1 (no) |
IL (2) | IL154301A0 (no) |
MX (1) | MXPA03001235A (no) |
MY (1) | MY128999A (no) |
NO (1) | NO20030635L (no) |
NZ (1) | NZ524012A (no) |
OA (1) | OA12361A (no) |
PE (1) | PE20020287A1 (no) |
PL (1) | PL204736B1 (no) |
PT (1) | PT1666487E (no) |
SI (2) | SI1666487T1 (no) |
SK (2) | SK288079B6 (no) |
UA (1) | UA79735C2 (no) |
UY (1) | UY26882A1 (no) |
WO (1) | WO2002012287A1 (no) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA79735C2 (uk) * | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
GB0202901D0 (en) * | 2002-02-07 | 2002-03-27 | Glaxosmithkline Biolog Sa | Novel vaccine |
EP1906997A2 (en) * | 2005-07-11 | 2008-04-09 | Globeimmune, Inc. | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
JP2009503051A (ja) * | 2005-08-02 | 2009-01-29 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 油含有アジュバントと界面活性剤含有アジュバントとの間の干渉の減少 |
GB0522765D0 (en) * | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
GB0612142D0 (en) | 2006-06-20 | 2006-08-02 | Secr Defence | Spreading modulation spectrum control |
PL2097102T3 (pl) | 2006-09-07 | 2012-10-31 | Glaxosmithkline Biologicals Sa | Szczepionka skojarzona o zmniejszonej ilości antygenu wirusa polio |
TW200914042A (en) | 2007-05-02 | 2009-04-01 | Glaxosmithkline Biolog Sa | Vaccine |
US8436514B2 (en) * | 2007-10-30 | 2013-05-07 | Kyocera Corporation | Acoustic wave device comprising an inter-digital transducer electrode |
US8250102B2 (en) * | 2008-03-14 | 2012-08-21 | Microsoft Corporation | Remote storage and management of binary object data |
KR100959145B1 (ko) | 2008-03-21 | 2010-05-25 | 중앙대학교 산학협력단 | 인유두종바이러스 바이러스 유사 입자의 생산 및 정제 방법 |
US8877208B2 (en) | 2008-05-23 | 2014-11-04 | The Regents Of The University Of Michigan | Multivalent nanoemulsion vaccines |
US8916514B2 (en) * | 2009-05-27 | 2014-12-23 | Glaxosmithkline Biologicals, S.A. | CASB7439 constructs |
DK2705365T3 (en) * | 2011-01-14 | 2016-10-24 | Hal Allergy Holding B V | Immunoassay for the direct determination of the antigen content in the products containing the adjuvant-linked antigen particles |
GB201105981D0 (en) | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
CN106222129A (zh) * | 2016-07-29 | 2016-12-14 | 广东东阳光药业有限公司 | 一种提高抗体纯度的细胞培养基和培养方法 |
SG11202000224SA (en) | 2017-07-18 | 2020-02-27 | Serum Inst Of India Pvt Ltd | An immunogenic composition having improved stability, enhanced immunogenicity and reduced reactogenicity and process for preparation thereof |
GB201721069D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B Immunisation regimen and compositions |
GB201721068D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B immunisation regimen and compositions |
CN113573730A (zh) | 2019-03-05 | 2021-10-29 | 葛兰素史密斯克莱生物公司 | 乙型肝炎免疫方案和组合物 |
EP4074334A1 (en) * | 2019-12-13 | 2022-10-19 | Grand Theravac Life Science (Nanjing) Co., Ltd. | Pharmaceutical composition and use thereof |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1030777A (en) * | 1963-12-06 | 1966-05-25 | Ciba Ltd | Method of preparing a vaccine against trypanosoma cruzi infections |
US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
US4720385A (en) * | 1983-03-29 | 1988-01-19 | Miles Laboratories, Inc. | Protein compositions substantially free from infectious agents |
JPS6013718A (ja) | 1983-07-05 | 1985-01-24 | Chemo Sero Therapeut Res Inst | B型肝炎ワクチン |
EP0135435A3 (en) | 1983-08-22 | 1987-03-25 | Merck & Co. Inc. | Immunogenic hbsag derived from transformed yeast |
US4683294A (en) | 1985-04-03 | 1987-07-28 | Smith Kline Rit, S.A. | Process for the extraction and purification of proteins from culture media producing them |
FI861417A0 (fi) | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
US4649192A (en) * | 1985-05-30 | 1987-03-10 | Smith Kline-Rit | Method for the isolation and purification of hepatitis B surface antigen using polysorbate |
US4895800A (en) | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
AP56A (en) | 1987-01-30 | 1989-09-26 | Smithkline Biologicals S A | Hepatitis B virus surface antigens and hybrid antigehs containing them. |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
EP0304578B1 (en) | 1987-06-22 | 2001-10-24 | Medeva Holdings Bv | Peptide comprising hepatitis B surface antigen |
ES2056799T3 (es) | 1987-07-17 | 1994-10-16 | Rhein Biotech Ges Fur Biotechn | Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso. |
EP0314240A3 (en) * | 1987-10-26 | 1990-03-28 | Merck & Co. Inc. | Process for purifying recombinant hepatitis antigens |
JPH085804B2 (ja) | 1988-04-28 | 1996-01-24 | 財団法人化学及血清療法研究所 | A型及びb型肝炎混合アジュバントワクチン |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
US5242812A (en) * | 1989-02-07 | 1993-09-07 | Bio-Technology General Corp. | Method for production and purification of hepatitis B vaccine |
US5274081A (en) * | 1989-09-20 | 1993-12-28 | Immuno A.G. | Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen |
GB9007024D0 (en) | 1990-03-29 | 1990-05-30 | Imperial College | Novel vaccine |
AU9052091A (en) | 1990-12-20 | 1992-07-22 | Smithkline Beecham Biologicals (Sa) | Vaccines based on hepatitis b surface antigen |
JP3026029B2 (ja) | 1991-04-26 | 2000-03-27 | 財団法人阪大微生物病研究会 | 組換え水痘ウイルスとその作製法 |
CA2096650A1 (en) | 1991-09-18 | 1993-03-21 | Keith E. Langley | Hepatitis b vaccine formulation incorporating a bile acid salt |
US6620414B2 (en) * | 1992-03-27 | 2003-09-16 | Smithkline Beecham Biologicals (S.A.) | Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A |
DK0671948T3 (da) | 1992-06-25 | 1997-09-01 | Smithkline Beecham Biolog | Vaccinepræparat indeholdende adjuvanser |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
ATE366312T1 (de) * | 1994-10-24 | 2007-07-15 | Ophidian Pharm Inc | Impfstoff und antitoxine zur behandlung und vorbeugung von c. difficile krankheiten |
KR960023066A (ko) * | 1994-12-10 | 1996-07-18 | 성재갑 | 전에스 (s) 2 펩티드 함유 비 (b) 형 간염 표면항원의 정제 방법 |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
EP1064025B1 (en) | 1998-03-09 | 2006-09-13 | GlaxoSmithKline Biologicals S.A. | Combined vaccine compositions |
DE69929444T2 (de) | 1998-08-10 | 2006-09-28 | Antigenics Inc., Woburn | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
JP2002532116A (ja) * | 1998-12-23 | 2002-10-02 | メルク エンド カムパニー インコーポレーテッド | 改良された組換えb型肝炎表面抗原 |
UA79735C2 (uk) * | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
-
2001
- 2001-07-08 UA UA2003021025A patent/UA79735C2/uk unknown
- 2001-08-07 SK SK50032-2012A patent/SK288079B6/sk not_active IP Right Cessation
- 2001-08-07 EP EP01960630A patent/EP1307473B1/en not_active Expired - Lifetime
- 2001-08-07 IL IL15430101A patent/IL154301A0/xx unknown
- 2001-08-07 AU AU2001282073A patent/AU2001282073B2/en not_active Expired
- 2001-08-07 PT PT05077471T patent/PT1666487E/pt unknown
- 2001-08-07 HU HU0302951A patent/HU228932B1/hu not_active IP Right Cessation
- 2001-08-07 AT AT05077471T patent/ATE412665T1/de active
- 2001-08-07 AU AU8207301A patent/AU8207301A/xx active Pending
- 2001-08-07 OA OA1200300038A patent/OA12361A/en unknown
- 2001-08-07 DE DE60116107T patent/DE60116107T2/de not_active Expired - Lifetime
- 2001-08-07 NZ NZ524012A patent/NZ524012A/en unknown
- 2001-08-07 CZ CZ20030385A patent/CZ303217B6/cs not_active IP Right Cessation
- 2001-08-07 EP EP05077471A patent/EP1666487B1/en not_active Expired - Lifetime
- 2001-08-07 BR BRPI0113155A patent/BRPI0113155C1/pt not_active IP Right Cessation
- 2001-08-07 ES ES01960630T patent/ES2254464T3/es not_active Expired - Lifetime
- 2001-08-07 AP APAP/P/2003/002734A patent/AP2003002734A0/en unknown
- 2001-08-07 SI SI200130884T patent/SI1666487T1/sl unknown
- 2001-08-07 SI SI200130489T patent/SI1307473T1/sl unknown
- 2001-08-07 WO PCT/EP2001/009100 patent/WO2002012287A1/en active IP Right Grant
- 2001-08-07 PL PL362322A patent/PL204736B1/pl unknown
- 2001-08-07 EA EA200300129A patent/EA006433B1/ru not_active IP Right Cessation
- 2001-08-07 KR KR1020037001933A patent/KR100804922B1/ko active IP Right Grant
- 2001-08-07 AT AT01960630T patent/ATE313558T1/de active
- 2001-08-07 CN CN018169988A patent/CN1468256B/zh not_active Expired - Lifetime
- 2001-08-07 DE DE60136400T patent/DE60136400D1/de not_active Expired - Lifetime
- 2001-08-07 CA CA2740282A patent/CA2740282A1/en not_active Abandoned
- 2001-08-07 US US10/344,211 patent/US20030235590A1/en not_active Abandoned
- 2001-08-07 CA CA2427475A patent/CA2427475C/en not_active Expired - Lifetime
- 2001-08-07 DZ DZ013470A patent/DZ3470A1/fr active
- 2001-08-07 SK SK169-2003A patent/SK288069B6/sk not_active IP Right Cessation
- 2001-08-07 JP JP2002518258A patent/JP2004505992A/ja active Pending
- 2001-08-07 MX MXPA03001235A patent/MXPA03001235A/es active IP Right Grant
- 2001-08-07 ES ES05077471T patent/ES2314555T3/es not_active Expired - Lifetime
- 2001-08-07 DK DK05077471T patent/DK1666487T3/da active
- 2001-08-07 DK DK01960630T patent/DK1307473T3/da active
- 2001-08-08 PE PE2001000786A patent/PE20020287A1/es not_active Application Discontinuation
- 2001-08-08 AR ARP010103790A patent/AR030325A1/es active IP Right Grant
- 2001-08-08 EG EG2001080869A patent/EG25829A/xx active
- 2001-08-10 UY UY26882A patent/UY26882A1/es not_active Application Discontinuation
- 2001-08-10 MY MYPI20013779A patent/MY128999A/en unknown
-
2003
- 2003-02-05 IL IL154301A patent/IL154301A/en active IP Right Grant
- 2003-02-07 BG BG107545A patent/BG66038B1/bg active Active
- 2003-02-07 NO NO20030635A patent/NO20030635L/no unknown
- 2003-10-14 HK HK03107371A patent/HK1056884A1/xx not_active IP Right Cessation
-
2005
- 2005-11-03 US US11/266,565 patent/US20060159705A1/en not_active Abandoned
-
2006
- 2006-03-07 CY CY20061100311T patent/CY1106310T1/el unknown
-
2008
- 2008-12-10 CY CY20081101440T patent/CY1108789T1/el unknown
- 2008-12-23 US US12/342,220 patent/US8624004B2/en not_active Expired - Lifetime
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2012
- 2012-08-16 JP JP2012180462A patent/JP5559847B2/ja not_active Expired - Lifetime
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