ES2056799T3 - Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso. - Google Patents

Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso.

Info

Publication number
ES2056799T3
ES2056799T3 ES87110417T ES87110417T ES2056799T3 ES 2056799 T3 ES2056799 T3 ES 2056799T3 ES 87110417 T ES87110417 T ES 87110417T ES 87110417 T ES87110417 T ES 87110417T ES 2056799 T3 ES2056799 T3 ES 2056799T3
Authority
ES
Spain
Prior art keywords
fmdh
dna molecules
dna
protein
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87110417T
Other languages
English (en)
Inventor
Cornelius P Hollenberg
Zbigniew Janowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynavax GmbH
Original Assignee
Rhein Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhein Biotech GmbH filed Critical Rhein Biotech GmbH
Application granted granted Critical
Publication of ES2056799T3 publication Critical patent/ES2056799T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C12N9/242—Fungal source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01002—Formate dehydrogenase (1.2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/02—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with a cytochrome as acceptor (1.2.2)
    • C12Y102/02001—Formate dehydrogenase (cytochrome) (1.2.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SE REFIERE A MOLECULAS DE ADN QUE COMPRENDEN SECUENCIAS DE ADN QUE CODIFICAN REGIONES DE CONTROL Y AL GEN ESTRCUTURAL PARA UNA PROTEINA QUE TIENE ACTIVIDAD DE FORMATO DESHIDROGENASA (FMDH). DICHAS MOLECULAS SE PUEDEN COMBINAR CON SECUENCIAS DE ADN QUE CODIFICAN GENES EXTRAÑOS PARA LLEVAR ESTOS GENES BAJO CONTROL ESTRICTO DE LA REGULACION DE SECUENCIAS REGULADORAS DE FMDH Y/O SE PUEDEN COMBINAR CON SECUENCIAS REGULADORAS DE ADN QUE CODIFICAN LAS SEÑALES SECRETORIAS. LA INVENCION SE REFIERE TAMBIEN A VECTORES RECOMBINANTES QUE CONTIENEN ESAS MOLECULAS DE ADN Y A MICROORGANISMOS QUE CONTIENEN LSO CITADOS VECTORES O MOLECULAS DE ADN. ADEMAS LA INVENCION SE REFIERE A UN PROCESO PARA LA PRODUCCION DE UNA SUSTANCIA UTIL PARA PRODUCIR ESTA SUSTANCIA, POR CULTIVO DE LOS INDICADOS MICROORGANISMOS Y RECUPERACION DE LA SUSTANCIA.
ES87110417T 1987-07-17 1987-07-17 Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso. Expired - Lifetime ES2056799T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP87110417A EP0299108B1 (en) 1987-07-17 1987-07-17 DNA-molecules coding for FMDH control regions and structured gene for a protein having FMDH-activity and their uses
AU24434/88A AU2443488A (en) 1987-07-17 1988-10-27 Dna-molecules coding for fmdh control regions and structured gene for a protein having fmdh-activity and their uses
JP63277205A JP3072993B2 (ja) 1987-07-17 1988-11-01 Ｄｎａ分子
US07/844,885 US5389525A (en) 1987-07-17 1992-03-03 DNA-molecules coding for FMDH control regions and structural gene for a protein having FMDH-activity and their use thereof

Publications (1)

Publication Number Publication Date
ES2056799T3 true ES2056799T3 (es) 1994-10-16

Family

ID=27422777

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87110417T Expired - Lifetime ES2056799T3 (es) 1987-07-17 1987-07-17 Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso.

Country Status (7)

Country Link
US (1) US5389525A (es)
EP (1) EP0299108B1 (es)
JP (1) JP3072993B2 (es)
AT (1) ATE105858T1 (es)
AU (1) AU2443488A (es)
DE (1) DE3789866T2 (es)
ES (1) ES2056799T3 (es)

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PL168787B1 (pl) * 1989-08-03 1996-04-30 Smithkline Beecham Biolog Sposób wytwarzania czastki kompozytowej PL
JP3626996B2 (ja) 1992-05-23 2005-03-09 グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニム Ｂ型肝炎表面抗原および他の抗原からなる複合ワクチン
NZ253137A (en) 1992-06-25 1996-08-27 Smithkline Beecham Biolog Vaccine comprising antigen and/or antigenic composition, qs21 (quillaja saponaria molina extract) and 3 de-o-acylated monophosphoryl lipid a.
WO1994021802A1 (en) * 1993-03-25 1994-09-29 Biosource Genetics Corporation PICHIA PASTORIS ALCOHOL OXIDASE ZZA1 and $i(ZZA2)
US6699704B1 (en) 1994-04-25 2004-03-02 Roche Vitamins Inc. Heat tolerant phytases
US6358722B1 (en) 1994-04-25 2002-03-19 Roche Vitamins, Inc. Heat tolerant phytases
US5712114A (en) * 1995-06-06 1998-01-27 Basf Aktiengesellschaft Compositions for expression of proteins in host cells using a preprocollagen signal sequence
US6001590A (en) * 1995-09-12 1999-12-14 Kirin Beer Kabushiki Kaisha Promoter and terminator sequences of formate dehydrogenase gene of Candida boidinii
US5955349A (en) * 1996-08-26 1999-09-21 Zymogenetics, Inc. Compositions and methods for producing heterologous polypeptides in Pichia methanolica
US5965389A (en) * 1995-11-09 1999-10-12 Zymogenetics, Inc. Production of GAD65 in methylotrophic yeast
US5716808A (en) * 1995-11-09 1998-02-10 Zymogenetics, Inc. Genetic engineering of pichia methanolica
US5747328A (en) * 1996-02-28 1998-05-05 Wisconsin Alumni Research Foundation Microbial system for formaldehyde sensing and remediation
GB9623233D0 (en) 1996-11-07 1997-01-08 Smithkline Beecham Biolog Vaccine composition
CA2231948C (en) 1997-03-25 2010-05-18 F. Hoffmann-La Roche Ag Modified phytases
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
DK0911416T3 (da) 1997-10-01 2006-08-14 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af protein
GB9724627D0 (en) * 1997-11-20 1998-01-21 Genencor Int Bv Gram positive microorganism formate pathway
DE122007000087I1 (de) 1998-10-16 2008-03-27 Glaxosmithkline Biolog Sa Adjuvanzsysteme und impfstoffe
US6720174B1 (en) 1999-01-28 2004-04-13 Novozymes A/S Phytases
UA79735C2 (uk) * 2000-08-10 2007-07-25 Глаксосмітклайн Байолоджікалз С.А. Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах
US6645739B2 (en) 2001-07-26 2003-11-11 Phoenix Pharmacologies, Inc. Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
AU2002359721A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Pichia pastoris formate dehydrogenase and uses therefor
CA2649688A1 (en) 2006-03-14 2007-09-20 Oregon Health & Science University Methods for detecting a mycobacterium tuberculosis infection
EP2491947A3 (en) 2006-09-07 2012-10-17 GlaxoSmithKline Biologicals S.A. Vaccine
JP5290997B2 (ja) 2007-01-26 2013-09-18 ノボザイムス アクティーゼルスカブ ピキアにおけるメタノール誘導性プロモーターからのメタノール非依存的誘導の方法
DK2918598T3 (en) 2007-02-28 2019-04-29 The Govt Of U S A As Represented By The Secretary Of The Dept Of Health And Human Services Brachyury polypeptides and methods of use
WO2008135514A1 (en) 2007-05-02 2008-11-13 Glaxosmithkline Biologicals S.A. Vaccine
CA2725329C (en) 2008-05-23 2013-10-01 The Regents Of The University Of Michigan Nanoemulsion vaccines
WO2010017209A2 (en) 2008-08-04 2010-02-11 The Government Of The Usa As Represented By The Secretary Of The Department Of Health And Human Services Membrane proximal region of hiv gp41 anchored to the lipid layer of a virus-like particle vaccine
WO2010099472A2 (en) 2009-02-27 2010-09-02 The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services Spanx-b polypeptides and their use
US9181306B2 (en) 2009-10-16 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Insertion of foreign genes in rubella virus and their stable expression in a live, attenuated viral vaccine
ES2523242T3 (es) 2009-12-21 2014-11-24 Süd-Chemie Ip Gmbh & Co. Kg Xilanasa termoestable para la hidrólisis selectiva de polisacáridos que contienen pentosa
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
US9566329B2 (en) 2012-04-06 2017-02-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Live, attenuated rubella vector to express vaccine antigens
ES2752190T3 (es) 2012-09-14 2020-04-03 Us Health Proteína Brachyury, vectores adenovirales que codifican proteína Brachyury y su uso
EP2863943B1 (en) 2013-03-08 2016-07-13 Crucell Holland B.V. Acellular pertussis vaccine
KR101957550B1 (ko) 2013-04-30 2019-06-28 도널드 댄포스 플랜트 사이언스 센터 항진균성 식물 단백질, 펩티드 및 사용 방법
CN103255163B (zh) * 2013-05-15 2016-01-27 北京民海生物科技有限公司 一种ev71病毒样颗粒及其制备方法与应用
WO2015064517A1 (ja) * 2013-10-28 2015-05-07 国立大学法人岐阜大学 ギ酸脱水素酵素とその利用
AU2016302237B2 (en) 2015-08-03 2022-08-04 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use
EP3922726A1 (en) 2020-06-10 2021-12-15 Erber Aktiengesellschaft Truncated promoter for recombinant gene expression

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GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids

Also Published As

Publication number Publication date
ATE105858T1 (de) 1994-06-15
US5389525A (en) 1995-02-14
AU2443488A (en) 1990-05-03
DE3789866T2 (de) 1994-09-22
JPH02124093A (ja) 1990-05-11
EP0299108A1 (en) 1989-01-18
JP3072993B2 (ja) 2000-08-07
DE3789866D1 (de) 1994-06-23
EP0299108B1 (en) 1994-05-18

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