GB1030777A - Method of preparing a vaccine against trypanosoma cruzi infections - Google Patents

Method of preparing a vaccine against trypanosoma cruzi infections

Info

Publication number
GB1030777A
GB1030777A GB46630/64A GB4663064A GB1030777A GB 1030777 A GB1030777 A GB 1030777A GB 46630/64 A GB46630/64 A GB 46630/64A GB 4663064 A GB4663064 A GB 4663064A GB 1030777 A GB1030777 A GB 1030777A
Authority
GB
United Kingdom
Prior art keywords
cruzi
preparing
vaccine against
trypanosoma cruzi
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46630/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1030777A publication Critical patent/GB1030777A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/005—Trypanosoma antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A vaccine for Trynanosoma cruzi infections is prepared by subjecting a suspension of T. cruzi obtained in their crithidial form from a culture medium to a mechanical or physical treatment which disrupts their cellular structure. The disruption may be brought about by shaking with solid materials e.g. glass beads, by application of sonic vibrations, or by release of the suspension of microorganisms under pressure (350-1430 atm.) through a small orifice. The T. cruzi are preferably suspended in a physiological solution, e.g. physiological saline, together with an anti-oxidant, e.g. glutathione, cysteine or mercaptoethanol.
GB46630/64A 1963-12-06 1964-11-16 Method of preparing a vaccine against trypanosoma cruzi infections Expired GB1030777A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32848163A 1963-12-06 1963-12-06

Publications (1)

Publication Number Publication Date
GB1030777A true GB1030777A (en) 1966-05-25

Family

ID=23281173

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46630/64A Expired GB1030777A (en) 1963-12-06 1964-11-16 Method of preparing a vaccine against trypanosoma cruzi infections

Country Status (2)

Country Link
FR (1) FR4005M (en)
GB (1) GB1030777A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2397194A1 (en) * 1977-07-12 1979-02-09 Behringwerke Ag VACCINE AGAINST CHAGAS'S DISEASE, BASED ON KILLED TRYPANOSOMES, ITS PREPARATION PROCESS AND APPLICATION OF KILLED TRYPANOSOMES TO THE PREPARATION OF CELLULAR CONSTITUENTS HAVING IMMUNOLOGICAL ACTIVITY
US4298596A (en) * 1979-03-29 1981-11-03 Burroughs Wellcome Co. Trypanosoma cruzi glycoprotein vaccine for inducing immunity to Chagas' disease
US4457915A (en) * 1979-11-06 1984-07-03 Goodger Brian V Babesiosis vaccine prepared from soluble parasitic antigen factors isolated from disintegration of Babesia infected erythrocites
WO2002012287A1 (en) * 2000-08-10 2002-02-14 Glaxosmithkline Biologicals S.A. Purification of hbv antigens for use in vaccines

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2397194A1 (en) * 1977-07-12 1979-02-09 Behringwerke Ag VACCINE AGAINST CHAGAS'S DISEASE, BASED ON KILLED TRYPANOSOMES, ITS PREPARATION PROCESS AND APPLICATION OF KILLED TRYPANOSOMES TO THE PREPARATION OF CELLULAR CONSTITUENTS HAVING IMMUNOLOGICAL ACTIVITY
US4298596A (en) * 1979-03-29 1981-11-03 Burroughs Wellcome Co. Trypanosoma cruzi glycoprotein vaccine for inducing immunity to Chagas' disease
US4457915A (en) * 1979-11-06 1984-07-03 Goodger Brian V Babesiosis vaccine prepared from soluble parasitic antigen factors isolated from disintegration of Babesia infected erythrocites
WO2002012287A1 (en) * 2000-08-10 2002-02-14 Glaxosmithkline Biologicals S.A. Purification of hbv antigens for use in vaccines
EP1666487A1 (en) * 2000-08-10 2006-06-07 GlaxoSmithKline Biologicals SA Purification of hbv antigens for use in vaccines
US8624004B2 (en) 2000-08-10 2014-01-07 Glaxosmithkline Biologicals, S.A. Purification of HBV antigens for use in vaccines

Also Published As

Publication number Publication date
FR4005M (en) 1966-03-14

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