JP2004137288A5 - - Google Patents
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- Publication number
- JP2004137288A5 JP2004137288A5 JP2003422779A JP2003422779A JP2004137288A5 JP 2004137288 A5 JP2004137288 A5 JP 2004137288A5 JP 2003422779 A JP2003422779 A JP 2003422779A JP 2003422779 A JP2003422779 A JP 2003422779A JP 2004137288 A5 JP2004137288 A5 JP 2004137288A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- hydroxyamidine
- thiocarboxamide
- carboxamide
- formamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- CYEBJEDOHLIWNP-UHFFFAOYSA-N methanethioamide Chemical compound NC=S CYEBJEDOHLIWNP-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24443800P | 2000-10-31 | 2000-10-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Division JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004137288A JP2004137288A (ja) | 2004-05-13 |
| JP2004137288A5 true JP2004137288A5 (enExample) | 2005-07-21 |
Family
ID=22922766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
| JP2003422779A Pending JP2004137288A (ja) | 2000-10-31 | 2003-12-19 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US6784187B2 (enExample) |
| EP (3) | EP1944292B9 (enExample) |
| JP (2) | JP4340437B2 (enExample) |
| AT (2) | ATE292625T1 (enExample) |
| AU (2) | AU2713502A (enExample) |
| CA (1) | CA2426942C (enExample) |
| DE (2) | DE60109960T2 (enExample) |
| ES (3) | ES2239170T3 (enExample) |
| WO (1) | WO2002036573A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2426942C (en) * | 2000-10-31 | 2014-06-03 | Mark P. Wentland | 8-carboxamido-2,6-methano-3-benzazocines |
| US6974824B2 (en) * | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| MXPA04011327A (es) * | 2002-05-17 | 2005-08-15 | Jenken Biosciences Inc | Opioides y compuestos similares a opioides y usos de los mismos. |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP1602374A4 (en) * | 2003-03-07 | 2007-03-07 | Toray Industries | MEANS FOR TREATMENT OF MEDICAMENT / SUBSTANCE DEPENDENCE |
| US7381721B2 (en) | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US6992090B2 (en) | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| EP1644373A1 (en) | 2003-06-27 | 2006-04-12 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| EP1595541A1 (en) | 2004-05-12 | 2005-11-16 | Alcasynn Pharmaceuticals Gmbh | Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin |
| AU2005245403B2 (en) * | 2004-05-14 | 2012-04-19 | Janssen Pharmaceutica N.V. | Carboxamido opioid compounds |
| EA200700403A1 (ru) | 2004-08-05 | 2007-08-31 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| AR053098A1 (es) * | 2004-11-04 | 2007-04-25 | Toray Industries | Analgesico derivado de morfinano |
| PT2251330E (pt) * | 2004-11-05 | 2012-07-20 | Rensselaer Polytech Inst | 4-hidroxibenzomorfanos |
| WO2006069276A2 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC ō-OPIOID MODULATORS |
| WO2006069277A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC δ-OPIOID MODULATORS |
| US7432257B2 (en) | 2005-01-06 | 2008-10-07 | Janssen Pharmaceutica N.V. | Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators |
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| AU2006259273A1 (en) | 2005-06-16 | 2006-12-28 | Janssen Pharmaceutica N.V. | Tricyclic opioid modulators |
| EP2266959B1 (en) * | 2005-07-21 | 2013-05-01 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| EP2190819B1 (en) | 2007-08-09 | 2016-05-25 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
| WO2010011619A1 (en) * | 2008-07-21 | 2010-01-28 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
| EP3170395A1 (en) * | 2009-03-19 | 2017-05-24 | Alkermes Pharma Ireland Limited | Morphinan derivatives with high oral bioavailability |
| WO2010151317A1 (en) | 2009-06-22 | 2010-12-29 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2010151318A1 (en) | 2009-06-22 | 2010-12-29 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| MX342548B (es) * | 2009-09-18 | 2016-10-04 | Merck Sharp & Dohme Corp * | Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal. |
| NZ600379A (en) * | 2009-12-04 | 2014-05-30 | Alkermes Pharma Ireland Ltd | Morphinan derivatives for the treatment of drug overdose |
| US8546588B2 (en) * | 2010-02-26 | 2013-10-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011106632A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| US8946223B2 (en) | 2010-04-12 | 2015-02-03 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012005795A1 (en) | 2010-07-08 | 2012-01-12 | Alkermes, Inc. | Process for the synthesis of substituted morphinans |
| AU2010357625B2 (en) | 2010-07-16 | 2015-04-23 | Mallinckrodt Llc | (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof |
| SI3446565T1 (sl) | 2010-08-23 | 2024-03-29 | Alkermes Pharma Ireland Limited | Metode zdravljenja povečanja teže, povzročene z antipsihotiki |
| WO2012027564A1 (en) | 2010-08-26 | 2012-03-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8765773B2 (en) | 2010-10-18 | 2014-07-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8778931B2 (en) | 2010-12-22 | 2014-07-15 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012138888A1 (en) | 2011-04-05 | 2012-10-11 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| RS56181B1 (sr) | 2011-06-29 | 2017-11-30 | Alkermes Inc | Periferno delujuća opioidna jedinjenja |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| HUE041883T2 (hu) | 2011-12-15 | 2019-06-28 | Alkermes Pharma Ireland Ltd | Samidorphan (ALKS 33) és buprenorfin kombináció, depressziós zavarok kezelésére |
| EP2917182B1 (en) * | 2012-11-09 | 2018-01-03 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| JP2016519161A (ja) | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| EP3074379B1 (en) * | 2013-11-27 | 2019-06-26 | Nektar Therapeutics (India) Pvt. Ltd. | Opioid agonists and uses thereof |
| US9975854B2 (en) | 2014-05-06 | 2018-05-22 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| US10239845B2 (en) | 2015-02-02 | 2019-03-26 | Forma Therapeutics, Inc. | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| WO2018125716A1 (en) * | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH581624A5 (enExample) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4032529A (en) * | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4373139A (en) | 1979-04-30 | 1983-02-08 | Motorola, Inc. | Detectors |
| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4374139A (en) * | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) * | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) * | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| JPH07502734A (ja) | 1991-12-31 | 1995-03-23 | ザイモジェネティクス，インコーポレイティド | 血液損失を減少する方法および組成物 |
| EP0632041A1 (en) * | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| AU706370B2 (en) | 1996-01-10 | 1999-06-17 | Smithkline Beecham Spa | Heterocycle-condensed morphinoid derivatives (II) |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| CA2426942C (en) | 2000-10-31 | 2014-06-03 | Mark P. Wentland | 8-carboxamido-2,6-methano-3-benzazocines |
| AU2003239389A1 (en) | 2002-05-30 | 2003-12-19 | Eli Lilly And Company | Opioid receptor antagonists |
| PT2251330E (pt) * | 2004-11-05 | 2012-07-20 | Rensselaer Polytech Inst | 4-hidroxibenzomorfanos |
| EP2266959B1 (en) * | 2005-07-21 | 2013-05-01 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents |
-
2001
- 2001-10-31 CA CA2426942A patent/CA2426942C/en not_active Expired - Lifetime
- 2001-10-31 EP EP08004779.8A patent/EP1944292B9/en not_active Expired - Lifetime
- 2001-10-31 EP EP01992702A patent/EP1353909B1/en not_active Expired - Lifetime
- 2001-10-31 AU AU2713502A patent/AU2713502A/xx active Pending
- 2001-10-31 JP JP2002539332A patent/JP4340437B2/ja not_active Expired - Lifetime
- 2001-10-31 WO PCT/US2001/045581 patent/WO2002036573A2/en not_active Ceased
- 2001-10-31 AT AT01992702T patent/ATE292625T1/de not_active IP Right Cessation
- 2001-10-31 ES ES01992702T patent/ES2239170T3/es not_active Expired - Lifetime
- 2001-10-31 DE DE60109960T patent/DE60109960T2/de not_active Expired - Lifetime
- 2001-10-31 ES ES08004779T patent/ES2572332T3/es not_active Expired - Lifetime
- 2001-10-31 ES ES03013544T patent/ES2304477T3/es not_active Expired - Lifetime
- 2001-10-31 EP EP03013544A patent/EP1359146B1/en not_active Expired - Lifetime
- 2001-10-31 AT AT03013544T patent/ATE391712T1/de not_active IP Right Cessation
- 2001-10-31 AU AU2002227135A patent/AU2002227135B2/en not_active Expired
- 2001-10-31 DE DE60133584T patent/DE60133584T2/de not_active Expired - Lifetime
-
2002
- 2002-11-26 US US10/305,287 patent/US6784187B2/en not_active Expired - Lifetime
-
2003
- 2003-04-09 US US10/409,803 patent/US6887998B2/en not_active Expired - Lifetime
- 2003-12-19 JP JP2003422779A patent/JP2004137288A/ja active Pending
-
2004
- 2004-11-12 US US10/987,527 patent/US7265226B2/en not_active Expired - Lifetime
-
2005
- 2005-08-17 US US11/205,354 patent/US20060030580A1/en not_active Abandoned
-
2008
- 2008-10-10 US US12/249,238 patent/US7956187B2/en not_active Expired - Fee Related
-
2011
- 2011-05-09 US US13/103,599 patent/US8252929B2/en not_active Expired - Fee Related
-
2012
- 2012-07-24 US US13/556,650 patent/US8642615B2/en not_active Expired - Lifetime
-
2013
- 2013-12-19 US US14/134,264 patent/US20140275545A1/en not_active Abandoned
-
2016
- 2016-09-09 US US15/260,610 patent/US9932349B2/en not_active Expired - Lifetime