AR005423A1 - Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados. - Google Patents

Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados.

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Publication number
AR005423A1
AR005423A1 ARP970100077A ARP970100077A AR005423A1 AR 005423 A1 AR005423 A1 AR 005423A1 AR P970100077 A ARP970100077 A AR P970100077A AR P970100077 A ARP970100077 A AR P970100077A AR 005423 A1 AR005423 A1 AR 005423A1
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Argentina
Prior art keywords
group
same meaning
derivatives
prepare
hydrogen
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ARP970100077A
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English (en)
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Smithkline Beecham Spa
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Priority claimed from ITMI960029 external-priority patent/IT1282950B1/it
Priority claimed from IT96MI002291 external-priority patent/IT1287130B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of AR005423A1 publication Critical patent/AR005423A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C08G77/50—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages
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Abstract

Estos derivados tienen la fórmula (I), en la cual R1 es hidrógeno, alquilo C1-6 estando opcionalmente sustituidos cada uno de los tres últimos grupos oR1 es un grupo A-B en el que A representa alquileno C1-10 y B representa arilo o heteroarilosust ituido o sin sustituir; R2 es hidrógeno, hidroxi o alcoxiC1-7, halógeno, nitro, NR10R11, SR10 en donde R10 y R11 tienen el mismo significado anteriormente descrito y, además, R10 es COR1; R3 es hidrógeno,alquilo C1-4, lineal oramificado, hid roxi, alcoxi C1-3, halógeno, o (CH2)mCOR en donde m y R tienen el mismo significado anteriormente descrito, SR10, nitro,NR10R11, NHCOR10, NHSO2R10, en donde R10 y R11 tienen el mismo significado anteriormente descrito; R4 y R5,que pueden ser i guales o diferentes, son cadauno independientemente hidrógeno, hidroxi, alcoxi C1-3, o fenilo, o pueden formar conjuntamente un grupo oxi (-O-); o R4 junto con R5 pueden formar ungrupo metilendioxi (-OCH2O-); R6 en un grupo(II) o un grupo heter oaromático de cinco o seis miembros que contienen hasta tres heteroátomos sustituido conR3, en el que R3 tiene el mismo significado anteriormente descrito, habiendo hasta tres grupos R3 en el anillo; o R6 es un grupoC(Z)R12, en el que Z esoxíg eno o azufre; o R6 es un grupo CH2WA, en el que W es oxígeno, azufre o NR14, y A es hidrógeno, alquilo lineal o ramificado o COR14, en donde R14se define anteriormente; o R6 es un grupo COCOR12, en el que R12 tiene elmismo significado anteriorme nte descrito; o R6 es un grupo NR13R14, en el que R13 yR14 tienen el mismo significado anteriormente descrito, o R13 puede ser un grupo (CH2)mCOR en el que m y R tienen los mismos significadosanteriormentedescritos; o R6 es un grupo R(Z)R12 en el Z y R12 tienen el mismo significado anteriormente descrito; o R16 es un grupo S(O)iR12 en el que i es 1,2 y R12
ARP970100077A 1996-01-10 1997-01-08 Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados. AR005423A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI960029 IT1282950B1 (it) 1996-01-10 1996-01-10 Derivati eterociclo-condensati di morfinoidi
IT96MI002291 IT1287130B1 (it) 1996-11-05 1996-11-05 Derivati eterociclo-condensati di morfinoidi

Publications (1)

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AR005423A1 true AR005423A1 (es) 1999-06-23

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ARP970100077A AR005423A1 (es) 1996-01-10 1997-01-08 Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados.

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US (1) US6365594B1 (es)
EP (1) EP0880526B1 (es)
JP (1) JP2000503019A (es)
KR (1) KR19990077125A (es)
CN (1) CN1090190C (es)
AR (1) AR005423A1 (es)
AT (1) ATE229958T1 (es)
AU (1) AU706370B2 (es)
BR (1) BR9707136A (es)
CA (1) CA2242609A1 (es)
CZ (1) CZ218298A3 (es)
DE (1) DE69717967T2 (es)
ES (1) ES2188888T3 (es)
HU (1) HUP9900974A3 (es)
IL (1) IL125226A0 (es)
NO (1) NO983169L (es)
NZ (1) NZ326331A (es)
PL (1) PL327943A1 (es)
TR (1) TR199801348T2 (es)
TW (1) TW357148B (es)
WO (1) WO1997025331A1 (es)

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ATE229958T1 (de) 2003-01-15
HUP9900974A2 (hu) 1999-08-30
CN1090190C (zh) 2002-09-04
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US6365594B1 (en) 2002-04-02
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TR199801348T2 (xx) 1998-10-21
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