HUP9900974A2 - Heterociklusos gyűrűkkel kondenzált morfinoid származékok eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Heterociklusos gyűrűkkel kondenzált morfinoid származékok eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9900974A2 HUP9900974A2 HU9900974A HUP9900974A HUP9900974A2 HU P9900974 A2 HUP9900974 A2 HU P9900974A2 HU 9900974 A HU9900974 A HU 9900974A HU P9900974 A HUP9900974 A HU P9900974A HU P9900974 A2 HUP9900974 A2 HU P9900974A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- pipe powder
- powder
- pipe
- hydroxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 14
- -1 cyclic alkyl Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 239000003402 opiate agonist Substances 0.000 abstract 1
- 239000003401 opiate antagonist Substances 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- C07F7/08—Compounds having one or more C—Si linkages
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány (I) általánős képletű, új mőrfinőid vegyületekre (I) - amelynek képletében R1 hidrőgénatőm, adőtt esetben szűbsztitűáltalkil-, ciklőalkil-, ciklőalkil-alkil-, alkenil-, aril-, aralkil-,fűril-alkil- vagy -(CH2)mCOR csőpőrt, ahől m értéke 0, 1, 2, 3, 4 vagy 5, és R alkil-, hidrőxi-, alkőxi-, alkenil-őxi-, alkil-aril-, -NR10R11csőpőrt; R1 -A-B általánős képletű csőpőrt, ahől A alkiléncsőpőrt, és B adőtt esetben szűbsztitűált aril-, heterőarilcsőpőrt; R2 hidrőgénatőm, hidrőxi-, alkőxicsőpőrt, halőgénatőm, nitrő-, -NR10R11 vagy -SR10 csőpőrt, R3 hidrőgén-, halőgénatőm, alkil-, nitrő-, hidrőxi-, alkőxi-, -(CH2)mCOR, -SR10, -NR10R11, -NHCOR10, -NHSO2R10 csőpőrt; R4 és R5 hidrőgénatőm, hidrőxi-, alkőxi-, fenőxicsőpőrt, vagy R4 és R5 együtt őxicsőpőrt; vagy R4 és R3 együtt metilén-diőxi-csőpőrt; R6 adőtt esetben szűbsztitűált heterőarőmás vagy fenilcsőpőrt; R6 -C(Z)R12 csőpőrt, ahől Z őxigén- vagy kénatőm, és R12 alkil-, hidrőxi-, alkőxi-, aralkil-őxi- vagy -NR13R14 csőpőrt;vagy R6 -CH2WA, -COCOR12, -NR13R14, P(Z)R12, -S(O)iR12 csőpőrt, ahől W őxigén-, kénatőm vagy >NR14 csőpőrt, és A hidrőgénatőm, alkil- vagy -COR14 csőpőrt, i értéke 1 vagy 2; R7 hidrőgén-, halőgénatőm, alkil-, alkenil-, halőgén-alkil-, -(CH2)mCOR csőpőrt, adőtt esetben szűbsztitűált heterőarőmás vagyfenilcsőpőrt; R8 hidrőgénatőm vagy alkilcsőpőrt; n értéke 0 vagy 1; ahől ha n értéke 0, akkőr X és Y őxigén-, kénatőm, metincsőpőrt, CR6 vagy CR7 vagy >NR9 csőpőrt,ahől R9 hidrőgénatőm, adőtt esetben szűbsztitűált alkil-, ciklőalkil-,ciklőalkil-alkil-, -NR10R11, alkenil-, aril-, aralkil- vagy -(CH2)mCORcsőpőrt; ha n értéke 1, akkőr X és Y mindegyikének jelentése nitrőgénatőm, vagy az egyik jelentésenitrőgénatőm és a másik metincsőpőrt - és sóikra vőnatkőzik. Atalálmány kiterjed a vegyületek előállítási eljárásaira,alkalmazásűkra és az azőkat tartalmazó gyógyszerkészítményekre. Atalálmány szerinti vegyületek szelektív L-őpiát receptőr agőnista ésantagőnista hatásúak. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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ITMI960029 IT1282950B1 (it) | 1996-01-10 | 1996-01-10 | Derivati eterociclo-condensati di morfinoidi |
IT96MI002291 IT1287130B1 (it) | 1996-11-05 | 1996-11-05 | Derivati eterociclo-condensati di morfinoidi |
Publications (2)
Publication Number | Publication Date |
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HUP9900974A2 true HUP9900974A2 (hu) | 1999-08-30 |
HUP9900974A3 HUP9900974A3 (en) | 2000-09-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HU9900974A HUP9900974A3 (en) | 1996-01-10 | 1997-01-08 | Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them |
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US (1) | US6365594B1 (hu) |
EP (1) | EP0880526B1 (hu) |
JP (1) | JP2000503019A (hu) |
KR (1) | KR19990077125A (hu) |
CN (1) | CN1090190C (hu) |
AR (1) | AR005423A1 (hu) |
AT (1) | ATE229958T1 (hu) |
AU (1) | AU706370B2 (hu) |
BR (1) | BR9707136A (hu) |
CA (1) | CA2242609A1 (hu) |
CZ (1) | CZ218298A3 (hu) |
DE (1) | DE69717967T2 (hu) |
ES (1) | ES2188888T3 (hu) |
HU (1) | HUP9900974A3 (hu) |
IL (1) | IL125226A0 (hu) |
NO (1) | NO983169L (hu) |
NZ (1) | NZ326331A (hu) |
PL (1) | PL327943A1 (hu) |
TR (1) | TR199801348T2 (hu) |
TW (1) | TW357148B (hu) |
WO (1) | WO1997025331A1 (hu) |
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EP1660088A4 (en) * | 2003-08-27 | 2009-04-29 | Southern Res Inst | PYRIDOMORPHINANES, PYRIDAZINOMORPHINANES AND USE THEREOF |
MX2007005389A (es) | 2004-11-05 | 2007-12-07 | Rensselaer Polytech Inst | 4-hidroxibenzomorfanos. |
CN1298720C (zh) * | 2005-03-18 | 2007-02-07 | 中国科学院上海有机化学研究所 | C环连接有五元杂环的青藤碱衍生物和合成方法 |
WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | 6,7-不飽和-7-カルバモイル置換モルヒナン誘導体 |
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EP2790702B1 (en) | 2011-12-15 | 2020-04-01 | Alkermes Pharma Ireland Limited | Compositions of buprenorphine and mu-opioid receptor antagonists |
EP2844661B1 (en) * | 2012-05-02 | 2019-01-09 | Southern Research Institute | Heterocycle-fused morphinans, use thereof and preparation thereof |
ES2621305T3 (es) | 2012-12-14 | 2017-07-03 | Purdue Pharma Lp | Morfinanos espirocíclicos y su uso |
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1997
- 1997-01-08 DE DE69717967T patent/DE69717967T2/de not_active Expired - Fee Related
- 1997-01-08 AR ARP970100077A patent/AR005423A1/es unknown
- 1997-01-08 TR TR1998/01348T patent/TR199801348T2/xx unknown
- 1997-01-08 AT AT97901009T patent/ATE229958T1/de not_active IP Right Cessation
- 1997-01-08 KR KR1019980705261A patent/KR19990077125A/ko not_active Application Discontinuation
- 1997-01-08 WO PCT/EP1997/000120 patent/WO1997025331A1/en not_active Application Discontinuation
- 1997-01-08 JP JP9524871A patent/JP2000503019A/ja not_active Withdrawn
- 1997-01-08 EP EP97901009A patent/EP0880526B1/en not_active Expired - Lifetime
- 1997-01-08 BR BR9707136-6A patent/BR9707136A/pt not_active IP Right Cessation
- 1997-01-08 PL PL97327943A patent/PL327943A1/xx unknown
- 1997-01-08 US US09/101,213 patent/US6365594B1/en not_active Expired - Fee Related
- 1997-01-08 ES ES97901009T patent/ES2188888T3/es not_active Expired - Lifetime
- 1997-01-08 CN CN97192879A patent/CN1090190C/zh not_active Expired - Fee Related
- 1997-01-08 CA CA002242609A patent/CA2242609A1/en not_active Abandoned
- 1997-01-08 HU HU9900974A patent/HUP9900974A3/hu unknown
- 1997-01-08 AU AU14410/97A patent/AU706370B2/en not_active Ceased
- 1997-01-08 CZ CZ982182A patent/CZ218298A3/cs unknown
- 1997-01-08 NZ NZ326331A patent/NZ326331A/xx unknown
- 1997-01-08 IL IL12522697A patent/IL125226A0/xx unknown
- 1997-01-10 TW TW086100197A patent/TW357148B/zh active
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- 1998-07-09 NO NO983169A patent/NO983169L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR19990077125A (ko) | 1999-10-25 |
NZ326331A (en) | 2000-01-28 |
JP2000503019A (ja) | 2000-03-14 |
HUP9900974A3 (en) | 2000-09-28 |
CA2242609A1 (en) | 1997-07-17 |
CZ218298A3 (cs) | 1999-08-11 |
PL327943A1 (en) | 1999-01-04 |
AR005423A1 (es) | 1999-06-23 |
IL125226A0 (en) | 1999-03-12 |
AU1441097A (en) | 1997-08-01 |
DE69717967D1 (de) | 2003-01-30 |
EP0880526A1 (en) | 1998-12-02 |
DE69717967T2 (de) | 2003-08-28 |
TW357148B (en) | 1999-05-01 |
US6365594B1 (en) | 2002-04-02 |
ATE229958T1 (de) | 2003-01-15 |
CN1213372A (zh) | 1999-04-07 |
CN1090190C (zh) | 2002-09-04 |
TR199801348T2 (xx) | 1998-10-21 |
ES2188888T3 (es) | 2003-07-01 |
BR9707136A (pt) | 1999-08-31 |
EP0880526B1 (en) | 2002-12-18 |
WO1997025331A1 (en) | 1997-07-17 |
AU706370B2 (en) | 1999-06-17 |
NO983169L (no) | 1998-09-09 |
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