JP2003531835A5 - - Google Patents
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- Publication number
- JP2003531835A5 JP2003531835A5 JP2001575615A JP2001575615A JP2003531835A5 JP 2003531835 A5 JP2003531835 A5 JP 2003531835A5 JP 2001575615 A JP2001575615 A JP 2001575615A JP 2001575615 A JP2001575615 A JP 2001575615A JP 2003531835 A5 JP2003531835 A5 JP 2003531835A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound according
- linker
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 21
- 125000000539 amino acid group Chemical group 0.000 description 16
- 235000001014 amino acid Nutrition 0.000 description 9
- 229940024606 amino acid Drugs 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 9
- 239000013522 chelant Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- -1 Amino Chemical group 0.000 description 5
- 239000004475 Arginine Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 4
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
- 239000002738 chelating agent Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- 235000003704 aspartic acid Nutrition 0.000 description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical group OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 125000000837 carbohydrate group Chemical group 0.000 description 2
- 238000002059 diagnostic imaging Methods 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Substances OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 125000001165 hydrophobic group Chemical group 0.000 description 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- UQTZMGFTRHFAAM-ZETCQYMHSA-N 3-iodo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(I)=C1 UQTZMGFTRHFAAM-ZETCQYMHSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- DTERQYGMUDWYAZ-ZETCQYMHSA-N N(6)-acetyl-L-lysine Chemical compound CC(=O)NCCCC[C@H]([NH3+])C([O-])=O DTERQYGMUDWYAZ-ZETCQYMHSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0009042.3 | 2000-04-12 | ||
| GB0009042A GB0009042D0 (en) | 2000-04-12 | 2000-04-12 | Contrast agents |
| GB0025070.4 | 2000-10-12 | ||
| GB0025070A GB0025070D0 (en) | 2000-10-12 | 2000-10-12 | Contrast agents |
| PCT/NO2001/000146 WO2001077145A2 (en) | 2000-04-12 | 2001-04-06 | Integrin binding peptide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003531835A JP2003531835A (ja) | 2003-10-28 |
| JP2003531835A5 true JP2003531835A5 (enExample) | 2011-08-04 |
| JP5043271B2 JP5043271B2 (ja) | 2012-10-10 |
Family
ID=26244091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001575615A Expired - Lifetime JP5043271B2 (ja) | 2000-04-12 | 2001-04-06 | ペプチドベースの化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7351790B2 (enExample) |
| EP (1) | EP1272507B1 (enExample) |
| JP (1) | JP5043271B2 (enExample) |
| KR (2) | KR100879702B1 (enExample) |
| CN (1) | CN1230441C (enExample) |
| AT (1) | ATE298763T1 (enExample) |
| AU (2) | AU5068301A (enExample) |
| CA (1) | CA2405469C (enExample) |
| DE (1) | DE60111733T2 (enExample) |
| DK (1) | DK1272507T3 (enExample) |
| ES (1) | ES2244607T3 (enExample) |
| HK (1) | HK1052711A1 (enExample) |
| NO (1) | NO331741B1 (enExample) |
| NZ (1) | NZ521735A (enExample) |
| PT (1) | PT1272507E (enExample) |
| WO (1) | WO2001077145A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
| ATE298763T1 (de) * | 2000-04-12 | 2005-07-15 | Amersham Health As | Integrinbindende peptidderivate |
| NO20004795D0 (no) * | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
| ES2719088T3 (es) | 2001-07-10 | 2019-07-08 | Ge Healthcare Ltd | Compuestos con base peptídica para localizar receptores de integrina |
| CA2481231A1 (en) * | 2002-04-05 | 2003-10-23 | University Of Utah Research Foundation | Colon tumor specific binding peptides |
| US7138489B2 (en) * | 2002-04-11 | 2006-11-21 | Daiichi Asubio Pharma Co., Ltd. | Method for producing a modified peptide |
| GB0224799D0 (en) * | 2002-10-25 | 2002-12-04 | Amersham Plc | Improved complex compositions |
| NO20030115D0 (no) | 2003-01-09 | 2003-01-09 | Amersham Health As | Kontrastmiddel |
| NO20033115D0 (no) * | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
| GB0317815D0 (en) | 2003-07-30 | 2003-09-03 | Amersham Health As | Imaging agents |
| EP1729823B1 (en) | 2004-03-04 | 2009-11-04 | GE Healthcare AS | Conjugates of angiotensin peptidic analogues and chelating agents for diagnosis and therapy |
| WO2005123768A1 (en) * | 2004-06-16 | 2005-12-29 | Ge Healthcare As | Peptide-based compounds |
| NZ551210A (en) * | 2004-06-16 | 2009-10-30 | Ge Healthcare As | Peptide-based compounds |
| AU2005265048B2 (en) * | 2004-06-18 | 2011-06-16 | Elamleh, David R. | Intravascular imaging device and uses thereof |
| BRPI0518328A2 (pt) | 2004-11-22 | 2008-11-11 | Ge Healthcare As | agente de contraste, composiÇço farmacÊutica, uso de um agente de contraste, mÉtodo para gerar imagens realÇadas de um corpo animal ou humano, e, kit para a preparaÇço de um composiÇço radiofarmacÊutica |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| WO2006073314A1 (en) * | 2005-01-06 | 2006-07-13 | Ge Healthcare As | Optical imaging |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| WO2008026040A2 (en) * | 2006-08-28 | 2008-03-06 | Ge Healthcare Limited | 68ga-labeled peptide-based radiopharmaceuticals |
| MX2009006028A (es) * | 2006-12-11 | 2009-06-17 | Ge Healthcare As | Compuestos basados en peptido radiomarcado y usos de los mismos. |
| US20090004119A1 (en) * | 2007-06-27 | 2009-01-01 | Ge Healthcare As | Polymers |
| DE102007036570A1 (de) * | 2007-08-03 | 2009-02-19 | Siemens Ag | Screeningtest zur Erkennung von Prostataerkrankungen sowie Vorrichtung und Diagnosesubstanz zur Durchführung des Tests |
| US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
| FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
| FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
| CN108699110B (zh) * | 2015-10-23 | 2023-04-28 | 特温特大学 | 整合素结合肽及其用途 |
| AU2018321825A1 (en) * | 2017-08-19 | 2020-03-05 | Ohio State Innovation Foundation | Novel peptide-based cancer imaging agents |
| WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
| CN113727991A (zh) * | 2019-05-14 | 2021-11-30 | 一丸自然美健有限公司 | Ras抑制肽 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3869251D1 (de) | 1987-07-16 | 1992-04-23 | Nycomed As | Aminopolycarbonsaeure und ihre derivate. |
| US5753627A (en) * | 1988-12-05 | 1998-05-19 | Novartis Ag | Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| IE901736L (en) | 1989-05-17 | 1990-11-17 | Fuller H B Licensing Financ | Polypeptide-antibody conjugate for inhibiting cell adhesion |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| UA43823C2 (uk) | 1992-07-06 | 2002-01-15 | Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН |
| US5981478A (en) * | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| CN1148812A (zh) | 1994-03-28 | 1997-04-30 | 尼科梅德成像有限公司 | “脂质体” |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| GB9420390D0 (en) | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
| DK0844874T3 (da) | 1995-08-14 | 2006-01-16 | Scripps Research Inst | Fremgangsmåder og sammensætninger egnet til inhibering af alfa v beta 5-medieret angiogenese |
| ES2299232T3 (es) | 1995-09-11 | 2008-05-16 | La Jolla Cancer Research Foundation | Moleculas que migran hacia un organo o tejido seleccionado in vivo. |
| PL327679A1 (en) | 1996-01-10 | 1998-12-21 | Nycomed Imaging As | Contast medium |
| AU709778B2 (en) | 1996-02-09 | 1999-09-09 | Steinel Gmbh & Co. Kg | Device for evaporating a liquid active substance |
| CA2265484C (en) | 1996-09-10 | 2008-12-02 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| CA2291323A1 (en) | 1997-05-28 | 1998-12-03 | Genvec, Inc. | Alternatively targeted adenovirus |
| GB9711115D0 (en) | 1997-05-29 | 1997-07-23 | Inst Of Child Health | Integrin-targeting vectors having enhanced transfection activity |
| JP2002507391A (ja) | 1998-02-06 | 2002-03-12 | ザ ユーエイビー リサーチ ファンデイション | 繊維ノブのｈｉループに異種ペプチドエピトープを含有するアデノウイルスベクター |
| AU2662999A (en) | 1998-02-09 | 1999-08-23 | Genzyme Corporation | Nucleic acid delivery vehicles |
| ATE298763T1 (de) * | 2000-04-12 | 2005-07-15 | Amersham Health As | Integrinbindende peptidderivate |
| NO20033115D0 (no) * | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
-
2001
- 2001-04-06 AT AT01924011T patent/ATE298763T1/de active
- 2001-04-06 ES ES01924011T patent/ES2244607T3/es not_active Expired - Lifetime
- 2001-04-06 EP EP01924011A patent/EP1272507B1/en not_active Expired - Lifetime
- 2001-04-06 DK DK01924011T patent/DK1272507T3/da active
- 2001-04-06 PT PT01924011T patent/PT1272507E/pt unknown
- 2001-04-06 JP JP2001575615A patent/JP5043271B2/ja not_active Expired - Lifetime
- 2001-04-06 AU AU5068301A patent/AU5068301A/xx active Pending
- 2001-04-06 HK HK03104595.8A patent/HK1052711A1/zh unknown
- 2001-04-06 CA CA2405469A patent/CA2405469C/en not_active Expired - Fee Related
- 2001-04-06 CN CNB018109411A patent/CN1230441C/zh not_active Expired - Lifetime
- 2001-04-06 DE DE60111733T patent/DE60111733T2/de not_active Expired - Lifetime
- 2001-04-06 AU AU2001250683A patent/AU2001250683B2/en not_active Ceased
- 2001-04-06 NZ NZ52173501A patent/NZ521735A/xx not_active IP Right Cessation
- 2001-04-06 KR KR1020087007515A patent/KR100879702B1/ko not_active Expired - Fee Related
- 2001-04-06 KR KR1020027013674A patent/KR100866666B1/ko not_active Expired - Fee Related
- 2001-04-06 WO PCT/NO2001/000146 patent/WO2001077145A2/en not_active Ceased
-
2002
- 2002-10-11 US US10/269,575 patent/US7351790B2/en not_active Expired - Lifetime
- 2002-10-14 NO NO20024932A patent/NO331741B1/no not_active IP Right Cessation
-
2008
- 2008-03-24 US US12/053,829 patent/US8404802B2/en not_active Expired - Fee Related
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