JP2008504237A5 - - Google Patents
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- Publication number
- JP2008504237A5 JP2008504237A5 JP2007516412A JP2007516412A JP2008504237A5 JP 2008504237 A5 JP2008504237 A5 JP 2008504237A5 JP 2007516412 A JP2007516412 A JP 2007516412A JP 2007516412 A JP2007516412 A JP 2007516412A JP 2008504237 A5 JP2008504237 A5 JP 2008504237A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound according
- compound
- group
- cyclized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000000975 dye Substances 0.000 claims 4
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- NMDDZEVVQDPECF-LURJTMIESA-N (2s)-2,7-diaminoheptanoic acid Chemical compound NCCCCC[C@H](N)C(O)=O NMDDZEVVQDPECF-LURJTMIESA-N 0.000 claims 1
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20042523 | 2004-06-16 | ||
| NO20042523 | 2004-06-16 | ||
| PCT/NO2005/000210 WO2005123768A1 (en) | 2004-06-16 | 2005-06-15 | Peptide-based compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008504237A JP2008504237A (ja) | 2008-02-14 |
| JP2008504237A5 true JP2008504237A5 (enExample) | 2008-07-31 |
| JP5280683B2 JP5280683B2 (ja) | 2013-09-04 |
Family
ID=34979156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516412A Expired - Fee Related JP5280683B2 (ja) | 2004-06-16 | 2005-06-15 | ペプチド系化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7897142B2 (enExample) |
| EP (1) | EP1765863B1 (enExample) |
| JP (1) | JP5280683B2 (enExample) |
| CN (2) | CN101001870A (enExample) |
| AT (1) | ATE538135T1 (enExample) |
| BR (1) | BRPI0512209A (enExample) |
| ES (1) | ES2376557T3 (enExample) |
| PL (1) | PL1765863T3 (enExample) |
| RU (1) | RU2393167C2 (enExample) |
| WO (1) | WO2005123768A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0210886B8 (pt) * | 2001-07-10 | 2021-05-25 | Amersham Health As | composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal |
| DE602005025911D1 (de) * | 2004-11-22 | 2011-02-24 | Ge Healthcare As | Kontrastmittel für eine extrazelluläre matrix |
| ITMI20050328A1 (it) | 2005-03-03 | 2006-09-04 | Univ Degli Studi Milano | Composti peptidomimetrici e preparazione di derivati biologicamente attivi |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| CN102026671B (zh) * | 2008-03-14 | 2014-09-03 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
| US20100291706A1 (en) * | 2009-05-15 | 2010-11-18 | Millipore Corporation | Dye conjugates and methods of use |
| ES2398042T3 (es) * | 2009-10-21 | 2013-03-13 | Cyanagen Srl | Kit y procedimiento para el marcaje de biomoléculas |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| CN103052690A (zh) | 2010-06-29 | 2013-04-17 | 通用电气医疗集团股份有限公司 | 染料组合物和染料合成 |
| CN104470546B (zh) * | 2012-07-20 | 2018-02-27 | 佳能株式会社 | 化合物和含有所述化合物的光声成像造影剂 |
| WO2014055253A1 (en) * | 2012-10-04 | 2014-04-10 | The General Hospital Corporation | Methods of synthesizing and using peg-like fluorochromes |
| WO2015059368A1 (fr) * | 2013-09-02 | 2015-04-30 | L'oreal | Procede de coloration des fibres keratiniques a partir de colorants cationiques styryles disulfures, et composition comprenant lesdits colorants |
| CN107022350A (zh) * | 2017-04-20 | 2017-08-08 | 深圳大学 | 一种荧光造影材料及其制备方法与应用 |
| CN107739528A (zh) * | 2017-09-30 | 2018-02-27 | 武汉工程大学 | 一种五肽改性菁染料化合物及其制备方法和应用 |
| IL287989B2 (en) | 2019-05-13 | 2025-07-01 | Bracco Imaging Spa | Modified cyanine dyes and their conjugates |
| JP7698318B2 (ja) * | 2020-03-30 | 2025-06-25 | 一丸ファルコス株式会社 | Ｖｉｐｒ２アンタゴニストペプチド |
| WO2022216450A1 (en) | 2021-04-07 | 2022-10-13 | Becton, Dickinson And Company | Water-soluble fluorescent polymeric dyes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| DE19917713A1 (de) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik |
| CA2405469C (en) * | 2000-04-12 | 2012-03-20 | Amersham Health As | Integrin binding peptide derivatives |
| BRPI0210886B8 (pt) * | 2001-07-10 | 2021-05-25 | Amersham Health As | composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal |
| NO20033115D0 (no) * | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
-
2005
- 2005-06-15 RU RU2006144279/04A patent/RU2393167C2/ru not_active IP Right Cessation
- 2005-06-15 AT AT05752383T patent/ATE538135T1/de active
- 2005-06-15 JP JP2007516412A patent/JP5280683B2/ja not_active Expired - Fee Related
- 2005-06-15 BR BRPI0512209-0A patent/BRPI0512209A/pt not_active IP Right Cessation
- 2005-06-15 US US11/570,156 patent/US7897142B2/en not_active Expired - Fee Related
- 2005-06-15 EP EP05752383A patent/EP1765863B1/en not_active Expired - Lifetime
- 2005-06-15 CN CNA2005800273703A patent/CN101001870A/zh active Pending
- 2005-06-15 WO PCT/NO2005/000210 patent/WO2005123768A1/en not_active Ceased
- 2005-06-15 CN CNA2005800198740A patent/CN1968963A/zh active Pending
- 2005-06-15 PL PL05752383T patent/PL1765863T3/pl unknown
- 2005-06-15 ES ES05752383T patent/ES2376557T3/es not_active Expired - Lifetime
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