JP2008504237A5 - - Google Patents
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- Publication number
- JP2008504237A5 JP2008504237A5 JP2007516412A JP2007516412A JP2008504237A5 JP 2008504237 A5 JP2008504237 A5 JP 2008504237A5 JP 2007516412 A JP2007516412 A JP 2007516412A JP 2007516412 A JP2007516412 A JP 2007516412A JP 2008504237 A5 JP2008504237 A5 JP 2008504237A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound according
- compound
- group
- cyclized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000000975 dye Substances 0.000 claims 4
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- NMDDZEVVQDPECF-LURJTMIESA-N (2s)-2,7-diaminoheptanoic acid Chemical compound NCCCCC[C@H](N)C(O)=O NMDDZEVVQDPECF-LURJTMIESA-N 0.000 claims 1
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20042523 | 2004-06-16 | ||
| NO20042523 | 2004-06-16 | ||
| PCT/NO2005/000210 WO2005123768A1 (en) | 2004-06-16 | 2005-06-15 | Peptide-based compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008504237A JP2008504237A (ja) | 2008-02-14 |
| JP2008504237A5 true JP2008504237A5 (enExample) | 2008-07-31 |
| JP5280683B2 JP5280683B2 (ja) | 2013-09-04 |
Family
ID=34979156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516412A Expired - Fee Related JP5280683B2 (ja) | 2004-06-16 | 2005-06-15 | ペプチド系化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7897142B2 (enExample) |
| EP (1) | EP1765863B1 (enExample) |
| JP (1) | JP5280683B2 (enExample) |
| CN (2) | CN1968963A (enExample) |
| AT (1) | ATE538135T1 (enExample) |
| BR (1) | BRPI0512209A (enExample) |
| ES (1) | ES2376557T3 (enExample) |
| PL (1) | PL1765863T3 (enExample) |
| RU (1) | RU2393167C2 (enExample) |
| WO (1) | WO2005123768A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2719088T3 (es) * | 2001-07-10 | 2019-07-08 | Ge Healthcare Ltd | Compuestos con base peptídica para localizar receptores de integrina |
| BRPI0518328A2 (pt) * | 2004-11-22 | 2008-11-11 | Ge Healthcare As | agente de contraste, composiÇço farmacÊutica, uso de um agente de contraste, mÉtodo para gerar imagens realÇadas de um corpo animal ou humano, e, kit para a preparaÇço de um composiÇço radiofarmacÊutica |
| ITMI20050328A1 (it) | 2005-03-03 | 2006-09-04 | Univ Degli Studi Milano | Composti peptidomimetrici e preparazione di derivati biologicamente attivi |
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| EP3673922A1 (en) | 2008-03-14 | 2020-07-01 | VisEn Medical, Inc. | Integrin targeting agents and methods of using same |
| US20100291706A1 (en) * | 2009-05-15 | 2010-11-18 | Millipore Corporation | Dye conjugates and methods of use |
| EP2314597B1 (en) * | 2009-10-21 | 2012-11-28 | Cyanagen Srl | Kit and method for the labelling of biomolecules |
| CN103052690A (zh) | 2010-06-29 | 2013-04-17 | 通用电气医疗集团股份有限公司 | 染料组合物和染料合成 |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| US9592307B2 (en) | 2012-07-20 | 2017-03-14 | Canon Kabushiki Kaisha | Compound and photoacoustic imaging contrast medium containing the compound |
| WO2014055253A1 (en) * | 2012-10-04 | 2014-04-10 | The General Hospital Corporation | Methods of synthesizing and using peg-like fluorochromes |
| WO2015059368A1 (fr) * | 2013-09-02 | 2015-04-30 | L'oreal | Procede de coloration des fibres keratiniques a partir de colorants cationiques styryles disulfures, et composition comprenant lesdits colorants |
| CN107022350A (zh) * | 2017-04-20 | 2017-08-08 | 深圳大学 | 一种荧光造影材料及其制备方法与应用 |
| CN107739528A (zh) * | 2017-09-30 | 2018-02-27 | 武汉工程大学 | 一种五肽改性菁染料化合物及其制备方法和应用 |
| IL287989B2 (en) | 2019-05-13 | 2025-07-01 | Bracco Imaging Spa | Modified cyanine dyes and their conjugates |
| EP4137502A4 (en) * | 2020-03-30 | 2024-02-28 | Ichimaru Pharcos Co., Ltd. | Vipr2 antagonist peptide |
| EP4267971A4 (en) | 2021-04-07 | 2024-08-07 | Becton, Dickinson and Company | Water-soluble fluorescent polymeric dyes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| DE19917713A1 (de) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik |
| ATE298763T1 (de) * | 2000-04-12 | 2005-07-15 | Amersham Health As | Integrinbindende peptidderivate |
| ES2719088T3 (es) * | 2001-07-10 | 2019-07-08 | Ge Healthcare Ltd | Compuestos con base peptídica para localizar receptores de integrina |
| NO20033115D0 (no) | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
-
2005
- 2005-06-15 WO PCT/NO2005/000210 patent/WO2005123768A1/en not_active Ceased
- 2005-06-15 EP EP05752383A patent/EP1765863B1/en not_active Expired - Lifetime
- 2005-06-15 AT AT05752383T patent/ATE538135T1/de active
- 2005-06-15 JP JP2007516412A patent/JP5280683B2/ja not_active Expired - Fee Related
- 2005-06-15 CN CNA2005800198740A patent/CN1968963A/zh active Pending
- 2005-06-15 PL PL05752383T patent/PL1765863T3/pl unknown
- 2005-06-15 CN CNA2005800273703A patent/CN101001870A/zh active Pending
- 2005-06-15 RU RU2006144279/04A patent/RU2393167C2/ru not_active IP Right Cessation
- 2005-06-15 BR BRPI0512209-0A patent/BRPI0512209A/pt not_active IP Right Cessation
- 2005-06-15 ES ES05752383T patent/ES2376557T3/es not_active Expired - Lifetime
- 2005-06-15 US US11/570,156 patent/US7897142B2/en not_active Expired - Fee Related
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