JP2012529433A5 - - Google Patents
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- Publication number
- JP2012529433A5 JP2012529433A5 JP2012514221A JP2012514221A JP2012529433A5 JP 2012529433 A5 JP2012529433 A5 JP 2012529433A5 JP 2012514221 A JP2012514221 A JP 2012514221A JP 2012514221 A JP2012514221 A JP 2012514221A JP 2012529433 A5 JP2012529433 A5 JP 2012529433A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- alkyl
- aryl
- cyclic peptide
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 102000001189 Cyclic Peptides Human genes 0.000 claims description 17
- 108010069514 Cyclic Peptides Proteins 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- -1 —O-alkyl Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 7
- 125000001424 substituent group Chemical group 0.000 claims description 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 229940124530 sulfonamide Drugs 0.000 claims description 4
- 150000003456 sulfonamides Chemical class 0.000 claims description 4
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical group NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 4
- 150000001336 alkenes Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003141 primary amines Chemical group 0.000 claims 3
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 2
- 102000004378 Melanocortin Receptors Human genes 0.000 claims 2
- 108090000950 Melanocortin Receptors Proteins 0.000 claims 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Chemical group CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Chemical group CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 2
- 150000003335 secondary amines Chemical class 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 150000003951 lactams Chemical class 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- MHHDMDLNVVCTAJ-UHFFFAOYSA-N Ic1ncc[nH]1 Chemical compound Ic1ncc[nH]1 MHHDMDLNVVCTAJ-UHFFFAOYSA-N 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N c1ccccc1 Chemical compound c1ccccc1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18492909P | 2009-06-08 | 2009-06-08 | |
| US61/184,929 | 2009-06-08 | ||
| PCT/US2010/037589 WO2010144344A2 (en) | 2009-06-08 | 2010-06-07 | Melanocortin receptor-specific peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529433A JP2012529433A (ja) | 2012-11-22 |
| JP2012529433A5 true JP2012529433A5 (enExample) | 2013-07-25 |
| JP5805632B2 JP5805632B2 (ja) | 2015-11-04 |
Family
ID=43309425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514221A Active JP5805632B2 (ja) | 2009-06-08 | 2010-06-07 | メラノコルチン受容体に特異的なペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8846601B2 (enExample) |
| EP (1) | EP2440227B1 (enExample) |
| JP (1) | JP5805632B2 (enExample) |
| KR (1) | KR101726893B1 (enExample) |
| CN (2) | CN105037502A (enExample) |
| AU (1) | AU2010259008C1 (enExample) |
| BR (1) | BRPI1009644B1 (enExample) |
| CA (1) | CA2761607C (enExample) |
| EA (1) | EA020959B1 (enExample) |
| IL (1) | IL216843A (enExample) |
| MX (1) | MX2011013117A (enExample) |
| NZ (1) | NZ596617A (enExample) |
| WO (1) | WO2010144344A2 (enExample) |
| ZA (1) | ZA201200112B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
| EA020959B1 (ru) | 2009-06-08 | 2015-03-31 | Палатин Текнолоджиз, Инк. | Пептиды, специфичные к меланокортиновым рецепторам |
| EA021897B1 (ru) * | 2009-11-23 | 2015-09-30 | Палатин Текнолоджиз, Инк. | Циклические пептиды, специфичные к рецептору меланокортина-1 |
| WO2012100342A1 (en) | 2011-01-27 | 2012-08-02 | Université de Montréal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
| CA3301962A1 (en) | 2011-12-29 | 2026-03-02 | Rhythm Pharmaceuticals, Inc. | Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers |
| WO2013116682A1 (en) * | 2012-02-02 | 2013-08-08 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
| US10196425B2 (en) * | 2013-03-15 | 2019-02-05 | Rhythm Pharmaceuticals, Inc. | Peptide compositions |
| PT2970389T (pt) * | 2013-03-15 | 2020-10-21 | Rhythm Pharmaceuticals Inc | Composições farmacêuticas |
| WO2015162287A1 (en) * | 2014-04-25 | 2015-10-29 | Phi Pharma Sa | Keratan sulfate specific transporter molecules |
| CN104436159A (zh) * | 2014-12-09 | 2015-03-25 | 天津医科大学眼科医院 | 一种新型滴眼液对治疗干眼的用途 |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| PT3356386T (pt) | 2015-09-30 | 2024-05-17 | Rhythm Pharmaceuticals Inc | Método de tratamento de distúrbios associados à via do receptor da melanocortina-4 |
| US11174298B2 (en) * | 2016-11-09 | 2021-11-16 | James P. Tam | Preparation and use of ginsentides and ginsentide-like peptides |
| EP3768245A4 (en) * | 2018-03-23 | 2023-10-18 | Palatin Technologies, Inc. | MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDE FORMULATIONS AND METHODS FOR GASTROINTESTINAL TRACT-SPECIFIC ADMINISTRATION |
| AU2019249255A1 (en) | 2018-04-06 | 2020-11-05 | Alastair GARFIELD | Compositions for treating kidney disease |
| AU2021216999A1 (en) * | 2020-02-03 | 2022-08-25 | Boehringer Ingelheim International Gmbh | Diamine-linked receptor-specific cyclic peptides |
| AU2021217939A1 (en) * | 2020-02-03 | 2022-09-15 | Palatin Technologies, Inc. | Reverse amide-linked melanocortin receptor-specific cyclic peptides |
| CN114890958B (zh) * | 2022-02-23 | 2023-10-20 | 四川警察学院 | 双光子染料化合物、其制备方法及其应用 |
| CN115521356B (zh) * | 2022-08-17 | 2024-04-02 | 桂林医学院 | 一种具有美白功效的多肽及其应用 |
| CN119529031B (zh) * | 2024-11-27 | 2025-12-05 | 润辉生物技术（威海）有限公司 | 一种环肽衍生物及其制备方法与应用 |
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| AU7880991A (en) | 1990-05-10 | 1991-11-27 | Novo Nordisk A/S | A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols |
| US6100048A (en) | 1992-04-10 | 2000-08-08 | Oregon Health Sciences University | Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals |
| US5977070A (en) | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
| US5731408A (en) | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
| US6054556A (en) | 1995-04-10 | 2000-04-25 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Melanocortin receptor antagonists and agonists |
| US7396814B2 (en) | 1995-06-07 | 2008-07-08 | Palatin Technologies, Inc. | Metallopeptide compositions for treatment of sexual dysfunction |
| WO1998027113A2 (en) | 1996-12-17 | 1998-06-25 | Quadrant Holdings Cambridge Limited | Melanocortin derivatives for specific binding of melanocortin receptor 3, 4 or 5 |
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| CN101302246B (zh) * | 2007-05-09 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 黑色素皮质激素受体七肽类激动剂及其制备方法和用途 |
| EP2167112A4 (en) | 2007-06-15 | 2012-01-25 | Ipsen Pharma Sas | CYCLIC PEPTIDE MELANOCORTIN RECEPTOR LIGANDS |
| TR201815292T4 (tr) | 2007-11-05 | 2018-11-21 | Board Of Supervisors Of Louisiana State Univ And Agriculture And Mechanical College | İnsüli̇n duyarliliğinin tedavi̇si̇nde melanokorti̇nleri̇n kullanimi. |
| WO2009152079A1 (en) * | 2008-06-09 | 2009-12-17 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides for treatment of sexual dysfunction |
| EA020959B1 (ru) * | 2009-06-08 | 2015-03-31 | Палатин Текнолоджиз, Инк. | Пептиды, специфичные к меланокортиновым рецепторам |
| UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
-
2010
- 2010-06-07 EA EA201190338A patent/EA020959B1/ru not_active IP Right Cessation
- 2010-06-07 WO PCT/US2010/037589 patent/WO2010144344A2/en not_active Ceased
- 2010-06-07 MX MX2011013117A patent/MX2011013117A/es active IP Right Grant
- 2010-06-07 BR BRPI1009644-2A patent/BRPI1009644B1/pt not_active IP Right Cessation
- 2010-06-07 KR KR1020127000543A patent/KR101726893B1/ko active Active
- 2010-06-07 CN CN201510295826.XA patent/CN105037502A/zh active Pending
- 2010-06-07 JP JP2012514221A patent/JP5805632B2/ja active Active
- 2010-06-07 NZ NZ596617A patent/NZ596617A/en not_active IP Right Cessation
- 2010-06-07 CN CN201080024349.9A patent/CN102458436B/zh active Active
- 2010-06-07 CA CA2761607A patent/CA2761607C/en active Active
- 2010-06-07 EP EP10786619.6A patent/EP2440227B1/en active Active
- 2010-06-07 AU AU2010259008A patent/AU2010259008C1/en not_active Ceased
-
2011
- 2011-12-06 US US13/311,824 patent/US8846601B2/en active Active
- 2011-12-08 IL IL216843A patent/IL216843A/en active IP Right Grant
-
2012
- 2012-01-07 ZA ZA2012/00112A patent/ZA201200112B/en unknown
-
2014
- 2014-07-11 US US14/328,995 patent/US9458201B2/en active Active
-
2016
- 2016-07-20 US US15/214,845 patent/US10179804B2/en active Active
-
2019
- 2019-01-11 US US16/245,735 patent/US10632171B2/en active Active
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