CN1968963A - 基于肽的化合物 - Google Patents

基于肽的化合物 Download PDF

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Publication number
CN1968963A
CN1968963A CNA2005800198740A CN200580019874A CN1968963A CN 1968963 A CN1968963 A CN 1968963A CN A2005800198740 A CNA2005800198740 A CN A2005800198740A CN 200580019874 A CN200580019874 A CN 200580019874A CN 1968963 A CN1968963 A CN 1968963A
Authority
CN
China
Prior art keywords
desired compound
previous
expression
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800198740A
Other languages
English (en)
Chinese (zh)
Inventor
A·卡思伯森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN1968963A publication Critical patent/CN1968963A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2005800198740A 2004-06-16 2005-06-15 基于肽的化合物 Pending CN1968963A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20042523 2004-06-16
NO20042523 2004-06-16
NO20042704 2004-06-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011104134209A Division CN102532264A (zh) 2004-06-16 2005-06-15 基于肽的化合物

Publications (1)

Publication Number Publication Date
CN1968963A true CN1968963A (zh) 2007-05-23

Family

ID=34979156

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005800273703A Pending CN101001870A (zh) 2004-06-16 2005-06-15 基于肽的化合物
CNA2005800198740A Pending CN1968963A (zh) 2004-06-16 2005-06-15 基于肽的化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2005800273703A Pending CN101001870A (zh) 2004-06-16 2005-06-15 基于肽的化合物

Country Status (10)

Country Link
US (1) US7897142B2 (enExample)
EP (1) EP1765863B1 (enExample)
JP (1) JP5280683B2 (enExample)
CN (2) CN101001870A (enExample)
AT (1) ATE538135T1 (enExample)
BR (1) BRPI0512209A (enExample)
ES (1) ES2376557T3 (enExample)
PL (1) PL1765863T3 (enExample)
RU (1) RU2393167C2 (enExample)
WO (1) WO2005123768A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2347771A1 (en) * 2001-07-10 2011-07-27 Ge Healthcare As Peptide-based compounds for targeted imaging
US8182790B2 (en) * 2004-11-22 2012-05-22 Ge Healthcare As Contrast agents
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
GB0718967D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Peptide imaging agents
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
AU2009223235B2 (en) * 2008-03-14 2014-09-11 Merck Sharp & Dohme Corp. Integrin targeting agents and in-vivo and in-vitro imaging methods using the same
US20100291706A1 (en) * 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
EP2314597B1 (en) * 2009-10-21 2012-11-28 Cyanagen Srl Kit and method for the labelling of biomolecules
WO2012001063A1 (en) 2010-06-29 2012-01-05 Ge Healthcare As Dye compositions and dye syntheses
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
CN104470546B (zh) * 2012-07-20 2018-02-27 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
WO2015059368A1 (fr) * 2013-09-02 2015-04-30 L'oreal Procede de coloration des fibres keratiniques a partir de colorants cationiques styryles disulfures, et composition comprenant lesdits colorants
CN107022350A (zh) * 2017-04-20 2017-08-08 深圳大学 一种荧光造影材料及其制备方法与应用
CN107739528A (zh) * 2017-09-30 2018-02-27 武汉工程大学 一种五肽改性菁染料化合物及其制备方法和应用
IL287989B2 (en) 2019-05-13 2025-07-01 Bracco Imaging Spa Modified cyanine dyes and their conjugates
US20230174582A1 (en) * 2020-03-30 2023-06-08 Ichimaru Pharcos Co., Ltd Vipr2 antagonist peptide
CN116917738A (zh) 2021-04-07 2023-10-20 贝克顿·迪金森公司 水溶性荧光聚合物染料

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
PT1272507E (pt) 2000-04-12 2005-11-30 Amersham Health As Derivados de peptidos para ligacao a integrina
EP2347771A1 (en) * 2001-07-10 2011-07-27 Ge Healthcare As Peptide-based compounds for targeted imaging
NO20033115D0 (no) 2003-07-08 2003-07-08 Amersham Health As Peptid-baserte forbindelser

Also Published As

Publication number Publication date
EP1765863B1 (en) 2011-12-21
CN101001870A (zh) 2007-07-18
BRPI0512209A (pt) 2008-02-19
EP1765863A1 (en) 2007-03-28
ES2376557T3 (es) 2012-03-14
RU2393167C2 (ru) 2010-06-27
WO2005123768A1 (en) 2005-12-29
JP5280683B2 (ja) 2013-09-04
ATE538135T1 (de) 2012-01-15
US20080095715A1 (en) 2008-04-24
RU2006144279A (ru) 2008-07-27
US7897142B2 (en) 2011-03-01
PL1765863T3 (pl) 2012-05-31
JP2008504237A (ja) 2008-02-14

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