JP2008522981A5 - - Google Patents

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Publication number
JP2008522981A5
JP2008522981A5 JP2007544636A JP2007544636A JP2008522981A5 JP 2008522981 A5 JP2008522981 A5 JP 2008522981A5 JP 2007544636 A JP2007544636 A JP 2007544636A JP 2007544636 A JP2007544636 A JP 2007544636A JP 2008522981 A5 JP2008522981 A5 JP 2008522981A5
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JP
Japan
Prior art keywords
alkyl
pharmaceutical composition
hydrogen
aryl
aralkyl
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JP2007544636A
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English (en)
Japanese (ja)
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JP4990155B2 (ja
JP2008522981A (ja
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Priority claimed from PCT/US2005/044451 external-priority patent/WO2006063154A1/en
Publication of JP2008522981A publication Critical patent/JP2008522981A/ja
Publication of JP2008522981A5 publication Critical patent/JP2008522981A5/ja
Application granted granted Critical
Publication of JP4990155B2 publication Critical patent/JP4990155B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007544636A 2004-12-07 2005-12-07 プロテアソームを阻害するための組成物 Expired - Lifetime JP4990155B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63436604P 2004-12-07 2004-12-07
US60/634,366 2004-12-07
US65593005P 2005-02-23 2005-02-23
US60/655,930 2005-02-23
PCT/US2005/044451 WO2006063154A1 (en) 2004-12-07 2005-12-07 Composition for proteasome inhibition

Publications (3)

Publication Number Publication Date
JP2008522981A JP2008522981A (ja) 2008-07-03
JP2008522981A5 true JP2008522981A5 (enExample) 2008-10-02
JP4990155B2 JP4990155B2 (ja) 2012-08-01

Family

ID=36143200

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007544636A Expired - Lifetime JP4990155B2 (ja) 2004-12-07 2005-12-07 プロテアソームを阻害するための組成物

Country Status (17)

Country Link
US (1) US7737112B2 (enExample)
EP (3) EP2261236B1 (enExample)
JP (1) JP4990155B2 (enExample)
KR (1) KR101299821B1 (enExample)
CN (2) CN101180071A (enExample)
AT (1) ATE499109T1 (enExample)
AU (1) AU2005313975B2 (enExample)
CA (1) CA2589921C (enExample)
CY (1) CY1111489T1 (enExample)
DE (1) DE602005026556D1 (enExample)
DK (1) DK1819353T3 (enExample)
ES (2) ES2549763T3 (enExample)
HU (1) HUE027850T2 (enExample)
IL (1) IL183607A (enExample)
PL (3) PL2260835T3 (enExample)
PT (3) PT1819353E (enExample)
WO (1) WO2006063154A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5616569B2 (ja) 2004-04-15 2014-10-29 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 酵素阻害のための化合物
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
CN102875642A (zh) * 2004-05-10 2013-01-16 普罗特奥里克斯公司 用于酶抑制的化合物
US9034846B2 (en) * 2004-10-10 2015-05-19 Universite De Liege Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases
AU2006311584B2 (en) 2005-11-09 2012-03-08 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
CN101506224B (zh) 2006-06-19 2016-03-30 欧尼斯治疗公司 蛋白酶体抑制用的肽环氧酮
PT2207791T (pt) 2007-10-04 2016-07-12 Onyx Therapeutics Inc Inibidores da epoxi cetona protease de péptido cristalino e a síntese de ceto-epóxidos de aminoácidos
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
EP2344165A4 (en) * 2008-10-01 2012-12-05 Reddys Lab Ltd Dr PHARMACEUTICAL COMPOSITIONS COMPRISING BORONIC ACID COMPOUNDS
EP3090737A1 (en) * 2008-10-21 2016-11-09 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2238973A1 (en) 2009-04-07 2010-10-13 Cephalon France Lyophilized preparations of proteasome inhibitors
JP5914328B2 (ja) 2009-05-29 2016-05-11 サイデックス・ファーマシューティカルズ・インコーポレイテッド シクロデキストリン誘導体を含む注射用メルファラン組成物並びにその製造及び使用方法
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
WO2011060179A1 (en) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
WO2011109355A1 (en) 2010-03-01 2011-09-09 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
JP2013525282A (ja) 2010-04-07 2013-06-20 オニキス セラピューティクス， インク． 結晶質ペプチドエポキシケトンイムノプロテアソーム阻害剤
NZ627781A (en) 2012-01-23 2016-10-28 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
EP3702374B1 (en) 2012-02-15 2022-03-23 CyDex Pharmaceuticals, Inc. Manufacturing process for cyclodextrin derivatives
MX390762B (es) 2012-02-28 2025-03-19 Cydex Pharmaceuticals Inc Composiciones de ciclodextrina alquilada y procesos para preparar y utilizar las mismas
US20150038541A1 (en) * 2012-03-19 2015-02-05 Aposignal Bioscience Llc Composition and methods for cell modulation
CN103781490A (zh) * 2012-05-08 2014-05-07 欧尼斯治疗公司 用于配制肽蛋白酶体抑制剂的环糊精络合法
HRP20240724T1 (hr) * 2012-05-08 2024-08-30 Onyx Therapeutics, Inc. Postupci kompleksiranja ciklodekstrina za formuliranje peptidnih inhibitora proteasoma
TW201414751A (zh) 2012-07-09 2014-04-16 歐尼克斯治療公司 肽環氧酮蛋白酶抑制劑之前驅藥物
WO2014015016A1 (en) * 2012-07-18 2014-01-23 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
WO2014018807A1 (en) * 2012-07-26 2014-01-30 Centrax International, Inc. Peptide epoxyketone compounds
CN103570806B (zh) * 2012-07-26 2020-04-07 圣特莱国际公司 多肽环氧酮化合物
HK1211947A1 (en) * 2012-08-14 2016-06-03 Trillium Therapeutics Inc. Fluorinated epoxyketone-based compounds and uses thereof as proteasome inhibitors
US9636376B2 (en) * 2012-09-11 2017-05-02 Innopharma, Inc. Stable compositions of peptide epoxy ketones
HK1213585A1 (zh) 2012-10-22 2016-07-08 Cydex Pharmaceuticals, Inc. 烷基化环糊精组合物及其制备和使用方法
KR102206432B1 (ko) * 2012-11-30 2021-01-22 노파르티스 아게 신규 제약 조성물
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
MX373308B (es) 2013-03-13 2020-04-20 Sanofi Sa Composiciones que comprenden anticuerpos anti-cd38 y carfilzomib.
AR095426A1 (es) 2013-03-14 2015-10-14 Onyx Therapeutics Inc Inhibidores tripeptídicos de la epoxicetona proteasa
CN105164117B (zh) 2013-03-14 2019-02-01 欧尼斯治疗公司 二肽和三肽环氧酮蛋白酶抑制剂
MX372671B (es) 2013-07-19 2020-04-23 Onyx Therapeutics Inc Inhibidores de proteasoma de epoxicetona peptídica en combinacion con inhibidores de cinasa pim para el tratamiento de canceres.
CN105960399B (zh) * 2014-07-14 2018-09-25 宁波圣健生物医药科技有限公司 酶抑制剂环氧酮化合物
PT3183295T (pt) 2014-08-22 2023-11-03 Cydex Pharmaceuticals Inc Composições de ciclodextrina alquilada fracionada e processos para preparação e utilização das mesmas
WO2016170489A1 (en) 2015-04-24 2016-10-27 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of proteasome inhibitor
CN108697697A (zh) * 2015-11-17 2018-10-23 台北医学大学 治疗及/或预防纤维性疾病的胺基萘醌化合物
TWI759301B (zh) 2016-05-24 2022-04-01 美商安美基公司 聚乙二醇化卡非佐米化合物
EP3494108B1 (en) 2016-08-05 2020-10-28 Amgen Inc. Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
WO2018038687A1 (en) 2016-08-22 2018-03-01 Mustafa Nevzat Ilaç Sanayii A.Ş. Pharmaceutical formulations comprising a bortezomib-cyclodextrin complex
US10098890B2 (en) 2016-10-29 2018-10-16 Cipla Limited Stable carfilzomib formulations
WO2018138557A1 (en) 2017-01-24 2018-08-02 Orbicular Pharmaceutical Technologies Pvt. Ltd. Ready-to-use carfilzomib compositions
BR112020005079A2 (pt) 2017-09-14 2020-09-15 Glaxosmithkline Intellectual Property Development Limited tratamento de combinação para câncer
EP3710063A1 (en) 2017-11-16 2020-09-23 Amgen Inc. Stable compositions of pegylated carfilzomib compounds
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
JP2025516629A (ja) 2022-05-11 2025-05-30 セルジーン コーポレーション Ｔ細胞療法に関連する方法および使用、ならびにその生成
EP4611798A1 (en) 2022-11-02 2025-09-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
WO2025035020A2 (en) 2023-08-09 2025-02-13 Amgen Inc. Methods of using carfilzomib
WO2025092827A1 (zh) * 2023-10-30 2025-05-08 上海汇伦医药股份有限公司 一种环氧类化合物及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
US5441944A (en) * 1989-04-23 1995-08-15 The Trustees Of The University Of Pennsylvania Substituted cyclodextrin sulfates and their uses as growth modulating agents
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5340736A (en) 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
AU4499697A (en) 1996-09-13 1998-04-02 New York University Method for treating parasitic diseases with proteasome inhibitors
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
AU750207B2 (en) * 1997-06-13 2002-07-11 Cydex Pharmaceuticals, Inc. Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof
US6831099B1 (en) 1999-05-12 2004-12-14 Yale University Enzyme inhibition
AU784304B2 (en) * 1999-10-20 2006-03-09 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
EP1463719A2 (en) * 2002-01-08 2004-10-06 Eisai Co., Ltd Eponemycin and epoxomicin analogs and uses thereof
EP1496916A2 (en) * 2002-04-09 2005-01-19 Greenville Hospital System Metastasis modulating activity of highly sulfated oligosaccharides
US7232818B2 (en) * 2004-04-15 2007-06-19 Proteolix, Inc. Compounds for enzyme inhibition
JP5616569B2 (ja) 2004-04-15 2014-10-29 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 酵素阻害のための化合物
CN102875642A (zh) 2004-05-10 2013-01-16 普罗特奥里克斯公司 用于酶抑制的化合物

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