JPH09509419A - ペプチド−キレート化剤複合体 - Google Patents
ペプチド−キレート化剤複合体Info
- Publication number
- JPH09509419A JPH09509419A JP7522045A JP52204595A JPH09509419A JP H09509419 A JPH09509419 A JP H09509419A JP 7522045 A JP7522045 A JP 7522045A JP 52204595 A JP52204595 A JP 52204595A JP H09509419 A JPH09509419 A JP H09509419A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- chelating agent
- acm
- ser
- cys
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.炎症部位を造影するのに有用なペプチド−キレート化剤複合体であって、 配列Thr−X−Pro−Pro−Arg(ここで、Xは、アミノ酸残基又はそ のアナログである)を有するペプチドと結合させた金属キレート化剤を含む複合 体。 2.Xが、生理学的条件下で電荷されるか又は極性である基を組み入れた側鎖 を有するアミノ酸残基又はそのアナログである、請求項1記載のペプチド−キレ ート化剤複合体。 3.Xが、Lys、Gln、Arg、Asn、Glu、Asp、Tyr、Th r及びそれらのアナログから選択される、請求項2記載のペプチド−キレート化 剤複合体。 4.Xが、Lys、Gln、Arg、Asn及びそれらのアナログから選択さ れる、請求項3記載のペプチド−キレート化剤複合体。 5.Xが、Lysである、請求項4記載のペプチド−キレート化剤複合体。 6.Xが、Glnである、請求項4記載のペプチド−キレート化剤複合体。 7.金属キレート化剤及びペプチドが、結合基により結合されている、前記請 求項のいずれかに記載のペプチド−キレート化剤複合体。 8.結合基が、1つ又はそれ以上のアミノ酸残基である、請求項7記載のペプ チド−キレート化剤複合体。 9.結合基が、−Gly−、−Gly−Asp−Gly−、−βAla−及び −βAla−βAla−から選択される、請求項7記載のペプチド−キレート化 剤複合体。 10.金属キレート化剤が、ペプチドのN末端と結合している、前記請 求項のいずれかに記載のペプチド−キレート化剤複合体。 11.金属キレート化剤が、ペプチドのC末端と結合している、前記請求項の いずれかに記載のペプチド−キレート化剤複合体。 12.金属キレート化剤が、一般式: (式中、R1及びR2は、一緒になって、場合により5員又は6員環と縮合してい てもよい5員又は6員複素環を形成し(ここで、いずれかの環は、場合によりア ルキル、アルコキシ、カルボキシル、ハロゲン、ヒドロキシル及び結合基から選 択される基で置換されていてもよい); R3は、H;アルキル;ならびにアミノ、アミノアシル、カルボキシル、グア ニジニル、ヒドロキシル、チオール、フェニル、フェノールイル、インドリル及 びイミダゾリルから選択される基で置換されているアルキルから選択され; R4は、ヒドロキシル、アルコキシ及び結合基から選択され;そして Tは、H又は硫黄保護基を示す) で示される、前記請求項のいずれかに記載のペプチド−キレート化剤複合体。 13.ペプチドが、R4で金属キレート化剤と結合している、請求項12記載 のペプチド−キレート化剤複合体。 14.ペプチドが、R4で結合基により金属キレート化剤と結合している、請 求項12記載のペプチド−キレート化剤複合体。 15.結合基が、−Gly−及び−Gly−Asp−Gly−から選択される 、請求項14記載のペプチド−キレート化剤複合体。 16. Pic−Ser−Cys(Acm)−G−TKPPR; Pic−Ser−Cys(Acm)−GDG−TKPPR; Pic−Ser−Cys(Acm)−G−TQPPR; DMG−Ser−Cys(Acm)−G−TKPPR; DMG−Ser−Cys(Acm)−G−TQPPR; DMG−Ser−Cys(Acm)−βAla−TKPPR; DMG−Ser−Cys(Acm)−βAla−βAla−TKPPR;及び Bz−MA−Ser−Cys(Acm)−GDG−TKPPR から選択される、請求項1記載のペプチド−キレート化剤複合体。 17. Pic−Ser−Cys(Acm)−G−TKPPR;及び DMG−Ser−Cys(Acm)−G−TKPPR から選択される、請求項1記載のペプチド−キレート化剤複合体。 18. Pic−Ser−Cys(Acm)−G−TQPPR;及び DMG−Ser−Cys(Acm)−G−TQPPR から選択される、請求項1記載のペプチド−キレート化剤複合体。 19. 及び から選択される、請求項1記載のペプチド−キレート化剤複合体。 20.診断上有用な金属あるいはその酸化物又は窒化物と錯体を形成した形で ある、請求項1〜19のいずれかに記載のペプチド−キレート化剤複合体。 21.99mTcあるいはその酸化物又は窒化物と錯体を形成した形である、請 求項1〜19のいずれかに記載のペプチド−キレート化剤複合体。 22.請求項20記載のペプチド−キレート化剤複合体を含有する組成物の診 断的有効量を投与する工程を有する、哺乳類における炎症部位の造影法。 23.請求項21記載のペプチド−キレート化剤複合体を含有する組成物の診 断的有効量を投与する工程を有する、哺乳類における炎症部位の造影法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/202,178 US5569745A (en) | 1994-02-25 | 1994-02-25 | Peptide-Chelator conjugates |
US08/202,178 | 1994-02-25 | ||
PCT/CA1995/000106 WO1995022996A2 (en) | 1994-02-25 | 1995-02-24 | Peptide-chelator conjugates |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005257424A Division JP4171484B2 (ja) | 1994-02-25 | 2005-09-06 | ペプチド−キレート化剤複合体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09509419A true JPH09509419A (ja) | 1997-09-22 |
JP3795521B2 JP3795521B2 (ja) | 2006-07-12 |
Family
ID=22748796
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52204595A Expired - Fee Related JP3795521B2 (ja) | 1994-02-25 | 1995-02-24 | ペプチド−キレート化剤複合体 |
JP2005257424A Expired - Fee Related JP4171484B2 (ja) | 1994-02-25 | 2005-09-06 | ペプチド−キレート化剤複合体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005257424A Expired - Fee Related JP4171484B2 (ja) | 1994-02-25 | 2005-09-06 | ペプチド−キレート化剤複合体 |
Country Status (8)
Country | Link |
---|---|
US (3) | US5569745A (ja) |
EP (1) | EP0746340B1 (ja) |
JP (2) | JP3795521B2 (ja) |
AT (1) | ATE377432T1 (ja) |
AU (1) | AU1803395A (ja) |
CA (1) | CA2182670A1 (ja) |
DE (1) | DE69535638T2 (ja) |
WO (1) | WO1995022996A2 (ja) |
Families Citing this family (25)
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WO1995013832A1 (en) * | 1993-11-16 | 1995-05-26 | Resolution Pharmaceuticals Inc. | Immobilized labelling method |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
US6551610B2 (en) | 1995-04-13 | 2003-04-22 | Poly-Med, Inc. | Multifaceted compositions for post-surgical adhesion prevention |
US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
US6551574B2 (en) * | 1995-06-07 | 2003-04-22 | Rhomed Incorporated | Tuftsin metallopeptide analogs and uses thereof |
US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
US6017511A (en) * | 1997-05-30 | 2000-01-25 | Resolution Pharmaceuticals Inc. | Glycopeptide-chelator conjugates |
EP1007106A1 (en) * | 1997-08-21 | 2000-06-14 | Resolution Pharmaceuticals Inc. | Combinatorial library |
AU1865899A (en) * | 1997-12-24 | 1999-07-19 | Resolution Pharmaceuticals Inc. | Peptide chelators that predominately form a single stereoisomeric species upon coordination to a metal center |
US6334996B1 (en) * | 1997-12-24 | 2002-01-01 | Resolution Pharmaceuticals Inc. | Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center |
EP1068222A1 (en) | 1998-04-03 | 2001-01-17 | Du Pont Pharmaceuticals Company | Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer |
CA2273609A1 (en) * | 1999-06-04 | 2000-12-04 | Resolution Pharmaceuticals Inc. | Radiopharmaceuticals and methods for imaging |
WO2001006260A1 (en) * | 1999-07-19 | 2001-01-25 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
US7105310B1 (en) * | 2000-07-19 | 2006-09-12 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
US8263739B2 (en) * | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
US7109167B2 (en) | 2000-06-02 | 2006-09-19 | Bracco International B.V. | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
AU2005295194A1 (en) | 2004-10-19 | 2006-04-27 | Massachusetts Institute Of Technology | Virus scaffold for self-assembled, flexible and light lithium battery |
WO2009105671A2 (en) * | 2008-02-21 | 2009-08-27 | Burnham Institute For Medical Research | Methods and compositions related to peptides and proteins with c-terminal elements cross-reference to related applications |
EP2445536B1 (en) | 2009-06-22 | 2016-06-08 | Burnham Institute for Medical Research | Methods and compositions using peptides and proteins with c-terminal elements |
US20130144035A1 (en) * | 2010-04-21 | 2013-06-06 | Dongfeng Pan | Compositions and methods for leukocyte-targeting multi-valent imaging probes |
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-
1994
- 1994-02-25 US US08/202,178 patent/US5569745A/en not_active Expired - Lifetime
-
1995
- 1995-02-24 DE DE69535638T patent/DE69535638T2/de not_active Expired - Fee Related
- 1995-02-24 AT AT95909606T patent/ATE377432T1/de not_active IP Right Cessation
- 1995-02-24 EP EP95909606A patent/EP0746340B1/en not_active Expired - Lifetime
- 1995-02-24 CA CA002182670A patent/CA2182670A1/en not_active Abandoned
- 1995-02-24 WO PCT/CA1995/000106 patent/WO1995022996A2/en active IP Right Grant
- 1995-02-24 JP JP52204595A patent/JP3795521B2/ja not_active Expired - Fee Related
- 1995-02-24 AU AU18033/95A patent/AU1803395A/en not_active Abandoned
-
1996
- 1996-09-13 US US08/713,484 patent/US5679642A/en not_active Expired - Lifetime
-
1997
- 1997-10-21 US US08/955,263 patent/US5866544A/en not_active Expired - Fee Related
-
2005
- 2005-09-06 JP JP2005257424A patent/JP4171484B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1995022996A3 (en) | 1995-10-12 |
DE69535638T2 (de) | 2008-08-28 |
DE69535638D1 (de) | 2007-12-20 |
US5679642A (en) | 1997-10-21 |
US5569745A (en) | 1996-10-29 |
JP2006056895A (ja) | 2006-03-02 |
US5866544A (en) | 1999-02-02 |
CA2182670A1 (en) | 1995-08-31 |
AU1803395A (en) | 1995-09-11 |
EP0746340A1 (en) | 1996-12-11 |
WO1995022996A2 (en) | 1995-08-31 |
JP4171484B2 (ja) | 2008-10-22 |
JP3795521B2 (ja) | 2006-07-12 |
EP0746340B1 (en) | 2007-11-07 |
ATE377432T1 (de) | 2007-11-15 |
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