DE69535638D1 - Peptid-chelator konjugate - Google Patents

Peptid-chelator konjugate

Info

Publication number
DE69535638D1
DE69535638D1 DE69535638T DE69535638T DE69535638D1 DE 69535638 D1 DE69535638 D1 DE 69535638D1 DE 69535638 T DE69535638 T DE 69535638T DE 69535638 T DE69535638 T DE 69535638T DE 69535638 D1 DE69535638 D1 DE 69535638D1
Authority
DE
Germany
Prior art keywords
peptide
chelator conjugates
peptide chelator
metals
chelator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69535638T
Other languages
English (en)
Other versions
DE69535638T2 (de
Inventor
Anne Goodbody
Alfred Pollak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of DE69535638D1 publication Critical patent/DE69535638D1/de
Publication of DE69535638T2 publication Critical patent/DE69535638T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE69535638T 1994-02-25 1995-02-24 Peptid-chelator konjugate Expired - Fee Related DE69535638T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/202,178 US5569745A (en) 1994-02-25 1994-02-25 Peptide-Chelator conjugates
US202178 1994-02-25
PCT/CA1995/000106 WO1995022996A2 (en) 1994-02-25 1995-02-24 Peptide-chelator conjugates

Publications (2)

Publication Number Publication Date
DE69535638D1 true DE69535638D1 (de) 2007-12-20
DE69535638T2 DE69535638T2 (de) 2008-08-28

Family

ID=22748796

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535638T Expired - Fee Related DE69535638T2 (de) 1994-02-25 1995-02-24 Peptid-chelator konjugate

Country Status (8)

Country Link
US (3) US5569745A (de)
EP (1) EP0746340B1 (de)
JP (2) JP3795521B2 (de)
AT (1) ATE377432T1 (de)
AU (1) AU1803395A (de)
CA (1) CA2182670A1 (de)
DE (1) DE69535638T2 (de)
WO (1) WO1995022996A2 (de)

Families Citing this family (25)

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JP4293632B2 (ja) * 1993-11-16 2009-07-08 ブラッコ インターナショナル ベースローテン フェンノートシャップ 固定化標識方法
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US6551610B2 (en) 1995-04-13 2003-04-22 Poly-Med, Inc. Multifaceted compositions for post-surgical adhesion prevention
US5804158A (en) * 1995-05-31 1998-09-08 Resolution Pharmaceuticals Inc. Sequestered imaging agents
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6027711A (en) * 1995-06-07 2000-02-22 Rhomed Incorporated Structurally determined metallo-constructs and applications
US6551574B2 (en) * 1995-06-07 2003-04-22 Rhomed Incorporated Tuftsin metallopeptide analogs and uses thereof
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
US6017511A (en) * 1997-05-30 2000-01-25 Resolution Pharmaceuticals Inc. Glycopeptide-chelator conjugates
AU8849398A (en) * 1997-08-21 1999-03-16 Resolution Pharmaceuticals Inc. Combinatorial library
US6334996B1 (en) * 1997-12-24 2002-01-01 Resolution Pharmaceuticals Inc. Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center
AU1865899A (en) * 1997-12-24 1999-07-19 Resolution Pharmaceuticals Inc. Peptide chelators that predominately form a single stereoisomeric species upon coordination to a metal center
WO1999051628A1 (en) * 1998-04-03 1999-10-14 Du Pont Pharmaceuticals Company Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
CA2273609A1 (en) * 1999-06-04 2000-12-04 Resolution Pharmaceuticals Inc. Radiopharmaceuticals and methods for imaging
US7105310B1 (en) * 2000-07-19 2006-09-12 California Institute Of Technology Detection of biomolecules by sensitizer-linked substrates
WO2001006260A1 (en) * 1999-07-19 2001-01-25 California Institute Of Technology Detection of biomolecules by sensitizer-linked substrates
EP2279757A3 (de) 2000-06-02 2011-08-03 Bracco Suisse SA Arzneimitteln zum Targeting von Endothelzellen
US8263739B2 (en) * 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
EP1820229A4 (de) * 2004-10-19 2011-06-08 Massachusetts Inst Technology Virus-gerüst für eine selbstaufgebaute flexible und leichte lithiumbatterie
WO2009105671A2 (en) * 2008-02-21 2009-08-27 Burnham Institute For Medical Research Methods and compositions related to peptides and proteins with c-terminal elements cross-reference to related applications
JP5906184B2 (ja) 2009-06-22 2016-04-20 バーナム インスティテュート フォー メディカル リサーチ Ｃ末端エレメントを有するペプチドおよびタンパク質を使用する方法および組成物
WO2011133773A2 (en) * 2010-04-21 2011-10-27 Pan Dongfeng Compositions and methods for leukocyte-targeting multi-valent imaging probes

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IT8021120A0 (it) * 1979-04-02 1980-04-01 Inst Organicheskogo Sinteza Ak Analogo ciclico del peptide naturale stimolante la fagocitosi: treonile-ciclo (n-lisile-prolile-arginile).
US4390528A (en) * 1981-11-16 1983-06-28 Research Corporation Tuftsinyl-tuftsin
US4729848A (en) * 1983-09-30 1988-03-08 Chevron Research Company Metal salts of alkyl catechol dithiophosphoric acids and oil compositions containing the salts
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5187264A (en) * 1986-05-28 1993-02-16 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
IT1196500B (it) * 1986-07-16 1988-11-16 Eniricerche Spa Derivati dell'acido malonico e metodi per la loro sintesi
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
FR2616663B1 (fr) * 1987-06-16 1989-08-18 Adir Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
US5202451A (en) * 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
US5202109A (en) * 1988-06-10 1993-04-13 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
US5071965A (en) * 1988-07-19 1991-12-10 Mallinckrodt Medical, Inc. Novel tc-99m complexes
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1230712B (it) * 1989-02-10 1991-10-29 Sclavo Spa Composizione per vaccini
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5196515A (en) * 1989-03-17 1993-03-23 The Johns Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
US5248764A (en) * 1989-06-16 1993-09-28 Merck Frosst Canada, Inc. Chelate derivatives of atrial natriuretic factor (ANF)
US5028593A (en) * 1989-08-15 1991-07-02 Board Of Regents, The University Of Texas System Tuftsin analogs
JPH05503072A (ja) * 1989-08-28 1993-05-27 ザ・ゼネラル・ホスピタル・コーポレーション 診断用ｎｍｒ映像化の為のヒドロキシ―アリール金属キレート
IT1232311B (it) * 1989-09-04 1992-01-28 Sclavo Spa Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
US5175257A (en) * 1989-12-29 1992-12-29 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
EP0454302A3 (en) * 1990-03-30 1992-10-14 Banyu Pharmaceutical Co., Ltd. Tuftsin derivatives
US5112595A (en) * 1990-12-21 1992-05-12 Mallinckrodt Medical, Inc. 99MTC(III) myocardial imaging agents and method of use
US5112594A (en) * 1991-04-04 1992-05-12 Mallinckrodt Medical, Inc. Kit for preparing a technetium-99m myocardial imaging agent
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
ATE188387T1 (de) * 1991-02-08 2000-01-15 Diatide Inc Technetium-99m markierte polypeptide zur bildformung
AU2225192A (en) * 1991-05-01 1992-12-21 Curators Of The University Of Missouri, The Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical
WO1992019274A1 (en) * 1991-05-08 1992-11-12 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5330737A (en) * 1991-12-06 1994-07-19 Mallinckrodt Medical, Inc. Nitrogen-sulfur ligands as opiate receptor drug mimics
US5220000A (en) * 1992-01-23 1993-06-15 Spyros Theodoropulos Bifunctional-bis-quinolinols, and their metal chelates
JPH08504166A (ja) * 1992-02-05 1996-05-07 マリンクロッド・メディカル・インコーポレイテッド 放射標識ペプチド化合物
JPH07504902A (ja) * 1992-03-13 1995-06-01 ダイアタイド・インコーポレイテッド 炎症造影用のテクネチウム−９９ｍ標識ペプチド
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
GB9209641D0 (en) * 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
KR950701229A (ko) * 1992-05-07 1995-03-23 로이스 이. 밈스 착화제와 타게팅 면역시약
US5433816A (en) * 1993-01-15 1995-07-18 Eastman Kodak Company Ultrasonic apparatus for forming individual pillowed chips of light lock material
DE69408145T2 (de) * 1993-07-19 1998-09-03 Resolution Pharm Inc Hydrazine mit einer n3s konfiguration als radionukleide chelatoren
JP4293632B2 (ja) * 1993-11-16 2009-07-08 ブラッコ インターナショナル ベースローテン フェンノートシャップ 固定化標識方法
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5596745A (en) * 1994-05-16 1997-01-21 International Business Machines Corporation System and procedure for concurrent database access by multiple user applications through shared connection processes

Also Published As

Publication number Publication date
US5679642A (en) 1997-10-21
JPH09509419A (ja) 1997-09-22
WO1995022996A3 (en) 1995-10-12
CA2182670A1 (en) 1995-08-31
JP3795521B2 (ja) 2006-07-12
US5569745A (en) 1996-10-29
WO1995022996A2 (en) 1995-08-31
DE69535638T2 (de) 2008-08-28
AU1803395A (en) 1995-09-11
JP4171484B2 (ja) 2008-10-22
EP0746340B1 (de) 2007-11-07
ATE377432T1 (de) 2007-11-15
JP2006056895A (ja) 2006-03-02
US5866544A (en) 1999-02-02
EP0746340A1 (de) 1996-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee