ATE237366T1 - Radioaktiv-markierte annexine - Google Patents

Radioaktiv-markierte annexine

Info

Publication number
ATE237366T1
ATE237366T1 AT95913955T AT95913955T ATE237366T1 AT E237366 T1 ATE237366 T1 AT E237366T1 AT 95913955 T AT95913955 T AT 95913955T AT 95913955 T AT95913955 T AT 95913955T AT E237366 T1 ATE237366 T1 AT E237366T1
Authority
AT
Austria
Prior art keywords
radioactive labeled
annexins
labeled annexins
radioactive
radiolabeled annexins
Prior art date
Application number
AT95913955T
Other languages
English (en)
Inventor
Sudhakar Kasina
Timothy A Dewhurst
John M Reno
Jonathan Tait
John Stratton
Original Assignee
Neorx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neorx Corp filed Critical Neorx Corp
Application granted granted Critical
Publication of ATE237366T1 publication Critical patent/ATE237366T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Lubricants (AREA)
AT95913955T 1994-01-24 1995-01-23 Radioaktiv-markierte annexine ATE237366T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18566094A 1994-01-24 1994-01-24
PCT/US1995/000953 WO1995019791A1 (en) 1994-01-24 1995-01-23 Radiolabeled annexins

Publications (1)

Publication Number Publication Date
ATE237366T1 true ATE237366T1 (de) 2003-05-15

Family

ID=22681925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95913955T ATE237366T1 (de) 1994-01-24 1995-01-23 Radioaktiv-markierte annexine

Country Status (6)

Country Link
EP (1) EP0743861B1 (de)
JP (1) JP3664727B2 (de)
AT (1) ATE237366T1 (de)
CA (1) CA2180555C (de)
DE (1) DE69530375T2 (de)
WO (1) WO1995019791A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19505960A1 (de) 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
DE19536783A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle Nicotinamid-Chelatbildner vom Typ N¶2¶S¶2¶ für radioaktive Isotope
NZ508873A (en) 1998-07-13 2003-10-31 Univ Texas Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
ES2533255T3 (es) 1998-07-13 2015-04-08 Board Of Regents, The University Of Texas System Utilización de anticuerpos anti-aminofosfolípidos para el tratamiento del cáncer
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US6323313B1 (en) 1999-06-01 2001-11-27 The University Of Washington Annexin derivative with endogenous chelation sites
EP1381839A4 (de) * 2001-04-03 2005-10-12 Univ Leland Stanford Junior Verfahren zur bildlichen darstellung von zelltod in vivo
WO2012029855A1 (ja) * 2010-09-01 2012-03-08 国立大学法人京都大学 血液凝固調節物質のスクリーニング方法
EP3355907B1 (de) * 2015-10-02 2021-01-20 Silver Creek Pharmaceuticals, Inc. Bispezifische therapeutische proteine zur gewebereparatur

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
ES2045669T3 (es) * 1989-07-15 1994-01-16 Boehringer Ingelheim Int Procedimiento para la purificacion de anexinas.
DE3937607A1 (de) * 1989-11-11 1991-05-16 Boehringer Ingelheim Int Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
EP0509026B1 (de) * 1989-12-27 1998-03-18 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verwendung eines antikoagulant als diagnostikum
CA2086437A1 (en) * 1991-05-09 1992-11-10 Jonathan Tait Phospholipid-targeted thrombolytic agents
WO1995034315A1 (en) * 1994-06-16 1995-12-21 Neorx Corporation Radiolabeled annexin-galactose conjugates
WO1996017618A1 (en) * 1994-12-07 1996-06-13 Neorx Corporation Radiolabeled annexin-galactose cluster conjugates
US5886143A (en) * 1994-12-07 1999-03-23 Neorx Corporation Hepatic-directed compounds and reagents for preparation thereof

Also Published As

Publication number Publication date
EP0743861A4 (de) 1999-03-31
EP0743861A1 (de) 1996-11-27
DE69530375T2 (de) 2004-02-05
CA2180555A1 (en) 1995-07-27
CA2180555C (en) 2004-12-14
JPH09509050A (ja) 1997-09-16
DE69530375D1 (de) 2003-05-22
JP3664727B2 (ja) 2005-06-29
EP0743861B1 (de) 2003-04-16
WO1995019791A1 (en) 1995-07-27

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties