ATE237366T1 - Radioaktiv-markierte annexine - Google Patents

Radioaktiv-markierte annexine

Info

Publication number
ATE237366T1
ATE237366T1 AT95913955T AT95913955T ATE237366T1 AT E237366 T1 ATE237366 T1 AT E237366T1 AT 95913955 T AT95913955 T AT 95913955T AT 95913955 T AT95913955 T AT 95913955T AT E237366 T1 ATE237366 T1 AT E237366T1
Authority
AT
Austria
Prior art keywords
radioactive labeled
annexins
labeled annexins
radioactive
radiolabeled annexins
Prior art date
Application number
AT95913955T
Other languages
English (en)
Inventor
Sudhakar Kasina
Timothy A Dewhurst
John M Reno
Jonathan Tait
John Stratton
Original Assignee
Neorx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neorx Corp filed Critical Neorx Corp
Application granted granted Critical
Publication of ATE237366T1 publication Critical patent/ATE237366T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Lubricants (AREA)
AT95913955T 1994-01-24 1995-01-23 Radioaktiv-markierte annexine ATE237366T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18566094A 1994-01-24 1994-01-24
PCT/US1995/000953 WO1995019791A1 (en) 1994-01-24 1995-01-23 Radiolabeled annexins

Publications (1)

Publication Number Publication Date
ATE237366T1 true ATE237366T1 (de) 2003-05-15

Family

ID=22681925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95913955T ATE237366T1 (de) 1994-01-24 1995-01-23 Radioaktiv-markierte annexine

Country Status (6)

Country Link
EP (1) EP0743861B1 (de)
JP (1) JP3664727B2 (de)
AT (1) ATE237366T1 (de)
CA (1) CA2180555C (de)
DE (1) DE69530375T2 (de)
WO (1) WO1995019791A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19505960A1 (de) 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
DE19536783A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle Nicotinamid-Chelatbildner vom Typ N¶2¶S¶2¶ für radioaktive Isotope
BR9911882A (pt) 1998-07-13 2005-02-15 Univ Texas Processo de tratamento de câncer empregando anticorpos a aminofosfolipìdios
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
CA2331789C (en) 1998-07-13 2013-09-10 Board Of Regents, The University Of Texas System Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US6323313B1 (en) 1999-06-01 2001-11-27 The University Of Washington Annexin derivative with endogenous chelation sites
US6726895B2 (en) * 2001-04-03 2004-04-27 Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
JP5855003B2 (ja) * 2010-09-01 2016-02-09 国立大学法人京都大学 血液凝固調節物質のスクリーニング方法
US10040840B2 (en) * 2015-10-02 2018-08-07 Silver Creek Pharmaceuticals, Inc. Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to promote regeneration and survival of tissue

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
FI95136C (fi) * 1989-07-15 1995-12-27 Boehringer Ingelheim Int Menetelmä anneksiinien puhdistamiseksi
DE3937607A1 (de) * 1989-11-11 1991-05-16 Boehringer Ingelheim Int Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
DE4040817A1 (de) * 1989-12-27 1991-07-04 Boehringer Ingelheim Int Verwendung eines antikoagulant als diagnostikum
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
EP0538459A4 (en) * 1991-05-09 1993-06-16 The Board Of Regents Of The University Of Washington Phospholipid-targeted thrombolytic agents
EP0765166B1 (de) * 1994-06-16 2003-05-21 Neorx Corporation Radioaktivmarkierte annexin-galaktose konjugate
US5886143A (en) * 1994-12-07 1999-03-23 Neorx Corporation Hepatic-directed compounds and reagents for preparation thereof
WO1996017618A1 (en) * 1994-12-07 1996-06-13 Neorx Corporation Radiolabeled annexin-galactose cluster conjugates

Also Published As

Publication number Publication date
EP0743861A4 (de) 1999-03-31
WO1995019791A1 (en) 1995-07-27
CA2180555A1 (en) 1995-07-27
JPH09509050A (ja) 1997-09-16
CA2180555C (en) 2004-12-14
JP3664727B2 (ja) 2005-06-29
EP0743861A1 (de) 1996-11-27
DE69530375T2 (de) 2004-02-05
DE69530375D1 (de) 2003-05-22
EP0743861B1 (de) 2003-04-16

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties