JP2003528924A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003528924A5 JP2003528924A5 JP2001572124A JP2001572124A JP2003528924A5 JP 2003528924 A5 JP2003528924 A5 JP 2003528924A5 JP 2001572124 A JP2001572124 A JP 2001572124A JP 2001572124 A JP2001572124 A JP 2001572124A JP 2003528924 A5 JP2003528924 A5 JP 2003528924A5
- Authority
- JP
- Japan
- Prior art keywords
- folate
- fitc
- immunogen
- pharmaceutical composition
- mice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1(CC(*C(C2*=C(C*(c(cc3)ccc3C(*(C(*)CCC(*(CC*(C(*(c(cc3NC)ccc3C(c(ccc(*)c3)c3O3)=C(C=C4)C3=CC4=O)=C)N)=*)=C)O)=C)=*)=C)C=*C22)=O)*2=C)CC1 Chemical compound CC1(CC(*C(C2*=C(C*(c(cc3)ccc3C(*(C(*)CCC(*(CC*(C(*(c(cc3NC)ccc3C(c(ccc(*)c3)c3O3)=C(C=C4)C3=CC4=O)=C)N)=*)=C)O)=C)=*)=C)C=*C22)=O)*2=C)CC1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19394400P | 2000-03-31 | 2000-03-31 | |
| US60/193,944 | 2000-03-31 | ||
| US25584600P | 2000-12-15 | 2000-12-15 | |
| US60/255,846 | 2000-12-15 | ||
| PCT/US2001/010254 WO2001074382A1 (en) | 2000-03-31 | 2001-03-30 | Method of treatment using ligand-immunogen conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011225070A Division JP5632813B2 (ja) | 2000-03-31 | 2011-10-12 | リガンド免疫原複合体を用いる処置方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528924A JP2003528924A (ja) | 2003-09-30 |
| JP2003528924A5 true JP2003528924A5 (enExample) | 2008-05-15 |
| JP5059271B2 JP5059271B2 (ja) | 2012-10-24 |
Family
ID=26889531
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001572124A Expired - Fee Related JP5059271B2 (ja) | 2000-03-31 | 2001-03-30 | リガンド免疫原複合体を用いる処置方法 |
| JP2011225070A Expired - Lifetime JP5632813B2 (ja) | 2000-03-31 | 2011-10-12 | リガンド免疫原複合体を用いる処置方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011225070A Expired - Lifetime JP5632813B2 (ja) | 2000-03-31 | 2011-10-12 | リガンド免疫原複合体を用いる処置方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7033594B2 (enExample) |
| EP (1) | EP1267918A4 (enExample) |
| JP (2) | JP5059271B2 (enExample) |
| KR (1) | KR100863632B1 (enExample) |
| CN (2) | CN102805868A (enExample) |
| AU (2) | AU5697001A (enExample) |
| BR (1) | BR0109704A (enExample) |
| CA (1) | CA2405299C (enExample) |
| CZ (1) | CZ304942B6 (enExample) |
| DZ (1) | DZ3332A1 (enExample) |
| EA (1) | EA005823B1 (enExample) |
| HR (1) | HRP20020787B1 (enExample) |
| HU (1) | HUP0300421A2 (enExample) |
| IL (2) | IL151927A0 (enExample) |
| MX (1) | MXPA02009454A (enExample) |
| NO (1) | NO332160B1 (enExample) |
| NZ (1) | NZ521898A (enExample) |
| PL (1) | PL211872B1 (enExample) |
| SK (1) | SK288201B6 (enExample) |
| WO (1) | WO2001074382A1 (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192698B1 (en) | 1999-08-17 | 2007-03-20 | Purdue Research Foundation | EphA2 as a diagnostic target for metastatic cancer |
| US6927203B1 (en) * | 1999-08-17 | 2005-08-09 | Purdue Research Foundation | Treatment of metastatic disease |
| CA2328356A1 (en) * | 1999-12-22 | 2001-06-22 | Itty Atcravi | Recreational vehicles |
| US7645743B2 (en) * | 1999-12-22 | 2010-01-12 | Altermune, Llc | Chemically programmable immunity |
| EP1267918A4 (en) * | 2000-03-31 | 2007-06-27 | Purdue Research Foundation | METHOD OF TREATMENT USING LIGAND-IMMUNOGENE CONJUGATES |
| US7101976B1 (en) | 2000-09-12 | 2006-09-05 | Purdue Research Foundation | EphA2 monoclonal antibodies and methods of making and using same |
| ATE427948T1 (de) * | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| NZ529808A (en) | 2001-05-02 | 2007-02-23 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| JP2005523878A (ja) * | 2001-09-28 | 2005-08-11 | パーデュー・リサーチ・ファウンデーション | リガンド・免疫原物質複合体を用いた処置方法 |
| US20030129188A1 (en) * | 2001-10-22 | 2003-07-10 | The Scripps Research Institute | Integrin targeting compounds |
| US8043602B2 (en) * | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043603B2 (en) * | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| CA2482924A1 (en) * | 2002-04-19 | 2003-10-30 | Endocyte, Inc. | Adjuvant enhanced immunotherapy |
| EP1575509B1 (en) * | 2002-05-10 | 2011-10-26 | Purdue Research Foundation | Epha2 agonistic monoclonal antibodies and methods of use thereof |
| US20050152899A1 (en) * | 2002-05-10 | 2005-07-14 | Kinch Michael S. | EphA2 agonistic monoclonal antibodies and methods of use thereof |
| CA2485373A1 (en) * | 2002-05-10 | 2003-11-20 | Medimmune, Inc. | Epha2 monoclonal antibodies and methods of use thereof |
| EP1504010B1 (en) * | 2002-05-15 | 2009-03-25 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| AR042942A1 (es) | 2003-01-27 | 2005-07-06 | Endocyte Inc | Conjugados de administracion de drogas de union de receptores de vitaminas |
| WO2004069873A2 (en) | 2003-02-06 | 2004-08-19 | Tripep Ab | Antigen/antibody or ligand/receptor glycosylated specificity exchangers |
| AU2004229543A1 (en) * | 2003-04-11 | 2004-10-28 | Medimmune, Llc | EphA2 and non-neoplastic hyperproliferative cell disorders |
| CA2524441C (en) * | 2003-05-06 | 2012-03-20 | Purdue Research Foundation | Treatment of lupus targeting the macrophages or the folate receptor |
| CA2527196C (en) * | 2003-05-30 | 2012-10-16 | Purdue Research Foundation | Diagnostic method for atherosclerosis |
| CA2545679A1 (en) * | 2003-11-12 | 2005-05-26 | The University Of Georgia Research Foundation, Inc. | Biotin-facilitated transport in gram negative bacteria |
| US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
| KR100790646B1 (ko) * | 2004-07-03 | 2008-01-02 | 재단법인 목암생명공학연구소 | 세포매개 면역반응을 효과적으로 유도하는 ｈｃｖ수퍼타입 에피토프, 그를 코딩하는 올리고뉴클레오타이드및 그의 용도 |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| RU2007128036A (ru) * | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| JP5289935B2 (ja) * | 2005-03-16 | 2013-09-11 | エンドサイト，インコーポレイテッド | プテロイン酸およびその結合体の合成と精製 |
| WO2006105141A1 (en) | 2005-03-30 | 2006-10-05 | Purdue Research Foundation | Method for cancer prognosis using cellular folate vitamin receptor quantification |
| JP5175723B2 (ja) | 2005-07-05 | 2013-04-03 | パーデュー・リサーチ・ファウンデーション | 単球介在性疾患を治療するための組成物の調製 |
| BRPI0615354A2 (pt) * | 2005-08-19 | 2011-05-17 | Endocyte Inc | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
| JP2009504783A (ja) * | 2005-08-19 | 2009-02-05 | エンドサイト，インコーポレイテッド | ビンカアルカロイド、類似体および誘導体のリガンド結合体 |
| EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US8357671B2 (en) | 2005-11-10 | 2013-01-22 | James Paulson | High affinity Siglec ligands |
| WO2007092299A2 (en) * | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
| WO2007139815A2 (en) * | 2006-05-23 | 2007-12-06 | Purdue Research Foundation | Imaging and therapeutic method using progenitor cells |
| US8486412B2 (en) | 2006-06-01 | 2013-07-16 | Mayo Foundation For Medical Education And Research | Immunity to folate receptors |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| EP2109466B1 (en) | 2007-02-07 | 2014-11-12 | Purdue Research Foundation | Positron emission tomography imaging method |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| WO2008112873A2 (en) * | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| US8961926B2 (en) * | 2007-05-25 | 2015-02-24 | Purdue Research Foundation | Method of imaging localized infections |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| CA2696627C (en) | 2007-08-17 | 2016-09-27 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| BRPI0816094A2 (pt) | 2007-08-30 | 2015-03-03 | Daiichi Sankyo Co Ltd | Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo. |
| WO2009055562A1 (en) | 2007-10-25 | 2009-04-30 | Endocyte, Inc. | Tubulysins and processes for preparing |
| WO2009065002A1 (en) * | 2007-11-15 | 2009-05-22 | Endocyte, Inc. | Method of administering conjugates |
| US8852630B2 (en) | 2008-05-13 | 2014-10-07 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
| EP2291659B1 (en) | 2008-05-13 | 2015-09-16 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
| BRPI1011269A2 (pt) * | 2009-05-05 | 2016-09-27 | Altermune Technologies Llc | imunidade quimicamente programável |
| SG10201501342UA (en) | 2010-02-24 | 2015-04-29 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| WO2011146638A1 (en) | 2010-05-18 | 2011-11-24 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| SI2694106T1 (en) | 2011-04-01 | 2018-04-30 | Immunogen, Inc. | Methods for increasing the effectiveness of treatment with FOLR1 receptor cancer |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US9629918B2 (en) | 2012-02-29 | 2017-04-25 | Purdue Research Foundation | Folate receptor alpha binding ligands |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| US9200073B2 (en) | 2012-08-31 | 2015-12-01 | Immunogen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| HK1212618A1 (zh) | 2012-10-16 | 2016-06-17 | 恩多塞特公司 | 含有非天然氨基酸的藥物遞送綴合物以及其使用方法 |
| KR102354613B1 (ko) | 2012-11-15 | 2022-01-21 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US20170232119A1 (en) | 2013-03-15 | 2017-08-17 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| JP6192799B2 (ja) | 2013-03-15 | 2017-09-06 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 腫瘍の標的画像化に使用される化合物にコンジュゲートしているアミノ酸連結基の合成および組成物 |
| CA3222465A1 (en) | 2013-08-30 | 2015-03-05 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| HUE066137T2 (hu) | 2013-10-18 | 2024-07-28 | Novartis Ag | A prosztata-specifikus membrán antigén (PSMA) jelzett inhibitorai, alkalmazásuk képalkotásban és gyógyszerkészítmények prosztatarák kezelésére |
| JP6464166B2 (ja) | 2013-11-14 | 2019-02-06 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 陽電子放出断層撮影用の化合物 |
| GB201411150D0 (en) | 2014-06-23 | 2014-08-06 | Altermune Technologies Llc | Novel aptamers and therapeutic uses thereof |
| AU2015307316A1 (en) * | 2014-08-28 | 2017-03-09 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | CD94/NKG2A and/or CD94/NKG2B antibody, vaccine combinations |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN116440279A (zh) | 2015-09-17 | 2023-07-18 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| US20180067121A1 (en) * | 2016-09-06 | 2018-03-08 | Nanoco Technologies Ltd. | Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| JP6990522B2 (ja) * | 2017-04-11 | 2022-02-03 | シスメックス株式会社 | 免疫細胞の免疫刺激応答性を測定する方法、免疫細胞における免疫シナプスの形成能を判定する方法及び細胞分析装置 |
| CN108051581A (zh) * | 2017-12-18 | 2018-05-18 | 河北中医学院 | 非共价键连接法半抗原---载体免疫原的制备 |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| CA3097381A1 (en) | 2018-04-17 | 2019-10-24 | Endocyte, Inc. | Methods of treating cancer |
| CN120097930A (zh) | 2019-05-20 | 2025-06-06 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2816110A (en) * | 1956-11-23 | 1957-12-10 | Merck & Co Inc | Methods for the production of substituted pteridines |
| US4314988A (en) * | 1979-10-31 | 1982-02-09 | Baker Instruments Corp. | Folic acid derivatives and process for preparation |
| US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| US4659655A (en) * | 1981-11-25 | 1987-04-21 | Bio-Response, Inc. | Method for isolating product-producing cells |
| US5140104A (en) * | 1982-03-09 | 1992-08-18 | Cytogen Corporation | Amine derivatives of folic acid analogs |
| DE3369466D1 (en) * | 1982-05-12 | 1987-03-05 | Harvard College | Fused genes encoding hybrid proteins, cloning vectors containing them and the use thereof |
| NL8401226A (nl) | 1984-04-16 | 1985-11-18 | Univ Utrecht | Farmaceutisch produkt met anti-tumorwerking; gebruik van een farmaceutisch produkt of van farmaceutische samenstellingen in een anti-tumortherapie. |
| EP0180171B1 (en) | 1984-10-31 | 1992-04-08 | Massachusetts Institute Of Technology | Process for making a targeted cell susceptible to lysis by cytotoxic t lymphocytes |
| US5266333A (en) * | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US4681760A (en) * | 1985-04-17 | 1987-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of conferring immunotolerance to a specific antigen |
| CA1282069C (en) * | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
| US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| NZ217821A (en) | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
| US5117022A (en) * | 1985-10-18 | 1992-05-26 | The Board Of Regents, The University Of Texas System | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| JPS6479125A (en) | 1986-08-13 | 1989-03-24 | Takeda Chemical Industries Ltd | Antitumor agent |
| GB8626413D0 (en) | 1986-11-05 | 1986-12-03 | Gilliland L K | Antibodies |
| US5888512A (en) | 1987-01-30 | 1999-03-30 | Board Of Trustees Of The Leland Stanford Junior University | Lymphocyte activity regulation by HLA peptides |
| US4971792A (en) * | 1987-03-27 | 1990-11-20 | The Wistar Institute | Monoclonal antibodies against glycolipid antigens |
| US5583112A (en) | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4946945A (en) * | 1987-06-23 | 1990-08-07 | Allergy Immuno Technologies, Inc. | Immunotherapy agents for treatment of IgE mediated allergies |
| ES2054753T3 (es) | 1987-09-02 | 1994-08-16 | Ciba Geigy Ag | Conjugados de citoquinas con inmunoglobulinas. |
| DK8189A (da) | 1988-01-12 | 1989-07-13 | Bunge Australia | Antigen-antistof-konjugater, deres fremstilling og anvendelse |
| GB8803365D0 (en) | 1988-02-13 | 1988-03-16 | Ciba Geigy Ag | Antiviral combination |
| EP0334300A1 (en) | 1988-03-21 | 1989-09-27 | Neorx Corporation | The use of monoclonal antibodies and conjugates thereof as signals to direct sensitized effector cells to tumor sites |
| DE3825615A1 (de) | 1988-07-28 | 1990-02-01 | Behringwerke Ag | Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung |
| KR900005995A (ko) | 1988-10-31 | 1990-05-07 | 우메모또 요시마사 | 변형 인터류킨-2 및 그의 제조방법 |
| DE68926380T2 (de) | 1988-11-14 | 1996-09-12 | Kanegafuchi Chemical Ind | Sphärische Vinylchloridharzgranulate und Verfahren zu ihrer Herstellung |
| JPH02169521A (ja) | 1988-12-22 | 1990-06-29 | Ajinomoto Co Inc | 自己免疫疾患治療剤 |
| DE69023900T4 (de) | 1989-02-24 | 1996-10-02 | The Regents Of The University Of California, Berkeley, Calif. | Gentechnologisch veränderte immunglobuline. |
| US5075287A (en) | 1989-03-03 | 1991-12-24 | Nisshin Oil Mills, Inc. | Muramyl peptide derivatives and immunoregulating compositions containing them |
| GB8907310D0 (en) | 1989-03-31 | 1989-05-17 | Medical Res Council | Heteroconjugates |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5217881A (en) * | 1989-04-25 | 1993-06-08 | Immunex Corporation | Hyperglycosylated cytokine conjugates |
| CA2035868A1 (en) | 1989-07-06 | 1991-01-07 | Richard C. Svrluga | Hybrid molecules |
| EP0482068A1 (en) | 1989-07-14 | 1992-04-29 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| JP2807831B2 (ja) | 1989-07-18 | 1998-10-08 | 国際試薬株式会社 | 免疫学的測定法 |
| JPH0686375B2 (ja) | 1989-09-25 | 1994-11-02 | 大塚製薬株式会社 | リポソーム製剤 |
| AU634314B2 (en) | 1989-11-13 | 1993-02-18 | Green Cross Corporation, The | Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen |
| ES2171392T3 (es) | 1990-08-29 | 2002-09-16 | Ct Hospitalier Regional De Nan | Poliligandos de proteina unidos a un nucleo de proteina estable. |
| JP3105629B2 (ja) | 1991-04-23 | 2000-11-06 | サングスタット メディカル コーポレイション | 特異的結合ペアのメンバーの細胞活性調節接合体 |
| IT1244983B (it) | 1991-04-29 | 1994-09-13 | Raggio Italgene Spa | Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione. |
| JP3173814B2 (ja) | 1991-05-30 | 2001-06-04 | 株式会社タムラ製作所 | フラックス塗布方法 |
| US6335434B1 (en) * | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US5159079A (en) * | 1991-12-20 | 1992-10-27 | Eli Lilly And Company | 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids |
| US5650398A (en) | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
| US5273965A (en) | 1992-07-02 | 1993-12-28 | Cambridge Biotech Corporation | Methods for enhancing drug delivery with modified saponins |
| ATE146075T1 (de) | 1992-10-01 | 1996-12-15 | Wellcome Found | Tucaresol als mittel zur immunopotentierung |
| DE4238416A1 (de) | 1992-11-13 | 1994-05-19 | Max Planck Gesellschaft | Bestimmung von Peptidmotiven auf MHC-Molekülen |
| US5747024A (en) | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| EP0689449B1 (fr) | 1993-03-19 | 2002-10-30 | Vacsyn S.A. | Compositions pour l'application en therapeutique humaine, caracterisees par l'association d'un muramyl-peptide a une cytokine |
| US5482698A (en) | 1993-04-22 | 1996-01-09 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin polymer conjugates |
| EP0708637B1 (en) | 1993-07-14 | 2004-01-28 | The Regents of the University of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| US5834441A (en) | 1993-09-13 | 1998-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Adeno-associated viral (AAV) liposomes and methods related thereto |
| CN1044781C (zh) * | 1994-02-05 | 1999-08-25 | 丹东市生物制品免疫技术应用研究中心 | 复方免疫抗生素 |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| JP2660661B2 (ja) | 1994-05-11 | 1997-10-08 | 株式会社バイオセンサー研究所 | 遺伝子の定量方法 |
| AU2705795A (en) | 1994-06-16 | 1996-01-05 | Board Of Trustees Of The Leland Stanford Junior University | Immune modulation with class ii alpha-chain fragments |
| US5547668A (en) * | 1995-05-05 | 1996-08-20 | The Board Of Trustees Of The University Of Illinois | Conjugates of folate anti-effector cell antibodies |
| US5753625A (en) | 1995-05-12 | 1998-05-19 | Sangstat Medical Corporation | Treatment for inhibiting the progression of autoimmune disease |
| US5602171A (en) * | 1995-06-07 | 1997-02-11 | Sugen Inc. | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof |
| WO1997024140A1 (en) | 1996-01-02 | 1997-07-10 | The Board Of Trustees Of Leland Stanford Junior University | Interaction of hla proteins with members of the hsp70 family of proteins |
| US6509313B1 (en) * | 1996-02-28 | 2003-01-21 | Cornell Research Foundation, Inc. | Stimulation of immune response with low doses of cytokines |
| AU2610097A (en) * | 1996-04-10 | 1997-10-29 | Sangstat Medical Corporation | Cytomodulating conjugates of members of specific binding pairs |
| US6231859B1 (en) | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| DE69828507T2 (de) * | 1997-05-20 | 2006-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene-saponin analoga mit adjuvans und immunostimulierender wirkung |
| US5891432A (en) * | 1997-07-29 | 1999-04-06 | The Immune Response Corporation | Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same |
| US6291673B1 (en) | 1997-10-17 | 2001-09-18 | Purdue Research Foundation | Folic acid derivatives |
| DE19746173A1 (de) * | 1997-10-18 | 1999-04-22 | Boehringer Ingelheim Int | Tumorvakzine |
| AU5565599A (en) * | 1998-08-14 | 2000-03-06 | Dante J. Marciani | Chemically modified saponins and the use thereof as adjuvants |
| CA2340692A1 (en) * | 1998-08-19 | 2000-03-02 | North American Vaccine, Inc. | Immunogenic .beta.-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide |
| WO2001032207A1 (en) * | 1998-10-30 | 2001-05-10 | United States Army Medical Research And Materiel Command | Methods for conferring active/passive immunotherapy |
| AUPQ071299A0 (en) | 1999-06-02 | 1999-06-24 | Access Pharmaceuticals Australia Pty Limited | Vitamin directed dual targeting therapy |
| JP2003516930A (ja) | 1999-08-17 | 2003-05-20 | パーデュー・リサーチ・ファウンデーション | 転移性疾患の治療 |
| ES2357296T3 (es) | 1999-08-17 | 2011-04-25 | Purdue Research Foundation | Anticuerpos dirigidos contra epha2 como un diagnóstico de cáncer. |
| AU7123500A (en) | 1999-09-08 | 2001-07-09 | Sloan-Kettering Institute For Cancer Research | Polysialic acid-klh conjugate vaccine |
| UA77152C2 (en) | 1999-09-25 | 2006-11-15 | Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma | |
| JP2003510290A (ja) | 1999-09-27 | 2003-03-18 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫刺激核酸誘導インターフェロンに関する方法 |
| US20020039583A1 (en) * | 1999-09-30 | 2002-04-04 | Subjeck John R. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| WO2001051083A2 (en) | 2000-01-13 | 2001-07-19 | Antigenics Inc. | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
| EP1267918A4 (en) | 2000-03-31 | 2007-06-27 | Purdue Research Foundation | METHOD OF TREATMENT USING LIGAND-IMMUNOGENE CONJUGATES |
| JP2005523878A (ja) * | 2001-09-28 | 2005-08-11 | パーデュー・リサーチ・ファウンデーション | リガンド・免疫原物質複合体を用いた処置方法 |
| CA2482924A1 (en) * | 2002-04-19 | 2003-10-30 | Endocyte, Inc. | Adjuvant enhanced immunotherapy |
| AR042942A1 (es) | 2003-01-27 | 2005-07-06 | Endocyte Inc | Conjugados de administracion de drogas de union de receptores de vitaminas |
| US20050222068A1 (en) | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
| WO2007092299A2 (en) | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
-
2001
- 2001-03-30 EP EP01930433A patent/EP1267918A4/en not_active Withdrawn
- 2001-03-30 US US09/822,379 patent/US7033594B2/en not_active Expired - Lifetime
- 2001-03-30 HU HU0300421A patent/HUP0300421A2/hu unknown
- 2001-03-30 BR BR0109704-0A patent/BR0109704A/pt not_active IP Right Cessation
- 2001-03-30 MX MXPA02009454A patent/MXPA02009454A/es active IP Right Grant
- 2001-03-30 AU AU5697001A patent/AU5697001A/xx active Pending
- 2001-03-30 PL PL357943A patent/PL211872B1/pl unknown
- 2001-03-30 CN CN2012102411983A patent/CN102805868A/zh active Pending
- 2001-03-30 WO PCT/US2001/010254 patent/WO2001074382A1/en not_active Ceased
- 2001-03-30 CZ CZ2002-3240A patent/CZ304942B6/cs not_active IP Right Cessation
- 2001-03-30 NZ NZ521898A patent/NZ521898A/en not_active IP Right Cessation
- 2001-03-30 EA EA200201042A patent/EA005823B1/ru not_active IP Right Cessation
- 2001-03-30 CA CA2405299A patent/CA2405299C/en not_active Expired - Fee Related
- 2001-03-30 DZ DZ013332A patent/DZ3332A1/fr active
- 2001-03-30 SK SK1396-2002A patent/SK288201B6/sk not_active IP Right Cessation
- 2001-03-30 CN CN018101852A patent/CN1441676B/zh not_active Expired - Fee Related
- 2001-03-30 JP JP2001572124A patent/JP5059271B2/ja not_active Expired - Fee Related
- 2001-03-30 HR HRP20020787AA patent/HRP20020787B1/xx not_active IP Right Cessation
- 2001-03-30 AU AU2001256970A patent/AU2001256970C1/en not_active Ceased
- 2001-03-30 IL IL15192701A patent/IL151927A0/xx unknown
- 2001-03-30 KR KR1020027012768A patent/KR100863632B1/ko not_active Expired - Fee Related
-
2002
- 2002-09-24 NO NO20024577A patent/NO332160B1/no not_active IP Right Cessation
-
2005
- 2005-11-16 US US11/274,973 patent/US8105608B2/en not_active Expired - Lifetime
-
2011
- 2011-05-31 IL IL213240A patent/IL213240A/en not_active IP Right Cessation
- 2011-10-12 JP JP2011225070A patent/JP5632813B2/ja not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003528924A5 (enExample) | ||
| JP5059271B2 (ja) | リガンド免疫原複合体を用いる処置方法 | |
| JP5746721B2 (ja) | 同時の化学療法及び免疫療法 | |
| JP2011012065A (ja) | アジュバントにより増強される免疫療法 | |
| AU2001256970A1 (en) | Method of treatment using ligand-immunogen conjugates | |
| JPH05504756A (ja) | 免疫刺激性を有する組成物と、そのヒトと獣医学用医薬への応用 | |
| US20240299567A1 (en) | Recombinant polypeptides, conjugates comprising the same, and uses thereof | |
| CN101061136B (zh) | 具有白介素-2中和能力的免疫治疗制剂 | |
| US6355256B1 (en) | Compositions containing a p53 derived protein or peptide, an adjuvant, and interleukin-12 and uses thereof | |
| HK1179518A (en) | Method of treatment using ligand-immunogen conjugates | |
| KR20050016350A (ko) | 어쥬번트 보강된 면역요법 | |
| HK1136486A (en) | Concurrent chemotherapy and immunotherapy | |
| HK1188137A (en) | Concurrent chemotherapy and immunotherapy | |
| ZA200207768B (en) | Method of treatment using ligand-immunogen conjugates. |