JP2003520288A - 新規の染料 - Google Patents
新規の染料Info
- Publication number
- JP2003520288A JP2003520288A JP2001552800A JP2001552800A JP2003520288A JP 2003520288 A JP2003520288 A JP 2003520288A JP 2001552800 A JP2001552800 A JP 2001552800A JP 2001552800 A JP2001552800 A JP 2001552800A JP 2003520288 A JP2003520288 A JP 2003520288A
- Authority
- JP
- Japan
- Prior art keywords
- group
- same
- different
- hydrogen
- dye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
- A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Cardiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Microscoopes, Condenser (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US09/484,318 | 2000-01-18 | ||
| PCT/US2001/001469 WO2001052745A1 (en) | 2000-01-18 | 2001-01-17 | Novel dyes |
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| JP2003520288A true JP2003520288A (ja) | 2003-07-02 |
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| US (1) | US6180085B1 (enExample) |
| EP (2) | EP1250092B1 (enExample) |
| JP (1) | JP2003520288A (enExample) |
| AT (2) | ATE399505T1 (enExample) |
| AU (1) | AU2001232819A1 (enExample) |
| DE (2) | DE60109740T8 (enExample) |
| ES (2) | ES2239122T3 (enExample) |
| WO (1) | WO2001052745A1 (enExample) |
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| US7255851B2 (en) * | 1994-07-01 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| US6939532B2 (en) * | 2000-01-18 | 2005-09-06 | Mallinckrodt, Inc. | Versatile hydrophilic dyes |
| US7230088B2 (en) * | 2001-07-03 | 2007-06-12 | Mallinckrodt, Inc. | Compounds for dual photodiagnosis and therapy |
| US6180085B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Dyes |
| US6395257B1 (en) | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US20030017164A1 (en) | 2001-07-03 | 2003-01-23 | Mallinckrodt Inc. | Dye-azide compounds for dual phototherapy |
| US20080233050A1 (en) * | 2000-01-18 | 2008-09-25 | Mallinckrodt Inc. | Diagnostic and therapeutic optical agents |
| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
| US20040180809A1 (en) * | 2000-10-16 | 2004-09-16 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
| US20070092450A1 (en) * | 2000-10-16 | 2007-04-26 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
| US7556797B2 (en) * | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| US20030105300A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Tumor targeted photodiagnostic-phototherapeutic agents |
| US20030105299A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications |
| EP2258776A1 (en) | 2002-05-10 | 2010-12-08 | Carnegie Mellon University | Fluorescent cyanine dyes containing functional groups |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| DE10302787A1 (de) * | 2003-01-24 | 2004-08-12 | Schering Ag | Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik |
| ES2431520T3 (es) * | 2003-01-25 | 2013-11-26 | Seno Medical Instruments, Inc. | Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas |
| ES2334923T3 (es) | 2004-01-08 | 2010-03-17 | Universitat Zurich | Complejos metalicos que utilizan la vitamina b12 como ligando. |
| DE102004002758A1 (de) * | 2004-01-20 | 2005-08-04 | Bayer Chemicals Ag | Metallkomplexe als lichtabsorbierende Verbindungen in der Informationsschicht von optischen Datenträgern |
| EP1901781A2 (en) * | 2005-06-21 | 2008-03-26 | Mallinckrodt, Inc. | Optical imaging contrast agents |
| US8227621B2 (en) * | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
| US20100022449A1 (en) * | 2006-03-09 | 2010-01-28 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US20110262354A1 (en) * | 2007-07-13 | 2011-10-27 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
| US8088163B1 (en) | 2008-02-06 | 2012-01-03 | Kleiner Jeffrey B | Tools and methods for spinal fusion |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| US20210378834A1 (en) | 2008-05-22 | 2021-12-09 | Spinal Surgical Strategies, Inc., A Nevada Corporation D/B/A Kleiner Device Labs | Spinal fusion cage system with inserter |
| USD853560S1 (en) | 2008-10-09 | 2019-07-09 | Nuvasive, Inc. | Spinal implant insertion device |
| US9717403B2 (en) | 2008-12-05 | 2017-08-01 | Jeffrey B. Kleiner | Method and apparatus for performing retro peritoneal dissection |
| US8366748B2 (en) | 2008-12-05 | 2013-02-05 | Kleiner Jeffrey | Apparatus and method of spinal implant and fusion |
| US8864654B2 (en) | 2010-04-20 | 2014-10-21 | Jeffrey B. Kleiner | Method and apparatus for performing retro peritoneal dissection |
| US9247943B1 (en) | 2009-02-06 | 2016-02-02 | Kleiner Intellectual Property, Llc | Devices and methods for preparing an intervertebral workspace |
| USD656610S1 (en) | 2009-02-06 | 2012-03-27 | Kleiner Jeffrey B | Spinal distraction instrument |
| WO2010121163A2 (en) * | 2009-04-17 | 2010-10-21 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
| US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| US9060877B2 (en) | 2009-09-18 | 2015-06-23 | Spinal Surgical Strategies, Llc | Fusion cage with combined biological delivery system |
| US8906028B2 (en) | 2009-09-18 | 2014-12-09 | Spinal Surgical Strategies, Llc | Bone graft delivery device and method of using the same |
| USD750249S1 (en) | 2014-10-20 | 2016-02-23 | Spinal Surgical Strategies, Llc | Expandable fusion cage |
| US8685031B2 (en) | 2009-09-18 | 2014-04-01 | Spinal Surgical Strategies, Llc | Bone graft delivery system |
| USD723682S1 (en) | 2013-05-03 | 2015-03-03 | Spinal Surgical Strategies, Llc | Bone graft delivery tool |
| US20170238984A1 (en) | 2009-09-18 | 2017-08-24 | Spinal Surgical Strategies, Llc | Bone graft delivery device with positioning handle |
| US10245159B1 (en) | 2009-09-18 | 2019-04-02 | Spinal Surgical Strategies, Llc | Bone graft delivery system and method for using same |
| US9186193B2 (en) | 2009-09-18 | 2015-11-17 | Spinal Surgical Strategies, Llc | Fusion cage with combined biological delivery system |
| US9629729B2 (en) | 2009-09-18 | 2017-04-25 | Spinal Surgical Strategies, Llc | Biological delivery system with adaptable fusion cage interface |
| US10973656B2 (en) | 2009-09-18 | 2021-04-13 | Spinal Surgical Strategies, Inc. | Bone graft delivery system and method for using same |
| US9173694B2 (en) | 2009-09-18 | 2015-11-03 | Spinal Surgical Strategies, Llc | Fusion cage with combined biological delivery system |
| US8690887B2 (en) * | 2010-02-08 | 2014-04-08 | Jeffrey B. Kleiner | Method and system for identification of a center of a vertebral disc space and corresponding central axis of a spinal column |
| US9808320B2 (en) | 2010-02-08 | 2017-11-07 | Jeffrey B. Kleiner | Method and system for identification of a center of a patient's body part |
| CN102260352B (zh) * | 2010-05-28 | 2013-11-20 | 山东先声麦得津生物制药有限公司 | 靶向性白细胞介素融合蛋白及其制备方法与应用 |
| EP2630196B1 (en) | 2010-10-20 | 2017-09-06 | Li-Cor, Inc. | Cyanine dyes and their conjugates |
| US9592307B2 (en) | 2012-07-20 | 2017-03-14 | Canon Kabushiki Kaisha | Compound and photoacoustic imaging contrast medium containing the compound |
| KR20150130557A (ko) | 2013-03-15 | 2015-11-23 | 글렌 레인 패밀리 리미티드 리에빌러티 리미티드 파트너쉽 | 조정 가능한 질량 분해 애퍼쳐 |
| WO2016179350A1 (en) * | 2015-05-06 | 2016-11-10 | Washington University | Compounds having rd targeting motifs and methods of use thereof |
| USD797290S1 (en) | 2015-10-19 | 2017-09-12 | Spinal Surgical Strategies, Llc | Bone graft delivery tool |
| US9862682B2 (en) | 2016-01-08 | 2018-01-09 | BroadPharm | Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof |
| KR101804063B1 (ko) | 2016-08-03 | 2017-12-01 | 전남대학교산학협력단 | 종양 표적화 근적외선 형광 탐지자 |
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-
2000
- 2000-01-18 US US09/484,318 patent/US6180085B1/en not_active Expired - Fee Related
-
2001
- 2001-01-17 EP EP01904883A patent/EP1250092B1/en not_active Expired - Lifetime
- 2001-01-17 WO PCT/US2001/001469 patent/WO2001052745A1/en not_active Ceased
- 2001-01-17 AT AT05005127T patent/ATE399505T1/de not_active IP Right Cessation
- 2001-01-17 JP JP2001552800A patent/JP2003520288A/ja active Pending
- 2001-01-17 ES ES01904883T patent/ES2239122T3/es not_active Expired - Lifetime
- 2001-01-17 DE DE60109740T patent/DE60109740T8/de active Active
- 2001-01-17 DE DE60134680T patent/DE60134680D1/de not_active Expired - Lifetime
- 2001-01-17 ES ES05005127T patent/ES2309609T3/es not_active Expired - Lifetime
- 2001-01-17 EP EP05005127A patent/EP1559374B1/en not_active Expired - Lifetime
- 2001-01-17 AT AT01904883T patent/ATE291878T1/de not_active IP Right Cessation
- 2001-01-17 AU AU2001232819A patent/AU2001232819A1/en not_active Abandoned
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| US5096801A (en) * | 1989-04-03 | 1992-03-17 | Fuji Photo Film Co., Ltd. | Color image recording method |
| JPH03132654A (ja) * | 1989-10-18 | 1991-06-06 | Konica Corp | ハロゲン化銀カラー写真感光材料 |
| JPH04186342A (ja) * | 1990-11-21 | 1992-07-03 | Fuji Photo Film Co Ltd | 写真感光材料を用いるカラープルーフの作成方法 |
| JPH06102624A (ja) * | 1992-09-18 | 1994-04-15 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1559374A1 (en) | 2005-08-03 |
| EP1250092A4 (en) | 2003-05-07 |
| EP1250092A1 (en) | 2002-10-23 |
| DE60109740D1 (de) | 2005-05-04 |
| ES2309609T3 (es) | 2008-12-16 |
| ES2239122T3 (es) | 2005-09-16 |
| DE60134680D1 (de) | 2008-08-14 |
| WO2001052745A1 (en) | 2001-07-26 |
| EP1250092B1 (en) | 2005-03-30 |
| DE60109740T2 (de) | 2006-02-23 |
| US6180085B1 (en) | 2001-01-30 |
| ATE291878T1 (de) | 2005-04-15 |
| AU2001232819A1 (en) | 2001-07-31 |
| DE60109740T8 (de) | 2006-04-27 |
| ATE399505T1 (de) | 2008-07-15 |
| EP1559374B1 (en) | 2008-07-02 |
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