ATE399505T1 - Cyaninfarbstoffe - Google Patents

Cyaninfarbstoffe

Info

Publication number
ATE399505T1
ATE399505T1 AT05005127T AT05005127T ATE399505T1 AT E399505 T1 ATE399505 T1 AT E399505T1 AT 05005127 T AT05005127 T AT 05005127T AT 05005127 T AT05005127 T AT 05005127T AT E399505 T1 ATE399505 T1 AT E399505T1
Authority
AT
Austria
Prior art keywords
therapy
detection
imaging
dyes
useful
Prior art date
Application number
AT05005127T
Other languages
English (en)
Inventor
Samuel Achilefu
Raghavan Rajagopalan
Richard Dorshow
Joseph Bugaj
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE399505T1 publication Critical patent/ATE399505T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT05005127T 2000-01-18 2001-01-17 Cyaninfarbstoffe ATE399505T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/484,318 US6180085B1 (en) 2000-01-18 2000-01-18 Dyes

Publications (1)

Publication Number Publication Date
ATE399505T1 true ATE399505T1 (de) 2008-07-15

Family

ID=23923647

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05005127T ATE399505T1 (de) 2000-01-18 2001-01-17 Cyaninfarbstoffe
AT01904883T ATE291878T1 (de) 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01904883T ATE291878T1 (de) 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung

Country Status (8)

Country Link
US (1) US6180085B1 (de)
EP (2) EP1250092B1 (de)
JP (1) JP2003520288A (de)
AT (2) ATE399505T1 (de)
AU (1) AU2001232819A1 (de)
DE (2) DE60109740T8 (de)
ES (2) ES2309609T3 (de)
WO (1) WO2001052745A1 (de)

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US7230088B2 (en) * 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US20030017164A1 (en) 2001-07-03 2003-01-23 Mallinckrodt Inc. Dye-azide compounds for dual phototherapy
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10302787A1 (de) * 2003-01-24 2004-08-12 Schering Ag Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
US7500953B2 (en) * 2003-01-25 2009-03-10 Seno Medical Instruments, Inc. High contrast optoacoustic imaging using nanoparticles
EP1704157B1 (de) 2004-01-08 2009-09-16 Universität Zürich Metallkomplexe mit vitamin b12 als ligand
DE102004002758A1 (de) * 2004-01-20 2005-08-04 Bayer Chemicals Ag Metallkomplexe als lichtabsorbierende Verbindungen in der Informationsschicht von optischen Datenträgern
CN101203248A (zh) * 2005-06-21 2008-06-18 马林克罗特公司 光学成像造影剂
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
FR2889700B1 (fr) * 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
WO2009012109A2 (en) * 2007-07-13 2009-01-22 Emory University Cyanine-containing compounds for cancer imaging and treatment
US8088163B1 (en) 2008-02-06 2012-01-03 Kleiner Jeffrey B Tools and methods for spinal fusion
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
USD853560S1 (en) 2008-10-09 2019-07-09 Nuvasive, Inc. Spinal implant insertion device
US9717403B2 (en) 2008-12-05 2017-08-01 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US8366748B2 (en) 2008-12-05 2013-02-05 Kleiner Jeffrey Apparatus and method of spinal implant and fusion
US8864654B2 (en) 2010-04-20 2014-10-21 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US9247943B1 (en) 2009-02-06 2016-02-02 Kleiner Intellectual Property, Llc Devices and methods for preparing an intervertebral workspace
USD656610S1 (en) 2009-02-06 2012-03-27 Kleiner Jeffrey B Spinal distraction instrument
CN102459469A (zh) * 2009-04-17 2012-05-16 利康股份有限公司 用取代的花青染料进行荧光成像
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US9629729B2 (en) 2009-09-18 2017-04-25 Spinal Surgical Strategies, Llc Biological delivery system with adaptable fusion cage interface
US9186193B2 (en) 2009-09-18 2015-11-17 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US10245159B1 (en) 2009-09-18 2019-04-02 Spinal Surgical Strategies, Llc Bone graft delivery system and method for using same
US9173694B2 (en) 2009-09-18 2015-11-03 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US20170238984A1 (en) 2009-09-18 2017-08-24 Spinal Surgical Strategies, Llc Bone graft delivery device with positioning handle
US10973656B2 (en) 2009-09-18 2021-04-13 Spinal Surgical Strategies, Inc. Bone graft delivery system and method for using same
US9060877B2 (en) 2009-09-18 2015-06-23 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
USD750249S1 (en) 2014-10-20 2016-02-23 Spinal Surgical Strategies, Llc Expandable fusion cage
US8685031B2 (en) 2009-09-18 2014-04-01 Spinal Surgical Strategies, Llc Bone graft delivery system
USD723682S1 (en) 2013-05-03 2015-03-03 Spinal Surgical Strategies, Llc Bone graft delivery tool
US8906028B2 (en) 2009-09-18 2014-12-09 Spinal Surgical Strategies, Llc Bone graft delivery device and method of using the same
US8690887B2 (en) 2010-02-08 2014-04-08 Jeffrey B. Kleiner Method and system for identification of a center of a vertebral disc space and corresponding central axis of a spinal column
US9808320B2 (en) 2010-02-08 2017-11-07 Jeffrey B. Kleiner Method and system for identification of a center of a patient's body part
CN102260352B (zh) * 2010-05-28 2013-11-20 山东先声麦得津生物制药有限公司 靶向性白细胞介素融合蛋白及其制备方法与应用
EP2630196B1 (de) 2010-10-20 2017-09-06 Li-Cor, Inc. Cyaninfarbstoffe und deren konjugate
WO2014013730A1 (en) * 2012-07-20 2014-01-23 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
JP6500009B2 (ja) 2013-03-15 2019-04-10 グレン レイン ファミリー リミテッド ライアビリティ リミテッド パートナーシップ 調節可能な質量分析アパーチャ
US10806804B2 (en) * 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
USD797290S1 (en) 2015-10-19 2017-09-12 Spinal Surgical Strategies, Llc Bone graft delivery tool
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof
KR101804063B1 (ko) 2016-08-03 2017-12-01 전남대학교산학협력단 종양 표적화 근적외선 형광 탐지자

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Also Published As

Publication number Publication date
DE60109740T2 (de) 2006-02-23
DE60109740D1 (de) 2005-05-04
JP2003520288A (ja) 2003-07-02
ES2309609T3 (es) 2008-12-16
ES2239122T3 (es) 2005-09-16
WO2001052745A1 (en) 2001-07-26
US6180085B1 (en) 2001-01-30
AU2001232819A1 (en) 2001-07-31
EP1250092A4 (de) 2003-05-07
ATE291878T1 (de) 2005-04-15
EP1250092B1 (de) 2005-03-30
EP1559374B1 (de) 2008-07-02
EP1559374A1 (de) 2005-08-03
DE60109740T8 (de) 2006-04-27
DE60134680D1 (de) 2008-08-14
EP1250092A1 (de) 2002-10-23

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Legal Events

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