DE60109740D1 - Verfahren zur vermeidung von fluoreszenzlöschung - Google Patents

Verfahren zur vermeidung von fluoreszenzlöschung

Info

Publication number
DE60109740D1
DE60109740D1 DE60109740T DE60109740T DE60109740D1 DE 60109740 D1 DE60109740 D1 DE 60109740D1 DE 60109740 T DE60109740 T DE 60109740T DE 60109740 T DE60109740 T DE 60109740T DE 60109740 D1 DE60109740 D1 DE 60109740D1
Authority
DE
Germany
Prior art keywords
therapy
detection
imaging
dyes
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60109740T
Other languages
English (en)
Other versions
DE60109740T2 (de
DE60109740T8 (de
Inventor
I Achilefu
Raghavan Rajagopalan
B Dorshow
E Bugaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE60109740D1 publication Critical patent/DE60109740D1/de
Publication of DE60109740T2 publication Critical patent/DE60109740T2/de
Application granted granted Critical
Publication of DE60109740T8 publication Critical patent/DE60109740T8/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE60109740T 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung Active DE60109740T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US484318 2000-01-18
US09/484,318 US6180085B1 (en) 2000-01-18 2000-01-18 Dyes
PCT/US2001/001469 WO2001052745A1 (en) 2000-01-18 2001-01-17 Novel dyes

Publications (3)

Publication Number Publication Date
DE60109740D1 true DE60109740D1 (de) 2005-05-04
DE60109740T2 DE60109740T2 (de) 2006-02-23
DE60109740T8 DE60109740T8 (de) 2006-04-27

Family

ID=23923647

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60134680T Expired - Lifetime DE60134680D1 (de) 2000-01-18 2001-01-17 Cyaninfarbstoffe
DE60109740T Active DE60109740T8 (de) 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60134680T Expired - Lifetime DE60134680D1 (de) 2000-01-18 2001-01-17 Cyaninfarbstoffe

Country Status (8)

Country Link
US (1) US6180085B1 (de)
EP (2) EP1250092B1 (de)
JP (1) JP2003520288A (de)
AT (2) ATE399505T1 (de)
AU (1) AU2001232819A1 (de)
DE (2) DE60134680D1 (de)
ES (2) ES2309609T3 (de)
WO (1) WO2001052745A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US7230088B2 (en) 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US20030017164A1 (en) 2001-07-03 2003-01-23 Mallinckrodt Inc. Dye-azide compounds for dual phototherapy
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
ATE517152T1 (de) 2002-05-10 2011-08-15 Univ Carnegie Mellon Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10302787A1 (de) * 2003-01-24 2004-08-12 Schering Ag Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
ES2431520T3 (es) * 2003-01-25 2013-11-26 Seno Medical Instruments, Inc. Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas
JP2007518727A (ja) * 2004-01-08 2007-07-12 ウニヴェルジテート・チューリッヒ 配位子としてビタミンｂ１２を有する金属錯体
DE102004002758A1 (de) * 2004-01-20 2005-08-04 Bayer Chemicals Ag Metallkomplexe als lichtabsorbierende Verbindungen in der Informationsschicht von optischen Datenträgern
US20100055040A1 (en) * 2005-06-21 2010-03-04 Periasamy Muthunadar P Optical Imaging Contrast Agents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
FR2889700B1 (fr) 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US20110262354A1 (en) * 2007-07-13 2011-10-27 Emory University Cyanine-containing compounds for cancer imaging and treatment
US8088163B1 (en) 2008-02-06 2012-01-03 Kleiner Jeffrey B Tools and methods for spinal fusion
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
USD853560S1 (en) 2008-10-09 2019-07-09 Nuvasive, Inc. Spinal implant insertion device
US8864654B2 (en) 2010-04-20 2014-10-21 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US9717403B2 (en) 2008-12-05 2017-08-01 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US8366748B2 (en) 2008-12-05 2013-02-05 Kleiner Jeffrey Apparatus and method of spinal implant and fusion
USD656610S1 (en) 2009-02-06 2012-03-27 Kleiner Jeffrey B Spinal distraction instrument
US9247943B1 (en) 2009-02-06 2016-02-02 Kleiner Intellectual Property, Llc Devices and methods for preparing an intervertebral workspace
EP2419478B1 (de) * 2009-04-17 2018-02-28 Li-Cor, Inc. Fluoreszenzbasierte bildgebung mit substituierten cyaninfarbstoffen
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US20170238984A1 (en) 2009-09-18 2017-08-24 Spinal Surgical Strategies, Llc Bone graft delivery device with positioning handle
USD750249S1 (en) 2014-10-20 2016-02-23 Spinal Surgical Strategies, Llc Expandable fusion cage
US9173694B2 (en) 2009-09-18 2015-11-03 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US10973656B2 (en) 2009-09-18 2021-04-13 Spinal Surgical Strategies, Inc. Bone graft delivery system and method for using same
US9629729B2 (en) 2009-09-18 2017-04-25 Spinal Surgical Strategies, Llc Biological delivery system with adaptable fusion cage interface
US8685031B2 (en) 2009-09-18 2014-04-01 Spinal Surgical Strategies, Llc Bone graft delivery system
US9186193B2 (en) 2009-09-18 2015-11-17 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
USD723682S1 (en) 2013-05-03 2015-03-03 Spinal Surgical Strategies, Llc Bone graft delivery tool
US8906028B2 (en) 2009-09-18 2014-12-09 Spinal Surgical Strategies, Llc Bone graft delivery device and method of using the same
US10245159B1 (en) 2009-09-18 2019-04-02 Spinal Surgical Strategies, Llc Bone graft delivery system and method for using same
US9060877B2 (en) 2009-09-18 2015-06-23 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US8690887B2 (en) * 2010-02-08 2014-04-08 Jeffrey B. Kleiner Method and system for identification of a center of a vertebral disc space and corresponding central axis of a spinal column
US9808320B2 (en) 2010-02-08 2017-11-07 Jeffrey B. Kleiner Method and system for identification of a center of a patient's body part
CN102260352B (zh) * 2010-05-28 2013-11-20 山东先声麦得津生物制药有限公司 靶向性白细胞介素融合蛋白及其制备方法与应用
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
WO2014013730A1 (en) * 2012-07-20 2014-01-23 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
WO2014145898A2 (en) 2013-03-15 2014-09-18 Glenn Lane Family Limited Liability Limited Partnership Adjustable mass resolving aperture
US10806804B2 (en) * 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
USD797290S1 (en) 2015-10-19 2017-09-12 Spinal Surgical Strategies, Llc Bone graft delivery tool
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof
KR101804063B1 (ko) 2016-08-03 2017-12-01 전남대학교산학협력단 종양 표적화 근적외선 형광 탐지자

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4040825A (en) * 1975-03-18 1977-08-09 Ciba-Geigy Ag Spectral sensitization of photographic material with natural colloids containing sensitizing dye groups
DD256768B5 (de) * 1984-09-27 1994-05-11 Wolfen Filmfab Gmbh Verfahren zum Einbringen von optischen Sensibilisatoren durch Dispergierung
US5096801A (en) * 1989-04-03 1992-03-17 Fuji Photo Film Co., Ltd. Color image recording method
JPH03132654A (ja) * 1989-10-18 1991-06-06 Konica Corp ハロゲン化銀カラー写真感光材料
JPH04186342A (ja) * 1990-11-21 1992-07-03 Fuji Photo Film Co Ltd 写真感光材料を用いるカラープルーフの作成方法
JPH06102624A (ja) * 1992-09-18 1994-04-15 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
JPH0735749A (ja) * 1993-07-19 1995-02-07 Ibiden Co Ltd Ｏ−アルキル化アミノグリカンを用いた免疫測定用標識試薬
JPH09227378A (ja) * 1996-02-20 1997-09-02 Fuji Photo Film Co Ltd 抗癌性組成物
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
ES2331671T3 (es) * 1998-04-03 2010-01-12 Mallinckrodt Inc. Bioconjugados no covalentes utiles para diagnostico y terapia.
DE19841985A1 (de) * 1998-09-03 2000-03-09 Schering Ag Dialkylsulfonsäure- und Dialkylcarbonsäure-Derivate
JP2000098524A (ja) * 1998-09-25 2000-04-07 Konica Corp ハロゲン化銀乳剤、ハロゲン化銀感光材料及び熱現像感光材料
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes

Also Published As

Publication number Publication date
EP1250092B1 (de) 2005-03-30
ATE399505T1 (de) 2008-07-15
WO2001052745A1 (en) 2001-07-26
JP2003520288A (ja) 2003-07-02
EP1250092A4 (de) 2003-05-07
EP1559374A1 (de) 2005-08-03
EP1559374B1 (de) 2008-07-02
ATE291878T1 (de) 2005-04-15
EP1250092A1 (de) 2002-10-23
DE60134680D1 (de) 2008-08-14
DE60109740T2 (de) 2006-02-23
DE60109740T8 (de) 2006-04-27
AU2001232819A1 (en) 2001-07-31
US6180085B1 (en) 2001-01-30
ES2309609T3 (es) 2008-12-16
ES2239122T3 (es) 2005-09-16

Similar Documents

Publication Publication Date Title
DE60109740D1 (de) Verfahren zur vermeidung von fluoreszenzlöschung
DE60109741D1 (de) Verfahren zur vermeidung von fluoreszenzlöschung
Walsh et al. Fluorescence imaging of nerves during surgery
Keereweer et al. Optical image-guided cancer surgery: challenges and limitations
Gioux et al. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation
Keereweer et al. Optical image-guided surgery—where do we stand?
Celli et al. Imaging and photodynamic therapy: mechanisms, monitoring, and optimization
Kosaka et al. Clinical implications of near-infrared fluorescence imaging in cancer
Mohs et al. Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration
Hillman et al. In vivo optical imaging and dynamic contrast methods for biomedical research
DK1178830T3 (da) Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser
Miwa The principle of ICG fluorescence method
WO2005000218A3 (en) Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications
Song et al. High‐speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array
Pogue et al. Fluorescence‐guided surgery and intervention—An AAPM emerging technology blue paper
US10996170B2 (en) Device and method for imaging shortwave infrared fluorescence
ATE518477T1 (de) Fluoreszenzvermittelte molekulartomographie
Meershoek et al. Multi-wavelength fluorescence imaging with a da Vinci Firefly—a technical look behind the scenes
Demos et al. Near-infrared autofluorescence imaging for detection of cancer
Ntziachristos Clinical translation of optical and optoacoustic imaging
Zhu et al. Non-invasive fluorescence imaging under ambient light conditions using a modulated ICCD and laser diode
Nguyen et al. Biocompatible astaxanthin as novel contrast agent for biomedical imaging
Azar et al. Translational multimodality optical imaging
Khilov et al. Two-wavelength fluorescence monitoring and planning of photodynamic therapy
Hien et al. Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement

Legal Events

Date Code Title Description
8364 No opposition during term of opposition