JP2003512458A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003512458A5 JP2003512458A5 JP2001533119A JP2001533119A JP2003512458A5 JP 2003512458 A5 JP2003512458 A5 JP 2003512458A5 JP 2001533119 A JP2001533119 A JP 2001533119A JP 2001533119 A JP2001533119 A JP 2001533119A JP 2003512458 A5 JP2003512458 A5 JP 2003512458A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- acetone
- solvent
- chloroperbenzoic acid
- addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 238000000034 method Methods 0.000 description 11
- 239000002904 solvent Substances 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000013078 crystal Substances 0.000 description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011736 potassium bicarbonate Substances 0.000 description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 235000011181 potassium carbonates Nutrition 0.000 description 2
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000017550 sodium carbonate Nutrition 0.000 description 2
- ULQQGOGMQRGFFR-UHFFFAOYSA-N 2-chlorobenzenecarboperoxoic acid Chemical compound OOC(=O)C1=CC=CC=C1Cl ULQQGOGMQRGFFR-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19951960A DE19951960C2 (de) | 1999-10-28 | 1999-10-28 | Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate |
| DE19951960.9 | 1999-10-28 | ||
| PCT/EP2000/010580 WO2001030765A2 (de) | 1999-10-28 | 2000-10-27 | Verfahren zur herstellung von ulkustherapeutika |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003512458A JP2003512458A (ja) | 2003-04-02 |
| JP2003512458A5 true JP2003512458A5 (enExample) | 2011-04-21 |
Family
ID=7927180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001533119A Pending JP2003512458A (ja) | 1999-10-28 | 2000-10-27 | 潰瘍治療薬の製造方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6686474B2 (enExample) |
| EP (1) | EP1226125B1 (enExample) |
| JP (1) | JP2003512458A (enExample) |
| KR (1) | KR100799472B1 (enExample) |
| CN (1) | CN1227247C (enExample) |
| AR (1) | AR029401A1 (enExample) |
| AT (1) | ATE284873T1 (enExample) |
| AU (1) | AU780944B2 (enExample) |
| BR (1) | BR0015220A (enExample) |
| CA (1) | CA2389163C (enExample) |
| CZ (1) | CZ20021467A3 (enExample) |
| DE (2) | DE19951960C2 (enExample) |
| DK (1) | DK1226125T3 (enExample) |
| ES (1) | ES2234691T3 (enExample) |
| HK (1) | HK1048805B (enExample) |
| HU (1) | HUP0203232A3 (enExample) |
| IL (2) | IL149358A0 (enExample) |
| MX (1) | MXPA02004116A (enExample) |
| NO (1) | NO322802B1 (enExample) |
| NZ (1) | NZ518699A (enExample) |
| PE (1) | PE20010762A1 (enExample) |
| PL (1) | PL212931B1 (enExample) |
| PT (1) | PT1226125E (enExample) |
| SI (1) | SI1226125T1 (enExample) |
| SK (1) | SK287227B6 (enExample) |
| WO (1) | WO2001030765A2 (enExample) |
| ZA (1) | ZA200204204B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101376360B1 (ko) * | 2004-09-13 | 2014-03-20 | 다케다 야쿠힌 고교 가부시키가이샤 | 산화 화합물 제조 방법 및 제조 장치 |
| KR100771659B1 (ko) * | 2005-03-23 | 2007-10-30 | 주식회사 카이로제닉스 | 판토프라졸 및 그 중간체의 제조방법 |
| KR100641534B1 (ko) | 2005-07-28 | 2006-11-01 | 한미약품 주식회사 | 에스오메프라졸 및 그의 염의 제조방법 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485869A (en) * | 1967-01-31 | 1969-12-23 | Fmc Corp | Production of organic peroxy acids |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4619997A (en) * | 1984-09-06 | 1986-10-28 | The Upjohn Company | Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents |
| US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
| JPS62108879A (ja) * | 1985-11-05 | 1987-05-20 | Grelan Pharmaceut Co Ltd | 置換ベンズイミダゾ−ル類 |
| JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
| JPH0717631B2 (ja) * | 1986-03-04 | 1995-03-01 | 武田薬品工業株式会社 | ピリジニウム誘導体およびその製造法 |
| JPS63183577A (ja) * | 1987-01-23 | 1988-07-28 | Grelan Pharmaceut Co Ltd | ベンズイミダゾ−ル誘導体 |
| DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| JPH01294673A (ja) * | 1988-05-23 | 1989-11-28 | Grelan Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
| GB2239453A (en) * | 1989-11-27 | 1991-07-03 | Haessle Ab | Omeprazole |
| SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
| ES2026761A6 (es) * | 1990-10-31 | 1992-05-01 | Genesis Para La Investigacion | Procedimiento de obtencion del omeprazol. |
| NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
| FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
| SE521100C2 (sv) * | 1995-12-15 | 2003-09-30 | Astra Ab | Förfarande för framställning av en bensimidazolförening |
| SK283805B6 (sk) * | 1996-09-09 | 2004-02-03 | Slovakofarma, A. S. | Spôsob prípravy omeprazolu |
| WO2000053752A2 (en) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
| JPH1171371A (ja) * | 1997-07-23 | 1999-03-16 | Eisai Co Ltd | ピリジン誘導体の製造方法 |
| GB9805558D0 (en) * | 1998-03-17 | 1998-05-13 | Knoll Ag | Chemical process` |
| SI20019A (sl) * | 1998-07-13 | 2000-02-29 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola |
| JP3926936B2 (ja) * | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
-
1999
- 1999-10-28 DE DE19951960A patent/DE19951960C2/de not_active Expired - Fee Related
-
2000
- 2000-10-26 AR ARP000105639A patent/AR029401A1/es not_active Application Discontinuation
- 2000-10-27 AU AU13884/01A patent/AU780944B2/en not_active Ceased
- 2000-10-27 DK DK00975934T patent/DK1226125T3/da active
- 2000-10-27 CN CNB008177325A patent/CN1227247C/zh not_active Expired - Fee Related
- 2000-10-27 PT PT00975934T patent/PT1226125E/pt unknown
- 2000-10-27 NZ NZ518699A patent/NZ518699A/en not_active IP Right Cessation
- 2000-10-27 JP JP2001533119A patent/JP2003512458A/ja active Pending
- 2000-10-27 SI SI200030595T patent/SI1226125T1/xx unknown
- 2000-10-27 WO PCT/EP2000/010580 patent/WO2001030765A2/de not_active Ceased
- 2000-10-27 BR BR0015220-0A patent/BR0015220A/pt not_active Application Discontinuation
- 2000-10-27 CA CA002389163A patent/CA2389163C/en not_active Expired - Fee Related
- 2000-10-27 HK HK03100752.5A patent/HK1048805B/zh not_active IP Right Cessation
- 2000-10-27 IL IL14935800A patent/IL149358A0/xx active IP Right Grant
- 2000-10-27 PE PE2000001151A patent/PE20010762A1/es not_active Application Discontinuation
- 2000-10-27 CZ CZ20021467A patent/CZ20021467A3/cs unknown
- 2000-10-27 EP EP00975934A patent/EP1226125B1/de not_active Expired - Lifetime
- 2000-10-27 PL PL355370A patent/PL212931B1/pl not_active IP Right Cessation
- 2000-10-27 KR KR1020027005438A patent/KR100799472B1/ko not_active Expired - Fee Related
- 2000-10-27 HU HU0203232A patent/HUP0203232A3/hu unknown
- 2000-10-27 AT AT00975934T patent/ATE284873T1/de active
- 2000-10-27 DE DE50008978T patent/DE50008978D1/de not_active Expired - Lifetime
- 2000-10-27 ES ES00975934T patent/ES2234691T3/es not_active Expired - Lifetime
- 2000-10-27 SK SK589-2002A patent/SK287227B6/sk not_active IP Right Cessation
- 2000-10-27 MX MXPA02004116A patent/MXPA02004116A/es active IP Right Grant
-
2002
- 2002-04-16 NO NO20021788A patent/NO322802B1/no not_active IP Right Cessation
- 2002-04-25 IL IL149358A patent/IL149358A/en not_active IP Right Cessation
- 2002-04-29 US US10/133,644 patent/US6686474B2/en not_active Expired - Fee Related
- 2002-05-27 ZA ZA200204204A patent/ZA200204204B/xx unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100433436B1 (ko) | 벤즈이미다졸화합물의합성방법 | |
| JP2004504403A5 (enExample) | ||
| CA2402635C (en) | Method for oxidizing a thioether group into a sulfoxide group | |
| JP2003512458A5 (enExample) | ||
| JP2023530640A (ja) | 芳香族エーテル化合物の調製方法 | |
| WO2001029004A1 (en) | Oxidation process for the preparation of intermediates useful in the synthesis of diarylpyridines | |
| JP2000003620A (ja) | イミダゾリウム系溶融塩型電解質 | |
| CN116396226A (zh) | 一种替戈拉生及其中间体化合物的制备方法 | |
| JP3042122B2 (ja) | Ｎ−シアノアセトアミジン誘導体の製造方法 | |
| JPS631952B2 (enExample) | ||
| KR100783020B1 (ko) | 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법 | |
| JPH0478638B2 (enExample) | ||
| JP2003517029A (ja) | トリフルオロメチルアセトフェノンの製造方法 | |
| KR100464174B1 (ko) | 설피닐 벤즈이미다졸 유도체의 제조방법 | |
| JP2544201B2 (ja) | スルホキシド類の製法 | |
| JP4479863B2 (ja) | Ｎ−モノブロモイソシアヌル酸金属塩水和物及びその製造法 | |
| KR100503267B1 (ko) | 2-아세틸옥시-4-트리플루오로메틸 벤조산의 제조 방법 | |
| WO2025251275A1 (zh) | 一种新的苄基亚磺酰基吡啶类化合物的制备方法 | |
| RU2247120C2 (ru) | Способ получения противоязвенных терапевтических средств | |
| CZ20021467A3 (cs) | Způsob výroby vředových terapeutik | |
| KR100209587B1 (ko) | 피리미딘 유도체의 제조방법 | |
| JPS6121942B2 (enExample) | ||
| JP2002275151A (ja) | スルホン酸化合物の精製方法 | |
| CS235425B1 (cs) | Způsob výroby a izolace alkensulfonátů sodných | |
| KR100406632B1 (ko) | 트롬빈억제제의새로운제조방법 |