JP2003510290A - 免疫刺激核酸誘導インターフェロンに関する方法 - Google Patents

免疫刺激核酸誘導インターフェロンに関する方法

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Publication number
JP2003510290A
JP2003510290A JP2001526199A JP2001526199A JP2003510290A JP 2003510290 A JP2003510290 A JP 2003510290A JP 2001526199 A JP2001526199 A JP 2001526199A JP 2001526199 A JP2001526199 A JP 2001526199A JP 2003510290 A JP2003510290 A JP 2003510290A
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Prior art keywords
nucleic acid
ifn
immunostimulatory nucleic
cpg
subject
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Pending
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JP2001526199A
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English (en)
Japanese (ja)
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JP2003510290A5 (enExample
Inventor
グンター ハルトマン，
ロバート エル． ブラッツラー，
アーサー クレイグ，
Original Assignee
コーリー ファーマシューティカル グループ，インコーポレイテッド
ユニバーシティ オブ アイオワ リサーチ ファウンデーション
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22558308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2003510290(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by コーリー ファーマシューティカル グループ，インコーポレイテッド, ユニバーシティ オブ アイオワ リサーチ ファウンデーション filed Critical コーリー ファーマシューティカル グループ，インコーポレイテッド
Publication of JP2003510290A publication Critical patent/JP2003510290A/ja
Publication of JP2003510290A5 publication Critical patent/JP2003510290A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/02—Immunomodulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
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  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
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  • AIDS & HIV (AREA)
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JP2001526199A 1999-09-27 2000-09-27 免疫刺激核酸誘導インターフェロンに関する方法 Pending JP2003510290A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15614799P 1999-09-27 1999-09-27
US60/156,147 1999-09-27
PCT/US2000/026527 WO2001022990A2 (en) 1999-09-27 2000-09-27 Methods related to immunostimulatory nucleic acid-induced interferon

Publications (2)

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JP2003510290A true JP2003510290A (ja) 2003-03-18
JP2003510290A5 JP2003510290A5 (enExample) 2007-11-22

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ID=22558308

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JP2001526199A Pending JP2003510290A (ja) 1999-09-27 2000-09-27 免疫刺激核酸誘導インターフェロンに関する方法

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Country Link
EP (1) EP1220684B2 (enExample)
JP (1) JP2003510290A (enExample)
AT (1) ATE333284T1 (enExample)
AU (1) AU783118B2 (enExample)
CA (1) CA2386019C (enExample)
DE (1) DE60029460T3 (enExample)
ES (1) ES2265980T5 (enExample)
IL (1) IL148844A0 (enExample)
MX (1) MXPA02003059A (enExample)
NZ (1) NZ517928A (enExample)
WO (1) WO2001022990A2 (enExample)
ZA (1) ZA200201959B (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
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WO2004094448A1 (ja) * 2003-04-23 2004-11-04 Taisho Pharmaceutical Co. Ltd. メチル化ＣｐＧポリヌクレオチド
WO2005083076A1 (ja) * 2004-02-27 2005-09-09 Emori & Co., Ltd. インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
WO2006035939A1 (ja) * 2004-09-30 2006-04-06 Osaka University 免疫刺激オリゴヌクレオチドおよびその医薬用途
JP2006515277A (ja) * 2002-10-29 2006-05-25 コーリー ファーマシューティカル グループ， リミテッド Ｃ型肝炎ウィルス感染の処置および予防に関する方法および製品
WO2007139190A1 (ja) 2006-05-31 2007-12-06 Toray Industries, Inc. 免疫刺激オリゴヌクレオチド及びその医薬用途
WO2015108046A1 (ja) * 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108047A1 (ja) * 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
WO2015108048A1 (ja) * 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2014010718A1 (ja) * 2012-07-13 2016-06-23 株式会社新日本科学 キラル核酸アジュバント
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
WO2020017590A1 (ja) * 2018-07-19 2020-01-23 一般財団法人阪大微生物病研究会 ＡタイプＣｐＧオリゴデオキシヌクレオチド含有脂質粒子
JP2020510052A (ja) * 2017-03-13 2020-04-02 フダン ユニバーシティ 免疫賦活薬、免疫療法用医薬組成物、ならびにその調製および使用

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US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
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US6552006B2 (en) 2000-01-31 2003-04-22 The Regents Of The University Of California Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
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US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
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US6943240B2 (en) 2000-09-15 2005-09-13 Coley Pharmaceuticals Gmbh Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist
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DK2423335T3 (da) 2001-06-21 2014-08-18 Dynavax Tech Corp Kimæriske immunmodulatoriske forbindelser og fremgangsmåder til anvendelse deraf
AU2002326561B2 (en) 2001-08-07 2008-04-03 Dynavax Technologies Corporation Immunomodulatory compositions, formulations, and methods for use thereof
WO2003020884A2 (en) 2001-08-14 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for rapid generation of mature dendritic cells
IL160157A0 (en) 2001-08-17 2004-07-25 Coley Pharm Group Inc Combination motif immune stimulation oligonucleotides with improved activity
ES2335979T3 (es) 2001-09-14 2010-04-07 Cytos Biotechnology Ag Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso.
CA2461877A1 (en) * 2001-09-28 2003-04-10 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
AU2002366710A1 (en) 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
EP1499187B1 (en) 2002-04-04 2015-06-17 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
CA2483012C (en) * 2002-04-22 2011-05-24 Bioniche Life Sciences Inc. Oligonucleotide compositions and their use for the modulation of immune responses
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JP5481068B2 (ja) 2005-08-31 2014-04-23 アメリカ合衆国 ＣｐＧオリゴデオキシヌクレオチドによって誘発される免疫応答を変化させる方法
EP1940472A1 (en) 2005-10-28 2008-07-09 Index Pharmaceuticals AB Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
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