|
US6207646B1
(en)
*
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US7935675B1
(en)
|
1994-07-15 |
2011-05-03 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
EP0855184A1
(en)
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
|
|
DE60044236D1
(de)
|
1999-02-17 |
2010-06-02 |
Csl Ltd |
Immunogene komplexe und methoden in bezug auf diese
|
|
EP1176966B1
(en)
|
1999-04-12 |
2013-04-03 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US7479285B1
(en)
|
1999-08-19 |
2009-01-20 |
Dynavax Technologies Corporation |
Methods of modulating an immune response using immunostimulatory sequences and compositions for use therein
|
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
WO2001051500A1
(en)
|
2000-01-14 |
2001-07-19 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US6552006B2
(en)
|
2000-01-31 |
2003-04-22 |
The Regents Of The University Of California |
Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
|
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
|
CA2399550A1
(en)
|
2000-02-23 |
2001-08-30 |
The Regents Of The University Of California |
Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
|
|
US20030129251A1
(en)
|
2000-03-10 |
2003-07-10 |
Gary Van Nest |
Biodegradable immunomodulatory formulations and methods for use thereof
|
|
US7129222B2
(en)
|
2000-03-10 |
2006-10-31 |
Dynavax Technologies Corporation |
Immunomodulatory formulations and methods for use thereof
|
|
DZ3332A1
(fr)
|
2000-03-31 |
2001-10-11 |
Purdue Research Foundation |
Methode de traitement a l'aide de conjugues ligand-immunogene
|
|
EP1366077B1
(en)
|
2000-09-15 |
2011-05-25 |
Coley Pharmaceutical GmbH |
PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
|
|
EP1364010B1
(en)
|
2000-12-27 |
2010-06-16 |
Dynavax Technologies Corporation |
Immunomodulatory polynucleotides and methods of using the same
|
|
KR20020083634A
(ko)
*
|
2001-04-27 |
2002-11-04 |
크레아젠 주식회사 |
수지상 세포를 포함하는 자가면역 질환의 치료용 약제학적조성물 및 이를 이용한 치료방법
|
|
KR100985457B1
(ko)
|
2001-06-21 |
2010-10-06 |
다이나박스 테크놀로지 코퍼레이션 |
키메라 면역조절 화합물 및 그것들의 사용 방법
|
|
AU2002326561B2
(en)
|
2001-08-07 |
2008-04-03 |
Dynavax Technologies Corporation |
Immunomodulatory compositions, formulations, and methods for use thereof
|
|
US7354909B2
(en)
|
2001-08-14 |
2008-04-08 |
The United States Of America As Represented By Secretary Of The Department Of Health And Human Services |
Method for rapid generation of mature dendritic cells
|
|
EA007232B1
(ru)
|
2001-08-17 |
2006-08-25 |
Коли Фармасьютикал Гмбх |
Иммуностимулирующие олигонуклеотиды, содержащие комбинацию мотивов и обладающие повышенной активностью
|
|
EP1450856B1
(en)
|
2001-09-14 |
2009-11-11 |
Cytos Biotechnology AG |
Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
|
|
DE60234782D1
(de)
*
|
2001-09-28 |
2010-01-28 |
Purdue Research Foundation |
Behandlungsverfahren mit liganden-immunogenkonjugaten
|
|
AU2002366710A1
(en)
|
2001-12-20 |
2003-07-09 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of |
USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
|
|
NZ535952A
(en)
|
2002-04-04 |
2009-01-31 |
Coley Pharm Gmbh |
Immunostimulatory G,U-containing oligoribonucleotides
|
|
CN101160399A
(zh)
*
|
2002-04-22 |
2008-04-09 |
拜奥尼茨生命科学公司 |
寡核苷酸组合物及其在调节免疫应答中的应用
|
|
CA2388049A1
(en)
*
|
2002-05-30 |
2003-11-30 |
Immunotech S.A. |
Immunostimulatory oligonucleotides and uses thereof
|
|
SG167667A1
(en)
*
|
2002-07-03 |
2011-01-28 |
Coley Pharm Group Inc |
Nucleic acid compositions for stimulating immune responses
|
|
SG166673A1
(en)
*
|
2002-08-19 |
2010-12-29 |
Coley Pharm Group Inc |
Immunostimulatory nucleic acids
|
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
NZ540098A
(en)
*
|
2002-10-29 |
2008-09-26 |
Coley Pharmaceutical Group Ltd |
Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
|
|
AU2003304107B2
(en)
|
2002-11-01 |
2008-05-15 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides
|
|
DK1992635T3
(da)
|
2002-12-23 |
2012-03-05 |
Dynavax Tech Corp |
Oligonukleotider med immunstimulatorisk sekvens og fremgangsmåder til anvendelse af disse
|
|
US8158768B2
(en)
|
2002-12-23 |
2012-04-17 |
Dynavax Technologies Corporation |
Immunostimulatory sequence oligonucleotides and methods of using the same
|
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
|
CN101675993A
(zh)
|
2003-03-26 |
2010-03-24 |
赛托斯生物技术公司 |
Melan-a肽类似物-病毒样颗粒偶联物
|
|
US7871984B2
(en)
|
2003-04-23 |
2011-01-18 |
Yukio Sato |
Methylated CpG polynucleotide
|
|
WO2004100965A1
(ja)
*
|
2003-05-15 |
2004-11-25 |
Japan Science And Technology Agency |
免疫刺激剤
|
|
JP3976742B2
(ja)
*
|
2004-02-27 |
2007-09-19 |
江守商事株式会社 |
インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
|
|
JP2008506789A
(ja)
|
2004-07-18 |
2008-03-06 |
シーエスエル、リミテッド |
インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物
|
|
JP2008000001A
(ja)
*
|
2004-09-30 |
2008-01-10 |
Osaka Univ |
免疫刺激オリゴヌクレオチドおよびその医薬用途
|
|
DE102005005642A1
(de)
*
|
2005-02-06 |
2006-08-10 |
Phenion Gmbh & Co. Kg |
Kosmetische oder pharmazeutische Zubereitungen enthaltend Nukleinsäuren, die zur Ausbildung von stem-loop-Sekundärstrukturen geeignete Sequenzen umfassen
|
|
WO2006110655A2
(en)
|
2005-04-08 |
2006-10-19 |
Chimerix, Inc. |
Compounds, compositions and methods for the treatment of poxvirus infections
|
|
PT2179737E
(pt)
|
2005-07-01 |
2013-12-05 |
Index Pharmaceuticals Ab |
Método para modular a capacidade de resposta aos esteróides
|
|
SI2380584T1
(sl)
|
2005-07-01 |
2014-04-30 |
Index Pharmaceuticals Ab |
Imunostimulatorni postopek
|
|
EP1929014B1
(en)
|
2005-08-31 |
2014-08-13 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Methods of altering an immune response induced by d-type cpg oligodeoxynucleotides
|
|
AU2006306805A1
(en)
|
2005-10-28 |
2007-05-03 |
Index Pharmaceuticals Ab |
Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
|
|
WO2007062107A2
(en)
|
2005-11-25 |
2007-05-31 |
Coley Pharmaceutical Gmbh |
Immunostimulatory oligoribonucleotides
|
|
AU2006325225B2
(en)
|
2005-12-14 |
2013-07-04 |
Cytos Biotechnology Ag |
Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
|
|
WO2007092299A2
(en)
|
2006-02-03 |
2007-08-16 |
Purdue Research Foundation |
Targeted conjugates and radiation
|
|
DK2034015T3
(da)
*
|
2006-05-31 |
2012-10-15 |
Toray Industries |
Immunstimulerende oligonucleotid og farmaceutisk anvendelse heraf
|
|
SI2032592T1
(sl)
|
2006-06-12 |
2013-10-30 |
Cytos Biotechnology Ag |
Postopki za pakiranje oligonukleotidov v virusu-podobne delce RNA bakteriofagov
|
|
JP2010500011A
(ja)
|
2006-08-08 |
2010-01-07 |
ガンサー ハートマン |
5’リン酸オリゴヌクレオチドの構造および使用
|
|
MX2009003398A
(es)
|
2006-09-27 |
2009-08-12 |
Coley Pharm Gmbh |
Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
|
|
EP2338499A1
(en)
|
2006-10-10 |
2011-06-29 |
Gunther Hartmann |
5' triphosphate oligonucleotide induces anti-viral response
|
|
EP2104738A2
(en)
*
|
2006-10-26 |
2009-09-30 |
Coley Pharmaceuticals GmbH |
Oligoribonucleotides and uses thereof
|
|
CN101611048B
(zh)
|
2006-12-12 |
2012-11-07 |
赛托斯生物技术公司 |
含有高浓度鸟嘌呤单体的寡核苷酸
|
|
BRPI0811621A2
(pt)
|
2007-05-17 |
2014-10-21 |
Coley Pharm Group Inc |
Oligonucleotídeos de classe a com potência imunoestimuladora, composição contendo os mesmos e uso da referida composição
|
|
SI2170353T1
(sl)
|
2007-05-18 |
2015-09-30 |
Adiu Tide Pharmaceuticals Gmbh |
Fosfatno modificirani oligonukleotidni analogi z imunostimulatorno aktivnostjo
|
|
DE102007044093A1
(de)
*
|
2007-09-14 |
2009-03-19 |
Phenion Gmbh & Co. Kg |
Nukleinsäurehaltige kosmetische und/oder pharmazeutische Zubereitungen zur Induktion antimikrobieller Peptide in epithelialen Deckgeweben
|
|
CN101820908A
(zh)
|
2007-10-09 |
2010-09-01 |
科利制药公司 |
包含改性糖部分的免疫刺激寡核苷酸类似物
|
|
CN105055432A
(zh)
|
2008-01-25 |
2015-11-18 |
奇默里克斯公司 |
治疗病毒感染的方法
|
|
US9738680B2
(en)
|
2008-05-21 |
2017-08-22 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5′ triphosphate oligonucleotide with blunt end and uses thereof
|
|
US9061001B2
(en)
|
2008-10-16 |
2015-06-23 |
University Of Saskatchewan |
Combination adjuvant formulation
|
|
WO2010049438A2
(en)
*
|
2008-10-30 |
2010-05-06 |
Innate Pharma |
Improved methods of using phosphoantigens for the treatment of diseases
|
|
BRPI0923225A2
(pt)
|
2008-12-02 |
2016-10-04 |
Chiralgen Ltd |
metodo para sintese de acidos nucleicos modificados no atomo de fosforo
|
|
BRPI0922561A2
(pt)
|
2008-12-09 |
2020-08-11 |
Pfizer Vaccines Llc |
vacina de peptídeo de ch3 da ige.
|
|
DK2424562T3
(en)
|
2009-04-30 |
2015-12-07 |
Coley Pharm Group Inc |
Pneumococcal vaccine and uses thereof
|
|
EP2451461A4
(en)
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
|
|
KR101660578B1
(ko)
|
2009-09-03 |
2016-09-27 |
화이자 백신스 엘엘씨 |
Pcsk9 백신
|
|
CA2789443C
(en)
|
2010-02-12 |
2016-09-13 |
Chimerix, Inc. |
Nucleoside phosphonate salts
|
|
EP2563367A4
(en)
|
2010-04-26 |
2013-12-04 |
Chimerix Inc |
Methods of treating retroviral infections and related dosage regimes
|
|
HRP20181039T1
(hr)
|
2010-05-28 |
2018-08-24 |
Zoetis Belgium S.A. |
Cjepiva koja sadrže kolesterol i cpg kao jedine molekule koje nose adjuvans
|
|
EP2575868A1
(en)
|
2010-06-07 |
2013-04-10 |
Pfizer Vaccines LLC |
Ige ch3 peptide vaccine
|
|
DK2620428T3
(da)
|
2010-09-24 |
2019-07-01 |
Wave Life Sciences Ltd |
Asymmetrisk hjælpegruppe
|
|
WO2012131504A1
(en)
|
2011-03-02 |
2012-10-04 |
Pfizer Inc. |
Pcsk9 vaccine
|
|
EP2508530A1
(en)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Purification of triphosphorylated oligonucleotides using capture tags
|
|
AU2012262021B2
(en)
|
2011-06-01 |
2016-07-28 |
Janus Biotherapeutics, Inc. |
Novel immune system modulators
|
|
BR112013030894A2
(pt)
|
2011-06-01 |
2016-08-16 |
Janus Biotherapeutics Inc |
moduladores do sistema imune
|
|
WO2013007703A1
(en)
|
2011-07-08 |
2013-01-17 |
Universität Zürich |
CLASS A CpG OLIGONUCLEOTIDES FOR PREVENTION OF VIRAL INFECTION IN CATS
|
|
CN107365339A
(zh)
|
2011-07-19 |
2017-11-21 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
CA2850932A1
(en)
|
2011-10-04 |
2013-04-11 |
Janus Biotherapeutics, Inc. |
Novel imidazole quinoline-based immune system modulators
|
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
|
DK2872147T3
(da)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
Fremgangsmåde til fremstilling af kirale oligonukleotider
|
|
SG11201500243WA
(en)
*
|
2012-07-13 |
2015-04-29 |
Shin Nippon Biomedical Lab Ltd |
Chiral nucleic acid adjuvant
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
EP3095459A4
(en)
*
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
WO2015108046A1
(ja)
*
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
EP3095461A4
(en)
*
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
|
EP3104877B1
(en)
|
2014-02-11 |
2020-01-22 |
The USA, as represented by The Secretary, Department of Health and Human Services |
Pcsk9 vaccine and methods of using the same
|
|
AU2015269412B2
(en)
|
2014-06-04 |
2020-03-12 |
Exicure Operating Company |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
|
US20170275287A1
(en)
|
2014-08-22 |
2017-09-28 |
Janus Biotherapeutics, Inc. |
Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof
|
|
US20190030153A1
(en)
|
2015-07-22 |
2019-01-31 |
University Of Saskatchewan |
Mycoplasma vaccines and uses thereof
|
|
WO2017121494A1
(en)
*
|
2016-01-15 |
2017-07-20 |
Riboxx Gmbh |
5'-triphosphated short immunostimulatory nucleotides, oligonucleotides and polynucleotides
|
|
CA3023451A1
(en)
|
2016-05-06 |
2017-11-09 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs presenting antisense oligonucleotides (aso) for specific knockdown of interleukin 17 receptor mrna
|
|
WO2017201390A1
(en)
|
2016-05-19 |
2017-11-23 |
The Regents Of The University Of Michigan |
Novel adjuvant compositions
|
|
US11013757B2
(en)
|
2016-06-03 |
2021-05-25 |
Wave Life Sciences Ltd. |
Oligonucleotides, compositions and methods thereof
|
|
CN108567977B
(zh)
*
|
2017-03-13 |
2022-04-12 |
复旦大学 |
一种免疫增强剂、免疫治疗药物组合物及其制备与用途
|
|
WO2018201090A1
(en)
|
2017-04-28 |
2018-11-01 |
Exicure, Inc. |
Synthesis of spherical nucleic acids using lipophilic moieties
|
|
PL3700564T3
(pl)
*
|
2017-12-15 |
2026-02-23 |
Elanco Animal Health Gmbh |
Kompozycje immunostymulujące
|
|
US11633471B2
(en)
|
2018-03-06 |
2023-04-25 |
Unm Rainforest Innovations |
Compositions and methods for reducing serum triglycerides
|
|
US20210261964A1
(en)
*
|
2018-07-19 |
2021-08-26 |
The Research Foundation For Microbial Diseases Of Osaka University |
LIPID PARTICLE CONTAINING A-TYPE CpG OLIGODEOXYNUCLEOTIDE
|
|
EP4138894A4
(en)
|
2020-04-20 |
2024-06-26 |
The University of Saskatchewan |
COMPOSITIONS AND METHODS FOR THE PREVENTION, CONTROL AND DIAGNOSIS OF MYCOBACTERIAL INFECTIONS
|
|
EP3909612A1
(en)
|
2020-05-12 |
2021-11-17 |
Life Science Inkubator Betriebs GmbH & Co. KG |
Composition of nanoparticles
|
|
CN116064554A
(zh)
*
|
2022-08-09 |
2023-05-05 |
常州市第三人民医院 |
一种具有免疫调节功能的核酸序列、应用及抗病毒药物
|