JP2005532315A5 - - Google Patents
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- Publication number
- JP2005532315A5 JP2005532315A5 JP2004503046A JP2004503046A JP2005532315A5 JP 2005532315 A5 JP2005532315 A5 JP 2005532315A5 JP 2004503046 A JP2004503046 A JP 2004503046A JP 2004503046 A JP2004503046 A JP 2004503046A JP 2005532315 A5 JP2005532315 A5 JP 2005532315A5
- Authority
- JP
- Japan
- Prior art keywords
- methylated
- formulation
- nucleic acid
- antigen
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 22
- 108091034117 Oligonucleotide Proteins 0.000 claims 20
- 210000004443 dendritic cell Anatomy 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 229960005486 vaccine Drugs 0.000 claims 15
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 14
- 239000002671 adjuvant Substances 0.000 claims 12
- 230000004936 stimulating effect Effects 0.000 claims 11
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108091029430 CpG site Proteins 0.000 claims 9
- 238000001727 in vivo Methods 0.000 claims 9
- 239000003550 marker Substances 0.000 claims 9
- 102100022297 Integrin alpha-X Human genes 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 150000002632 lipids Chemical class 0.000 claims 7
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 230000007503 antigenic stimulation Effects 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- -1 cationic lipid Chemical class 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 230000004044 response Effects 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical group [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37934302P | 2002-05-10 | 2002-05-10 | |
| US10/290,545 US20030125292A1 (en) | 2001-11-07 | 2002-11-07 | Mucoscal vaccine and methods for using the same |
| US46064603P | 2003-04-04 | 2003-04-04 | |
| PCT/CA2003/000678 WO2003094963A2 (en) | 2002-05-10 | 2003-05-12 | Methylated immunostimulatory oligonucleotides and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532315A JP2005532315A (ja) | 2005-10-27 |
| JP2005532315A5 true JP2005532315A5 (enExample) | 2006-06-29 |
Family
ID=29424457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004503046A Pending JP2005532315A (ja) | 2002-05-10 | 2003-05-12 | メチル化免疫刺激性オリゴヌクレオチド及びその使用方法 |
| JP2004502917A Pending JP2005530761A (ja) | 2002-05-10 | 2003-05-12 | 癌ワクチン及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004502917A Pending JP2005530761A (ja) | 2002-05-10 | 2003-05-12 | 癌ワクチン及びその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1503793A2 (enExample) |
| JP (2) | JP2005532315A (enExample) |
| CN (1) | CN1665531A (enExample) |
| AT (1) | ATE411815T1 (enExample) |
| AU (2) | AU2003229434A1 (enExample) |
| CA (2) | CA2484266A1 (enExample) |
| DE (1) | DE60324270D1 (enExample) |
| IL (1) | IL165107A0 (enExample) |
| MX (1) | MXPA04011127A (enExample) |
| WO (2) | WO2003094828A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ATE335510T1 (de) | 1998-05-22 | 2006-09-15 | Ottawa Health Research Inst | Methoden und produkte zur induzierung mukosaler immunität |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7576066B2 (en) | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| MXPA05004588A (es) | 2002-10-29 | 2005-12-14 | Coley Pharmaceutical Group Ltd | Metodos y productos relacionados con el tratamiento y prevencion de infeccion de virus de hepatitis c. |
| AU2004275876B2 (en) | 2003-09-25 | 2011-03-31 | Coley Pharmaceutical Gmbh | Nucleic acid-lipophilic conjugates |
| MX2009003398A (es) | 2006-09-27 | 2009-08-12 | Coley Pharm Gmbh | Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada. |
| JP2012507565A (ja) | 2008-10-30 | 2012-03-29 | グオ・ペイシュエン | Ｄｎａのシークエンシング及び他の用途のための、膜に組み込まれたウイルスｄｎａパッケージングモータタンパク質コネクタバイオセンサ |
| WO2011037262A1 (ja) * | 2009-09-28 | 2011-03-31 | シスメックス株式会社 | 抗メチル化ｄｎａ抗体を産生するハイブリドーマおよびその利用 |
| CN109985234A (zh) * | 2019-04-12 | 2019-07-09 | 南华大学 | 一种梅毒螺旋体dna疫苗及其应用 |
| AU2021307553A1 (en) * | 2020-07-14 | 2023-02-16 | Evaxion Biotech A/S | APC targeting units for immunotherapy |
| CN116602920B (zh) * | 2023-04-18 | 2024-03-19 | 中国科学技术大学 | 一种透皮肽修饰、含有Ce6和CpG的脂质体及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0772619B2 (en) * | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| FI107974B (fi) * | 1999-07-14 | 2001-10-31 | Nokia Networks Oy | Menetelmä ja järjestelmä tilastointiin puhelinkeskusjärjestelmässä |
| MXPA02002107A (es) * | 1999-08-27 | 2003-08-20 | Inex Pharmaceuticals Corp | Composiciones para estimular la secrecion de citoquina e inducir una respuesta inmune. |
| US20030119774A1 (en) * | 2001-09-25 | 2003-06-26 | Marianna Foldvari | Compositions and methods for stimulating an immune response |
| AU2002340662B2 (en) * | 2001-11-07 | 2008-07-03 | Tekmira Pharmaceuticals Corporation | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
-
2003
- 2003-05-12 CN CN038162296A patent/CN1665531A/zh active Pending
- 2003-05-12 CA CA002484266A patent/CA2484266A1/en not_active Abandoned
- 2003-05-12 MX MXPA04011127A patent/MXPA04011127A/es active IP Right Grant
- 2003-05-12 JP JP2004503046A patent/JP2005532315A/ja active Pending
- 2003-05-12 CA CA002485400A patent/CA2485400A1/en not_active Abandoned
- 2003-05-12 WO PCT/CA2003/000679 patent/WO2003094828A2/en not_active Ceased
- 2003-05-12 EP EP03722134A patent/EP1503793A2/en not_active Withdrawn
- 2003-05-12 JP JP2004502917A patent/JP2005530761A/ja active Pending
- 2003-05-12 AU AU2003229434A patent/AU2003229434A1/en not_active Abandoned
- 2003-05-12 DE DE60324270T patent/DE60324270D1/de not_active Expired - Fee Related
- 2003-05-12 AT AT03722133T patent/ATE411815T1/de not_active IP Right Cessation
- 2003-05-12 AU AU2003229433A patent/AU2003229433B2/en not_active Ceased
- 2003-05-12 WO PCT/CA2003/000678 patent/WO2003094963A2/en not_active Ceased
- 2003-05-12 EP EP03722133A patent/EP1506010B1/en not_active Expired - Lifetime
-
2004
- 2004-11-09 IL IL16510704A patent/IL165107A0/xx unknown
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