JP2003503072A5 - - Google Patents
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- Publication number
- JP2003503072A5 JP2003503072A5 JP2001507069A JP2001507069A JP2003503072A5 JP 2003503072 A5 JP2003503072 A5 JP 2003503072A5 JP 2001507069 A JP2001507069 A JP 2001507069A JP 2001507069 A JP2001507069 A JP 2001507069A JP 2003503072 A5 JP2003503072 A5 JP 2003503072A5
- Authority
- JP
- Japan
- Prior art keywords
- memapsin
- protein
- seq
- composition
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710150192 Beta-secretase 1 Proteins 0.000 description 30
- 102100021257 Beta-secretase 1 Human genes 0.000 description 30
- 239000000203 mixture Substances 0.000 description 13
- 125000000539 amino acid group Chemical group 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 5
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000012062 aqueous buffer Substances 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010053070 Glutathione Disulfide Proteins 0.000 description 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 102000044297 human BACE1 Human genes 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14136399P | 1999-06-28 | 1999-06-28 | |
| US60/141,363 | 1999-06-28 | ||
| US16806099P | 1999-11-30 | 1999-11-30 | |
| US60/168,060 | 1999-11-30 | ||
| US17783600P | 2000-01-25 | 2000-01-25 | |
| US60/177,836 | 2000-01-25 | ||
| US17836800P | 2000-01-27 | 2000-01-27 | |
| US60/178,368 | 2000-01-27 | ||
| US21029200P | 2000-06-08 | 2000-06-08 | |
| US60/210,292 | 2000-06-08 | ||
| PCT/US2000/017661 WO2001000663A2 (en) | 1999-06-28 | 2000-06-27 | Catalytically active recombinant memapsin and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503072A JP2003503072A (ja) | 2003-01-28 |
| JP2003503072A5 true JP2003503072A5 (enExample) | 2007-09-13 |
| JP5138851B2 JP5138851B2 (ja) | 2013-02-06 |
Family
ID=27538142
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001507069A Expired - Fee Related JP5138851B2 (ja) | 1999-06-28 | 2000-06-27 | 触媒的に活性な組換えメマプシンおよびその使用方法 |
| JP2001507071A Expired - Fee Related JP4484410B2 (ja) | 1999-06-28 | 2000-06-27 | メマプシン２のインヒビターおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001507071A Expired - Fee Related JP4484410B2 (ja) | 1999-06-28 | 2000-06-27 | メマプシン２のインヒビターおよびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US6545127B1 (enExample) |
| EP (2) | EP1196609A2 (enExample) |
| JP (2) | JP5138851B2 (enExample) |
| CN (1) | CN1379819A (enExample) |
| AT (1) | ATE482233T1 (enExample) |
| AU (2) | AU5771500A (enExample) |
| CA (2) | CA2374346C (enExample) |
| DE (1) | DE60045005D1 (enExample) |
| WO (2) | WO2001000665A2 (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9701684D0 (en) | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
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| CN1198936C (zh) | 1998-09-24 | 2005-04-27 | 法玛西雅厄普约翰美国公司 | 阿尔茨海默氏疾病分泌酶 |
| US6844148B1 (en) | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
| US7115410B1 (en) | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| US7456007B1 (en) | 1998-12-31 | 2008-11-25 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| CN1390232A (zh) | 1999-02-10 | 2003-01-08 | 艾兰制药公司 | 人β分泌酶、抑制剂、其组合物和用途 |
| EP1196609A2 (en) | 1999-06-28 | 2002-04-17 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
| US20090162883A1 (en) * | 1999-09-23 | 2009-06-25 | Pharmacia & Upjohn Company | Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof |
| GB9924957D0 (en) * | 1999-10-21 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
| GB9925136D0 (en) * | 1999-10-22 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
| US7514408B1 (en) | 1999-12-02 | 2009-04-07 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| AU779875B2 (en) * | 2000-01-24 | 2005-02-17 | Merck Sharp & Dohme Limited | Gamma-secretase inhibitors |
| DK1255769T3 (da) | 2000-01-25 | 2007-09-03 | Oklahoma Med Res Found | Universel procedure til genfoldning af rekombinante proteiner |
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| US7601528B1 (en) * | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
| US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
| EP1233021A3 (en) * | 2001-02-20 | 2002-11-20 | Pfizer Products Inc. | An inhibitor of Beta amyloid cleavage enzyme |
| NZ527422A (en) * | 2001-02-23 | 2005-02-25 | Dsm Ip Assets B | Tripeptidyl aminopeptidases from Aspergillus niger |
| US7384773B1 (en) | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
| US7524668B1 (en) | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
| US7196163B2 (en) | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
| IL159015A0 (en) | 2001-05-25 | 2004-05-12 | Genset Sa | Polypeptides, their preparation and use |
| US7361688B2 (en) * | 2001-06-11 | 2008-04-22 | Elan Pharmaceuticals, Inc. | Substituted aminoalcohols useful in treatment of Alzheimer's disease |
| MXPA04000140A (es) | 2001-06-27 | 2004-06-03 | Elan Pharm Inc | Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer. |
| JP2005503144A (ja) * | 2001-07-26 | 2005-02-03 | アステック テクノロジー リミテッド | 新規ｂａｃｅタンパク質、その核酸分子、新規ｂａｃｅタンパク質の新規結晶構造、並びに製造及び使用方法 |
| US7186539B1 (en) | 2001-08-31 | 2007-03-06 | Pharmacia & Upjohn Company | Method for refolding enzymes |
| EP1448218A4 (en) | 2001-10-23 | 2009-01-14 | Oklahoma Med Res Found | BETA SECRETASE INHIBITORS AND METHODS OF USE |
| US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
| AU2002351009A1 (en) * | 2001-11-06 | 2003-05-19 | Decode Genetics Ehf. | Nucleic acids encoding proteases |
| CH698246B1 (de) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test zur Identifizierung von Inhibitoren von Beta-Sekretasen. |
| AU2003213252A1 (en) | 2002-02-21 | 2003-09-09 | Pharmacia And Upjohn Company | Modified bace |
| WO2003074046A1 (en) | 2002-03-01 | 2003-09-12 | Takeda Chemical Industries, Ltd. | Antidepressant |
| US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
| US7205336B2 (en) | 2002-05-17 | 2007-04-17 | Merck & Co., Inc. | β-secretase inhibitors |
| US7166454B1 (en) | 2002-05-24 | 2007-01-23 | Schering Corporation | Codon-optimized β-secretase and methods of refolding and processing |
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| US20040096950A1 (en) * | 2002-07-26 | 2004-05-20 | Vuillard Laurent Michel Marie | Crystal structure of beta site APP cleaving enzyme (BACE) and methods of use thereof |
| US20050074456A1 (en) * | 2002-12-04 | 2005-04-07 | Marcus Ballinger | Constructs for homogenously processed preparations of beta site APP-cleaving enzyme |
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| FR2860796B1 (fr) * | 2003-10-14 | 2006-02-10 | Centre Nat Rech Scient | Procede de dissociation de la molecule d'hemoglobine extracellulaire d'arenicola marina, chaines proteiques constituant ladite molecule et sequences nucleotidiques codant pour lesdites chaines proteiques |
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| EP1923388A4 (en) | 2005-08-12 | 2011-03-09 | Takeda Pharmaceutical | BRAIN / NEURONAL CELL PROTECTIVE AGENT AND THERAPEUTIC AGENT FOR SLEEP DISORDERS |
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| JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
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-
2000
- 2000-06-27 EP EP00943208A patent/EP1196609A2/en not_active Withdrawn
- 2000-06-27 WO PCT/US2000/017742 patent/WO2001000665A2/en not_active Ceased
- 2000-06-27 US US09/604,608 patent/US6545127B1/en not_active Expired - Lifetime
- 2000-06-27 EP EP00943236A patent/EP1194449B1/en not_active Expired - Lifetime
- 2000-06-27 AT AT00943236T patent/ATE482233T1/de not_active IP Right Cessation
- 2000-06-27 CN CN00810930A patent/CN1379819A/zh active Pending
- 2000-06-27 DE DE60045005T patent/DE60045005D1/de not_active Expired - Lifetime
- 2000-06-27 WO PCT/US2000/017661 patent/WO2001000663A2/en not_active Ceased
- 2000-06-27 JP JP2001507069A patent/JP5138851B2/ja not_active Expired - Fee Related
- 2000-06-27 JP JP2001507071A patent/JP4484410B2/ja not_active Expired - Fee Related
- 2000-06-27 AU AU57715/00A patent/AU5771500A/en not_active Abandoned
- 2000-06-27 CA CA2374346A patent/CA2374346C/en not_active Expired - Fee Related
- 2000-06-27 CA CA002374610A patent/CA2374610A1/en not_active Abandoned
- 2000-06-27 AU AU57735/00A patent/AU5773500A/en not_active Abandoned
-
2001
- 2001-02-28 US US09/795,903 patent/US20020164760A1/en not_active Abandoned
- 2001-04-30 US US09/845,226 patent/US20020115600A1/en not_active Abandoned
-
2004
- 2004-02-06 US US10/773,754 patent/US20040220079A1/en not_active Abandoned
- 2004-04-08 US US10/820,953 patent/US7244708B2/en not_active Expired - Fee Related
-
2007
- 2007-06-14 US US11/763,342 patent/US7678760B2/en not_active Expired - Fee Related
- 2007-08-03 US US11/888,920 patent/US7829669B2/en not_active Expired - Fee Related
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