DE60045005D1 - Inhibitoren des memapsin 2 und ihre verwendung - Google Patents
Inhibitoren des memapsin 2 und ihre verwendungInfo
- Publication number
- DE60045005D1 DE60045005D1 DE60045005T DE60045005T DE60045005D1 DE 60045005 D1 DE60045005 D1 DE 60045005D1 DE 60045005 T DE60045005 T DE 60045005T DE 60045005 T DE60045005 T DE 60045005T DE 60045005 D1 DE60045005 D1 DE 60045005D1
- Authority
- DE
- Germany
- Prior art keywords
- memapsin
- substrate
- ala
- bond
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100021257 Beta-secretase 1 Human genes 0.000 title abstract 9
- 101710150192 Beta-secretase 1 Proteins 0.000 title abstract 8
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 239000000758 substrate Substances 0.000 abstract 9
- NIOCOJFPGCXNKL-ZKZXETMPSA-N (4s)-4-amino-5-[[(2s)-1-[[(2s)-4-amino-1-[[(4s,5s,7r)-8-[[(2s)-1-[[(2s)-4-carboxy-1-[[(1s)-1-carboxy-2-phenylethyl]amino]-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-ox Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 NIOCOJFPGCXNKL-ZKZXETMPSA-N 0.000 abstract 4
- 108010011140 OM99-2 Proteins 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002050 diffraction method Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14136399P | 1999-06-28 | 1999-06-28 | |
US16806099P | 1999-11-30 | 1999-11-30 | |
US17783600P | 2000-01-25 | 2000-01-25 | |
US17836800P | 2000-01-27 | 2000-01-27 | |
US21029200P | 2000-06-08 | 2000-06-08 | |
PCT/US2000/017742 WO2001000665A2 (en) | 1999-06-28 | 2000-06-27 | Inhibitors of memapsin 2 and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60045005D1 true DE60045005D1 (de) | 2010-11-04 |
Family
ID=27538142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60045005T Expired - Lifetime DE60045005D1 (de) | 1999-06-28 | 2000-06-27 | Inhibitoren des memapsin 2 und ihre verwendung |
Country Status (9)
Country | Link |
---|---|
US (7) | US6545127B1 (de) |
EP (2) | EP1194449B1 (de) |
JP (2) | JP4484410B2 (de) |
CN (1) | CN1379819A (de) |
AT (1) | ATE482233T1 (de) |
AU (2) | AU5771500A (de) |
CA (2) | CA2374346C (de) |
DE (1) | DE60045005D1 (de) |
WO (2) | WO2001000665A2 (de) |
Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9701684D0 (en) | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
NZ527053A (en) | 1998-09-24 | 2005-04-29 | Upjohn Co | Modified amyloid precursor protein polynucleotides and polypeptides |
US20040234976A1 (en) * | 1998-09-24 | 2004-11-25 | Gurney Mark E. | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
US6844148B1 (en) | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
US6699671B1 (en) | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
US7115410B1 (en) | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
US7456007B1 (en) | 1998-12-31 | 2008-11-25 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
NZ534876A (en) | 1999-02-10 | 2006-02-24 | Elan Pharm Inc | Human beta-secretase enzyme, inhibitors and their compositions and uses |
AU5771500A (en) * | 1999-06-28 | 2001-01-31 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
US20090162883A1 (en) * | 1999-09-23 | 2009-06-25 | Pharmacia & Upjohn Company | Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof |
GB9924957D0 (en) * | 1999-10-21 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
GB9925136D0 (en) * | 1999-10-22 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
US7514408B1 (en) | 1999-12-02 | 2009-04-07 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
CA2397543A1 (en) * | 2000-01-24 | 2001-07-26 | Timothy Harrison | Gamma-secretase inhibitors |
EP1255769B1 (de) * | 2000-01-25 | 2007-05-02 | Oklahoma Medical Research Foundation | Allgemeines verfahren zur rückfaltung rekombinanter proteine |
EP1265849B1 (de) | 2000-03-23 | 2006-10-25 | Elan Pharmaceuticals, Inc. | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
EP1666452A2 (de) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Verbindungen zur Behandlung der Alzheimerischen Krankheit |
WO2002006306A2 (en) * | 2000-07-19 | 2002-01-24 | Pharmacia & Upjohn Company | SUBSTRATES AND ASSAYS FOR β-SECRETASE ACTIVITY |
EP1327143B1 (de) * | 2000-09-22 | 2007-02-28 | Wyeth | Kristallstruktur von bace und verwendungen dafür |
US7601528B1 (en) | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
US7806980B2 (en) * | 2000-12-23 | 2010-10-05 | Elan Pharmaceuticals, Inc. | Method for crystallizing human beta secretase in complex with an inhibitor |
US7217556B1 (en) | 2000-12-23 | 2007-05-15 | Pfizer Inc | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease |
US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
EP1233021A3 (de) * | 2001-02-20 | 2002-11-20 | Pfizer Products Inc. | Inhibitor des Beta-amyloid spaltenden Enzyms |
EP2316276A3 (de) * | 2001-02-23 | 2011-08-03 | DSM IP Assets B.V. | Genes qui codant pour l'enzymes proteolytiques derivees de aspargilli |
US7524668B1 (en) * | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
US7384773B1 (en) | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
US7196163B2 (en) | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
WO2002094864A2 (en) | 2001-05-25 | 2002-11-28 | Genset S.A. | Human cdnas and proteins and uses thereof |
US7361688B2 (en) * | 2001-06-11 | 2008-04-22 | Elan Pharmaceuticals, Inc. | Substituted aminoalcohols useful in treatment of Alzheimer's disease |
JP2005503144A (ja) * | 2001-07-26 | 2005-02-03 | アステック テクノロジー リミテッド | 新規baceタンパク質、その核酸分子、新規baceタンパク質の新規結晶構造、並びに製造及び使用方法 |
US7186539B1 (en) | 2001-08-31 | 2007-03-06 | Pharmacia & Upjohn Company | Method for refolding enzymes |
JP4547152B2 (ja) * | 2001-10-23 | 2010-09-22 | オクラホマ メディカル リサーチ ファウンデーション | β−セクレターゼ阻害剤および使用方法 |
US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
WO2003040393A2 (en) * | 2001-11-06 | 2003-05-15 | Decode Genetics Ehf. | Nucleic acids encoding proteases |
CH698246B1 (de) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test zur Identifizierung von Inhibitoren von Beta-Sekretasen. |
JP4272070B2 (ja) | 2002-02-21 | 2009-06-03 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 修飾bace |
WO2003074046A1 (fr) | 2002-03-01 | 2003-09-12 | Takeda Chemical Industries, Ltd. | Antidepresseur |
US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
AU2003230392A1 (en) | 2002-05-17 | 2003-12-12 | Merck And Co., Inc. | Beta-secretase inhibitors |
US7166454B1 (en) | 2002-05-24 | 2007-01-23 | Schering Corporation | Codon-optimized β-secretase and methods of refolding and processing |
US6746303B2 (en) | 2002-05-31 | 2004-06-08 | Mattel, Inc. | Flexible toy figure with wire armature |
AU2003251344A1 (en) * | 2002-07-26 | 2004-02-16 | Astex Technology Limited | Crystal structure of beta-site app-cleaving enzyme (bace) mutants and uses thereof |
US20050074456A1 (en) * | 2002-12-04 | 2005-04-07 | Marcus Ballinger | Constructs for homogenously processed preparations of beta site APP-cleaving enzyme |
US7371853B2 (en) | 2003-01-07 | 2008-05-13 | Merck & Co., Inc. | Macrocyclic β-secretase inhibitors for the treatment of Alzheimer's disease |
JP4739192B2 (ja) | 2003-05-02 | 2011-08-03 | イーラン ファーマスーティカルズ、インコーポレイテッド | Baceのグリコシル化変異体 |
AU2004255183A1 (en) | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
AU2004255191A1 (en) | 2003-07-01 | 2005-01-20 | Merck & Co., Inc. | Phenylcarboxylate beta-secretase inhibitors for the treatment of Alzheimer's disease |
AU2004277981B2 (en) | 2003-10-03 | 2009-10-01 | Merck & Co., Inc. | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease |
FR2860796B1 (fr) * | 2003-10-14 | 2006-02-10 | Centre Nat Rech Scient | Procede de dissociation de la molecule d'hemoglobine extracellulaire d'arenicola marina, chaines proteiques constituant ladite molecule et sequences nucleotidiques codant pour lesdites chaines proteiques |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US20060019368A1 (en) * | 2004-07-20 | 2006-01-26 | Marcus Ballinger | Constructs for homogenously processed preparations of beta site APP-cleaving enzyme |
EP1841455A1 (de) * | 2005-01-24 | 2007-10-10 | Amgen Inc. | Humanisierter anti-amyloid-antikörper |
CA2600570C (en) * | 2005-03-14 | 2011-12-06 | Transtech Pharma, Inc. | Benzazole derivatives, compositions, and methods of use as .beta.-secretase inhibitors |
JP2008534541A (ja) | 2005-03-30 | 2008-08-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換1,2−エチレンジアミン、前記化合物を含む薬物、それらの使用及びそれらの製造方法 |
WO2007021886A2 (en) * | 2005-08-10 | 2007-02-22 | Oklahoma Medical Research Foundation | Truncated memapsin 2 for use for treating alzheimer's disease |
EP1923388A4 (de) | 2005-08-12 | 2011-03-09 | Takeda Pharmaceutical | Gehirn-/nervenzellenschutzmittel und therapeutikum für schlafstörungen |
US7816387B2 (en) | 2005-09-05 | 2010-10-19 | Dainippon Sumitomo Pharma Co., Ltd. | β secretase inhibitor |
WO2007081534A2 (en) * | 2005-12-22 | 2007-07-19 | Pfizer Products Inc | Method of producing catalytically active bace2 enzymes |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
EP2168947A4 (de) | 2007-06-22 | 2010-07-28 | Yoshiaki Kiso | Neuartige verbindung mit sekretasehemmender wirkung |
CA2687750C (en) | 2007-07-06 | 2016-10-18 | Boehringer Ingelheim International Gmbh | Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture |
MX2010002938A (es) * | 2007-09-24 | 2010-04-01 | Comentis Inc | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
US8414893B2 (en) | 2007-12-21 | 2013-04-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
US7989597B2 (en) | 2008-06-20 | 2011-08-02 | Oklahoma Medical Research Foundation | Immunogenic memapsin 2 β-secretase peptides and methods of use |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
EP2281824A1 (de) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-Imidazolon-Derivate zur Behandlung von kognitiven, neurodegenerativen oder neuronalen Erkrankungen oder Funktionsstörungen |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
JP6163429B2 (ja) | 2010-11-10 | 2017-07-12 | ジェネンテック, インコーポレイテッド | 神経疾患免疫治療のための方法及び組成物 |
EP2643299B1 (de) | 2010-11-22 | 2016-06-22 | Noscira, S.A. | Bipyridinsulfonamidderivate zur behandlung von neurodegenerativen erkrankungen oder zuständen |
SG2014010417A (en) | 2011-10-07 | 2014-06-27 | Takeda Pharmaceutical | 1 - arylcarbonyl - 4 - oxy - piperidine compounds useful for the treatment of neurodegenerative diseases |
CN104394862A (zh) | 2012-05-30 | 2015-03-04 | 科门蒂斯公司 | 色满化合物 |
JP6249952B2 (ja) | 2012-10-16 | 2017-12-20 | 武田薬品工業株式会社 | 複素環化合物 |
EA029056B1 (ru) | 2012-12-11 | 2018-02-28 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение |
JP6272833B2 (ja) | 2013-04-04 | 2018-01-31 | 武田薬品工業株式会社 | 複素環化合物 |
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2000
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- 2000-06-27 CN CN00810930A patent/CN1379819A/zh active Pending
- 2000-06-27 JP JP2001507071A patent/JP4484410B2/ja not_active Expired - Fee Related
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- 2000-06-27 EP EP00943208A patent/EP1196609A2/de not_active Withdrawn
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WO2001000663A2 (en) | 2001-01-04 |
CA2374610A1 (en) | 2001-01-04 |
EP1196609A2 (de) | 2002-04-17 |
JP4484410B2 (ja) | 2010-06-16 |
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US20040220079A1 (en) | 2004-11-04 |
WO2001000663A3 (en) | 2001-10-04 |
US7829669B2 (en) | 2010-11-09 |
CN1379819A (zh) | 2002-11-13 |
US20020115600A1 (en) | 2002-08-22 |
AU5773500A (en) | 2001-01-31 |
US7244708B2 (en) | 2007-07-17 |
WO2001000665A9 (en) | 2002-07-25 |
JP2003506322A (ja) | 2003-02-18 |
WO2001000665A3 (en) | 2001-09-27 |
CA2374346C (en) | 2010-06-22 |
EP1194449A2 (de) | 2002-04-10 |
US20020164760A1 (en) | 2002-11-07 |
US6545127B1 (en) | 2003-04-08 |
US20080112946A1 (en) | 2008-05-15 |
EP1194449B1 (de) | 2010-09-22 |
ATE482233T1 (de) | 2010-10-15 |
WO2001000665A2 (en) | 2001-01-04 |
AU5771500A (en) | 2001-01-31 |
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