IL139739A0 - Polypeptides with beta-secretase type activity - Google Patents

Polypeptides with beta-secretase type activity

Info

Publication number
IL139739A0
IL139739A0 IL13973999A IL13973999A IL139739A0 IL 139739 A0 IL139739 A0 IL 139739A0 IL 13973999 A IL13973999 A IL 13973999A IL 13973999 A IL13973999 A IL 13973999A IL 139739 A0 IL139739 A0 IL 139739A0
Authority
IL
Israel
Prior art keywords
polypeptides
beta
type activity
secretase
secretase type
Prior art date
Application number
IL13973999A
Original Assignee
Aventis Pharma Sa
Univ Paris Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9807068A external-priority patent/FR2779444A1/en
Application filed by Aventis Pharma Sa, Univ Paris Curie filed Critical Aventis Pharma Sa
Publication of IL139739A0 publication Critical patent/IL139739A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL13973999A 1998-06-05 1999-06-04 Polypeptides with beta-secretase type activity IL139739A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9807068A FR2779444A1 (en) 1998-06-05 1998-06-05 Polypeptide with beta-secretase activity, specific for wild-type amyloid precursor protein, useful in treating Alzheimer's disease
US12259999P 1999-03-03 1999-03-03
PCT/FR1999/001326 WO1999064587A1 (en) 1998-06-05 1999-06-04 Polypeptides with beta-secretase type activity

Publications (1)

Publication Number Publication Date
IL139739A0 true IL139739A0 (en) 2002-02-10

Family

ID=26234362

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13973999A IL139739A0 (en) 1998-06-05 1999-06-04 Polypeptides with beta-secretase type activity

Country Status (7)

Country Link
EP (1) EP1084240A1 (en)
KR (1) KR20010052499A (en)
AU (1) AU4045599A (en)
CA (1) CA2330242A1 (en)
HU (1) HUP0104022A2 (en)
IL (1) IL139739A0 (en)
WO (1) WO1999064587A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699671B1 (en) 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
CA2343004A1 (en) 1998-09-24 2000-03-30 Pharmacia & Upjohn Company Alzheimer's disease secretase
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
EP1165609A2 (en) 1999-02-10 2002-01-02 Elan Pharmaceuticals, Inc. Human beta-secretase enzyme, inhibitors and their compositions and uses
WO2000058479A1 (en) 1999-03-26 2000-10-05 Amgen Inc. Beta secretase genes and polypeptides
WO2001000665A2 (en) 1999-06-28 2001-01-04 Oklahoma Medical Research Foundation Inhibitors of memapsin 2 and use thereof
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
EP1301604B1 (en) * 2000-07-19 2008-05-28 Pharmacia & Upjohn Company LLC Substrates and assays for beta-secretase activity
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US7196163B2 (en) 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
AU2002359301B2 (en) 2001-10-23 2008-07-03 Comentis, Inc. Beta-secretase inhibitors and methods of use
CA2641588C (en) 2006-02-07 2014-06-17 Shire Human Genetic Therapies, Inc. Stabilized compositions of proteins having a free thiol moiety
EP2459212B1 (en) 2009-07-28 2018-03-14 Shire Human Genetic Therapies, Inc. Compositions and methods for treating gaucher disease
US9453847B2 (en) 2010-07-19 2016-09-27 Shire Human Genetic Therapies, Inc. Mannose receptor C type 1 (MRC1) codon optimized cell line and uses thereof
SG195304A1 (en) 2011-06-10 2013-12-30 Temasek Life Sciences Lab Ltd Genetic manipulation and expression systems for pucciniomycotina and ustilaginomycotina subphyla
AU2013225816B2 (en) 2012-03-02 2017-10-26 Takeda Pharmaceutical Company Limited Compositions and methods for treating Type III Gaucher Disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT62312A (en) * 1990-03-05 1993-04-28 Cephalon Inc Process for producing chymotrypsin-like proteases and their inhibitors
EP0546084A4 (en) * 1990-08-17 1994-10-19 Univ Boston Proteases causing abnormal degradation of amyloid -g(b)-protein precursor
US5292652A (en) * 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
AU679675B2 (en) * 1992-05-11 1997-07-10 Bayer Corporation Methods for detecting beta amyloid precursor protein processing enzymes
IL105793A0 (en) * 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
WO1996040885A2 (en) * 1995-06-07 1996-12-19 Athena Neurosciences, Inc. β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION

Also Published As

Publication number Publication date
EP1084240A1 (en) 2001-03-21
KR20010052499A (en) 2001-06-25
AU4045599A (en) 1999-12-30
WO1999064587A1 (en) 1999-12-16
CA2330242A1 (en) 1999-12-16
WO1999064587A8 (en) 2001-08-02
HUP0104022A2 (en) 2002-03-28

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