IL139739A0 - Polypeptides with beta-secretase type activity - Google Patents
Polypeptides with beta-secretase type activityInfo
- Publication number
- IL139739A0 IL139739A0 IL13973999A IL13973999A IL139739A0 IL 139739 A0 IL139739 A0 IL 139739A0 IL 13973999 A IL13973999 A IL 13973999A IL 13973999 A IL13973999 A IL 13973999A IL 139739 A0 IL139739 A0 IL 139739A0
- Authority
- IL
- Israel
- Prior art keywords
- polypeptides
- beta
- type activity
- secretase
- secretase type
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9807068A FR2779444A1 (en) | 1998-06-05 | 1998-06-05 | Polypeptide with beta-secretase activity, specific for wild-type amyloid precursor protein, useful in treating Alzheimer's disease |
US12259999P | 1999-03-03 | 1999-03-03 | |
PCT/FR1999/001326 WO1999064587A1 (en) | 1998-06-05 | 1999-06-04 | Polypeptides with beta-secretase type activity |
Publications (1)
Publication Number | Publication Date |
---|---|
IL139739A0 true IL139739A0 (en) | 2002-02-10 |
Family
ID=26234362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13973999A IL139739A0 (en) | 1998-06-05 | 1999-06-04 | Polypeptides with beta-secretase type activity |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1084240A1 (en) |
KR (1) | KR20010052499A (en) |
AU (1) | AU4045599A (en) |
CA (1) | CA2330242A1 (en) |
HU (1) | HUP0104022A2 (en) |
IL (1) | IL139739A0 (en) |
WO (1) | WO1999064587A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6699671B1 (en) | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
US6844148B1 (en) | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
CA2343004A1 (en) | 1998-09-24 | 2000-03-30 | Pharmacia & Upjohn Company | Alzheimer's disease secretase |
US7456007B1 (en) | 1998-12-31 | 2008-11-25 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
US7115410B1 (en) | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
EP1165609A2 (en) | 1999-02-10 | 2002-01-02 | Elan Pharmaceuticals, Inc. | Human beta-secretase enzyme, inhibitors and their compositions and uses |
WO2000058479A1 (en) | 1999-03-26 | 2000-10-05 | Amgen Inc. | Beta secretase genes and polypeptides |
WO2001000665A2 (en) | 1999-06-28 | 2001-01-04 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
US7514408B1 (en) | 1999-12-02 | 2009-04-07 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
EP1301604B1 (en) * | 2000-07-19 | 2008-05-28 | Pharmacia & Upjohn Company LLC | Substrates and assays for beta-secretase activity |
US7138262B1 (en) * | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
US7196163B2 (en) | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
AU2002359301B2 (en) | 2001-10-23 | 2008-07-03 | Comentis, Inc. | Beta-secretase inhibitors and methods of use |
CA2641588C (en) | 2006-02-07 | 2014-06-17 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
EP2459212B1 (en) | 2009-07-28 | 2018-03-14 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating gaucher disease |
US9453847B2 (en) | 2010-07-19 | 2016-09-27 | Shire Human Genetic Therapies, Inc. | Mannose receptor C type 1 (MRC1) codon optimized cell line and uses thereof |
SG195304A1 (en) | 2011-06-10 | 2013-12-30 | Temasek Life Sciences Lab Ltd | Genetic manipulation and expression systems for pucciniomycotina and ustilaginomycotina subphyla |
AU2013225816B2 (en) | 2012-03-02 | 2017-10-26 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Type III Gaucher Disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT62312A (en) * | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
EP0546084A4 (en) * | 1990-08-17 | 1994-10-19 | Univ Boston | Proteases causing abnormal degradation of amyloid -g(b)-protein precursor |
US5292652A (en) * | 1990-10-05 | 1994-03-08 | Athena Neurosciences, Inc. | Amyloidin protease and uses thereof |
AU679675B2 (en) * | 1992-05-11 | 1997-07-10 | Bayer Corporation | Methods for detecting beta amyloid precursor protein processing enzymes |
IL105793A0 (en) * | 1992-05-28 | 1993-09-22 | Lilly Co Eli | Protease and related dna compounds |
WO1996040885A2 (en) * | 1995-06-07 | 1996-12-19 | Athena Neurosciences, Inc. | β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION |
-
1999
- 1999-06-04 EP EP99923674A patent/EP1084240A1/en not_active Withdrawn
- 1999-06-04 WO PCT/FR1999/001326 patent/WO1999064587A1/en not_active Application Discontinuation
- 1999-06-04 KR KR1020007013630A patent/KR20010052499A/en not_active Application Discontinuation
- 1999-06-04 AU AU40455/99A patent/AU4045599A/en not_active Abandoned
- 1999-06-04 CA CA002330242A patent/CA2330242A1/en not_active Abandoned
- 1999-06-04 HU HU0104022A patent/HUP0104022A2/en unknown
- 1999-06-04 IL IL13973999A patent/IL139739A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1084240A1 (en) | 2001-03-21 |
KR20010052499A (en) | 2001-06-25 |
AU4045599A (en) | 1999-12-30 |
WO1999064587A1 (en) | 1999-12-16 |
CA2330242A1 (en) | 1999-12-16 |
WO1999064587A8 (en) | 2001-08-02 |
HUP0104022A2 (en) | 2002-03-28 |
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