JP2003292443A5 - - Google Patents
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- Publication number
- JP2003292443A5 JP2003292443A5 JP2003094873A JP2003094873A JP2003292443A5 JP 2003292443 A5 JP2003292443 A5 JP 2003292443A5 JP 2003094873 A JP2003094873 A JP 2003094873A JP 2003094873 A JP2003094873 A JP 2003094873A JP 2003292443 A5 JP2003292443 A5 JP 2003292443A5
- Authority
- JP
- Japan
- Prior art keywords
- glibenclamide
- oral dosage
- metformin
- solid oral
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960004580 glibenclamide Drugs 0.000 description 54
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 54
- 239000007787 solid Substances 0.000 description 42
- 239000006186 oral dosage form Substances 0.000 description 41
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 34
- 229960003105 metformin Drugs 0.000 description 30
- 239000000203 mixture Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 13
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- 241000282412 Homo Species 0.000 description 8
- 239000002245 particle Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98401781.4 | 1998-07-15 | ||
| EP98401781A EP0974356B1 (en) | 1998-07-15 | 1998-07-15 | Tablets comprising a combination of metformin and glibenclamide |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559876A Division JP2002520371A (ja) | 1998-07-15 | 1999-07-12 | メトホルミンおよびグリベンクラミドの組み合わせを含んでなる固体経口投与形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003292443A JP2003292443A (ja) | 2003-10-15 |
| JP2003292443A5 true JP2003292443A5 (enExample) | 2006-08-24 |
Family
ID=8235441
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559876A Pending JP2002520371A (ja) | 1998-07-15 | 1999-07-12 | メトホルミンおよびグリベンクラミドの組み合わせを含んでなる固体経口投与形態 |
| JP2003094873A Pending JP2003292443A (ja) | 1998-07-15 | 2003-03-31 | メトホルミンおよびグリベンクラミドの組み合わせを含んでなる固体経口投与形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559876A Pending JP2002520371A (ja) | 1998-07-15 | 1999-07-12 | メトホルミンおよびグリベンクラミドの組み合わせを含んでなる固体経口投与形態 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6303146B1 (enExample) |
| EP (4) | EP0974356B1 (enExample) |
| JP (2) | JP2002520371A (enExample) |
| KR (2) | KR20040053177A (enExample) |
| CN (2) | CN1486698A (enExample) |
| AP (1) | AP1450A (enExample) |
| AR (2) | AR013052A1 (enExample) |
| AT (1) | ATE250418T1 (enExample) |
| AU (2) | AU753604B2 (enExample) |
| BR (1) | BR9906600A (enExample) |
| CA (1) | CA2303537C (enExample) |
| DE (1) | DE69818444T2 (enExample) |
| DK (1) | DK0974356T3 (enExample) |
| DZ (1) | DZ2846A1 (enExample) |
| ES (1) | ES2206868T3 (enExample) |
| ID (1) | ID25784A (enExample) |
| MA (1) | MA24930A1 (enExample) |
| MY (1) | MY129552A (enExample) |
| NZ (1) | NZ503248A (enExample) |
| OA (1) | OA11400A (enExample) |
| PT (1) | PT974356E (enExample) |
| RU (2) | RU2226396C2 (enExample) |
| SI (1) | SI0974356T1 (enExample) |
| TW (2) | TWI245632B (enExample) |
| UY (1) | UY25611A1 (enExample) |
| WO (1) | WO2000003742A2 (enExample) |
| ZA (1) | ZA200001159B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| IL149139A0 (en) * | 1999-11-03 | 2002-11-10 | Bristol Myers Squibb Co | Pharmaceutical compositions containing metformin and glyburide |
| US20010036479A1 (en) | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
| FR2816840B1 (fr) | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
| FR2816841B1 (fr) * | 2000-11-22 | 2004-02-06 | Lipha | Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation |
| EP1738751B1 (en) * | 2001-01-12 | 2011-05-11 | Sun Pharma Advanced Research Company Ltd | Spaced drug delivery system |
| FR2825023B1 (fr) * | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
| US7767249B2 (en) * | 2001-06-07 | 2010-08-03 | Hewlett-Packard Development Company, L.P. | Preparation of nanoparticles |
| US20050271737A1 (en) * | 2001-06-07 | 2005-12-08 | Chinea Vanessa I | Application of a bioactive agent to a substrate |
| US8206753B2 (en) * | 2001-06-20 | 2012-06-26 | Metaproteomics, Llc | Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes |
| CN1270724C (zh) * | 2001-07-30 | 2006-08-23 | 三菱制药株式会社 | 餐后高血糖改善剂 |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| ITFI20010230A1 (it) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
| US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| US9045438B2 (en) * | 2002-01-25 | 2015-06-02 | Silanes S.A. De C.V. | Pharmaceutical composition containing glimepiride and metformin hydrochloride |
| ATE536173T1 (de) * | 2002-02-21 | 2011-12-15 | Biovail Lab Int Srl | Formulierungen mit modifizierter freisetzung von mindestens einer form von tramadol |
| US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
| US20030219482A1 (en) * | 2002-03-21 | 2003-11-27 | Chaudhari Sunil Sudhakar | Multiparticulate compositions for once-a-day administration |
| PT1492511E (pt) | 2002-04-09 | 2009-04-09 | Flamel Tech Sa | Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s) |
| CA2480824A1 (fr) | 2002-04-09 | 2003-10-16 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline |
| WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
| US7445796B2 (en) * | 2002-08-19 | 2008-11-04 | L. Perrigo Company | Pharmaceutically active particles of a monomodal particle size distribution and method |
| EP1562607A1 (en) * | 2002-11-15 | 2005-08-17 | Ranbaxy Laboratories, Ltd. | Pharmaceutical dosage forms of biguanide-sulfonylurea combinations |
| FR2853831A1 (fr) * | 2003-03-05 | 2004-10-22 | Usv Ltd | Forme posologique solide a usage oral de metformine et de glyburide et son procede de preparation |
| CN1780642A (zh) * | 2003-04-15 | 2006-05-31 | 中外制药株式会社 | 糖尿病治疗剂 |
| US20060121108A1 (en) * | 2004-12-02 | 2006-06-08 | Prasad C K | System and method for producing a directly compressible, high-potency formulation of metformin hydrochloride |
| CN100341495C (zh) * | 2004-12-29 | 2007-10-10 | 三九医药股份有限公司 | 格列本脲固体分散体、口服组合物及其制备方法 |
| KR100760430B1 (ko) * | 2004-12-31 | 2007-10-04 | 한미약품 주식회사 | 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법 |
| PE20061245A1 (es) * | 2005-03-30 | 2007-01-06 | Generex Pharm Inc | Composiciones para la transmision transmucosa oral de la metformina |
| US8529537B2 (en) * | 2005-08-05 | 2013-09-10 | Kimberly-Clark Worldwide, Inc. | Absorbent article with enclosures |
| MXPA05009633A (es) * | 2005-09-08 | 2007-03-07 | Silanes Sa De Cv Lab | Composicion farmaceutica estable de glimepirida de liberacion inmediata y metformina de liberacion prolongada. |
| EP2452683A3 (en) | 2006-06-26 | 2012-08-22 | Amgen Inc. | Methods for treating atherosclerosis |
| WO2008062273A2 (en) * | 2006-11-20 | 2008-05-29 | Cadila Pharmaceuticals Limited | Solid oral dosage form having antidiabetic drug combination |
| JO3272B1 (ar) | 2007-07-19 | 2018-09-16 | Takeda Pharmaceuticals Co | مستحضر صلب يشمل ألوجليبتين وميتفورمين هيدروكلوريد |
| NZ597885A (en) | 2007-07-26 | 2013-08-30 | Amgen Inc | Modified lecithin-cholesterol acyltransferase enzymes |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| WO2011135106A1 (es) * | 2010-04-26 | 2011-11-03 | Smart Pharma Solutions, S.L | Granulado altamente dispersable para la preparación de formulaciones de sustancias activas de altas dosis y procedimiento de obtención del mismo |
| RU2451506C1 (ru) | 2011-06-02 | 2012-05-27 | Сергей Юрьевич Лешков | Комбинация для лечения сахарного диабета и его осложнений |
| WO2013086443A1 (en) | 2011-12-08 | 2013-06-13 | Amgen Inc. | Agonistic human lcat antigen binding proteins and their use in therapy |
| EP2790729A4 (en) * | 2011-12-12 | 2015-08-12 | Orbis Biosciences Inc | PARTICULATE FORMULATIONS WITH DELAYED RELEASE |
| CN104127424A (zh) * | 2014-07-30 | 2014-11-05 | 沈阳药科大学 | 格列本脲衍生物及其制备方法和应用 |
| CN105030793A (zh) * | 2015-08-25 | 2015-11-11 | 瑞阳制药有限公司 | 二甲双胍格列本脲胶囊及其制备方法 |
| WO2019070109A1 (es) * | 2017-10-03 | 2019-04-11 | Infinite Clinical Research International, S.A. De C.V. | Triconjugado para el tratamiento de diabetes mellitus |
| CN115315426B (zh) | 2020-04-01 | 2023-12-12 | 杭州中美华东制药有限公司 | Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法 |
| EP4130005A4 (en) | 2020-04-01 | 2024-04-24 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | CRYSTALLINE FORM A OF A GLP-1 RECEPTOR AGONIST AND METHOD OF MANUFACTURING THEREOF |
| KR102484756B1 (ko) * | 2020-11-13 | 2023-01-06 | 한국생산기술연구원 | 용해성 증대 및 취급용이성을 갖는 파우더 배지의 과립화 방법 |
| CN113143940A (zh) * | 2020-12-30 | 2021-07-23 | 成都恒瑞制药有限公司 | 一种抗糖尿病药物组合物的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE362704C (de) * | 1921-08-09 | 1922-11-02 | Naamlooze Vennootschap Interna | Vorrichtung zum Senken einer Last, insbesondere eines Rettungsbootes |
| US3174901A (en) | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| US4060634A (en) * | 1973-09-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Rapidly resorbable glibenclamide |
| DE2348334C2 (de) | 1973-09-26 | 1982-11-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs |
| US4916163A (en) | 1985-06-04 | 1990-04-10 | The Upjohn Company | Spray-dried lactose formulation of micronized glyburide |
| DE3833439A1 (de) | 1988-10-01 | 1991-09-12 | Hoechst Ag | Verfahren zur mikronisierung von glibenclamid |
| IE63463B1 (en) * | 1989-02-06 | 1995-04-19 | Zeneca Ltd | Phenylsulphone derivatives |
| GB9016978D0 (en) * | 1990-08-02 | 1990-09-19 | Ici Plc | Acetamide derivatives |
| DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| IT1276130B1 (it) * | 1995-11-14 | 1997-10-27 | Gentili Ist Spa | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
| AU8539398A (en) | 1997-06-18 | 1999-01-04 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
| US6544564B1 (en) * | 2001-11-27 | 2003-04-08 | Michael Donald Farley | Cytotoxic pharmaceutical composition |
-
1998
- 1998-07-15 SI SI9830517T patent/SI0974356T1/xx unknown
- 1998-07-15 ES ES98401781T patent/ES2206868T3/es not_active Expired - Lifetime
- 1998-07-15 AT AT98401781T patent/ATE250418T1/de not_active IP Right Cessation
- 1998-07-15 DE DE69818444T patent/DE69818444T2/de not_active Revoked
- 1998-07-15 EP EP98401781A patent/EP0974356B1/en not_active Revoked
- 1998-07-15 DK DK98401781T patent/DK0974356T3/da active
- 1998-07-15 PT PT98401781T patent/PT974356E/pt unknown
-
1999
- 1999-07-12 CN CNA031092314A patent/CN1486698A/zh active Pending
- 1999-07-12 WO PCT/EP1999/005571 patent/WO2000003742A2/en not_active Ceased
- 1999-07-12 ID IDW20000482D patent/ID25784A/id unknown
- 1999-07-12 EP EP04008415A patent/EP1435240A3/en not_active Ceased
- 1999-07-12 AU AU54179/99A patent/AU753604B2/en not_active Expired
- 1999-07-12 CA CA002303537A patent/CA2303537C/en not_active Expired - Lifetime
- 1999-07-12 EP EP99940114A patent/EP1011684A2/en not_active Ceased
- 1999-07-12 CN CNB998013625A patent/CN1146427C/zh not_active Expired - Lifetime
- 1999-07-12 RU RU2000109583/15A patent/RU2226396C2/ru active
- 1999-07-12 BR BR9906600-9A patent/BR9906600A/pt not_active Application Discontinuation
- 1999-07-12 AP APAP/P/2000/001757A patent/AP1450A/en active
- 1999-07-12 KR KR10-2004-7005583A patent/KR20040053177A/ko not_active Ceased
- 1999-07-12 JP JP2000559876A patent/JP2002520371A/ja active Pending
- 1999-07-12 EP EP10185329A patent/EP2269613A3/en not_active Ceased
- 1999-07-12 NZ NZ503248A patent/NZ503248A/xx not_active IP Right Cessation
- 1999-07-12 KR KR10-2000-7002714A patent/KR100478347B1/ko not_active Expired - Lifetime
- 1999-07-12 RU RU2003126257/15A patent/RU2286788C2/ru active
- 1999-07-13 MA MA25681A patent/MA24930A1/fr unknown
- 1999-07-14 TW TW092113257A patent/TWI245632B/zh not_active IP Right Cessation
- 1999-07-14 US US09/353,141 patent/US6303146B1/en not_active Expired - Lifetime
- 1999-07-14 MY MYPI99002968A patent/MY129552A/en unknown
- 1999-07-14 TW TW088111959A patent/TW555560B/zh not_active IP Right Cessation
- 1999-07-14 DZ DZ990146A patent/DZ2846A1/xx active
- 1999-07-15 UY UY25611A patent/UY25611A1/es not_active Application Discontinuation
- 1999-07-15 AR ARP990103470A patent/AR013052A1/es not_active Application Discontinuation
-
2000
- 2000-03-07 ZA ZA200001159A patent/ZA200001159B/xx unknown
- 2000-03-15 OA OA1200000076A patent/OA11400A/en unknown
-
2002
- 2002-12-27 US US10/329,426 patent/USRE38629E1/en not_active Expired - Lifetime
-
2003
- 2003-03-31 JP JP2003094873A patent/JP2003292443A/ja active Pending
- 2003-11-11 AU AU2003261560A patent/AU2003261560A1/en not_active Abandoned
-
2008
- 2008-04-07 AR ARP080101435A patent/AR065970A2/es not_active Application Discontinuation
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