JP2010538066A5 - - Google Patents

Info

Publication number

JP2010538066A5

JP2010538066A5 JP2010524023A JP2010524023A JP2010538066A5 JP 2010538066 A5 JP2010538066 A5 JP 2010538066A5 JP 2010524023 A JP2010524023 A JP 2010524023A JP 2010524023 A JP2010524023 A JP 2010524023A JP 2010538066 A5 JP2010538066 A5 JP 2010538066A5

Authority

JP

Japan

Prior art keywords

azithromycin

pharmaceutical preparation

less

amount

pharmaceutical

Prior art date

2008-09-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 229960004099 azithromycin Drugs 0.000 claims description 34
• MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims description 34
• 206010000496 acne Diseases 0.000 claims description 17
• 208000002874 Acne Vulgaris Diseases 0.000 claims description 16
• 208000017520 skin disease Diseases 0.000 claims description 10
• 229940079593 drug Drugs 0.000 claims description 6
• 239000003814 drug Substances 0.000 claims description 6
• 230000036470 plasma concentration Effects 0.000 claims description 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 24
• 239000002775 capsule Substances 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 239000007787 solid Substances 0.000 claims 5
• 238000002360 preparation method Methods 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000007909 solid dosage form Substances 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000006186 oral dosage form Substances 0.000 claims 1
• 239000007892 solid unit dosage form Substances 0.000 claims 1
• 239000004098 Tetracycline Substances 0.000 description 7
• 229960002180 tetracycline Drugs 0.000 description 7
• 235000019364 tetracycline Nutrition 0.000 description 7
• 229930101283 tetracycline Natural products 0.000 description 7
• 150000003522 tetracyclines Chemical class 0.000 description 5
• 230000003115 biocidal effect Effects 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 241000894006 Bacteria Species 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 239000003120 macrolide antibiotic agent Substances 0.000 description 2
• 238000001243 protein synthesis Methods 0.000 description 2
• -1 tetracycline compounds Chemical class 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• 230000014616 translation Effects 0.000 description 2
• FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
• 239000004100 Oxytetracycline Substances 0.000 description 1
• 241001303601 Rosacea Species 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 229940041033 macrolides Drugs 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 229960004023 minocycline Drugs 0.000 description 1
• 229940127249 oral antibiotic Drugs 0.000 description 1
• 229960000625 oxytetracycline Drugs 0.000 description 1
• IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
• 235000019366 oxytetracycline Nutrition 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 201000004700 rosacea Diseases 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1