JP2019513706A5 - - Google Patents

Info

Publication number

JP2019513706A5

JP2019513706A5 JP2018549568A JP2018549568A JP2019513706A5 JP 2019513706 A5 JP2019513706 A5 JP 2019513706A5 JP 2018549568 A JP2018549568 A JP 2018549568A JP 2018549568 A JP2018549568 A JP 2018549568A JP 2019513706 A5 JP2019513706 A5 JP 2019513706A5

Authority

JP

Japan

Prior art keywords

cells

pharmaceutical composition

onapristone

methyl

patient

Prior art date

2017-03-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 16
• 210000004027 cell Anatomy 0.000 claims 13
• -1 methyl onapristone Chemical compound 0.000 claims 11
• 229950011093 onapristone Drugs 0.000 claims 11
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 6
• 229960004679 doxorubicin Drugs 0.000 claims 4
• 102000003998 progesterone receptors Human genes 0.000 claims 3
• 108090000468 progesterone receptors Proteins 0.000 claims 3
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 2
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
• 229930012538 Paclitaxel Natural products 0.000 claims 2
• RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
• 229940123237 Taxane Drugs 0.000 claims 2
• 239000008186 active pharmaceutical agent Substances 0.000 claims 2
• RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical compound C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 claims 2
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 2
• 229940043275 anti-HER2 drug Drugs 0.000 claims 2
• 229960000397 bevacizumab Drugs 0.000 claims 2
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
• 229960004316 cisplatin Drugs 0.000 claims 2
• 229960004397 cyclophosphamide Drugs 0.000 claims 2
• 229960003668 docetaxel Drugs 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 229960005167 everolimus Drugs 0.000 claims 2
• 229960002949 fluorouracil Drugs 0.000 claims 2
• 229960005277 gemcitabine Drugs 0.000 claims 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 210000005265 lung cell Anatomy 0.000 claims 2
• 229960001592 paclitaxel Drugs 0.000 claims 2
• 229940046159 pegylated liposomal doxorubicin Drugs 0.000 claims 2
• 210000005267 prostate cell Anatomy 0.000 claims 2
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
• 229960000575 trastuzumab Drugs 0.000 claims 2
• 190000008236 Carboplatin Chemical compound 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
• GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 claims 1
• 229960000853 abiraterone Drugs 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 230000000259 anti-tumor effect Effects 0.000 claims 1
• 229940034982 antineoplastic agent Drugs 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000000601 blood cell Anatomy 0.000 claims 1
• 210000004958 brain cell Anatomy 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 229960004562 carboplatin Drugs 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 230000002254 contraceptive effect Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000005168 endometrial cell Anatomy 0.000 claims 1
• 210000003238 esophagus Anatomy 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 210000003494 hepatocyte Anatomy 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 230000000968 intestinal effect Effects 0.000 claims 1
• 210000003292 kidney cell Anatomy 0.000 claims 1
• 201000010260 leiomyoma Diseases 0.000 claims 1
• 210000004216 mammary stem cell Anatomy 0.000 claims 1
• 206010027191 meningioma Diseases 0.000 claims 1
• 239000002207 metabolite Substances 0.000 claims 1
• 210000004409 osteocyte Anatomy 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000006187 pill Substances 0.000 claims 1
• 239000000186 progesterone Substances 0.000 claims 1
• 229960003387 progesterone Drugs 0.000 claims 1
• 210000004927 skin cell Anatomy 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 239000003826 tablet Substances 0.000 claims 1
• 210000001685 thyroid gland Anatomy 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000001635 urinary tract Anatomy 0.000 claims 1
• 201000007954 uterine fibroid Diseases 0.000 claims 1